Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2P4_LEIMA

TriTrypDb:

LmjF.34.3000 , LMJLV39_340035300 , LMJSD75_340035600

Length:

627

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2P4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2P4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.507
CLV_C14_Caspase3-7	47	51	PF00656	0.449
CLV_C14_Caspase3-7	594	598	PF00656	0.511
CLV_C14_Caspase3-7	609	613	PF00656	0.546
CLV_NRD_NRD_1	167	169	PF00675	0.408
CLV_NRD_NRD_1	214	216	PF00675	0.572
CLV_NRD_NRD_1	35	37	PF00675	0.505
CLV_NRD_NRD_1	485	487	PF00675	0.664
CLV_NRD_NRD_1	54	56	PF00675	0.432
CLV_NRD_NRD_1	617	619	PF00675	0.601
CLV_PCSK_KEX2_1	167	169	PF00082	0.408
CLV_PCSK_KEX2_1	192	194	PF00082	0.593
CLV_PCSK_KEX2_1	35	37	PF00082	0.505
CLV_PCSK_KEX2_1	461	463	PF00082	0.553
CLV_PCSK_KEX2_1	54	56	PF00082	0.480
CLV_PCSK_KEX2_1	617	619	PF00082	0.601
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.602
CLV_PCSK_PC1ET2_1	461	463	PF00082	0.518
CLV_PCSK_SKI1_1	549	553	PF00082	0.552
CLV_PCSK_SKI1_1	618	622	PF00082	0.734
DEG_APCC_DBOX_1	616	624	PF00400	0.570
DEG_Nend_UBRbox_1	1	4	PF02207	0.640
DEG_SCF_FBW7_1	290	295	PF00400	0.670
DEG_SCF_FBW7_1	335	341	PF00400	0.687
DEG_SPOP_SBC_1	111	115	PF00917	0.391
DEG_SPOP_SBC_1	418	422	PF00917	0.633
DEG_SPOP_SBC_1	539	543	PF00917	0.542
DOC_CKS1_1	13	18	PF01111	0.617
DOC_CKS1_1	335	340	PF01111	0.651
DOC_CYCLIN_yCln2_LP_2	518	524	PF00134	0.615
DOC_MAPK_DCC_7	154	162	PF00069	0.345
DOC_MAPK_gen_1	154	162	PF00069	0.359
DOC_MAPK_gen_1	35	42	PF00069	0.497
DOC_MAPK_gen_1	617	625	PF00069	0.594
DOC_MAPK_MEF2A_6	154	162	PF00069	0.345
DOC_MAPK_MEF2A_6	35	42	PF00069	0.473
DOC_MAPK_MEF2A_6	617	625	PF00069	0.594
DOC_MAPK_RevD_3	472	487	PF00069	0.562
DOC_PP2B_LxvP_1	155	158	PF13499	0.486
DOC_PP2B_LxvP_1	354	357	PF13499	0.571
DOC_PP2B_LxvP_1	512	515	PF13499	0.630
DOC_PP4_FxxP_1	253	256	PF00568	0.616
DOC_USP7_MATH_1	106	110	PF00917	0.626
DOC_USP7_MATH_1	125	129	PF00917	0.263
DOC_USP7_MATH_1	16	20	PF00917	0.581
DOC_USP7_MATH_1	292	296	PF00917	0.684
DOC_USP7_MATH_1	314	318	PF00917	0.598
DOC_USP7_MATH_1	338	342	PF00917	0.587
DOC_USP7_MATH_1	355	359	PF00917	0.659
DOC_USP7_MATH_1	364	368	PF00917	0.533
DOC_USP7_MATH_1	418	422	PF00917	0.619
DOC_USP7_MATH_1	443	447	PF00917	0.696
DOC_USP7_MATH_1	475	479	PF00917	0.614
DOC_USP7_MATH_1	488	492	PF00917	0.667
DOC_USP7_MATH_1	576	580	PF00917	0.690
DOC_USP7_MATH_1	604	608	PF00917	0.568
DOC_USP7_UBL2_3	297	301	PF12436	0.648
DOC_USP7_UBL2_3	90	94	PF12436	0.387
DOC_WW_Pin1_4	12	17	PF00397	0.643
