Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CK1/TTBK protein kinase, putative

Species:

Leishmania major

UniProt:

Q4Q2P2_LEIMA

TriTrypDb:

LmjF.34.3020 , LMJLV39_340035500 , LMJSD75_340035800

Length:

940

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2P2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2P2

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0007165	signal transduction	2	2
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0018105	peptidyl-serine phosphorylation	6	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018209	peptidyl-serine modification	6	2
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0065007	biological regulation	1	2
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0004674	protein serine/threonine kinase activity	4	3
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	332	336	PF00656	0.476
CLV_C14_Caspase3-7	613	617	PF00656	0.543
CLV_MEL_PAP_1	702	708	PF00089	0.649
CLV_NRD_NRD_1	305	307	PF00675	0.412
CLV_NRD_NRD_1	416	418	PF00675	0.314
CLV_NRD_NRD_1	479	481	PF00675	0.310
CLV_NRD_NRD_1	482	484	PF00675	0.310
CLV_NRD_NRD_1	537	539	PF00675	0.310
CLV_NRD_NRD_1	597	599	PF00675	0.471
CLV_NRD_NRD_1	60	62	PF00675	0.617
CLV_NRD_NRD_1	671	673	PF00675	0.682
CLV_NRD_NRD_1	85	87	PF00675	0.616
CLV_NRD_NRD_1	872	874	PF00675	0.670
CLV_PCSK_FUR_1	303	307	PF00082	0.476
CLV_PCSK_FUR_1	480	484	PF00082	0.310
CLV_PCSK_KEX2_1	305	307	PF00082	0.412
CLV_PCSK_KEX2_1	415	417	PF00082	0.310
CLV_PCSK_KEX2_1	479	481	PF00082	0.310
CLV_PCSK_KEX2_1	482	484	PF00082	0.310
CLV_PCSK_KEX2_1	597	599	PF00082	0.475
CLV_PCSK_KEX2_1	60	62	PF00082	0.617
CLV_PCSK_KEX2_1	671	673	PF00082	0.682
CLV_PCSK_KEX2_1	85	87	PF00082	0.614
CLV_PCSK_KEX2_1	871	873	PF00082	0.660
CLV_PCSK_KEX2_1	890	892	PF00082	0.548
CLV_PCSK_PC1ET2_1	871	873	PF00082	0.656
CLV_PCSK_PC1ET2_1	890	892	PF00082	0.547
CLV_PCSK_PC7_1	593	599	PF00082	0.420
CLV_PCSK_PC7_1	867	873	PF00082	0.653
CLV_PCSK_SKI1_1	368	372	PF00082	0.331
CLV_PCSK_SKI1_1	450	454	PF00082	0.310
DEG_Nend_UBRbox_3	1	3	PF02207	0.622
DEG_SCF_FBW7_1	461	468	PF00400	0.294
DEG_SPOP_SBC_1	145	149	PF00917	0.647
DEG_SPOP_SBC_1	151	155	PF00917	0.642
DOC_CKS1_1	212	217	PF01111	0.560
DOC_CKS1_1	462	467	PF01111	0.294
DOC_CKS1_1	688	693	PF01111	0.608
DOC_CYCLIN_yCln2_LP_2	187	190	PF00134	0.700
DOC_CYCLIN_yCln2_LP_2	192	198	PF00134	0.574
DOC_CYCLIN_yCln2_LP_2	820	826	PF00134	0.534
DOC_MAPK_DCC_7	178	187	PF00069	0.557
DOC_MAPK_gen_1	303	310	PF00069	0.460
DOC_MAPK_HePTP_8	175	187	PF00069	0.552
DOC_MAPK_MEF2A_6	178	187	PF00069	0.557
DOC_MAPK_MEF2A_6	356	363	PF00069	0.412
DOC_PIKK_1	342	350	PF02985	0.546
DOC_PP1_RVXF_1	602	609	PF00149	0.447
DOC_PP2B_LxvP_1	187	190	PF13499	0.624
