DM10 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoside diphosphate kinase 3

Species:

Leishmania major

UniProt:

Q4Q2P6_LEIMA

TriTrypDb:

LmjF.34.2980 , LMJLV39_340035100 , LMJSD75_340035400

Length:

343

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005813	centrosome	3	3
GO:0005815	microtubule organizing center	2	3
GO:0005930	axoneme	2	3
GO:0110165	cellular anatomical entity	1	3
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

Q4Q2P6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2P6

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	16
GO:0006796	phosphate-containing compound metabolic process	4	16
GO:0008152	metabolic process	1	16
GO:0009987	cellular process	1	16
GO:0016310	phosphorylation	5	16
GO:0044237	cellular metabolic process	2	16

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	16
GO:0016301	kinase activity	4	16
GO:0016740	transferase activity	2	16
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	16
GO:0004550	nucleoside diphosphate kinase activity	5	9
GO:0016776	phosphotransferase activity, phosphate group as acceptor	4	9
GO:0019205	nucleobase-containing compound kinase activity	5	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	318	322	PF00656	0.358
CLV_NRD_NRD_1	156	158	PF00675	0.517
CLV_PCSK_KEX2_1	51	53	PF00082	0.389
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.409
CLV_PCSK_PC7_1	47	53	PF00082	0.429
CLV_PCSK_SKI1_1	338	342	PF00082	0.317
CLV_PCSK_SKI1_1	9	13	PF00082	0.357
DOC_MAPK_gen_1	51	57	PF00069	0.342
DOC_MAPK_RevD_3	38	52	PF00069	0.500
DOC_PP4_FxxP_1	139	142	PF00568	0.357
DOC_PP4_FxxP_1	251	254	PF00568	0.462
DOC_USP7_MATH_1	204	208	PF00917	0.389
DOC_USP7_MATH_1	90	94	PF00917	0.455
DOC_USP7_UBL2_3	159	163	PF12436	0.310
DOC_USP7_UBL2_3	305	309	PF12436	0.536
LIG_Actin_WH2_2	36	53	PF00022	0.450
LIG_BIR_II_1	1	5	PF00653	0.559
LIG_FHA_1	1	7	PF00498	0.661
LIG_FHA_1	146	152	PF00498	0.367
LIG_FHA_1	204	210	PF00498	0.350
LIG_FHA_1	270	276	PF00498	0.455
LIG_FHA_1	35	41	PF00498	0.424
LIG_FHA_1	65	71	PF00498	0.417
LIG_FHA_1	83	89	PF00498	0.433
LIG_FHA_1	94	100	PF00498	0.351
LIG_FHA_2	122	128	PF00498	0.404
LIG_LIR_Apic_2	137	142	PF02991	0.467
LIG_LIR_Apic_2	250	254	PF02991	0.464
LIG_LIR_Gen_1	162	169	PF02991	0.481
LIG_LIR_Nem_3	102	108	PF02991	0.392
LIG_LIR_Nem_3	162	168	PF02991	0.473
LIG_LIR_Nem_3	253	258	PF02991	0.475
LIG_MYND_3	259	263	PF01753	0.441
LIG_SH2_CRK	255	259	PF00017	0.456
LIG_SH2_CRK	298	302	PF00017	0.536
LIG_SH2_STAP1	298	302	PF00017	0.536
LIG_SH2_STAP1	336	340	PF00017	0.456
LIG_SH2_STAT5	111	114	PF00017	0.342
LIG_SH2_STAT5	255	258	PF00017	0.358
LIG_SH2_STAT5	31	34	PF00017	0.393
LIG_SH2_STAT5	336	339	PF00017	0.474
LIG_SH2_STAT5	49	52	PF00017	0.505