DOC_WW_Pin1_4	252	257	PF00397	0.651
DOC_WW_Pin1_4	26	31	PF00397	0.522
DOC_WW_Pin1_4	288	293	PF00397	0.609
DOC_WW_Pin1_4	331	336	PF00397	0.657
DOC_WW_Pin1_4	4	9	PF00397	0.636
DOC_WW_Pin1_4	520	525	PF00397	0.648
DOC_WW_Pin1_4	540	545	PF00397	0.567
DOC_WW_Pin1_4	583	588	PF00397	0.543
DOC_WW_Pin1_4	67	72	PF00397	0.457
DOC_WW_Pin1_4	80	85	PF00397	0.438
LIG_14-3-3_CanoR_1	127	136	PF00244	0.429
LIG_14-3-3_CanoR_1	257	262	PF00244	0.531
LIG_14-3-3_CanoR_1	316	325	PF00244	0.567
LIG_14-3-3_CanoR_1	343	351	PF00244	0.581
LIG_14-3-3_CanoR_1	72	82	PF00244	0.363
LIG_APCC_ABBA_1	452	457	PF00400	0.687
LIG_BRCT_BRCA1_1	254	258	PF00533	0.633
LIG_BRCT_BRCA1_1	262	266	PF00533	0.610
LIG_BRCT_BRCA1_1	309	313	PF00533	0.552
LIG_Clathr_ClatBox_1	362	366	PF01394	0.672
LIG_EVH1_1	584	588	PF00568	0.603
LIG_FHA_1	13	19	PF00498	0.590
LIG_FHA_1	232	238	PF00498	0.561
LIG_FHA_1	449	455	PF00498	0.791
LIG_FHA_1	478	484	PF00498	0.654
LIG_FHA_1	560	566	PF00498	0.780
LIG_FHA_1	74	80	PF00498	0.362
LIG_FHA_2	112	118	PF00498	0.420
LIG_FHA_2	136	142	PF00498	0.404
LIG_FHA_2	148	154	PF00498	0.399
LIG_FHA_2	369	375	PF00498	0.575
LIG_FHA_2	42	48	PF00498	0.441
LIG_FHA_2	468	474	PF00498	0.675
LIG_FHA_2	56	62	PF00498	0.418
LIG_FHA_2	589	595	PF00498	0.535
LIG_Integrin_RGD_1	241	243	PF01839	0.646
LIG_LIR_Apic_2	251	256	PF02991	0.624
LIG_LIR_Gen_1	115	126	PF02991	0.445
LIG_LIR_Gen_1	19	28	PF02991	0.584
LIG_LIR_Gen_1	255	266	PF02991	0.557
LIG_LIR_Gen_1	349	357	PF02991	0.612
LIG_LIR_Gen_1	376	385	PF02991	0.598
LIG_LIR_Gen_1	53	64	PF02991	0.569
LIG_LIR_Nem_3	115	121	PF02991	0.434
LIG_LIR_Nem_3	19	24	PF02991	0.584
LIG_LIR_Nem_3	255	261	PF02991	0.629
LIG_LIR_Nem_3	349	354	PF02991	0.623
LIG_LIR_Nem_3	376	382	PF02991	0.595
LIG_LIR_Nem_3	53	59	PF02991	0.558
LIG_LIR_Nem_3	597	602	PF02991	0.562
LIG_MLH1_MIPbox_1	309	313	PF16413	0.552
LIG_PCNA_yPIPBox_3	140	154	PF02747	0.414
LIG_PDZ_Class_2	622	627	PF00595	0.566
LIG_Pex14_1	52	56	PF04695	0.458
LIG_PTB_Apo_2	306	313	PF02174	0.530
LIG_PTB_Phospho_1	306	312	PF10480	0.528
LIG_SH2_CRK	118	122	PF00017	0.412
LIG_SH2_CRK	21	25	PF00017	0.562
LIG_SH2_CRK	503	507	PF00017	0.572
LIG_SH2_GRB2like	21	24	PF00017	0.611
LIG_SH2_GRB2like	503	506	PF00017	0.567
LIG_SH2_NCK_1	503	507	PF00017	0.579
LIG_SH2_SRC	201	204	PF00017	0.604
LIG_SH2_SRC	21	24	PF00017	0.611
LIG_SH2_STAP1	276	280	PF00017	0.593
LIG_SH2_STAT5	312	315	PF00017	0.627
LIG_SH2_STAT5	503	506	PF00017	0.610
LIG_SH2_STAT5	602	605	PF00017	0.567
LIG_SH3_1	60	66	PF00018	0.569
LIG_SH3_3	296	302	PF00018	0.571
