Putative selenocysteine-specific elongation factor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

selenocysteine-specific elongation factor, putative

Species:

Leishmania major

UniProt:

Q4Q2R0_LEIMA

TriTrypDb:

LmjF.34.2840 , LMJLV39_340033900 , LMJSD75_340034100

Length:

678

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2R0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2R0

Function

Biological processes
Term	Name	Level	Count
GO:0001514	selenocysteine incorporation	7	2
GO:0006414	translational elongation	5	2
GO:0006417	regulation of translation	6	2
GO:0006451	translational readthrough	6	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009059	macromolecule biosynthetic process	4	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0009987	cellular process	1	2
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0010608	post-transcriptional regulation of gene expression	6	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0034248	regulation of amide metabolic process	5	2
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051246	regulation of protein metabolic process	5	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0071704	organic substance metabolic process	2	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1901576	organic substance biosynthetic process	3	2
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003676	nucleic acid binding	3	10
GO:0003746	translation elongation factor activity	4	10
GO:0003824	catalytic activity	1	11
GO:0003924	GTPase activity	7	11
GO:0005488	binding	1	11
GO:0005525	GTP binding	5	11
GO:0008135	translation factor activity, RNA binding	3	10
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	11
GO:0019001	guanyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032561	guanyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0045182	translation regulator activity	1	10
GO:0090079	translation regulator activity, nucleic acid binding	2	10
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	573	577	PF00656	0.565
CLV_C14_Caspase3-7	585	589	PF00656	0.616
CLV_C14_Caspase3-7	644	648	PF00656	0.559
CLV_NRD_NRD_1	156	158	PF00675	0.262
CLV_NRD_NRD_1	164	166	PF00675	0.266
CLV_NRD_NRD_1	263	265	PF00675	0.443
CLV_NRD_NRD_1	489	491	PF00675	0.516
CLV_NRD_NRD_1	540	542	PF00675	0.714
CLV_NRD_NRD_1	632	634	PF00675	0.692
CLV_NRD_NRD_1	656	658	PF00675	0.543
CLV_PCSK_FUR_1	633	637	PF00082	0.712
CLV_PCSK_KEX2_1	156	158	PF00082	0.265
CLV_PCSK_KEX2_1	164	166	PF00082	0.276
CLV_PCSK_KEX2_1	489	491	PF00082	0.505
CLV_PCSK_KEX2_1	540	542	PF00082	0.723
CLV_PCSK_KEX2_1	635	637	PF00082	0.714