LIG_SH3_3	16	22	PF00018	0.575
LIG_SH3_3	207	213	PF00018	0.450
LIG_SH3_3	52	58	PF00018	0.381
LIG_SUMO_SIM_anti_2	206	212	PF11976	0.311
LIG_SUMO_SIM_anti_2	34	42	PF11976	0.475
LIG_SUMO_SIM_par_1	150	156	PF11976	0.463
LIG_SUMO_SIM_par_1	34	42	PF11976	0.476
LIG_SUMO_SIM_par_1	93	103	PF11976	0.392
LIG_WRC_WIRS_1	266	271	PF05994	0.399
MOD_CK1_1	60	66	PF00069	0.401
MOD_CK1_1	93	99	PF00069	0.387
MOD_CK2_1	121	127	PF00069	0.449
MOD_CK2_1	277	283	PF00069	0.510
MOD_CK2_1	33	39	PF00069	0.410
MOD_GlcNHglycan	136	139	PF01048	0.464
MOD_GlcNHglycan	216	219	PF01048	0.297
MOD_GlcNHglycan	222	225	PF01048	0.296
MOD_GlcNHglycan	244	247	PF01048	0.300
MOD_GlcNHglycan	44	47	PF01048	0.491
MOD_GlcNHglycan	59	62	PF01048	0.213
MOD_GSK3_1	233	240	PF00069	0.496
MOD_GSK3_1	265	272	PF00069	0.512
MOD_GSK3_1	60	67	PF00069	0.428
MOD_GSK3_1	90	97	PF00069	0.466
MOD_N-GLC_1	204	209	PF02516	0.342
MOD_N-GLC_2	293	295	PF02516	0.192
MOD_NEK2_1	1	6	PF00069	0.550
MOD_NEK2_1	145	150	PF00069	0.360
MOD_NEK2_1	262	267	PF00069	0.476
MOD_NEK2_1	269	274	PF00069	0.460
MOD_NEK2_1	32	37	PF00069	0.532
MOD_NEK2_1	50	55	PF00069	0.487
MOD_NEK2_2	287	292	PF00069	0.479
MOD_PKA_2	169	175	PF00069	0.408
MOD_Plk_1	204	210	PF00069	0.309
MOD_Plk_1	33	39	PF00069	0.375
MOD_Plk_1	93	99	PF00069	0.391
MOD_Plk_2-3	34	40	PF00069	0.376
MOD_Plk_4	204	210	PF00069	0.309
MOD_Plk_4	265	271	PF00069	0.514
MOD_Plk_4	297	303	PF00069	0.522
MOD_Plk_4	64	70	PF00069	0.388
MOD_Plk_4	94	100	PF00069	0.350
TRG_DiLeu_BaEn_3	102	108	PF01217	0.276
TRG_ENDOCYTIC_2	111	114	PF00928	0.376
TRG_ENDOCYTIC_2	255	258	PF00928	0.450
TRG_ENDOCYTIC_2	298	301	PF00928	0.536
TRG_ENDOCYTIC_2	336	339	PF00928	0.460
TRG_NLS_MonoExtC_3	156	162	PF00514	0.321
TRG_Pf-PMV_PEXEL_1	86	91	PF00026	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJQ8	Leptomonas seymouri	71%	100%
A0A0N1PC23	Leptomonas seymouri	29%	100%
A0A0S4IXH2	Bodo saltans	29%	100%
A0A1X0P5C0	Trypanosomatidae	31%	100%
A0A1X0PAT4	Trypanosomatidae	45%	98%
A0A3Q8IJQ8	Leishmania donovani	29%	100%
A0A3R7M6K1	Trypanosoma rangeli	46%	99%
A0A3R7N390	Trypanosoma rangeli	31%	100%
A0A3S7X855	Leishmania donovani	94%	100%
A4HB17	Leishmania braziliensis	82%	100%
A4HN58	Leishmania braziliensis	29%	100%
A4IA74	Leishmania infantum	94%	100%
A4IBS5	Leishmania infantum	29%	100%
C9ZM33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	98%
C9ZYU7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AFL1	Leishmania major	29%	99%
E9B587	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9B6R5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
Q5E9Y9	Bos taurus	24%	91%
Q9QXL7	Rattus norvegicus	24%	87%
Q9QXL8	Mus musculus	24%	87%
Q9Y5B8	Homo sapiens	24%	91%
V5BXY9	Trypanosoma cruzi	30%	99%
V5DLW4	Trypanosoma cruzi	44%	98%