Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2Q0_LEIMA

TriTrypDb:

LmjF.34.2940 , LMJLV39_340034700 , LMJSD75_340035000

Length:

295

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2Q0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2Q0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.742
CLV_NRD_NRD_1	154	156	PF00675	0.660
CLV_NRD_NRD_1	215	217	PF00675	0.594
CLV_NRD_NRD_1	218	220	PF00675	0.588
CLV_NRD_NRD_1	37	39	PF00675	0.540
CLV_NRD_NRD_1	52	54	PF00675	0.560
CLV_PCSK_KEX2_1	10	12	PF00082	0.742
CLV_PCSK_KEX2_1	152	154	PF00082	0.676
CLV_PCSK_KEX2_1	266	268	PF00082	0.533
CLV_PCSK_KEX2_1	36	38	PF00082	0.533
CLV_PCSK_KEX2_1	52	54	PF00082	0.553
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.689
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.533
CLV_PCSK_SKI1_1	42	46	PF00082	0.654
DEG_SCF_FBW7_1	285	292	PF00400	0.519
DOC_PP4_FxxP_1	66	69	PF00568	0.683
DOC_USP7_MATH_1	116	120	PF00917	0.670
DOC_USP7_MATH_1	227	231	PF00917	0.556
DOC_WW_Pin1_4	285	290	PF00397	0.743
LIG_14-3-3_CanoR_1	115	125	PF00244	0.644
LIG_14-3-3_CanoR_1	281	286	PF00244	0.728
LIG_BRCT_BRCA1_1	276	280	PF00533	0.589
LIG_FHA_1	193	199	PF00498	0.673
LIG_FHA_1	28	34	PF00498	0.607
LIG_FHA_1	93	99	PF00498	0.654
LIG_FHA_2	161	167	PF00498	0.740
LIG_FHA_2	57	63	PF00498	0.683
LIG_IBAR_NPY_1	274	276	PF08397	0.566
LIG_LIR_Apic_2	199	205	PF02991	0.571
LIG_LIR_Gen_1	95	105	PF02991	0.653
LIG_LIR_Nem_3	21	27	PF02991	0.513
LIG_LIR_Nem_3	250	255	PF02991	0.485
LIG_LIR_Nem_3	75	81	PF02991	0.644
LIG_SH2_CRK	276	280	PF00017	0.615
LIG_SH2_NCK_1	276	280	PF00017	0.615
LIG_SH2_PTP2	202	205	PF00017	0.569
LIG_SH2_STAP1	276	280	PF00017	0.589
LIG_SH2_STAT3	235	238	PF00017	0.658
LIG_SH2_STAT5	202	205	PF00017	0.592
LIG_SH3_1	22	28	PF00018	0.538
LIG_SH3_3	22	28	PF00018	0.587
LIG_SH3_3	287	293	PF00018	0.558
LIG_SUMO_SIM_par_1	256	261	PF11976	0.580
LIG_TYR_ITSM	74	81	PF00017	0.727
LIG_UBA3_1	264	272	PF00899	0.557
LIG_WW_3	288	292	PF00397	0.677
MOD_CDK_SPxK_1	285	291	PF00069	0.673
MOD_CK1_1	230	236	PF00069	0.562
MOD_CK2_1	160	166	PF00069	0.743
MOD_CK2_1	212	218	PF00069	0.545
MOD_CK2_1	56	62	PF00069	0.680
MOD_Cter_Amidation	50	53	PF01082	0.709
MOD_Cter_Amidation	8	11	PF01082	0.661
MOD_GlcNHglycan	198	201	PF01048	0.698
MOD_GSK3_1	117	124	PF00069	0.630
MOD_GSK3_1	135	142	PF00069	0.686
MOD_GSK3_1	192	199	PF00069	0.652
MOD_GSK3_1	230	237	PF00069	0.573
MOD_GSK3_1	27	34	PF00069	0.557
MOD_GSK3_1	275	282	PF00069	0.583
MOD_GSK3_1	285	292	PF00069	0.726
MOD_GSK3_1	88	95	PF00069	0.600
MOD_N-GLC_1	190	195	PF02516	0.601
MOD_N-GLC_1	212	217	PF02516	0.571
MOD_N-GLC_1	71	76	PF02516	0.655
MOD_NEK2_1	1	6	PF00069	0.659
MOD_NEK2_1	100	105	PF00069	0.661
MOD_NEK2_1	13	18	PF00069	0.509
MOD_NEK2_1	139	144	PF00069	0.613
MOD_NEK2_1	190	195	PF00069	0.617
MOD_NEK2_1	212	217	PF00069	0.487
MOD_NEK2_1	234	239	PF00069	0.526
MOD_NEK2_1	244	249	PF00069	0.434
MOD_NEK2_1	280	285	PF00069	0.723
MOD_NEK2_1	71	76	PF00069	0.699
MOD_NEK2_2	275	280	PF00069	0.591
MOD_PIKK_1	234	240	PF00454	0.617
MOD_PKA_2	116	122	PF00069	0.630
MOD_PKA_2	196	202	PF00069	0.711
MOD_PKA_2	280	286	PF00069	0.599
MOD_PKB_1	115	123	PF00069	0.483
MOD_Plk_1	190	196	PF00069	0.672
MOD_Plk_2-3	251	257	PF00069	0.523
MOD_Plk_4	100	106	PF00069	0.669
MOD_Plk_4	135	141	PF00069	0.601
MOD_Plk_4	227	233	PF00069	0.604
MOD_Plk_4	275	281	PF00069	0.599
MOD_ProDKin_1	285	291	PF00069	0.748
MOD_SUMO_rev_2	179	186	PF00179	0.674
MOD_SUMO_rev_2	214	222	PF00179	0.473
MOD_SUMO_rev_2	269	273	PF00179	0.538
TRG_DiLeu_BaEn_2	38	44	PF01217	0.674
TRG_DiLeu_BaLyEn_6	9	14	PF01217	0.496
TRG_ENDOCYTIC_2	276	279	PF00928	0.609
TRG_ENDOCYTIC_2	78	81	PF00928	0.665
TRG_ER_diArg_1	10	12	PF00400	0.741
TRG_ER_diArg_1	153	155	PF00400	0.684
TRG_ER_diArg_1	35	38	PF00400	0.525
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.586
TRG_Pf-PMV_PEXEL_1	42	47	PF00026	0.682

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAU8	Leptomonas seymouri	59%	100%
A0A0S4IYA0	Bodo saltans	23%	100%
A0A1X0PA38	Trypanosomatidae	29%	100%
A0A3Q8ILA3	Leishmania donovani	90%	96%
A0A3R7KSA4	Trypanosoma rangeli	31%	100%
A4HB13	Leishmania braziliensis	74%	100%
A4IA70	Leishmania infantum	91%	100%
C9ZM36	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9B583	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BV16	Trypanosoma cruzi	32%	100%