LeishMANIAdb
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Regulatory subunit of protein kinase a-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Regulatory subunit of protein kinase a-like protein
Gene product:
regulatory subunit of protein kinase a-like protein
Species:
Leishmania major
UniProt:
Q4Q2R2_LEIMA
TriTrypDb:
LmjF.34.2820 , LMJLV39_340033700 , LMJSD75_340033900
Length:
648

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. yes yes: 4
Pissara et al. yes yes: 12
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 7
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2R2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2R2

Function

Biological processes
Term Name Level Count
GO:0006793 phosphorus metabolic process 3 5
GO:0006796 phosphate-containing compound metabolic process 4 5
GO:0008152 metabolic process 1 5
GO:0009987 cellular process 1 5
GO:0016310 phosphorylation 5 5
GO:0044237 cellular metabolic process 2 5
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 5
GO:0016301 kinase activity 4 5
GO:0016740 transferase activity 2 5
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 291 295 PF00656 0.825
CLV_NRD_NRD_1 172 174 PF00675 0.790
CLV_NRD_NRD_1 316 318 PF00675 0.699
CLV_NRD_NRD_1 461 463 PF00675 0.478
CLV_NRD_NRD_1 477 479 PF00675 0.556
CLV_NRD_NRD_1 49 51 PF00675 0.651
CLV_NRD_NRD_1 586 588 PF00675 0.478
CLV_NRD_NRD_1 59 61 PF00675 0.698
CLV_NRD_NRD_1 63 65 PF00675 0.545
CLV_NRD_NRD_1 73 75 PF00675 0.773
CLV_PCSK_FUR_1 71 75 PF00082 0.710
CLV_PCSK_KEX2_1 172 174 PF00082 0.820
CLV_PCSK_KEX2_1 227 229 PF00082 0.811
CLV_PCSK_KEX2_1 315 317 PF00082 0.695
CLV_PCSK_KEX2_1 461 463 PF00082 0.478
CLV_PCSK_KEX2_1 475 477 PF00082 0.555
CLV_PCSK_KEX2_1 58 60 PF00082 0.681
CLV_PCSK_KEX2_1 586 588 PF00082 0.422
CLV_PCSK_KEX2_1 615 617 PF00082 0.689
CLV_PCSK_KEX2_1 73 75 PF00082 0.797
CLV_PCSK_PC1ET2_1 227 229 PF00082 0.811
CLV_PCSK_PC1ET2_1 475 477 PF00082 0.545
CLV_PCSK_PC1ET2_1 58 60 PF00082 0.719
CLV_PCSK_PC1ET2_1 615 617 PF00082 0.631
CLV_PCSK_PC7_1 168 174 PF00082 0.688
CLV_PCSK_SKI1_1 271 275 PF00082 0.695
CLV_PCSK_SKI1_1 363 367 PF00082 0.551
CLV_PCSK_SKI1_1 465 469 PF00082 0.558
CLV_PCSK_SKI1_1 580 584 PF00082 0.457
CLV_PCSK_SKI1_1 64 68 PF00082 0.715
DEG_SPOP_SBC_1 85 89 PF00917 0.655
DOC_CKS1_1 345 350 PF01111 0.629
DOC_CYCLIN_yCln2_LP_2 41 47 PF00134 0.698
DOC_MAPK_gen_1 144 152 PF00069 0.761
DOC_MAPK_gen_1 21 31 PF00069 0.694
DOC_MAPK_gen_1 353 362 PF00069 0.560
DOC_MAPK_gen_1 475 482 PF00069 0.518
DOC_MAPK_MEF2A_6 144 152 PF00069 0.646
DOC_MAPK_MEF2A_6 24 31 PF00069 0.685
DOC_MAPK_NFAT4_5 24 32 PF00069 0.692
DOC_PP1_RVXF_1 151 158 PF00149 0.703
DOC_PP1_RVXF_1 476 483 PF00149 0.532
DOC_PP2B_LxvP_1 256 259 PF13499 0.759
DOC_PP4_FxxP_1 631 634 PF00568 0.672
DOC_PP4_MxPP_1 229 232 PF00568 0.838
DOC_USP7_MATH_1 112 116 PF00917 0.741
DOC_USP7_MATH_1 450 454 PF00917 0.580
DOC_USP7_MATH_1 490 494 PF00917 0.591
DOC_USP7_MATH_1 86 90 PF00917 0.712
DOC_USP7_MATH_1 97 101 PF00917 0.684
