PNPLA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

patatin-like phospholipase, putative

Species:

Leishmania major

UniProt:

Q4Q2Q3_LEIMA

TriTrypDb:

LmjF.34.2910 , LMJLV39_340034400 , LMJSD75_340034700

Length:

432

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005811	lipid droplet	5	2
GO:0016020	membrane	2	10
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q2Q3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2Q3

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	13
GO:0006638	neutral lipid metabolic process	4	2
GO:0006639	acylglycerol metabolic process	5	2
GO:0006641	triglyceride metabolic process	6	2
GO:0008152	metabolic process	1	13
GO:0009056	catabolic process	2	13
GO:0009987	cellular process	1	2
GO:0016042	lipid catabolic process	4	13
GO:0019433	triglyceride catabolic process	7	2
GO:0042592	homeostatic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	13
GO:0044242	cellular lipid catabolic process	4	2
GO:0044248	cellular catabolic process	3	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0046461	neutral lipid catabolic process	5	2
GO:0046464	acylglycerol catabolic process	6	2
GO:0046486	glycerolipid metabolic process	4	2
GO:0046503	glycerolipid catabolic process	5	2
GO:0048878	chemical homeostasis	4	2
GO:0055088	lipid homeostasis	5	2
GO:0065007	biological regulation	1	2
GO:0065008	regulation of biological quality	2	2
GO:0071704	organic substance metabolic process	2	13
GO:1901575	organic substance catabolic process	3	13