LIG_SH3_3	332	338	PF00018	0.728
LIG_SH3_3	518	524	PF00018	0.660
LIG_SH3_3	582	588	PF00018	0.618
LIG_SH3_3	59	65	PF00018	0.500
LIG_SUMO_SIM_anti_2	398	403	PF11976	0.620
LIG_SUMO_SIM_anti_2	406	413	PF11976	0.575
LIG_SUMO_SIM_par_1	361	368	PF11976	0.665
LIG_SUMO_SIM_par_1	371	378	PF11976	0.536
LIG_SUMO_SIM_par_1	38	44	PF11976	0.385
LIG_SUMO_SIM_par_1	619	624	PF11976	0.568
LIG_TRAF2_1	138	141	PF00917	0.439
LIG_TRAF2_1	150	153	PF00917	0.371
LIG_TRAF2_1	44	47	PF00917	0.441
LIG_WRC_WIRS_1	126	131	PF05994	0.388
MOD_CDK_SPK_2	252	257	PF00069	0.622
MOD_CDK_SPK_2	67	72	PF00069	0.457
MOD_CDK_SPxxK_3	290	297	PF00069	0.672
MOD_CDK_SPxxK_3	336	343	PF00069	0.570
MOD_CDK_SPxxK_3	540	547	PF00069	0.635
MOD_CK1_1	191	197	PF00069	0.752
MOD_CK1_1	222	228	PF00069	0.762
MOD_CK1_1	260	266	PF00069	0.568
MOD_CK1_1	31	37	PF00069	0.592
MOD_CK1_1	317	323	PF00069	0.573
MOD_CK1_1	334	340	PF00069	0.613
MOD_CK1_1	368	374	PF00069	0.664
MOD_CK1_1	377	383	PF00069	0.553
MOD_CK1_1	400	406	PF00069	0.583
MOD_CK1_1	448	454	PF00069	0.611
MOD_CK1_1	492	498	PF00069	0.567
MOD_CK1_1	569	575	PF00069	0.611
MOD_CK1_1	579	585	PF00069	0.627
MOD_CK1_1	70	76	PF00069	0.435
MOD_CK1_1	83	89	PF00069	0.424
MOD_CK2_1	111	117	PF00069	0.492
MOD_CK2_1	125	131	PF00069	0.371
MOD_CK2_1	135	141	PF00069	0.435
MOD_CK2_1	147	153	PF00069	0.394
MOD_CK2_1	220	226	PF00069	0.615
MOD_CK2_1	404	410	PF00069	0.651
MOD_CK2_1	41	47	PF00069	0.439
MOD_CK2_1	417	423	PF00069	0.519
MOD_CK2_1	467	473	PF00069	0.677
MOD_CK2_1	479	485	PF00069	0.638
MOD_CK2_1	542	548	PF00069	0.654
MOD_CK2_1	588	594	PF00069	0.540
MOD_Cter_Amidation	615	618	PF01082	0.598
MOD_DYRK1A_RPxSP_1	26	30	PF00069	0.577
MOD_DYRK1A_RPxSP_1	520	524	PF00069	0.544
MOD_GlcNHglycan	123	126	PF01048	0.500
MOD_GlcNHglycan	197	200	PF01048	0.711
MOD_GlcNHglycan	2	5	PF01048	0.640
MOD_GlcNHglycan	203	206	PF01048	0.573
MOD_GlcNHglycan	294	297	PF01048	0.595
MOD_GlcNHglycan	571	574	PF01048	0.801
MOD_GSK3_1	106	113	PF00069	0.557
MOD_GSK3_1	12	19	PF00069	0.629
MOD_GSK3_1	121	128	PF00069	0.327
MOD_GSK3_1	188	195	PF00069	0.659
MOD_GSK3_1	22	29	PF00069	0.547
MOD_GSK3_1	225	232	PF00069	0.613
MOD_GSK3_1	248	255	PF00069	0.635
MOD_GSK3_1	256	263	PF00069	0.659
MOD_GSK3_1	288	295	PF00069	0.714
MOD_GSK3_1	330	337	PF00069	0.635
MOD_GSK3_1	364	371	PF00069	0.695
MOD_GSK3_1	400	407	PF00069	0.712
MOD_GSK3_1	475	482	PF00069	0.592
MOD_GSK3_1	488	495	PF00069	0.579
MOD_GSK3_1	538	545	PF00069	0.581
MOD_GSK3_1	559	566	PF00069	0.597
MOD_GSK3_1	579	586	PF00069	0.466
MOD_GSK3_1	606	613	PF00069	0.551