DOC_USP7_UBL2_3 101 105 PF12436 0.780
DOC_USP7_UBL2_3 110 114 PF12436 0.639
DOC_USP7_UBL2_3 349 353 PF12436 0.610
DOC_WW_Pin1_4 194 199 PF00397 0.815
DOC_WW_Pin1_4 221 226 PF00397 0.895
DOC_WW_Pin1_4 227 232 PF00397 0.811
DOC_WW_Pin1_4 344 349 PF00397 0.626
DOC_WW_Pin1_4 625 630 PF00397 0.708
LIG_14-3-3_CanoR_1 175 181 PF00244 0.659
LIG_14-3-3_CanoR_1 216 226 PF00244 0.686
LIG_14-3-3_CanoR_1 326 336 PF00244 0.701
LIG_14-3-3_CanoR_1 340 345 PF00244 0.662
LIG_14-3-3_CanoR_1 429 434 PF00244 0.580
LIG_14-3-3_CanoR_1 451 455 PF00244 0.526
LIG_14-3-3_CanoR_1 461 465 PF00244 0.419
LIG_14-3-3_CanoR_1 586 590 PF00244 0.478
LIG_BIR_II_1 1 5 PF00653 0.660
LIG_BIR_III_2 632 636 PF00653 0.784
LIG_BRCT_BRCA1_1 189 193 PF00533 0.651
LIG_BRCT_BRCA1_1 587 591 PF00533 0.502
LIG_EVH1_1 81 85 PF00568 0.778
LIG_FHA_1 253 259 PF00498 0.725
LIG_FHA_1 389 395 PF00498 0.528
LIG_FHA_1 400 406 PF00498 0.406
LIG_FHA_1 579 585 PF00498 0.457
LIG_FHA_2 367 373 PF00498 0.561
LIG_FHA_2 430 436 PF00498 0.470
LIG_LIR_Apic_2 628 634 PF02991 0.678
LIG_LIR_Gen_1 154 165 PF02991 0.675
LIG_LIR_Gen_1 36 45 PF02991 0.718
LIG_LIR_Gen_1 401 411 PF02991 0.419
LIG_LIR_Gen_1 561 572 PF02991 0.468
LIG_LIR_Gen_1 588 596 PF02991 0.575
LIG_LIR_Gen_1 636 646 PF02991 0.600
LIG_LIR_Nem_3 154 160 PF02991 0.683
LIG_LIR_Nem_3 2 7 PF02991 0.631
LIG_LIR_Nem_3 268 273 PF02991 0.809
LIG_LIR_Nem_3 36 41 PF02991 0.708
LIG_LIR_Nem_3 401 407 PF02991 0.419
LIG_LIR_Nem_3 431 436 PF02991 0.580
LIG_LIR_Nem_3 463 467 PF02991 0.542
LIG_LIR_Nem_3 561 567 PF02991 0.468
LIG_LIR_Nem_3 588 592 PF02991 0.478
LIG_LIR_Nem_3 607 613 PF02991 0.611
LIG_LIR_Nem_3 636 642 PF02991 0.592
LIG_PDZ_Class_3 643 648 PF00595 0.756
LIG_SH2_CRK 38 42 PF00017 0.755
LIG_SH2_CRK 464 468 PF00017 0.545
LIG_SH2_NCK_1 178 182 PF00017 0.656
LIG_SH2_SRC 440 443 PF00017 0.463
LIG_SH2_SRC 509 512 PF00017 0.463
LIG_SH2_STAT3 7 10 PF00017 0.617
LIG_SH2_STAT5 479 482 PF00017 0.524
LIG_SH2_STAT5 509 512 PF00017 0.580
LIG_SH2_STAT5 7 10 PF00017 0.617
LIG_SH3_3 139 145 PF00018 0.730
LIG_SH3_3 342 348 PF00018 0.635
LIG_SH3_3 420 426 PF00018 0.566
LIG_SH3_3 532 538 PF00018 0.478
LIG_SH3_3 79 85 PF00018 0.727
LIG_SUMO_SIM_anti_2 25 30 PF11976 0.539
LIG_SUMO_SIM_anti_2 547 552 PF11976 0.590
LIG_SUMO_SIM_par_1 571 576 PF11976 0.502
LIG_TRAF2_1 183 186 PF00917 0.758
LIG_TRAF2_1 265 268 PF00917 0.764
LIG_TRAF2_1 603 606 PF00917 0.703
LIG_TRAF2_1 66 69 PF00917 0.671
LIG_UBA3_1 27 32 PF00899 0.693
LIG_WRC_WIRS_1 1 6 PF05994 0.763
LIG_WRC_WIRS_1 270 275 PF05994 0.749
MOD_CDK_SPK_2 344 349 PF00069 0.626
MOD_CDK_SPxK_1 221 227 PF00069 0.683
MOD_CDK_SPxxK_3 221 228 PF00069 0.898
MOD_CK1_1 121 127 PF00069 0.819
MOD_CK1_1 252 258 PF00069 0.643
MOD_CK1_1 330 336 PF00069 0.631
MOD_CK1_1 343 349 PF00069 0.610
MOD_CK1_1 585 591 PF00069 0.478
MOD_CK2_1 121 127 PF00069 0.798
MOD_CK2_1 180 186 PF00069 0.764
MOD_CK2_1 239 245 PF00069 0.785
MOD_CK2_1 262 268 PF00069 0.748
MOD_CK2_1 283 289 PF00069 0.876
MOD_CK2_1 505 511 PF00069 0.532
MOD_Cter_Amidation 170 173 PF01082 0.693