DOC_PP2B_LxvP_1	192	195	PF13499	0.659
DOC_PP2B_LxvP_1	666	669	PF13499	0.681
DOC_PP2B_LxvP_1	820	823	PF13499	0.535
DOC_PP4_FxxP_1	169	172	PF00568	0.537
DOC_USP7_MATH_1	150	154	PF00917	0.661
DOC_USP7_MATH_1	160	164	PF00917	0.556
DOC_USP7_MATH_1	265	269	PF00917	0.612
DOC_USP7_MATH_1	431	435	PF00917	0.383
DOC_USP7_MATH_1	717	721	PF00917	0.647
DOC_USP7_MATH_1	729	733	PF00917	0.562
DOC_USP7_MATH_1	787	791	PF00917	0.609
DOC_USP7_MATH_1	795	799	PF00917	0.639
DOC_USP7_MATH_1	830	834	PF00917	0.655
DOC_USP7_MATH_1	893	897	PF00917	0.573
DOC_USP7_UBL2_3	539	543	PF12436	0.310
DOC_USP7_UBL2_3	926	930	PF12436	0.592
DOC_WW_Pin1_4	110	115	PF00397	0.661
DOC_WW_Pin1_4	120	125	PF00397	0.639
DOC_WW_Pin1_4	146	151	PF00397	0.692
DOC_WW_Pin1_4	201	206	PF00397	0.568
DOC_WW_Pin1_4	211	216	PF00397	0.555
DOC_WW_Pin1_4	230	235	PF00397	0.501
DOC_WW_Pin1_4	287	292	PF00397	0.614
DOC_WW_Pin1_4	461	466	PF00397	0.294
DOC_WW_Pin1_4	552	557	PF00397	0.422
DOC_WW_Pin1_4	687	692	PF00397	0.605
DOC_WW_Pin1_4	789	794	PF00397	0.588
DOC_WW_Pin1_4	815	820	PF00397	0.642
LIG_14-3-3_CanoR_1	146	150	PF00244	0.667
LIG_14-3-3_CanoR_1	415	423	PF00244	0.383
LIG_14-3-3_CanoR_1	502	507	PF00244	0.326
LIG_14-3-3_CanoR_1	736	742	PF00244	0.700
LIG_14-3-3_CanoR_1	794	802	PF00244	0.680
LIG_14-3-3_CanoR_1	85	90	PF00244	0.630
LIG_14-3-3_CanoR_1	99	103	PF00244	0.639
LIG_Actin_WH2_2	366	381	PF00022	0.310
LIG_BIR_III_4	620	624	PF00653	0.645
LIG_BIR_III_4	649	653	PF00653	0.689
LIG_BRCT_BRCA1_1	521	525	PF00533	0.310
LIG_deltaCOP1_diTrp_1	518	525	PF00928	0.310
LIG_FHA_1	133	139	PF00498	0.633
LIG_FHA_1	420	426	PF00498	0.310
LIG_FHA_1	467	473	PF00498	0.315
LIG_FHA_1	530	536	PF00498	0.310
LIG_FHA_1	780	786	PF00498	0.669
LIG_FHA_1	902	908	PF00498	0.623
LIG_FHA_2	861	867	PF00498	0.681
LIG_LIR_Apic_2	167	172	PF02991	0.537
LIG_LIR_Apic_2	763	769	PF02991	0.605
LIG_LIR_Gen_1	320	330	PF02991	0.432
LIG_LIR_Gen_1	500	507	PF02991	0.348
LIG_LIR_Gen_1	518	528	PF02991	0.380
LIG_LIR_Gen_1	581	591	PF02991	0.379
LIG_LIR_Nem_3	422	426	PF02991	0.326
LIG_LIR_Nem_3	500	506	PF02991	0.348
LIG_LIR_Nem_3	518	524	PF02991	0.380
LIG_LIR_Nem_3	534	540	PF02991	0.310
LIG_LIR_Nem_3	565	569	PF02991	0.369
LIG_LIR_Nem_3	581	587	PF02991	0.383
LIG_LIR_Nem_3	814	820	PF02991	0.696
LIG_MYND_1	127	131	PF01753	0.664
LIG_NRBOX	519	525	PF00104	0.310
LIG_Pex14_1	521	525	PF04695	0.310
LIG_Pex14_2	318	322	PF04695	0.435
LIG_SH2_CRK	426	430	PF00017	0.310
LIG_SH2_CRK	503	507	PF00017	0.310
LIG_SH2_CRK	584	588	PF00017	0.376
LIG_SH2_CRK	766	770	PF00017	0.550
LIG_SH2_CRK	817	821	PF00017	0.645
LIG_SH2_GRB2like	63	66	PF00017	0.619
LIG_SH2_NCK_1	503	507	PF00017	0.310
LIG_SH2_STAP1	503	507	PF00017	0.310
LIG_SH2_STAP1	584	588	PF00017	0.449
