Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q2P5_LEIMA

TriTrypDb:

LmjF.34.2990 , LMJLV39_340035200 , LMJSD75_340035500

Length:

419

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7

Expansion

Sequence features

Q4Q2P5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2P5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	17	21	PF00656	0.489
CLV_MEL_PAP_1	236	242	PF00089	0.592
CLV_NRD_NRD_1	106	108	PF00675	0.631
CLV_NRD_NRD_1	113	115	PF00675	0.565
CLV_NRD_NRD_1	219	221	PF00675	0.605
CLV_NRD_NRD_1	32	34	PF00675	0.682
CLV_NRD_NRD_1	361	363	PF00675	0.514
CLV_NRD_NRD_1	415	417	PF00675	0.436
CLV_PCSK_FUR_1	111	115	PF00082	0.634
CLV_PCSK_KEX2_1	106	108	PF00082	0.631
CLV_PCSK_KEX2_1	113	115	PF00082	0.565
CLV_PCSK_KEX2_1	218	220	PF00082	0.601
CLV_PCSK_KEX2_1	32	34	PF00082	0.680
CLV_PCSK_KEX2_1	361	363	PF00082	0.563
CLV_PCSK_PC7_1	357	363	PF00082	0.448
CLV_PCSK_SKI1_1	372	376	PF00082	0.460
DEG_APCC_DBOX_1	356	364	PF00400	0.437
DOC_CKS1_1	150	155	PF01111	0.602
DOC_MAPK_gen_1	106	112	PF00069	0.611
DOC_MAPK_gen_1	218	230	PF00069	0.545
DOC_MAPK_gen_1	361	368	PF00069	0.454
DOC_MAPK_MEF2A_6	331	339	PF00069	0.480
DOC_PIKK_1	68	76	PF02985	0.614
DOC_USP7_MATH_1	175	179	PF00917	0.641
DOC_WW_Pin1_4	123	128	PF00397	0.648
DOC_WW_Pin1_4	149	154	PF00397	0.579
DOC_WW_Pin1_4	259	264	PF00397	0.601
DOC_WW_Pin1_4	267	272	PF00397	0.627
DOC_WW_Pin1_4	274	279	PF00397	0.681
DOC_WW_Pin1_4	386	391	PF00397	0.474
LIG_14-3-3_CanoR_1	106	112	PF00244	0.618
LIG_14-3-3_CanoR_1	121	129	PF00244	0.555
LIG_14-3-3_CanoR_1	15	22	PF00244	0.528
LIG_14-3-3_CanoR_1	281	287	PF00244	0.526
LIG_14-3-3_CanoR_1	331	335	PF00244	0.455
LIG_14-3-3_CanoR_1	398	403	PF00244	0.459
LIG_14-3-3_CanoR_1	404	408	PF00244	0.419
LIG_Actin_WH2_2	283	299	PF00022	0.545
LIG_BIR_II_1	1	5	PF00653	0.603
LIG_DLG_GKlike_1	398	406	PF00625	0.419
LIG_FHA_1	145	151	PF00498	0.634
LIG_FHA_1	183	189	PF00498	0.590
LIG_FHA_1	198	204	PF00498	0.593
LIG_FHA_1	270	276	PF00498	0.531
LIG_FHA_1	287	293	PF00498	0.529
LIG_FHA_1	373	379	PF00498	0.399
LIG_FHA_1	61	67	PF00498	0.509
LIG_FHA_2	126	132	PF00498	0.692
LIG_FHA_2	137	143	PF00498	0.609
LIG_FHA_2	178	184	PF00498	0.637
LIG_FHA_2	371	377	PF00498	0.418
LIG_FHA_2	79	85	PF00498	0.558
LIG_LIR_Gen_1	10	16	PF02991	0.673
LIG_LIR_Gen_1	282	291	PF02991	0.539
LIG_LIR_Nem_3	10	14	PF02991	0.678
LIG_LIR_Nem_3	282	286	PF02991	0.552
LIG_SH2_STAT3	201	204	PF00017	0.580
LIG_SH2_STAT5	145	148	PF00017	0.558
LIG_SH2_STAT5	201	204	PF00017	0.532
LIG_SH2_STAT5	221	224	PF00017	0.453
LIG_SH2_STAT5	359	362	PF00017	0.507
LIG_SH3_3	257	263	PF00018	0.633
LIG_SUMO_SIM_par_1	289	295	PF11976	0.647
