Regulatory subunit of protein kinase a-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

regulatory subunit of protein kinase a-like protein

Species:

Leishmania major

UniProt:

Q4Q2R2_LEIMA

TriTrypDb:

LmjF.34.2820 , LMJLV39_340033700 , LMJSD75_340033900

Length:

648

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	yes	yes: 4
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2R2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2R2

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	5
GO:0006796	phosphate-containing compound metabolic process	4	5
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016310	phosphorylation	5	5
GO:0044237	cellular metabolic process	2	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0016301	kinase activity	4	5
GO:0016740	transferase activity	2	5
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	291	295	PF00656	0.825
CLV_NRD_NRD_1	172	174	PF00675	0.790
CLV_NRD_NRD_1	316	318	PF00675	0.699
CLV_NRD_NRD_1	461	463	PF00675	0.478
CLV_NRD_NRD_1	477	479	PF00675	0.556
CLV_NRD_NRD_1	49	51	PF00675	0.651
CLV_NRD_NRD_1	586	588	PF00675	0.478
CLV_NRD_NRD_1	59	61	PF00675	0.698
CLV_NRD_NRD_1	63	65	PF00675	0.545
CLV_NRD_NRD_1	73	75	PF00675	0.773
CLV_PCSK_FUR_1	71	75	PF00082	0.710
CLV_PCSK_KEX2_1	172	174	PF00082	0.820
CLV_PCSK_KEX2_1	227	229	PF00082	0.811
CLV_PCSK_KEX2_1	315	317	PF00082	0.695
CLV_PCSK_KEX2_1	461	463	PF00082	0.478
CLV_PCSK_KEX2_1	475	477	PF00082	0.555
CLV_PCSK_KEX2_1	58	60	PF00082	0.681
CLV_PCSK_KEX2_1	586	588	PF00082	0.422
CLV_PCSK_KEX2_1	615	617	PF00082	0.689
CLV_PCSK_KEX2_1	73	75	PF00082	0.797
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.811
CLV_PCSK_PC1ET2_1	475	477	PF00082	0.545
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.719
CLV_PCSK_PC1ET2_1	615	617	PF00082	0.631
CLV_PCSK_PC7_1	168	174	PF00082	0.688
CLV_PCSK_SKI1_1	271	275	PF00082	0.695
CLV_PCSK_SKI1_1	363	367	PF00082	0.551
CLV_PCSK_SKI1_1	465	469	PF00082	0.558
CLV_PCSK_SKI1_1	580	584	PF00082	0.457
CLV_PCSK_SKI1_1	64	68	PF00082	0.715
DEG_SPOP_SBC_1	85	89	PF00917	0.655
DOC_CKS1_1	345	350	PF01111	0.629
DOC_CYCLIN_yCln2_LP_2	41	47	PF00134	0.698
DOC_MAPK_gen_1	144	152	PF00069	0.761
DOC_MAPK_gen_1	21	31	PF00069	0.694
DOC_MAPK_gen_1	353	362	PF00069	0.560
DOC_MAPK_gen_1	475	482	PF00069	0.518
DOC_MAPK_MEF2A_6	144	152	PF00069	0.646
DOC_MAPK_MEF2A_6	24	31	PF00069	0.685
DOC_MAPK_NFAT4_5	24	32	PF00069	0.692
DOC_PP1_RVXF_1	151	158	PF00149	0.703
DOC_PP1_RVXF_1	476	483	PF00149	0.532
DOC_PP2B_LxvP_1	256	259	PF13499	0.759
DOC_PP4_FxxP_1	631	634	PF00568	0.672
DOC_PP4_MxPP_1	229	232	PF00568	0.838
DOC_USP7_MATH_1	112	116	PF00917	0.741
DOC_USP7_MATH_1	450	454	PF00917	0.580
DOC_USP7_MATH_1	490	494	PF00917	0.591
DOC_USP7_MATH_1	86	90	PF00917	0.712
DOC_USP7_MATH_1	97	101	PF00917	0.684
DOC_USP7_UBL2_3	101	105	PF12436	0.780
DOC_USP7_UBL2_3	110	114	PF12436	0.639
DOC_USP7_UBL2_3	349	353	PF12436	0.610
DOC_WW_Pin1_4	194	199	PF00397	0.815