CLV_PCSK_KEX2_1	656	658	PF00082	0.410
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.265
CLV_PCSK_PC1ET2_1	635	637	PF00082	0.700
CLV_PCSK_SKI1_1	16	20	PF00082	0.327
CLV_PCSK_SKI1_1	210	214	PF00082	0.567
CLV_PCSK_SKI1_1	264	268	PF00082	0.396
CLV_PCSK_SKI1_1	41	45	PF00082	0.247
CLV_PCSK_SKI1_1	424	428	PF00082	0.416
CLV_PCSK_SKI1_1	448	452	PF00082	0.388
CLV_PCSK_SKI1_1	467	471	PF00082	0.519
CLV_PCSK_SKI1_1	605	609	PF00082	0.394
CLV_PCSK_SKI1_1	660	664	PF00082	0.489
DEG_COP1_1	253	260	PF00400	0.500
DEG_Nend_Nbox_1	1	3	PF02207	0.480
DEG_SCF_FBW7_1	579	585	PF00400	0.650
DEG_SPOP_SBC_1	22	26	PF00917	0.462
DOC_CKS1_1	579	584	PF01111	0.653
DOC_CYCLIN_yCln2_LP_2	126	132	PF00134	0.430
DOC_CYCLIN_yCln2_LP_2	422	428	PF00134	0.372
DOC_MAPK_gen_1	164	173	PF00069	0.494
DOC_MAPK_gen_1	495	503	PF00069	0.390
DOC_MAPK_gen_1	540	548	PF00069	0.496
DOC_MAPK_gen_1	562	570	PF00069	0.454
DOC_MAPK_gen_1	600	608	PF00069	0.402
DOC_MAPK_gen_1	656	665	PF00069	0.438
DOC_MAPK_MEF2A_6	164	173	PF00069	0.448
DOC_MAPK_MEF2A_6	41	49	PF00069	0.450
DOC_MAPK_MEF2A_6	562	570	PF00069	0.395
DOC_MAPK_MEF2A_6	600	608	PF00069	0.402
DOC_MAPK_MEF2A_6	656	665	PF00069	0.514
DOC_PP1_RVXF_1	603	609	PF00149	0.372
DOC_PP2B_LxvP_1	364	367	PF13499	0.584
DOC_PP2B_LxvP_1	427	430	PF13499	0.449
DOC_PP4_FxxP_1	272	275	PF00568	0.438
DOC_PP4_FxxP_1	608	611	PF00568	0.414
DOC_PP4_FxxP_1	613	616	PF00568	0.451
DOC_PP4_FxxP_1	655	658	PF00568	0.561
DOC_SPAK_OSR1_1	337	341	PF12202	0.279
DOC_USP7_MATH_1	208	212	PF00917	0.484
DOC_USP7_MATH_1	22	26	PF00917	0.462
DOC_USP7_MATH_1	305	309	PF00917	0.550
DOC_USP7_MATH_1	360	364	PF00917	0.585
DOC_USP7_MATH_1	473	477	PF00917	0.707
DOC_USP7_MATH_1	525	529	PF00917	0.644
DOC_USP7_MATH_1	533	537	PF00917	0.681
DOC_USP7_MATH_1	582	586	PF00917	0.619
DOC_USP7_MATH_1	624	628	PF00917	0.657
DOC_USP7_MATH_1	648	652	PF00917	0.684
DOC_USP7_MATH_1	671	675	PF00917	0.522
DOC_USP7_UBL2_3	634	638	PF12436	0.700
DOC_WW_Pin1_4	141	146	PF00397	0.478
DOC_WW_Pin1_4	32	37	PF00397	0.447
DOC_WW_Pin1_4	578	583	PF00397	0.657
LIG_14-3-3_CanoR_1	310	319	PF00244	0.461
LIG_14-3-3_CanoR_1	392	402	PF00244	0.418
LIG_14-3-3_CanoR_1	41	46	PF00244	0.448
LIG_14-3-3_CanoR_1	636	643	PF00244	0.763
LIG_Actin_WH2_2	119	137	PF00022	0.511
LIG_Actin_WH2_2	194	212	PF00022	0.535
LIG_APCC_ABBAyCdc20_2	553	559	PF00400	0.447
LIG_CtBP_PxDLS_1	275	279	PF00389	0.436
LIG_eIF4E_1	416	422	PF01652	0.344
LIG_FHA_1	107	113	PF00498	0.471
LIG_FHA_1	168	174	PF00498	0.522
LIG_FHA_1	191	197	PF00498	0.532
LIG_FHA_1	239	245	PF00498	0.352
LIG_FHA_1	252	258	PF00498	0.379
LIG_FHA_1	261	267	PF00498	0.549
LIG_FHA_1	397	403	PF00498	0.619