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0004806	triglyceride lipase activity	5	2
GO:0016298	lipase activity	4	2
GO:0016787	hydrolase activity	2	13
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0052689	carboxylic ester hydrolase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.210
CLV_C14_Caspase3-7	277	281	PF00656	0.413
CLV_NRD_NRD_1	400	402	PF00675	0.521
CLV_NRD_NRD_1	423	425	PF00675	0.477
CLV_PCSK_KEX2_1	423	425	PF00082	0.492
CLV_PCSK_KEX2_1	73	75	PF00082	0.483
CLV_PCSK_PC1ET2_1	73	75	PF00082	0.489
CLV_PCSK_SKI1_1	123	127	PF00082	0.543
CLV_PCSK_SKI1_1	146	150	PF00082	0.562
CLV_PCSK_SKI1_1	283	287	PF00082	0.623
CLV_PCSK_SKI1_1	336	340	PF00082	0.359
CLV_PCSK_SKI1_1	364	368	PF00082	0.368
DOC_CDC14_PxL_1	412	420	PF14671	0.712
DOC_MAPK_gen_1	283	291	PF00069	0.454
DOC_MAPK_gen_1	383	393	PF00069	0.585
DOC_MAPK_MEF2A_6	315	324	PF00069	0.375
DOC_MAPK_MEF2A_6	35	42	PF00069	0.390
DOC_MAPK_MEF2A_6	386	395	PF00069	0.506
DOC_PP1_RVXF_1	362	368	PF00149	0.598
DOC_PP1_RVXF_1	71	78	PF00149	0.280
DOC_PP2B_LxvP_1	247	250	PF13499	0.307
DOC_PP2B_LxvP_1	276	279	PF13499	0.404
DOC_USP7_MATH_1	8	12	PF00917	0.568
DOC_USP7_UBL2_3	398	402	PF12436	0.719
DOC_WW_Pin1_4	211	216	PF00397	0.294
DOC_WW_Pin1_4	3	8	PF00397	0.520
DOC_WW_Pin1_4	416	421	PF00397	0.689
DOC_WW_Pin1_4	425	430	PF00397	0.707
LIG_14-3-3_CanoR_1	112	116	PF00244	0.289
LIG_14-3-3_CanoR_1	167	173	PF00244	0.313
LIG_14-3-3_CanoR_1	354	360	PF00244	0.594
LIG_14-3-3_CanoR_1	401	411	PF00244	0.566
LIG_14-3-3_CanoR_1	423	427	PF00244	0.567
LIG_14-3-3_CanoR_1	67	75	PF00244	0.291
LIG_Actin_WH2_2	122	139	PF00022	0.349
LIG_APCC_ABBA_1	320	325	PF00400	0.368
LIG_BIR_II_1	1	5	PF00653	0.543
LIG_BRCT_BRCA1_1	112	116	PF00533	0.338
LIG_BRCT_BRCA1_1	381	385	PF00533	0.602
LIG_deltaCOP1_diTrp_1	31	42	PF00928	0.449
LIG_EH1_1	303	311	PF00400	0.436
LIG_FHA_1	124	130	PF00498	0.294
LIG_FHA_1	212	218	PF00498	0.296
LIG_FHA_1	220	226	PF00498	0.285
LIG_FHA_1	354	360	PF00498	0.653
LIG_FHA_2	125	131	PF00498	0.210
LIG_FHA_2	15	21	PF00498	0.571
LIG_IRF3_LxIS_1	322	329	PF10401	0.472
LIG_LIR_Gen_1	113	124	PF02991	0.286
LIG_LIR_Gen_1	173	183	PF02991	0.289
LIG_LIR_Gen_1	295	305	PF02991	0.414
LIG_LIR_Gen_1	92	103	PF02991	0.318
LIG_LIR_Nem_3	113	119	PF02991	0.297
LIG_LIR_Nem_3	170	175	PF02991	0.281
LIG_LIR_Nem_3	243	247	PF02991	0.353
LIG_LIR_Nem_3	295	300	PF02991	0.432
LIG_LIR_Nem_3	303	308	PF02991	0.356
LIG_LIR_Nem_3	345	349	PF02991	0.594
LIG_LIR_Nem_3	382	388	PF02991	0.549
LIG_LIR_Nem_3	92	98	PF02991	0.304
LIG_MYND_1	416	420	PF01753	0.678
LIG_PCNA_yPIPBox_3	377	388	PF02747	0.651
LIG_Pex14_1	47	51	PF04695	0.271
LIG_Pex14_2	240	244	PF04695	0.314
LIG_Pex14_2	48	52	PF04695	0.335
LIG_SH2_CRK	175	179	PF00017	0.377
LIG_SH2_CRK	255	259	PF00017	0.382
LIG_SH2_CRK	95	99	PF00017	0.362
LIG_SH2_NCK_1	57	61	PF00017	0.377
LIG_SH2_PTP2	313	316	PF00017	0.410
LIG_SH2_PTP2	323	326	PF00017	0.369
LIG_SH2_SRC	297	300	PF00017	0.440
LIG_SH2_STAT5	12	15	PF00017	0.523
LIG_SH2_STAT5	124	127	PF00017	0.271
LIG_SH2_STAT5	229	232	PF00017	0.367
LIG_SH2_STAT5	269	272	PF00017	0.323
LIG_SH2_STAT5	297	300	PF00017	0.437
LIG_SH2_STAT5	313	316	PF00017	0.302
LIG_SH2_STAT5	323	326	PF00017	0.347
LIG_SH2_STAT5	51	54	PF00017	0.362
LIG_SH2_STAT5	69	72	PF00017	0.249
LIG_SH3_3	189	195	PF00018	0.272
LIG_SH3_3	236	242	PF00018	0.397
LIG_SH3_3	384	390	PF00018	0.596
