EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

EF-hand domain pair, putative

Species:

Leishmania major

UniProt:

Q4Q2P9_LEIMA

TriTrypDb:

LmjF.34.2950 , LMJLV39_340034800 , LMJSD75_340035100

Length:

422

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2P9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2P9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005509	calcium ion binding	5	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.406
CLV_C14_Caspase3-7	309	313	PF00656	0.274
CLV_C14_Caspase3-7	345	349	PF00656	0.377
CLV_NRD_NRD_1	103	105	PF00675	0.367
CLV_NRD_NRD_1	109	111	PF00675	0.384
CLV_NRD_NRD_1	151	153	PF00675	0.457
CLV_NRD_NRD_1	359	361	PF00675	0.590
CLV_PCSK_KEX2_1	109	111	PF00082	0.334
CLV_PCSK_KEX2_1	19	21	PF00082	0.380
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.472
CLV_PCSK_SKI1_1	113	117	PF00082	0.474
CLV_PCSK_SKI1_1	19	23	PF00082	0.374
CLV_PCSK_SKI1_1	242	246	PF00082	0.442
CLV_PCSK_SKI1_1	332	336	PF00082	0.378
CLV_PCSK_SKI1_1	370	374	PF00082	0.409
DEG_APCC_DBOX_1	241	249	PF00400	0.469
DEG_Nend_UBRbox_3	1	3	PF02207	0.637
DOC_CYCLIN_RxL_1	16	26	PF00134	0.404
DOC_CYCLIN_RxL_1	262	270	PF00134	0.388
DOC_PP2B_LxvP_1	296	299	PF13499	0.393
DOC_PP2B_LxvP_1	323	326	PF13499	0.417
DOC_USP7_MATH_1	179	183	PF00917	0.423
DOC_USP7_MATH_1	202	206	PF00917	0.470
DOC_USP7_MATH_1	234	238	PF00917	0.563
DOC_USP7_MATH_1	240	244	PF00917	0.530
DOC_USP7_MATH_1	257	261	PF00917	0.373
DOC_USP7_MATH_1	299	303	PF00917	0.422
DOC_USP7_MATH_1	326	330	PF00917	0.348
DOC_WW_Pin1_4	23	28	PF00397	0.519
DOC_WW_Pin1_4	324	329	PF00397	0.452
DOC_WW_Pin1_4	363	368	PF00397	0.463
LIG_14-3-3_CanoR_1	25	31	PF00244	0.510
LIG_Actin_WH2_2	88	106	PF00022	0.453
LIG_BRCT_BRCA1_1	204	208	PF00533	0.494
LIG_BRCT_BRCA1_1	340	344	PF00533	0.386
LIG_eIF4E_1	319	325	PF01652	0.460
LIG_FHA_1	16	22	PF00498	0.411
LIG_FHA_1	291	297	PF00498	0.463
LIG_FHA_1	299	305	PF00498	0.454
LIG_FHA_1	312	318	PF00498	0.239
LIG_FHA_1	88	94	PF00498	0.329
LIG_FHA_2	145	151	PF00498	0.527
LIG_FHA_2	161	167	PF00498	0.403
LIG_FHA_2	307	313	PF00498	0.285
LIG_FHA_2	373	379	PF00498	0.433
LIG_FHA_2	50	56	PF00498	0.297
LIG_FHA_2	75	81	PF00498	0.417
LIG_LIR_Apic_2	348	354	PF02991	0.480
LIG_LIR_Gen_1	188	198	PF02991	0.367
LIG_LIR_Gen_1	406	413	PF02991	0.403
LIG_LIR_Gen_1	90	100	PF02991	0.463
LIG_LIR_Nem_3	173	177	PF02991	0.323
LIG_LIR_Nem_3	188	194	PF02991	0.321
LIG_LIR_Nem_3	406	412	PF02991	0.427
LIG_LIR_Nem_3	90	95	PF02991	0.463
LIG_Pex14_1	340	344	PF04695	0.454
LIG_Pex14_2	155	159	PF04695	0.376
LIG_Pex14_2	373	377	PF04695	0.340
LIG_RPA_C_Fungi	233	245	PF08784	0.437
LIG_SH2_CRK	178	182	PF00017	0.328
LIG_SH2_CRK	351	355	PF00017	0.470
LIG_SH2_STAP1	320	324	PF00017	0.457
LIG_SH2_STAT3	396	399	PF00017	0.421