LIG_SUMO_SIM_par_1	364	369	PF11976	0.434
LIG_SUMO_SIM_par_1	46	53	PF11976	0.569
LIG_TRAF2_1	189	192	PF00917	0.639
LIG_TRAF2_1	81	84	PF00917	0.574
LIG_UBA3_1	41	47	PF00899	0.498
LIG_WRC_WIRS_1	252	257	PF05994	0.569
MOD_CDK_SPxxK_3	123	130	PF00069	0.534
MOD_CDK_SPxxK_3	274	281	PF00069	0.648
MOD_CK1_1	123	129	PF00069	0.602
MOD_CK1_1	151	157	PF00069	0.686
MOD_CK1_1	178	184	PF00069	0.668
MOD_CK1_1	262	268	PF00069	0.665
MOD_CK1_1	403	409	PF00069	0.381
MOD_CK2_1	178	184	PF00069	0.744
MOD_CK2_1	78	84	PF00069	0.623
MOD_GlcNHglycan	157	160	PF01048	0.594
MOD_GlcNHglycan	232	235	PF01048	0.686
MOD_GlcNHglycan	306	310	PF01048	0.502
MOD_GlcNHglycan	367	371	PF01048	0.435
MOD_GSK3_1	144	151	PF00069	0.615
MOD_GSK3_1	178	185	PF00069	0.617
MOD_GSK3_1	244	251	PF00069	0.663
MOD_GSK3_1	270	277	PF00069	0.709
MOD_GSK3_1	282	289	PF00069	0.495
MOD_GSK3_1	366	373	PF00069	0.371
MOD_GSK3_1	398	405	PF00069	0.433
MOD_GSK3_1	60	67	PF00069	0.656
MOD_GSK3_1	74	81	PF00069	0.607
MOD_N-GLC_1	370	375	PF02516	0.381
MOD_N-GLC_1	74	79	PF02516	0.592
MOD_NEK2_1	1	6	PF00069	0.605
MOD_NEK2_1	14	19	PF00069	0.554
MOD_NEK2_1	248	253	PF00069	0.613
MOD_NEK2_1	339	344	PF00069	0.395
MOD_NEK2_1	366	371	PF00069	0.431
MOD_NEK2_1	385	390	PF00069	0.461
MOD_NEK2_1	402	407	PF00069	0.399
MOD_PIKK_1	1	7	PF00454	0.663
MOD_PIKK_1	160	166	PF00454	0.555
MOD_PIKK_1	86	92	PF00454	0.513
MOD_PKA_2	105	111	PF00069	0.567
MOD_PKA_2	120	126	PF00069	0.499
MOD_PKA_2	14	20	PF00069	0.537
MOD_PKA_2	230	236	PF00069	0.547
MOD_PKA_2	238	244	PF00069	0.577
MOD_PKA_2	330	336	PF00069	0.455
MOD_PKA_2	397	403	PF00069	0.453
MOD_Plk_1	160	166	PF00069	0.621
MOD_Plk_1	175	181	PF00069	0.631
MOD_Plk_1	370	376	PF00069	0.382
MOD_Plk_1	74	80	PF00069	0.634
MOD_Plk_1	9	15	PF00069	0.563
MOD_Plk_4	197	203	PF00069	0.653
MOD_Plk_4	270	276	PF00069	0.587
MOD_Plk_4	286	292	PF00069	0.458
MOD_Plk_4	330	336	PF00069	0.487
MOD_Plk_4	37	43	PF00069	0.541
MOD_ProDKin_1	123	129	PF00069	0.650
MOD_ProDKin_1	149	155	PF00069	0.581
MOD_ProDKin_1	259	265	PF00069	0.600
MOD_ProDKin_1	267	273	PF00069	0.625
MOD_ProDKin_1	274	280	PF00069	0.677
MOD_ProDKin_1	386	392	PF00069	0.466
TRG_DiLeu_BaEn_1	37	42	PF01217	0.509
TRG_DiLeu_BaEn_4	193	199	PF01217	0.643
TRG_DiLeu_BaLyEn_6	387	392	PF01217	0.399
TRG_ER_diArg_1	110	113	PF00400	0.580
TRG_ER_diArg_1	217	220	PF00400	0.599
TRG_ER_diArg_1	236	239	PF00400	0.457
TRG_ER_diArg_1	360	362	PF00400	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBH6	Leptomonas seymouri	44%	100%
A0A3Q8IIQ7	Leishmania donovani	90%	100%
A4HB18	Leishmania braziliensis	67%	100%
A4IA75	Leishmania infantum	90%	100%
E9B588	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%