DOC_WW_Pin1_4	221	226	PF00397	0.895
DOC_WW_Pin1_4	227	232	PF00397	0.811
DOC_WW_Pin1_4	344	349	PF00397	0.626
DOC_WW_Pin1_4	625	630	PF00397	0.708
LIG_14-3-3_CanoR_1	175	181	PF00244	0.659
LIG_14-3-3_CanoR_1	216	226	PF00244	0.686
LIG_14-3-3_CanoR_1	326	336	PF00244	0.701
LIG_14-3-3_CanoR_1	340	345	PF00244	0.662
LIG_14-3-3_CanoR_1	429	434	PF00244	0.580
LIG_14-3-3_CanoR_1	451	455	PF00244	0.526
LIG_14-3-3_CanoR_1	461	465	PF00244	0.419
LIG_14-3-3_CanoR_1	586	590	PF00244	0.478
LIG_BIR_II_1	1	5	PF00653	0.660
LIG_BIR_III_2	632	636	PF00653	0.784
LIG_BRCT_BRCA1_1	189	193	PF00533	0.651
LIG_BRCT_BRCA1_1	587	591	PF00533	0.502
LIG_EVH1_1	81	85	PF00568	0.778
LIG_FHA_1	253	259	PF00498	0.725
LIG_FHA_1	389	395	PF00498	0.528
LIG_FHA_1	400	406	PF00498	0.406
LIG_FHA_1	579	585	PF00498	0.457
LIG_FHA_2	367	373	PF00498	0.561
LIG_FHA_2	430	436	PF00498	0.470
LIG_LIR_Apic_2	628	634	PF02991	0.678
LIG_LIR_Gen_1	154	165	PF02991	0.675
LIG_LIR_Gen_1	36	45	PF02991	0.718
LIG_LIR_Gen_1	401	411	PF02991	0.419
LIG_LIR_Gen_1	561	572	PF02991	0.468
LIG_LIR_Gen_1	588	596	PF02991	0.575
LIG_LIR_Gen_1	636	646	PF02991	0.600
LIG_LIR_Nem_3	154	160	PF02991	0.683
LIG_LIR_Nem_3	2	7	PF02991	0.631
LIG_LIR_Nem_3	268	273	PF02991	0.809
LIG_LIR_Nem_3	36	41	PF02991	0.708
LIG_LIR_Nem_3	401	407	PF02991	0.419
LIG_LIR_Nem_3	431	436	PF02991	0.580
LIG_LIR_Nem_3	463	467	PF02991	0.542
LIG_LIR_Nem_3	561	567	PF02991	0.468
LIG_LIR_Nem_3	588	592	PF02991	0.478
LIG_LIR_Nem_3	607	613	PF02991	0.611
LIG_LIR_Nem_3	636	642	PF02991	0.592
LIG_PDZ_Class_3	643	648	PF00595	0.756
LIG_SH2_CRK	38	42	PF00017	0.755
LIG_SH2_CRK	464	468	PF00017	0.545
LIG_SH2_NCK_1	178	182	PF00017	0.656
LIG_SH2_SRC	440	443	PF00017	0.463
LIG_SH2_SRC	509	512	PF00017	0.463
LIG_SH2_STAT3	7	10	PF00017	0.617
LIG_SH2_STAT5	479	482	PF00017	0.524
LIG_SH2_STAT5	509	512	PF00017	0.580
LIG_SH2_STAT5	7	10	PF00017	0.617
LIG_SH3_3	139	145	PF00018	0.730
LIG_SH3_3	342	348	PF00018	0.635
LIG_SH3_3	420	426	PF00018	0.566
LIG_SH3_3	532	538	PF00018	0.478
LIG_SH3_3	79	85	PF00018	0.727
LIG_SUMO_SIM_anti_2	25	30	PF11976	0.539
LIG_SUMO_SIM_anti_2	547	552	PF11976	0.590
LIG_SUMO_SIM_par_1	571	576	PF11976	0.502
LIG_TRAF2_1	183	186	PF00917	0.758
LIG_TRAF2_1	265	268	PF00917	0.764
LIG_TRAF2_1	603	606	PF00917	0.703
LIG_TRAF2_1	66	69	PF00917	0.671
LIG_UBA3_1	27	32	PF00899	0.693
LIG_WRC_WIRS_1	1	6	PF05994	0.763
LIG_WRC_WIRS_1	270	275	PF05994	0.749
MOD_CDK_SPK_2	344	349	PF00069	0.626
MOD_CDK_SPxK_1	221	227	PF00069	0.683
MOD_CDK_SPxxK_3	221	228	PF00069	0.898
MOD_CK1_1	121	127	PF00069	0.819
MOD_CK1_1	252	258	PF00069	0.643
MOD_CK1_1	330	336	PF00069	0.631
MOD_CK1_1	343	349	PF00069	0.610
MOD_CK1_1	585	591	PF00069	0.478
MOD_CK2_1	121	127	PF00069	0.798
MOD_CK2_1	180	186	PF00069	0.764
MOD_CK2_1	239	245	PF00069	0.785
MOD_CK2_1	262	268	PF00069	0.748
MOD_CK2_1	283	289	PF00069	0.876
MOD_CK2_1	505	511	PF00069	0.532
MOD_Cter_Amidation	170	173	PF01082	0.693
MOD_GlcNHglycan	110	113	PF01048	0.835
