Thioredoxin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Thioredoxin

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2Q1_LEIMA

TriTrypDb:

LmjF.34.2930 , LMJLV39_340034600 , LMJSD75_340034900

Length:

190

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2Q1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2Q1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	81	83	PF00675	0.569
CLV_PCSK_SKI1_1	12	16	PF00082	0.574
CLV_PCSK_SKI1_1	127	131	PF00082	0.384
CLV_PCSK_SKI1_1	174	178	PF00082	0.402
CLV_PCSK_SKI1_1	184	188	PF00082	0.507
CLV_PCSK_SKI1_1	4	8	PF00082	0.558
DEG_Nend_Nbox_1	1	3	PF02207	0.597
DEG_SPOP_SBC_1	62	66	PF00917	0.447
DEG_SPOP_SBC_1	90	94	PF00917	0.574
DOC_MAPK_gen_1	44	52	PF00069	0.414
DOC_MAPK_MEF2A_6	44	52	PF00069	0.434
DOC_USP7_MATH_1	61	65	PF00917	0.652
DOC_USP7_MATH_1	72	76	PF00917	0.721
DOC_USP7_MATH_1	78	82	PF00917	0.664
DOC_USP7_UBL2_3	12	16	PF12436	0.615
DOC_WW_Pin1_4	68	73	PF00397	0.689
LIG_14-3-3_CanoR_1	109	118	PF00244	0.446
LIG_14-3-3_CanoR_1	4	10	PF00244	0.583
LIG_BRCT_BRCA1_1	150	154	PF00533	0.472
LIG_eIF4E_1	148	154	PF01652	0.415
LIG_FHA_1	148	154	PF00498	0.379
LIG_FHA_1	166	172	PF00498	0.412
LIG_FHA_1	43	49	PF00498	0.427
LIG_FHA_1	98	104	PF00498	0.639
LIG_FHA_2	21	27	PF00498	0.609
LIG_LIR_Gen_1	38	43	PF02991	0.408
LIG_LIR_Gen_1	5	14	PF02991	0.601
LIG_LIR_Nem_3	38	42	PF02991	0.393
LIG_LIR_Nem_3	5	9	PF02991	0.550
LIG_Pex14_2	2	6	PF04695	0.596
LIG_SH2_CRK	161	165	PF00017	0.531
LIG_SH2_NCK_1	25	29	PF00017	0.437
LIG_SH2_NCK_1	58	62	PF00017	0.626
LIG_SH2_SRC	25	28	PF00017	0.432
LIG_SH2_STAP1	58	62	PF00017	0.614
LIG_SH3_3	128	134	PF00018	0.395
LIG_SH3_3	14	20	PF00018	0.571
LIG_SUMO_SIM_par_1	48	54	PF11976	0.503
MOD_CK1_1	110	116	PF00069	0.454
MOD_CK1_1	172	178	PF00069	0.448
MOD_CK1_1	5	11	PF00069	0.623
MOD_CK1_1	54	60	PF00069	0.612
MOD_CK1_1	66	72	PF00069	0.649
MOD_CK1_1	77	83	PF00069	0.683
MOD_CK1_1	92	98	PF00069	0.490
MOD_CK2_1	20	26	PF00069	0.511
MOD_GlcNHglycan	53	56	PF01048	0.412
MOD_GlcNHglycan	65	68	PF01048	0.571
MOD_GlcNHglycan	74	77	PF01048	0.734
MOD_GlcNHglycan	84	87	PF01048	0.757
MOD_GSK3_1	107	114	PF00069	0.437
MOD_GSK3_1	144	151	PF00069	0.450
MOD_GSK3_1	165	172	PF00069	0.448
MOD_GSK3_1	62	69	PF00069	0.638
MOD_GSK3_1	72	79	PF00069	0.724
MOD_GSK3_1	82	89	PF00069	0.611
MOD_GSK3_1	93	100	PF00069	0.539
MOD_NEK2_1	107	112	PF00069	0.423
MOD_NEK2_1	2	7	PF00069	0.543
MOD_NEK2_1	42	47	PF00069	0.434
MOD_PK_1	169	175	PF00069	0.423
MOD_PKA_1	82	88	PF00069	0.580
MOD_PKB_1	167	175	PF00069	0.424
MOD_Plk_1	169	175	PF00069	0.423
MOD_Plk_4	148	154	PF00069	0.353
MOD_Plk_4	172	178	PF00069	0.446
MOD_Plk_4	5	11	PF00069	0.621
MOD_ProDKin_1	68	74	PF00069	0.692
MOD_SUMO_for_1	98	101	PF00179	0.644
MOD_SUMO_rev_2	124	129	PF00179	0.477
TRG_ENDOCYTIC_2	161	164	PF00928	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXG2	Leptomonas seymouri	69%	96%
A0A0S4J1H8	Bodo saltans	39%	100%
A0A0S4J255	Bodo saltans	39%	98%
A0A1X0PAS6	Trypanosomatidae	50%	100%
A0A3Q8IHE2	Leishmania donovani	91%	100%
A0A3R7K5Q8	Trypanosoma rangeli	52%	100%
A4HB12	Leishmania braziliensis	78%	100%
A4IA69	Leishmania infantum	91%	100%
C9ZM37	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9B582	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%