Regulatory subunit of protein kinase a-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

regulatory subunit of protein kinase a-like protein

Species:

Leishmania major

UniProt:

Q4Q2R2_LEIMA

TriTrypDb:

LmjF.34.2820 , LMJLV39_340033700 , LMJSD75_340033900

Length:

648

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	yes	yes: 4
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2R2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2R2

Function

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Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	5
GO:0006796	phosphate-containing compound metabolic process	4	5
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016310	phosphorylation	5	5
GO:0044237	cellular metabolic process	2	5

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0016301	kinase activity	4	5
GO:0016740	transferase activity	2	5
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	5

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	291	295	PF00656	0.825
CLV_NRD_NRD_1	172	174	PF00675	0.790
CLV_NRD_NRD_1	316	318	PF00675	0.699
CLV_NRD_NRD_1	461	463	PF00675	0.478
CLV_NRD_NRD_1	477	479	PF00675	0.556
CLV_NRD_NRD_1	49	51	PF00675	0.651
CLV_NRD_NRD_1	586	588	PF00675	0.478
CLV_NRD_NRD_1	59	61	PF00675	0.698
CLV_NRD_NRD_1	63	65	PF00675	0.545
CLV_NRD_NRD_1	73	75	PF00675	0.773

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC94	Leptomonas seymouri	46%	93%
A0A3S7X836	Leishmania donovani	90%	100%
A4HB05	Leishmania braziliensis	64%	100%
A4IA61	Leishmania infantum	89%	100%
E9B573	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%

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