MOD_GSK3_1	80	87	PF00069	0.464
MOD_LATS_1	239	245	PF00433	0.618
MOD_N-GLC_1	195	200	PF02516	0.719
MOD_N-GLC_1	22	27	PF02516	0.563
MOD_N-GLC_1	308	313	PF02516	0.666
MOD_N-GLC_1	314	319	PF02516	0.563
MOD_N-GLC_1	404	409	PF02516	0.651
MOD_N-GLC_1	80	85	PF02516	0.466
MOD_NEK2_1	121	126	PF00069	0.381
MOD_NEK2_1	220	225	PF00069	0.592
MOD_NEK2_1	229	234	PF00069	0.532
MOD_NEK2_1	307	312	PF00069	0.665
MOD_NEK2_1	346	351	PF00069	0.555
MOD_NEK2_1	404	409	PF00069	0.624
MOD_NEK2_1	417	422	PF00069	0.503
MOD_NEK2_1	559	564	PF00069	0.569
MOD_NEK2_1	621	626	PF00069	0.640
MOD_NEK2_2	16	21	PF00069	0.582
MOD_NEK2_2	314	319	PF00069	0.601
MOD_PIKK_1	136	142	PF00454	0.383
MOD_PIKK_1	355	361	PF00454	0.651
MOD_PIKK_1	404	410	PF00454	0.651
MOD_PIKK_1	489	495	PF00454	0.821
MOD_PIKK_1	588	594	PF00454	0.519
MOD_PIKK_1	9	15	PF00454	0.635
MOD_PKA_1	192	198	PF00069	0.581
MOD_PKA_2	192	198	PF00069	0.581
MOD_PKA_2	256	262	PF00069	0.571
MOD_Plk_1	225	231	PF00069	0.687
MOD_Plk_1	308	314	PF00069	0.572
MOD_Plk_1	365	371	PF00069	0.682
MOD_Plk_1	377	383	PF00069	0.559
MOD_Plk_1	397	403	PF00069	0.589
MOD_Plk_1	404	410	PF00069	0.575
MOD_Plk_1	526	532	PF00069	0.527
MOD_Plk_2-3	41	47	PF00069	0.439
MOD_Plk_4	16	22	PF00069	0.585
MOD_Plk_4	308	314	PF00069	0.577
MOD_Plk_4	368	374	PF00069	0.650
MOD_Plk_4	397	403	PF00069	0.593
MOD_Plk_4	450	456	PF00069	0.608
MOD_Plk_4	508	514	PF00069	0.630
MOD_Plk_4	606	612	PF00069	0.637
MOD_ProDKin_1	12	18	PF00069	0.641
MOD_ProDKin_1	252	258	PF00069	0.653
MOD_ProDKin_1	26	32	PF00069	0.522
MOD_ProDKin_1	288	294	PF00069	0.608
MOD_ProDKin_1	331	337	PF00069	0.657
MOD_ProDKin_1	4	10	PF00069	0.635
MOD_ProDKin_1	520	526	PF00069	0.648
MOD_ProDKin_1	540	546	PF00069	0.567
MOD_ProDKin_1	583	589	PF00069	0.542
MOD_ProDKin_1	67	73	PF00069	0.447
MOD_ProDKin_1	80	86	PF00069	0.440
MOD_SUMO_rev_2	482	489	PF00179	0.635
TRG_DiLeu_BaEn_1	117	122	PF01217	0.421
TRG_DiLeu_BaEn_3	594	600	PF01217	0.615
TRG_DiLeu_BaLyEn_6	358	363	PF01217	0.666
TRG_DiLeu_BaLyEn_6	585	590	PF01217	0.575
TRG_DiLeu_BaLyEn_6	63	68	PF01217	0.545
TRG_ENDOCYTIC_2	118	121	PF00928	0.421
TRG_ENDOCYTIC_2	21	24	PF00928	0.562
TRG_ENDOCYTIC_2	56	59	PF00928	0.489
TRG_ER_diArg_1	166	168	PF00400	0.394
TRG_ER_diArg_1	54	56	PF00400	0.493
TRG_Pf-PMV_PEXEL_1	164	169	PF00026	0.401

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P512	Leptomonas seymouri	40%	98%
A0A3Q8IIC9	Leishmania donovani	87%	100%
A4HB19	Leishmania braziliensis	57%	100%
A4IA76	Leishmania infantum	87%	100%
E9B589	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%