LIG_SH2_STAT5	297	300	PF00017	0.374
LIG_SH2_STAT5	396	399	PF00017	0.377
LIG_SUMO_SIM_anti_2	188	196	PF11976	0.337
LIG_SUMO_SIM_anti_2	90	97	PF11976	0.350
LIG_SUMO_SIM_par_1	254	260	PF11976	0.460
LIG_TRAF2_1	170	173	PF00917	0.358
LIG_TRAF2_1	52	55	PF00917	0.416
LIG_TRAF2_1	59	62	PF00917	0.353
LIG_TRAF2_1	66	69	PF00917	0.325
LIG_UBA3_1	10	19	PF00899	0.375
LIG_UBA3_1	75	84	PF00899	0.350
LIG_WRC_WIRS_1	33	38	PF05994	0.427
MOD_CDK_SPxxK_3	363	370	PF00069	0.458
MOD_CK1_1	222	228	PF00069	0.614
MOD_CK1_1	26	32	PF00069	0.481
MOD_CK2_1	144	150	PF00069	0.549
MOD_CK2_1	167	173	PF00069	0.362
MOD_CK2_1	183	189	PF00069	0.364
MOD_CK2_1	225	231	PF00069	0.545
MOD_CK2_1	299	305	PF00069	0.507
MOD_CK2_1	49	55	PF00069	0.346
MOD_CK2_1	63	69	PF00069	0.256
MOD_GlcNHglycan	156	159	PF01048	0.511
MOD_GlcNHglycan	169	172	PF01048	0.498
MOD_GlcNHglycan	242	245	PF01048	0.549
MOD_GlcNHglycan	259	262	PF01048	0.366
MOD_GlcNHglycan	278	281	PF01048	0.474
MOD_GlcNHglycan	328	331	PF01048	0.404
MOD_GlcNHglycan	399	402	PF01048	0.438
MOD_GSK3_1	179	186	PF00069	0.531
MOD_GSK3_1	202	209	PF00069	0.442
MOD_GSK3_1	230	237	PF00069	0.534
MOD_GSK3_1	276	283	PF00069	0.428
MOD_GSK3_1	32	39	PF00069	0.456
MOD_GSK3_1	45	52	PF00069	0.396
MOD_GSK3_1	79	86	PF00069	0.405
MOD_N-GLC_1	159	164	PF02516	0.434
MOD_N-GLC_1	299	304	PF02516	0.390
MOD_N-GLC_1	63	68	PF02516	0.400
MOD_NEK2_1	159	164	PF00069	0.424
MOD_NEK2_1	208	213	PF00069	0.427
MOD_NEK2_1	267	272	PF00069	0.495
MOD_NEK2_1	36	41	PF00069	0.507
MOD_NEK2_1	46	51	PF00069	0.442
MOD_NEK2_1	79	84	PF00069	0.319
MOD_PIKK_1	46	52	PF00454	0.475
MOD_Plk_1	187	193	PF00069	0.343
MOD_Plk_1	206	212	PF00069	0.292
MOD_Plk_1	225	231	PF00069	0.521
MOD_Plk_1	299	305	PF00069	0.470
MOD_Plk_1	63	69	PF00069	0.378
MOD_Plk_4	187	193	PF00069	0.341
MOD_Plk_4	299	305	PF00069	0.446
MOD_ProDKin_1	23	29	PF00069	0.518
MOD_ProDKin_1	324	330	PF00069	0.453
MOD_ProDKin_1	363	369	PF00069	0.458
MOD_SUMO_for_1	213	216	PF00179	0.424
MOD_SUMO_rev_2	161	170	PF00179	0.537
MOD_SUMO_rev_2	341	349	PF00179	0.338
TRG_DiLeu_BaEn_1	388	393	PF01217	0.353
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.363
TRG_ENDOCYTIC_2	178	181	PF00928	0.328
TRG_ENDOCYTIC_2	320	323	PF00928	0.316
TRG_ER_diArg_1	108	110	PF00400	0.381
TRG_Pf-PMV_PEXEL_1	20	24	PF00026	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2R2	Leptomonas seymouri	66%	100%
A0A0S4J207	Bodo saltans	35%	97%
A0A1X0PAP2	Trypanosomatidae	41%	100%
A0A3Q8IHP2	Leishmania donovani	95%	100%
A0A422N4H8	Trypanosoma rangeli	42%	100%
A4HB14	Leishmania braziliensis	83%	100%
A4IA71	Leishmania infantum	95%	100%
C9ZM35	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9B584	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5B5A3	Trypanosoma cruzi	41%	100%