LIG_SUMO_SIM_par_1	218	226	PF11976	0.323
LIG_SUMO_SIM_par_1	355	361	PF11976	0.594
LIG_TYR_ITIM	55	60	PF00017	0.294
LIG_WRC_WIRS_1	169	174	PF05994	0.362
MOD_CDK_SPK_2	211	216	PF00069	0.320
MOD_CDK_SPxxK_3	416	423	PF00069	0.690
MOD_CDK_SPxxK_3	425	432	PF00069	0.734
MOD_CK1_1	11	17	PF00069	0.521
MOD_CK1_1	170	176	PF00069	0.361
MOD_CK1_1	211	217	PF00069	0.330
MOD_CK1_1	221	227	PF00069	0.289
MOD_CK1_1	3	9	PF00069	0.568
MOD_CK1_1	358	364	PF00069	0.578
MOD_CK1_1	369	375	PF00069	0.615
MOD_CK1_1	379	385	PF00069	0.619
MOD_CK1_1	396	402	PF00069	0.651
MOD_CK2_1	197	203	PF00069	0.362
MOD_CK2_1	293	299	PF00069	0.444
MOD_CK2_1	369	375	PF00069	0.674
MOD_Cter_Amidation	399	402	PF01082	0.499
MOD_Cter_Amidation	71	74	PF01082	0.491
MOD_GlcNHglycan	104	107	PF01048	0.501
MOD_GlcNHglycan	150	153	PF01048	0.562
MOD_GlcNHglycan	225	228	PF01048	0.533
MOD_GlcNHglycan	271	274	PF01048	0.553
MOD_GlcNHglycan	406	409	PF01048	0.499
MOD_GlcNHglycan	61	64	PF01048	0.502
MOD_GlcNHglycan	80	83	PF01048	0.463
MOD_GlcNHglycan	91	94	PF01048	0.461
MOD_GSK3_1	163	170	PF00069	0.302
MOD_GSK3_1	178	185	PF00069	0.257
MOD_GSK3_1	219	226	PF00069	0.311
MOD_GSK3_1	36	43	PF00069	0.328
MOD_GSK3_1	366	373	PF00069	0.657
MOD_GSK3_1	8	15	PF00069	0.539
MOD_GSK3_1	85	92	PF00069	0.317
MOD_N-GLC_1	211	216	PF02516	0.562
MOD_NEK2_1	168	173	PF00069	0.324
MOD_NEK2_1	182	187	PF00069	0.210
MOD_NEK2_1	326	331	PF00069	0.413
MOD_NEK2_1	353	358	PF00069	0.602
MOD_NEK2_1	393	398	PF00069	0.678
MOD_NEK2_1	59	64	PF00069	0.320
MOD_NEK2_1	85	90	PF00069	0.320
MOD_NEK2_2	111	116	PF00069	0.362
MOD_PKA_2	111	117	PF00069	0.280
MOD_PKA_2	178	184	PF00069	0.373
MOD_PKA_2	353	359	PF00069	0.637
MOD_PKA_2	376	382	PF00069	0.588
MOD_PKA_2	422	428	PF00069	0.647
MOD_PKA_2	75	81	PF00069	0.348
MOD_Plk_1	218	224	PF00069	0.388
MOD_Plk_1	231	237	PF00069	0.378
MOD_Plk_1	324	330	PF00069	0.238
MOD_Plk_1	36	42	PF00069	0.300
MOD_Plk_4	111	117	PF00069	0.280
MOD_Plk_4	156	162	PF00069	0.346
MOD_Plk_4	178	184	PF00069	0.338
MOD_Plk_4	240	246	PF00069	0.335
MOD_Plk_4	293	299	PF00069	0.438
MOD_ProDKin_1	211	217	PF00069	0.294
MOD_ProDKin_1	3	9	PF00069	0.521
MOD_ProDKin_1	416	422	PF00069	0.686
MOD_ProDKin_1	425	431	PF00069	0.713
MOD_SUMO_for_1	196	199	PF00179	0.362
TRG_DiLeu_BaEn_1	307	312	PF01217	0.362
TRG_DiLeu_BaLyEn_6	164	169	PF01217	0.354
TRG_DiLeu_BaLyEn_6	280	285	PF01217	0.402
TRG_DiLeu_BaLyEn_6	361	366	PF01217	0.567
TRG_ENDOCYTIC_2	175	178	PF00928	0.293
TRG_ENDOCYTIC_2	255	258	PF00928	0.322
TRG_ENDOCYTIC_2	263	266	PF00928	0.265
TRG_ENDOCYTIC_2	297	300	PF00928	0.461
TRG_ENDOCYTIC_2	323	326	PF00928	0.331
TRG_ENDOCYTIC_2	350	353	PF00928	0.566
TRG_ENDOCYTIC_2	57	60	PF00928	0.377
TRG_ENDOCYTIC_2	95	98	PF00928	0.343
TRG_ER_diArg_1	235	238	PF00400	0.398
TRG_ER_diArg_1	74	77	PF00400	0.285
TRG_Pf-PMV_PEXEL_1	283	287	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	347	351	PF00026	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P509	Leptomonas seymouri	73%	100%
A0A0S4IY58	Bodo saltans	35%	100%
A0A0S4J309	Bodo saltans	38%	92%
A0A1X0P9X6	Trypanosomatidae	43%	100%
A0A3S5H7X3	Leishmania donovani	93%	100%
A0A422N4J2	Trypanosoma rangeli	40%	100%
A4HB10	Leishmania braziliensis	80%	100%
A4IA67	Leishmania infantum	93%	100%
C9ZM39	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9B580	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5DLV7	Trypanosoma cruzi	40%	100%