Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q2P8_LEIMA

TriTrypDb:

LmjF.34.2960 , LMJLV39_340034900 , LMJSD75_340035200

Length:

230

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q2P8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2P8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	70	72	PF00675	0.413
CLV_PCSK_KEX2_1	70	72	PF00082	0.413
CLV_PCSK_SKI1_1	124	128	PF00082	0.423
DEG_APCC_DBOX_1	123	131	PF00400	0.592
DEG_Nend_Nbox_1	1	3	PF02207	0.688
DOC_CYCLIN_yCln2_LP_2	9	15	PF00134	0.639
DOC_MAPK_MEF2A_6	120	129	PF00069	0.607
DOC_SPAK_OSR1_1	89	93	PF12202	0.656
DOC_USP7_MATH_1	63	67	PF00917	0.655
DOC_WW_Pin1_4	144	149	PF00397	0.540
LIG_14-3-3_CanoR_1	132	139	PF00244	0.664
LIG_14-3-3_CanoR_1	188	193	PF00244	0.683
LIG_14-3-3_CanoR_1	207	211	PF00244	0.688
LIG_14-3-3_CanoR_1	89	93	PF00244	0.735
LIG_Actin_RPEL_3	82	101	PF02755	0.638
LIG_Actin_WH2_2	105	122	PF00022	0.617
LIG_Clathr_ClatBox_1	100	104	PF01394	0.661
LIG_DCNL_PONY_1	1	4	PF03556	0.658
LIG_EH1_1	89	97	PF00400	0.657
LIG_eIF4E_1	146	152	PF01652	0.653
LIG_eIF4E_1	21	27	PF01652	0.340
LIG_eIF4E_1	45	51	PF01652	0.388
LIG_FHA_1	114	120	PF00498	0.632
LIG_FHA_1	29	35	PF00498	0.341
LIG_FHA_1	8	14	PF00498	0.663
LIG_FHA_2	207	213	PF00498	0.688
LIG_GBD_Chelix_1	46	54	PF00786	0.327
LIG_GBD_Chelix_1	92	100	PF00786	0.410
LIG_IRF3_LxIS_1	9	16	PF10401	0.638
LIG_NRBOX	22	28	PF00104	0.388
LIG_NRBOX	50	56	PF00104	0.267
LIG_SH2_NCK_1	146	150	PF00017	0.648
LIG_SH2_PTP2	128	131	PF00017	0.582
LIG_SH2_STAT5	113	116	PF00017	0.614
LIG_SH2_STAT5	128	131	PF00017	0.582
LIG_SH2_STAT5	150	153	PF00017	0.635
LIG_SH2_STAT5	45	48	PF00017	0.388
LIG_SH2_STAT5	81	84	PF00017	0.617
LIG_SH3_3	119	125	PF00018	0.659
LIG_SUMO_SIM_par_1	25	31	PF11976	0.388
LIG_TYR_ITIM	126	131	PF00017	0.608
MOD_CK1_1	134	140	PF00069	0.663
MOD_CK2_1	88	94	PF00069	0.619
MOD_GlcNHglycan	133	136	PF01048	0.430
MOD_GlcNHglycan	164	167	PF01048	0.471
MOD_GlcNHglycan	175	178	PF01048	0.555
MOD_GlcNHglycan	183	186	PF01048	0.430
MOD_GlcNHglycan	199	202	PF01048	0.508
MOD_GlcNHglycan	67	70	PF01048	0.431
MOD_GSK3_1	134	141	PF00069	0.638
MOD_GSK3_1	158	165	PF00069	0.755
MOD_GSK3_1	188	195	PF00069	0.683
MOD_N-GLC_1	217	222	PF02516	0.440
MOD_N-GLC_2	206	208	PF02516	0.490
MOD_NEK2_1	13	18	PF00069	0.480
MOD_NEK2_1	131	136	PF00069	0.625
MOD_NEK2_1	151	156	PF00069	0.661
MOD_NEK2_1	217	222	PF00069	0.650
MOD_NEK2_1	27	32	PF00069	0.305
MOD_NEK2_1	88	93	PF00069	0.618
MOD_PIKK_1	63	69	PF00454	0.595
MOD_PIKK_1	7	13	PF00454	0.633
MOD_PKA_2	131	137	PF00069	0.702
MOD_PKA_2	141	147	PF00069	0.578
MOD_PKA_2	187	193	PF00069	0.677
MOD_PKA_2	206	212	PF00069	0.733
MOD_PKA_2	218	224	PF00069	0.679
MOD_PKA_2	88	94	PF00069	0.732
MOD_Plk_4	206	212	PF00069	0.690
MOD_ProDKin_1	144	150	PF00069	0.544
TRG_DiLeu_BaLyEn_6	122	127	PF01217	0.600
TRG_DiLeu_BaLyEn_6	32	37	PF01217	0.479
TRG_ENDOCYTIC_2	128	131	PF00928	0.666
TRG_ENDOCYTIC_2	45	48	PF00928	0.388
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCS2	Leptomonas seymouri	52%	100%
A0A3Q8IUS4	Leishmania donovani	95%	100%
A4HB15	Leishmania braziliensis	69%	100%
A4IA72	Leishmania infantum	95%	100%
E9B585	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%