MOD_GlcNHglycan 110 113 PF01048 0.835
MOD_GlcNHglycan 120 123 PF01048 0.631
MOD_GlcNHglycan 124 127 PF01048 0.779
MOD_GlcNHglycan 202 205 PF01048 0.907
MOD_GlcNHglycan 221 224 PF01048 0.652
MOD_GlcNHglycan 541 544 PF01048 0.532
MOD_GlcNHglycan 575 578 PF01048 0.539
MOD_GlcNHglycan 618 621 PF01048 0.684
MOD_GSK3_1 108 115 PF00069 0.712
MOD_GSK3_1 117 124 PF00069 0.778
MOD_GSK3_1 176 183 PF00069 0.757
MOD_GSK3_1 217 224 PF00069 0.791
MOD_GSK3_1 258 265 PF00069 0.804
MOD_GSK3_1 340 347 PF00069 0.619
MOD_GSK3_1 366 373 PF00069 0.556
MOD_GSK3_1 578 585 PF00069 0.478
MOD_GSK3_1 95 102 PF00069 0.765
MOD_N-GLC_1 118 123 PF02516 0.849
MOD_N-GLC_1 281 286 PF02516 0.815
MOD_N-GLC_1 399 404 PF02516 0.478
MOD_NEK2_1 15 20 PF00069 0.686
MOD_NEK2_1 180 185 PF00069 0.802
MOD_NEK2_1 234 239 PF00069 0.857
MOD_NEK2_1 365 370 PF00069 0.506
MOD_NEK2_1 466 471 PF00069 0.561
MOD_NEK2_1 482 487 PF00069 0.544
MOD_NEK2_1 638 643 PF00069 0.816
MOD_NEK2_2 266 271 PF00069 0.868
MOD_PIKK_1 181 187 PF00454 0.763
MOD_PIKK_1 289 295 PF00454 0.872
MOD_PIKK_1 347 353 PF00454 0.560
MOD_PIKK_1 388 394 PF00454 0.463
MOD_PK_1 146 152 PF00069 0.698
MOD_PK_1 377 383 PF00069 0.548
MOD_PKA_1 315 321 PF00069 0.708
MOD_PKA_2 210 216 PF00069 0.741
MOD_PKA_2 315 321 PF00069 0.708
MOD_PKA_2 322 328 PF00069 0.703
MOD_PKA_2 428 434 PF00069 0.580
MOD_PKA_2 450 456 PF00069 0.526
MOD_PKA_2 460 466 PF00069 0.419
MOD_PKA_2 585 591 PF00069 0.478
MOD_Plk_1 234 240 PF00069 0.878
MOD_Plk_1 252 258 PF00069 0.798
MOD_Plk_1 330 336 PF00069 0.631
MOD_Plk_1 399 405 PF00069 0.478
MOD_Plk_1 411 417 PF00069 0.478
MOD_Plk_1 505 511 PF00069 0.580
MOD_Plk_1 606 612 PF00069 0.585
MOD_Plk_2-3 262 268 PF00069 0.833
MOD_Plk_2-3 283 289 PF00069 0.671
MOD_Plk_4 377 383 PF00069 0.533
MOD_Plk_4 399 405 PF00069 0.422
MOD_Plk_4 411 417 PF00069 0.425
MOD_Plk_4 505 511 PF00069 0.580
MOD_ProDKin_1 194 200 PF00069 0.817
MOD_ProDKin_1 221 227 PF00069 0.897
MOD_ProDKin_1 344 350 PF00069 0.625
MOD_ProDKin_1 625 631 PF00069 0.711
MOD_SUMO_for_1 66 69 PF00179 0.695
MOD_SUMO_rev_2 539 548 PF00179 0.580
TRG_AP2beta_CARGO_1 268 277 PF09066 0.870
TRG_DiLeu_BaEn_2 302 308 PF01217 0.752
TRG_DiLeu_BaLyEn_6 596 601 PF01217 0.547
TRG_ENDOCYTIC_2 38 41 PF00928 0.721
TRG_ENDOCYTIC_2 464 467 PF00928 0.543
TRG_ENDOCYTIC_2 479 482 PF00928 0.533
TRG_ENDOCYTIC_2 564 567 PF00928 0.468
TRG_ER_diArg_1 172 175 PF00400 0.794
TRG_ER_diArg_1 315 317 PF00400 0.695
TRG_ER_diArg_1 476 478 PF00400 0.566
TRG_ER_diArg_1 71 74 PF00400 0.664
TRG_NES_CRM1_1 151 164 PF08389 0.596
TRG_NES_CRM1_1 374 388 PF08389 0.554
TRG_NES_CRM1_1 559 571 PF08389 0.463
TRG_NLS_MonoCore_2 56 61 PF00514 0.712
TRG_NLS_MonoExtN_4 57 62 PF00514 0.712
TRG_Pf-PMV_PEXEL_1 495 499 PF00026 0.435

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PC94 Leptomonas seymouri 46% 93%
A0A3S7X836 Leishmania donovani 90% 100%
A4HB05 Leishmania braziliensis 64% 100%
A4IA61 Leishmania infantum 89% 100%
E9B573 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS