Serine O-acetyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine acetyltransferase

Species:

Leishmania major

UniProt:

Q4Q2Q9_LEIMA

TriTrypDb:

LmjF.34.2850 , LMJLV39_340034000 , LMJSD75_340034200

Length:

411

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2Q9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2Q9

Function

Biological processes
Term	Name	Level	Count
GO:0000096	sulfur amino acid metabolic process	4	2
GO:0000097	sulfur amino acid biosynthetic process	5	2
GO:0006082	organic acid metabolic process	3	2
GO:0006520	amino acid metabolic process	3	2
GO:0006534	cysteine metabolic process	5	2
GO:0006535	cysteine biosynthetic process from serine	7	2
GO:0006563	L-serine metabolic process	6	2
GO:0006790	sulfur compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008652	amino acid biosynthetic process	4	2
GO:0009058	biosynthetic process	2	2
GO:0009069	serine family amino acid metabolic process	5	2
GO:0009070	serine family amino acid biosynthetic process	6	2
GO:0009987	cellular process	1	2
GO:0016053	organic acid biosynthetic process	4	2
GO:0019344	cysteine biosynthetic process	6	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044272	sulfur compound biosynthetic process	4	2
GO:0044281	small molecule metabolic process	2	2
GO:0044283	small molecule biosynthetic process	3	2
GO:0046394	carboxylic acid biosynthetic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901566	organonitrogen compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2
GO:1901605	alpha-amino acid metabolic process	4	2
GO:1901607	alpha-amino acid biosynthetic process	5	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0008374	O-acyltransferase activity	5	6
GO:0009001	serine O-acetyltransferase activity	7	6
GO:0016407	acetyltransferase activity	5	6
GO:0016412	serine O-acyltransferase activity	6	6
GO:0016413	O-acetyltransferase activity	6	6
GO:0016740	transferase activity	2	7
GO:0016746	acyltransferase activity	3	7
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	201	203	PF00675	0.475
CLV_PCSK_KEX2_1	2	4	PF00082	0.519
CLV_PCSK_KEX2_1	200	202	PF00082	0.496
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.519
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.496
CLV_PCSK_SKI1_1	100	104	PF00082	0.670
CLV_PCSK_SKI1_1	119	123	PF00082	0.481
CLV_PCSK_SKI1_1	272	276	PF00082	0.424
CLV_PCSK_SKI1_1	401	405	PF00082	0.624
CLV_PCSK_SKI1_1	8	12	PF00082	0.525
DEG_APCC_DBOX_1	28	36	PF00400	0.576
DEG_APCC_DBOX_1	7	15	PF00400	0.584
DEG_Nend_UBRbox_1	1	4	PF02207	0.529
DOC_PP2B_LxvP_1	264	267	PF13499	0.399
DOC_USP7_MATH_1	127	131	PF00917	0.707
DOC_WW_Pin1_4	235	240	PF00397	0.449
DOC_WW_Pin1_4	55	60	PF00397	0.619
LIG_14-3-3_CanoR_1	119	124	PF00244	0.733
LIG_14-3-3_CanoR_1	29	33	PF00244	0.526
LIG_APCC_ABBA_1	87	92	PF00400	0.510
LIG_Clathr_ClatBox_1	125	129	PF01394	0.713
LIG_FHA_1	120	126	PF00498	0.697
LIG_FHA_1	182	188	PF00498	0.724
LIG_FHA_1	206	212	PF00498	0.442
LIG_FHA_1	269	275	PF00498	0.462
LIG_FHA_1	300	306	PF00498	0.420
LIG_FHA_1	307	313	PF00498	0.411
LIG_FHA_2	109	115	PF00498	0.695
LIG_FHA_2	222	228	PF00498	0.405
LIG_FHA_2	280	286	PF00498	0.445
LIG_FHA_2	363	369	PF00498	0.550
LIG_FHA_2	58	64	PF00498	0.577
LIG_LIR_Gen_1	81	89	PF02991	0.537
LIG_LIR_Nem_3	317	322	PF02991	0.411
LIG_LIR_Nem_3	40	46	PF02991	0.404
LIG_LIR_Nem_3	81	87	PF02991	0.458
LIG_LIR_Nem_3	99	105	PF02991	0.606
LIG_LYPXL_yS_3	246	249	PF13949	0.409
LIG_PDZ_Class_1	406	411	PF00595	0.608
LIG_Pex14_2	43	47	PF04695	0.446
LIG_SH2_CRK	319	323	PF00017	0.421
LIG_SH2_GRB2like	355	358	PF00017	0.512
LIG_SH2_SRC	355	358	PF00017	0.512
LIG_SH2_STAP1	355	359	PF00017	0.512
LIG_SH2_STAT5	44	47	PF00017	0.431
LIG_SH2_STAT5	84	87	PF00017	0.457
LIG_SH3_1	340	346	PF00018	0.555
LIG_SH3_3	340	346	PF00018	0.555
LIG_SH3_3	392	398	PF00018	0.636
LIG_SH3_3	42	48	PF00018	0.452
LIG_SH3_3	98	104	PF00018	0.627
LIG_SUMO_SIM_anti_2	122	127	PF11976	0.715
LIG_TRAF2_1	151	154	PF00917	0.673
LIG_TYR_ITIM	244	249	PF00017	0.430
LIG_WRC_WIRS_1	23	28	PF05994	0.689
MOD_CK1_1	108	114	PF00069	0.633
MOD_CK1_1	130	136	PF00069	0.736
MOD_CK1_1	170	176	PF00069	0.765
MOD_CK1_1	237	243	PF00069	0.451
MOD_CK1_1	328	334	PF00069	0.603
MOD_CK1_1	55	61	PF00069	0.544
MOD_CK2_1	108	114	PF00069	0.703
MOD_CK2_1	148	154	PF00069	0.573
MOD_CK2_1	221	227	PF00069	0.367
MOD_CK2_1	235	241	PF00069	0.411
MOD_CK2_1	362	368	PF00069	0.550
MOD_CK2_1	57	63	PF00069	0.623
MOD_GlcNHglycan	172	175	PF01048	0.643
MOD_GlcNHglycan	189	192	PF01048	0.508
MOD_GlcNHglycan	385	388	PF01048	0.386
MOD_GlcNHglycan	407	411	PF01048	0.612
MOD_GSK3_1	104	111	PF00069	0.616
MOD_GSK3_1	163	170	PF00069	0.760
MOD_GSK3_1	18	25	PF00069	0.645
MOD_GSK3_1	268	275	PF00069	0.429
MOD_GSK3_1	328	335	PF00069	0.604
MOD_GSK3_1	48	55	PF00069	0.525
MOD_N-GLC_1	105	110	PF02516	0.648
MOD_N-GLC_1	187	192	PF02516	0.494
MOD_N-GLC_1	268	273	PF02516	0.435
MOD_NEK2_1	105	110	PF00069	0.641
MOD_NEK2_1	155	160	PF00069	0.773
MOD_NEK2_2	28	33	PF00069	0.592
MOD_PIKK_1	105	111	PF00454	0.620
MOD_PIKK_1	78	84	PF00454	0.448
MOD_PKA_2	130	136	PF00069	0.602
MOD_PKA_2	181	187	PF00069	0.532
MOD_PKA_2	28	34	PF00069	0.587
MOD_PKA_2	362	368	PF00069	0.550
MOD_PKB_1	161	169	PF00069	0.784
MOD_Plk_1	19	25	PF00069	0.561
MOD_Plk_1	268	274	PF00069	0.431
MOD_Plk_1	314	320	PF00069	0.336
MOD_Plk_1	367	373	PF00069	0.550
MOD_Plk_2-3	63	69	PF00069	0.426
MOD_Plk_4	121	127	PF00069	0.630
MOD_Plk_4	314	320	PF00069	0.414
MOD_Plk_4	350	356	PF00069	0.512
MOD_Plk_4	63	69	PF00069	0.501
MOD_ProDKin_1	235	241	PF00069	0.447
MOD_ProDKin_1	55	61	PF00069	0.624
MOD_SUMO_rev_2	328	335	PF00179	0.550
MOD_SUMO_rev_2	92	102	PF00179	0.613
TRG_DiLeu_BaEn_1	63	68	PF01217	0.549
TRG_ENDOCYTIC_2	246	249	PF00928	0.409
TRG_ENDOCYTIC_2	319	322	PF00928	0.394
TRG_ENDOCYTIC_2	44	47	PF00928	0.393
TRG_ENDOCYTIC_2	84	87	PF00928	0.457
TRG_ER_diArg_1	161	164	PF00400	0.782
TRG_NES_CRM1_1	77	92	PF08389	0.423
TRG_Pf-PMV_PEXEL_1	272	276	PF00026	0.438
TRG_Pf-PMV_PEXEL_1	36	40	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3B6	Leptomonas seymouri	69%	100%
A0A1X0P9S3	Trypanosomatidae	47%	100%
A0A3Q8IFQ2	Leishmania donovani	93%	100%
A4IA64	Leishmania infantum	93%	100%
E9B576	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%