Rhodanese domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

rhodanese-like domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q2P3_LEIMA

TriTrypDb:

LmjF.34.3010 , LMJLV39_340035400 , LMJSD75_340035700

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005815	microtubule organizing center	2	2
GO:0036064	ciliary basal body	3	2
GO:0097542	ciliary tip	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2P3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2P3

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006996	organelle organization	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0018095	protein polyglutamylation	7	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018200	peptidyl-glutamic acid modification	6	2
GO:0019538	protein metabolic process	3	2
GO:0022607	cellular component assembly	4	2
GO:0030030	cell projection organization	4	2
GO:0030031	cell projection assembly	5	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0044782	cilium organization	5	2
GO:0060271	cilium assembly	6	2
GO:0070925	organelle assembly	5	2
GO:0071704	organic substance metabolic process	2	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0120031	plasma membrane bounded cell projection assembly	6	2
GO:0120036	plasma membrane bounded cell projection organization	5	2
GO:1901564	organonitrogen compound metabolic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.441
CLV_NRD_NRD_1	213	215	PF00675	0.603
CLV_NRD_NRD_1	244	246	PF00675	0.574
CLV_PCSK_FUR_1	210	214	PF00082	0.532
CLV_PCSK_KEX2_1	121	123	PF00082	0.187
CLV_PCSK_KEX2_1	15	17	PF00082	0.459
CLV_PCSK_KEX2_1	212	214	PF00082	0.481
CLV_PCSK_KEX2_1	50	52	PF00082	0.541
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.187
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.446
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.499
CLV_PCSK_SKI1_1	10	14	PF00082	0.499
CLV_PCSK_SKI1_1	121	125	PF00082	0.257
CLV_PCSK_SKI1_1	43	47	PF00082	0.509
CLV_PCSK_SKI1_1	75	79	PF00082	0.550
CLV_PCSK_SKI1_1	99	103	PF00082	0.352
DEG_APCC_KENBOX_2	147	151	PF00400	0.430
DOC_MAPK_gen_1	146	155	PF00069	0.417
DOC_MAPK_MEF2A_6	122	131	PF00069	0.368
DOC_MAPK_RevD_3	1	16	PF00069	0.578
DOC_PP2B_PxIxI_1	126	132	PF00149	0.420
DOC_PP4_FxxP_1	83	86	PF00568	0.473
DOC_USP7_MATH_1	100	104	PF00917	0.298
DOC_USP7_MATH_1	225	229	PF00917	0.543
DOC_USP7_MATH_1	241	245	PF00917	0.596
DOC_USP7_UBL2_3	46	50	PF12436	0.501
LIG_14-3-3_CanoR_1	15	23	PF00244	0.499
LIG_14-3-3_CanoR_1	226	236	PF00244	0.511
LIG_BIR_II_1	1	5	PF00653	0.482
LIG_EH_1	135	139	PF12763	0.473
LIG_FHA_1	100	106	PF00498	0.252
LIG_FHA_1	33	39	PF00498	0.408
LIG_LIR_Apic_2	80	86	PF02991	0.476
LIG_LIR_Apic_2	88	93	PF02991	0.458
LIG_LIR_Gen_1	102	112	PF02991	0.288
LIG_LIR_Gen_1	149	158	PF02991	0.520
LIG_LIR_Gen_1	191	200	PF02991	0.380
LIG_LIR_Gen_1	55	65	PF02991	0.341
LIG_LIR_Nem_3	102	107	PF02991	0.288
LIG_LIR_Nem_3	149	155	PF02991	0.500
LIG_LIR_Nem_3	191	195	PF02991	0.397
LIG_LIR_Nem_3	55	60	PF02991	0.345
LIG_LYPXL_yS_3	126	129	PF13949	0.471
LIG_PTB_Apo_2	165	172	PF02174	0.498
LIG_PTB_Apo_2	17	24	PF02174	0.495
LIG_PTB_Phospho_1	165	171	PF10480	0.368
LIG_PTB_Phospho_1	17	23	PF10480	0.494
LIG_Rb_LxCxE_1	102	116	PF01857	0.300
LIG_SH2_CRK	23	27	PF00017	0.567
LIG_SH2_GRB2like	192	195	PF00017	0.309
LIG_SH2_NCK_1	23	27	PF00017	0.439
LIG_SH2_PTP2	152	155	PF00017	0.488
LIG_SH2_STAP1	192	196	PF00017	0.364
LIG_SH2_STAT5	104	107	PF00017	0.417
LIG_SH2_STAT5	152	155	PF00017	0.464
LIG_SH3_3	134	140	PF00018	0.417
LIG_SH3_3	197	203	PF00018	0.399
LIG_SUMO_SIM_anti_2	176	182	PF11976	0.417
LIG_TRAF2_1	70	73	PF00917	0.403
LIG_TYR_ITIM	124	129	PF00017	0.511
LIG_TYR_ITSM	100	107	PF00017	0.209
MOD_CK1_1	32	38	PF00069	0.477
MOD_CK2_1	67	73	PF00069	0.503
MOD_GlcNHglycan	17	20	PF01048	0.576
MOD_GlcNHglycan	31	34	PF01048	0.460
MOD_GSK3_1	216	223	PF00069	0.470
MOD_GSK3_1	236	243	PF00069	0.599
MOD_NEK2_1	166	171	PF00069	0.540
MOD_NEK2_1	236	241	PF00069	0.509
MOD_PIKK_1	216	222	PF00454	0.525
MOD_PKA_1	15	21	PF00069	0.563
MOD_PKA_2	14	20	PF00069	0.602
MOD_PKA_2	225	231	PF00069	0.626
MOD_PKA_2	241	247	PF00069	0.597
MOD_Plk_2-3	73	79	PF00069	0.519
MOD_Plk_4	100	106	PF00069	0.209
MOD_Plk_4	166	172	PF00069	0.450
MOD_Plk_4	73	79	PF00069	0.519
MOD_SUMO_rev_2	70	77	PF00179	0.485
TRG_ENDOCYTIC_2	104	107	PF00928	0.417
TRG_ENDOCYTIC_2	126	129	PF00928	0.511
TRG_ENDOCYTIC_2	152	155	PF00928	0.521
TRG_ENDOCYTIC_2	192	195	PF00928	0.350
TRG_ENDOCYTIC_2	23	26	PF00928	0.446
TRG_ER_diArg_1	59	62	PF00400	0.340

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5F3	Leptomonas seymouri	68%	100%
A0A1X0PB71	Trypanosomatidae	47%	100%
A0A3S7X866	Leishmania donovani	94%	100%
A0A422N4N2	Trypanosoma rangeli	50%	99%
A4HB20	Leishmania braziliensis	84%	100%
A4IA77	Leishmania infantum	93%	100%
C9ZM32	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9B590	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q9BYV8	Homo sapiens	25%	67%
V5BQF3	Trypanosoma cruzi	53%	100%