LIG_SH2_STAT5	390	393	PF00017	0.310
LIG_SH2_STAT5	401	404	PF00017	0.294
LIG_SH2_STAT5	426	429	PF00017	0.351
LIG_SH2_STAT5	471	474	PF00017	0.310
LIG_SH2_STAT5	766	769	PF00017	0.559
LIG_SH3_3	121	127	PF00018	0.656
LIG_SH3_3	324	330	PF00018	0.468
LIG_SH3_3	459	465	PF00018	0.294
LIG_SH3_3	599	605	PF00018	0.444
LIG_SH3_3	662	668	PF00018	0.682
LIG_SH3_3	688	694	PF00018	0.669
LIG_TRAF2_1	330	333	PF00917	0.612
LIG_TRAF2_1	352	355	PF00917	0.531
LIG_WW_3	489	493	PF00397	0.310
LIG_WW_3	668	672	PF00397	0.672
MOD_CDK_SPK_2	110	115	PF00069	0.644
MOD_CDK_SPK_2	287	292	PF00069	0.614
MOD_CDK_SPK_2	789	794	PF00069	0.737
MOD_CK1_1	118	124	PF00069	0.686
MOD_CK1_1	16	22	PF00069	0.545
MOD_CK1_1	161	167	PF00069	0.642
MOD_CK1_1	174	180	PF00069	0.568
MOD_CK1_1	393	399	PF00069	0.310
MOD_CK1_1	434	440	PF00069	0.383
MOD_CK1_1	505	511	PF00069	0.346
MOD_CK1_1	701	707	PF00069	0.674
MOD_CK1_1	92	98	PF00069	0.627
MOD_CK2_1	16	22	PF00069	0.545
MOD_CK2_1	314	320	PF00069	0.445
MOD_CK2_1	481	487	PF00069	0.310
MOD_CK2_1	795	801	PF00069	0.689
MOD_CK2_1	805	811	PF00069	0.562
MOD_CK2_1	847	853	PF00069	0.606
MOD_CK2_1	860	866	PF00069	0.631
MOD_GlcNHglycan	115	118	PF01048	0.675
MOD_GlcNHglycan	19	22	PF01048	0.499
MOD_GlcNHglycan	266	270	PF01048	0.751
MOD_GlcNHglycan	38	41	PF01048	0.697
MOD_GlcNHglycan	392	395	PF01048	0.310
MOD_GlcNHglycan	636	639	PF01048	0.596
MOD_GlcNHglycan	707	710	PF01048	0.705
MOD_GlcNHglycan	719	722	PF01048	0.573
MOD_GlcNHglycan	731	734	PF01048	0.619
MOD_GlcNHglycan	744	747	PF01048	0.631
MOD_GlcNHglycan	774	777	PF01048	0.574
MOD_GlcNHglycan	798	801	PF01048	0.663
MOD_GlcNHglycan	813	816	PF01048	0.529
MOD_GlcNHglycan	832	835	PF01048	0.516
MOD_GlcNHglycan	849	852	PF01048	0.601
MOD_GlcNHglycan	94	97	PF01048	0.617
MOD_GSK3_1	109	116	PF00069	0.698
MOD_GSK3_1	12	19	PF00069	0.578
MOD_GSK3_1	132	139	PF00069	0.634
MOD_GSK3_1	146	153	PF00069	0.554
MOD_GSK3_1	160	167	PF00069	0.537
MOD_GSK3_1	207	214	PF00069	0.751
MOD_GSK3_1	314	321	PF00069	0.445
MOD_GSK3_1	36	43	PF00069	0.630
MOD_GSK3_1	415	422	PF00069	0.310
MOD_GSK3_1	452	459	PF00069	0.310
MOD_GSK3_1	461	468	PF00069	0.310
MOD_GSK3_1	498	505	PF00069	0.316
MOD_GSK3_1	610	617	PF00069	0.530
MOD_GSK3_1	701	708	PF00069	0.685
MOD_GSK3_1	731	738	PF00069	0.707
MOD_GSK3_1	811	818	PF00069	0.648
MOD_GSK3_1	85	92	PF00069	0.626
MOD_N-GLC_1	12	17	PF02516	0.562
MOD_N-GLC_1	151	156	PF02516	0.691
MOD_N-GLC_1	158	163	PF02516	0.623
MOD_N-GLC_1	247	252	PF02516	0.668
MOD_N-GLC_1	6	11	PF02516	0.627
MOD_N-GLC_1	659	664	PF02516	0.678
MOD_N-GLC_1	78	83	PF02516	0.685
MOD_N-GLC_1	811	816	PF02516	0.647
MOD_N-GLC_1	855	860	PF02516	0.604
MOD_N-GLC_1	89	94	PF02516	0.560
MOD_N-GLC_2	881	883	PF02516	0.662
MOD_NEK2_1	136	141	PF00069	0.664