LIG_FHA_1	42	48	PF00498	0.447
LIG_FHA_1	599	605	PF00498	0.398
LIG_FHA_1	62	68	PF00498	0.314
LIG_FHA_1	620	626	PF00498	0.702
LIG_FHA_2	293	299	PF00498	0.522
LIG_FHA_2	392	398	PF00498	0.507
LIG_FHA_2	76	82	PF00498	0.447
LIG_LIR_Apic_2	653	658	PF02991	0.501
LIG_LIR_Gen_1	415	425	PF02991	0.363
LIG_LIR_Gen_1	444	452	PF02991	0.481
LIG_LIR_Gen_1	555	564	PF02991	0.534
LIG_LIR_Nem_3	166	171	PF02991	0.439
LIG_LIR_Nem_3	413	419	PF02991	0.386
LIG_LIR_Nem_3	444	449	PF02991	0.502
LIG_LIR_Nem_3	555	560	PF02991	0.541
LIG_Pex14_2	292	296	PF04695	0.466
LIG_SH2_CRK	327	331	PF00017	0.519
LIG_SH2_CRK	417	421	PF00017	0.358
LIG_SH2_CRK	498	502	PF00017	0.551
LIG_SH2_STAP1	417	421	PF00017	0.358
LIG_SH2_STAT5	353	356	PF00017	0.378
LIG_SH2_STAT5	381	384	PF00017	0.395
LIG_SH2_STAT5	393	396	PF00017	0.475
LIG_SH3_1	405	411	PF00018	0.541
LIG_SH3_3	252	258	PF00018	0.452
LIG_SH3_3	400	406	PF00018	0.491
LIG_SH3_3	566	572	PF00018	0.530
LIG_SH3_3	576	582	PF00018	0.563
LIG_SH3_3	77	83	PF00018	0.447
LIG_SUMO_SIM_anti_2	170	175	PF11976	0.523
LIG_SUMO_SIM_par_1	100	107	PF11976	0.447
LIG_SUMO_SIM_par_1	169	175	PF11976	0.523
LIG_SUMO_SIM_par_1	253	259	PF11976	0.498
LIG_SUMO_SIM_par_1	418	423	PF11976	0.348
LIG_SUMO_SIM_par_1	515	522	PF11976	0.588
LIG_SUMO_SIM_par_1	565	571	PF11976	0.497
LIG_TYR_ITIM	325	330	PF00017	0.512
LIG_UBA3_1	661	667	PF00899	0.495
LIG_ULM_U2AF65_1	164	169	PF00076	0.527
LIG_WRC_WIRS_1	625	630	PF05994	0.664
MOD_CDK_SPxxK_3	141	148	PF00069	0.478
MOD_CK1_1	14	20	PF00069	0.447
MOD_CK1_1	25	31	PF00069	0.447
MOD_CK1_1	304	310	PF00069	0.586
MOD_CK1_1	35	41	PF00069	0.439
MOD_CK1_1	376	382	PF00069	0.554
MOD_CK1_1	395	401	PF00069	0.573
MOD_CK1_1	476	482	PF00069	0.680
MOD_CK1_1	519	525	PF00069	0.609
MOD_CK1_1	627	633	PF00069	0.669
MOD_CK1_1	637	643	PF00069	0.557
MOD_CK2_1	208	214	PF00069	0.478
MOD_CK2_1	292	298	PF00069	0.513
MOD_CK2_1	47	53	PF00069	0.527
MOD_CK2_1	671	677	PF00069	0.641
MOD_GlcNHglycan	13	16	PF01048	0.247
MOD_GlcNHglycan	210	213	PF01048	0.499
MOD_GlcNHglycan	303	306	PF01048	0.425
MOD_GlcNHglycan	307	310	PF01048	0.497
MOD_GlcNHglycan	378	381	PF01048	0.534
MOD_GlcNHglycan	477	481	PF01048	0.726
MOD_GlcNHglycan	49	52	PF01048	0.247
MOD_GlcNHglycan	527	530	PF01048	0.664
MOD_GlcNHglycan	535	538	PF01048	0.652
MOD_GlcNHglycan	629	632	PF01048	0.712
MOD_GlcNHglycan	644	647	PF01048	0.672
MOD_GlcNHglycan	650	653	PF01048	0.621
MOD_GlcNHglycan	673	676	PF01048	0.629
MOD_GSK3_1	163	170	PF00069	0.458
MOD_GSK3_1	208	215	PF00069	0.482
MOD_GSK3_1	21	28	PF00069	0.478
MOD_GSK3_1	301	308	PF00069	0.495
MOD_GSK3_1	343	350	PF00069	0.370
MOD_GSK3_1	37	44	PF00069	0.447
MOD_GSK3_1	391	398	PF00069	0.571
MOD_GSK3_1	472	479	PF00069	0.695
MOD_GSK3_1	578	585	PF00069	0.732
MOD_GSK3_1	594	601	PF00069	0.530
MOD_GSK3_1	84	91	PF00069	0.423
MOD_N-GLC_1	360	365	PF02516	0.590
MOD_N-GLC_2	445	447	PF02516	0.408
MOD_NEK2_1	163	168	PF00069	0.447
MOD_NEK2_1	23	28	PF00069	0.461
MOD_NEK2_1	240	245	PF00069	0.348
MOD_NEK2_1	260	265	PF00069	0.231
MOD_NEK2_1	312	317	PF00069	0.418
MOD_NEK2_1	338	343	PF00069	0.400
MOD_NEK2_1	451	456	PF00069	0.449
MOD_NEK2_1	47	52	PF00069	0.447
MOD_NEK2_1	598	603	PF00069	0.426
MOD_NEK2_1	88	93	PF00069	0.447
MOD_NEK2_2	235	240	PF00069	0.366
MOD_NEK2_2	650	655	PF00069	0.434
MOD_PIKK_1	313	319	PF00454	0.491
MOD_PIKK_1	35	41	PF00454	0.461
MOD_PIKK_1	61	67	PF00454	0.411
MOD_PKA_1	634	640	PF00069	0.593
MOD_PKA_2	163	169	PF00069	0.512
MOD_PKA_2	391	397	PF00069	0.394
MOD_PKB_1	165	173	PF00069	0.461
MOD_Plk_1	360	366	PF00069	0.661
MOD_Plk_1	52	58	PF00069	0.550
MOD_Plk_1	594	600	PF00069	0.539
MOD_Plk_1	61	67	PF00069	0.444
MOD_Plk_4	235	241	PF00069	0.364
MOD_Plk_4	251	257	PF00069	0.380
MOD_Plk_4	292	298	PF00069	0.520
MOD_Plk_4	343	349	PF00069	0.366
MOD_Plk_4	430	436	PF00069	0.456
MOD_Plk_4	624	630	PF00069	0.661
MOD_Plk_4	650	656	PF00069	0.494
MOD_Plk_4	75	81	PF00069	0.447
MOD_Plk_4	84	90	PF00069	0.447
MOD_ProDKin_1	141	147	PF00069	0.478
MOD_ProDKin_1	32	38	PF00069	0.447
MOD_ProDKin_1	578	584	PF00069	0.656
TRG_DiLeu_BaEn_2	558	564	PF01217	0.413
TRG_ENDOCYTIC_2	224	227	PF00928	0.489
TRG_ENDOCYTIC_2	327	330	PF00928	0.515
TRG_ENDOCYTIC_2	416	419	PF00928	0.347
TRG_ENDOCYTIC_2	498	501	PF00928	0.543
TRG_ER_diArg_1	163	165	PF00400	0.461
TRG_ER_diArg_1	324	327	PF00400	0.410
TRG_ER_diArg_1	488	490	PF00400	0.523
TRG_ER_diArg_1	655	657	PF00400	0.360
TRG_NLS_MonoCore_2	632	637	PF00514	0.750
TRG_NLS_MonoExtC_3	633	638	PF00514	0.743
TRG_NLS_MonoExtN_4	633	639	PF00514	0.712
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.327
TRG_Pf-PMV_PEXEL_1	499	504	PF00026	0.377

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZH5	Leptomonas seymouri	66%	96%
A0A1X0PAN1	Trypanosomatidae	49%	100%
A0A3Q8IIB7	Leishmania donovani	93%	100%
A0A3S5IRQ8	Trypanosoma rangeli	50%	100%
A0A3S7WV40	Leishmania donovani	27%	100%
A4H9I5	Leishmania braziliensis	25%	100%
A4HB07	Leishmania braziliensis	79%	100%
A4IA63	Leishmania infantum	93%	100%
C9ZM43	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AGQ3	Leishmania infantum	27%	100%
E9ARL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B575	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
P57772	Homo sapiens	35%	100%
Q4QDW8	Leishmania major	25%	100%
Q9JHW4	Mus musculus	36%	100%
V5BQE1	Trypanosoma cruzi	48%	100%