MOD_GlcNHglycan	120	123	PF01048	0.631
MOD_GlcNHglycan	124	127	PF01048	0.779
MOD_GlcNHglycan	202	205	PF01048	0.907
MOD_GlcNHglycan	221	224	PF01048	0.652
MOD_GlcNHglycan	541	544	PF01048	0.532
MOD_GlcNHglycan	575	578	PF01048	0.539
MOD_GlcNHglycan	618	621	PF01048	0.684
MOD_GSK3_1	108	115	PF00069	0.712
MOD_GSK3_1	117	124	PF00069	0.778
MOD_GSK3_1	176	183	PF00069	0.757
MOD_GSK3_1	217	224	PF00069	0.791
MOD_GSK3_1	258	265	PF00069	0.804
MOD_GSK3_1	340	347	PF00069	0.619
MOD_GSK3_1	366	373	PF00069	0.556
MOD_GSK3_1	578	585	PF00069	0.478
MOD_GSK3_1	95	102	PF00069	0.765
MOD_N-GLC_1	118	123	PF02516	0.849
MOD_N-GLC_1	281	286	PF02516	0.815
MOD_N-GLC_1	399	404	PF02516	0.478
MOD_NEK2_1	15	20	PF00069	0.686
MOD_NEK2_1	180	185	PF00069	0.802
MOD_NEK2_1	234	239	PF00069	0.857
MOD_NEK2_1	365	370	PF00069	0.506
MOD_NEK2_1	466	471	PF00069	0.561
MOD_NEK2_1	482	487	PF00069	0.544
MOD_NEK2_1	638	643	PF00069	0.816
MOD_NEK2_2	266	271	PF00069	0.868
MOD_PIKK_1	181	187	PF00454	0.763
MOD_PIKK_1	289	295	PF00454	0.872
MOD_PIKK_1	347	353	PF00454	0.560
MOD_PIKK_1	388	394	PF00454	0.463
MOD_PK_1	146	152	PF00069	0.698
MOD_PK_1	377	383	PF00069	0.548
MOD_PKA_1	315	321	PF00069	0.708
MOD_PKA_2	210	216	PF00069	0.741
MOD_PKA_2	315	321	PF00069	0.708
MOD_PKA_2	322	328	PF00069	0.703
MOD_PKA_2	428	434	PF00069	0.580
MOD_PKA_2	450	456	PF00069	0.526
MOD_PKA_2	460	466	PF00069	0.419
MOD_PKA_2	585	591	PF00069	0.478
MOD_Plk_1	234	240	PF00069	0.878
MOD_Plk_1	252	258	PF00069	0.798
MOD_Plk_1	330	336	PF00069	0.631
MOD_Plk_1	399	405	PF00069	0.478
MOD_Plk_1	411	417	PF00069	0.478
MOD_Plk_1	505	511	PF00069	0.580
MOD_Plk_1	606	612	PF00069	0.585
MOD_Plk_2-3	262	268	PF00069	0.833
MOD_Plk_2-3	283	289	PF00069	0.671
MOD_Plk_4	377	383	PF00069	0.533
MOD_Plk_4	399	405	PF00069	0.422
MOD_Plk_4	411	417	PF00069	0.425
MOD_Plk_4	505	511	PF00069	0.580
MOD_ProDKin_1	194	200	PF00069	0.817
MOD_ProDKin_1	221	227	PF00069	0.897
MOD_ProDKin_1	344	350	PF00069	0.625
MOD_ProDKin_1	625	631	PF00069	0.711
MOD_SUMO_for_1	66	69	PF00179	0.695
MOD_SUMO_rev_2	539	548	PF00179	0.580
TRG_AP2beta_CARGO_1	268	277	PF09066	0.870
TRG_DiLeu_BaEn_2	302	308	PF01217	0.752
TRG_DiLeu_BaLyEn_6	596	601	PF01217	0.547
TRG_ENDOCYTIC_2	38	41	PF00928	0.721
TRG_ENDOCYTIC_2	464	467	PF00928	0.543
TRG_ENDOCYTIC_2	479	482	PF00928	0.533
TRG_ENDOCYTIC_2	564	567	PF00928	0.468
TRG_ER_diArg_1	172	175	PF00400	0.794
TRG_ER_diArg_1	315	317	PF00400	0.695
TRG_ER_diArg_1	476	478	PF00400	0.566
TRG_ER_diArg_1	71	74	PF00400	0.664
TRG_NES_CRM1_1	151	164	PF08389	0.596
TRG_NES_CRM1_1	374	388	PF08389	0.554
TRG_NES_CRM1_1	559	571	PF08389	0.463
TRG_NLS_MonoCore_2	56	61	PF00514	0.712
TRG_NLS_MonoExtN_4	57	62	PF00514	0.712
TRG_Pf-PMV_PEXEL_1	495	499	PF00026	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC94	Leptomonas seymouri	46%	93%
A0A3S7X836	Leishmania donovani	90%	100%
A4HB05	Leishmania braziliensis	64%	100%
A4IA61	Leishmania infantum	89%	100%
E9B573	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%