MOD_NEK2_1	293	298	PF00069	0.493
MOD_NEK2_1	318	323	PF00069	0.403
MOD_NEK2_1	481	486	PF00069	0.339
MOD_NEK2_1	497	502	PF00069	0.396
MOD_NEK2_1	586	591	PF00069	0.373
MOD_NEK2_1	614	619	PF00069	0.583
MOD_NEK2_1	847	852	PF00069	0.605
MOD_NEK2_1	89	94	PF00069	0.611
MOD_NEK2_1	907	912	PF00069	0.636
MOD_NEK2_2	6	11	PF00069	0.595
MOD_PIKK_1	118	124	PF00454	0.679
MOD_PIKK_1	415	421	PF00454	0.310
MOD_PIKK_1	55	61	PF00454	0.619
MOD_PIKK_1	855	861	PF00454	0.579
MOD_PK_1	502	508	PF00069	0.310
MOD_PK_1	550	556	PF00069	0.412
MOD_PKA_1	415	421	PF00069	0.310
MOD_PKA_1	85	91	PF00069	0.613
MOD_PKA_2	145	151	PF00069	0.665
MOD_PKA_2	164	170	PF00069	0.485
MOD_PKA_2	415	421	PF00069	0.310
MOD_PKA_2	481	487	PF00069	0.339
MOD_PKA_2	497	503	PF00069	0.396
MOD_PKA_2	735	741	PF00069	0.704
MOD_PKA_2	84	90	PF00069	0.629
MOD_PKA_2	860	866	PF00069	0.633
MOD_PKA_2	92	98	PF00069	0.629
MOD_Plk_1	158	164	PF00069	0.639
MOD_Plk_1	550	556	PF00069	0.412
MOD_Plk_1	6	12	PF00069	0.627
MOD_Plk_1	610	616	PF00069	0.562
MOD_Plk_1	760	766	PF00069	0.624
MOD_Plk_1	78	84	PF00069	0.667
MOD_Plk_1	805	811	PF00069	0.646
MOD_Plk_1	855	861	PF00069	0.602
MOD_Plk_1	907	913	PF00069	0.634
MOD_Plk_4	13	19	PF00069	0.553
MOD_Plk_4	164	170	PF00069	0.627
MOD_Plk_4	207	213	PF00069	0.555
MOD_Plk_4	586	592	PF00069	0.379
MOD_ProDKin_1	110	116	PF00069	0.662
MOD_ProDKin_1	120	126	PF00069	0.639
MOD_ProDKin_1	146	152	PF00069	0.694
MOD_ProDKin_1	201	207	PF00069	0.564
MOD_ProDKin_1	211	217	PF00069	0.590
MOD_ProDKin_1	230	236	PF00069	0.498
MOD_ProDKin_1	287	293	PF00069	0.602
MOD_ProDKin_1	461	467	PF00069	0.294
MOD_ProDKin_1	552	558	PF00069	0.415
MOD_ProDKin_1	687	693	PF00069	0.607
MOD_ProDKin_1	789	795	PF00069	0.589
MOD_ProDKin_1	815	821	PF00069	0.643
MOD_SUMO_for_1	361	364	PF00179	0.377
MOD_SUMO_for_1	889	892	PF00179	0.570
MOD_SUMO_rev_2	364	370	PF00179	0.310
MOD_SUMO_rev_2	918	928	PF00179	0.716
TRG_DiLeu_BaEn_1	342	347	PF01217	0.542
TRG_DiLeu_BaEn_2	564	570	PF01217	0.376
TRG_DiLeu_BaEn_4	332	338	PF01217	0.613
TRG_ENDOCYTIC_2	401	404	PF00928	0.340
TRG_ENDOCYTIC_2	426	429	PF00928	0.351
TRG_ENDOCYTIC_2	503	506	PF00928	0.310
TRG_ENDOCYTIC_2	584	587	PF00928	0.378
TRG_ENDOCYTIC_2	817	820	PF00928	0.555
TRG_ER_diArg_1	302	305	PF00400	0.415
TRG_ER_diArg_1	414	417	PF00400	0.310
TRG_ER_diArg_1	479	481	PF00400	0.310
TRG_ER_diArg_1	60	62	PF00400	0.601
TRG_ER_diArg_1	670	672	PF00400	0.674
TRG_NES_CRM1_1	518	529	PF08389	0.310
TRG_Pf-PMV_PEXEL_1	560	565	PF00026	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK71	Leptomonas seymouri	49%	100%
A0A3Q8IFR1	Leishmania donovani	90%	100%
A4HB21	Leishmania braziliensis	62%	100%
A4IA78	Leishmania infantum	91%	100%
E9B591	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%