Cilia- and flagella-associated protein 418

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Retinal Maintenance, putative

Species:

Leishmania major

UniProt:

Q4Q2P1_LEIMA

TriTrypDb:

LmjF.34.3030 , LMJLV39_340035600 , LMJSD75_340035900

Length:

350

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0001917	photoreceptor inner segment	2	10
GO:0005737	cytoplasm	2	10
GO:0005829	cytosol	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q2P1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2P1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.644
CLV_C14_Caspase3-7	240	244	PF00656	0.424
CLV_C14_Caspase3-7	91	95	PF00656	0.755
CLV_NRD_NRD_1	192	194	PF00675	0.308
CLV_NRD_NRD_1	31	33	PF00675	0.768
CLV_NRD_NRD_1	338	340	PF00675	0.598
CLV_PCSK_KEX2_1	30	32	PF00082	0.777
CLV_PCSK_KEX2_1	338	340	PF00082	0.601
CLV_PCSK_SKI1_1	120	124	PF00082	0.735
CLV_PCSK_SKI1_1	127	131	PF00082	0.683
CLV_PCSK_SKI1_1	194	198	PF00082	0.300
CLV_PCSK_SKI1_1	278	282	PF00082	0.361
CLV_PCSK_SKI1_1	300	304	PF00082	0.361
CLV_PCSK_SKI1_1	46	50	PF00082	0.712
DEG_APCC_DBOX_1	149	157	PF00400	0.699
DOC_CKS1_1	156	161	PF01111	0.618
DOC_MAPK_DCC_7	127	135	PF00069	0.734
DOC_MAPK_gen_1	338	344	PF00069	0.604
DOC_MAPK_HePTP_8	224	236	PF00069	0.561
DOC_MAPK_MEF2A_6	227	236	PF00069	0.556
DOC_PP2B_LxvP_1	330	333	PF13499	0.701
DOC_PP4_FxxP_1	131	134	PF00568	0.688
DOC_USP7_MATH_1	102	106	PF00917	0.729
DOC_USP7_MATH_1	134	138	PF00917	0.703
DOC_USP7_MATH_1	146	150	PF00917	0.557
DOC_USP7_MATH_1	26	30	PF00917	0.721
DOC_USP7_MATH_1	276	280	PF00917	0.558
DOC_USP7_MATH_1	69	73	PF00917	0.728
DOC_WW_Pin1_4	155	160	PF00397	0.616
DOC_WW_Pin1_4	263	268	PF00397	0.531
LIG_14-3-3_CanoR_1	120	126	PF00244	0.671
LIG_14-3-3_CanoR_1	150	154	PF00244	0.475
LIG_14-3-3_CanoR_1	261	270	PF00244	0.490
LIG_14-3-3_CanoR_1	282	290	PF00244	0.591
LIG_14-3-3_CanoR_1	30	39	PF00244	0.688
LIG_14-3-3_CanoR_1	309	315	PF00244	0.715
LIG_14-3-3_CanoR_1	59	65	PF00244	0.783
LIG_14-3-3_CanoR_1	82	86	PF00244	0.606
LIG_BIR_II_1	1	5	PF00653	0.561
LIG_BIR_III_4	94	98	PF00653	0.784
LIG_BRCT_BRCA1_1	127	131	PF00533	0.576
LIG_FHA_1	156	162	PF00498	0.666
LIG_FHA_1	183	189	PF00498	0.536
LIG_FHA_1	275	281	PF00498	0.492
LIG_LIR_Apic_2	128	134	PF02991	0.617
LIG_LIR_Gen_1	258	267	PF02991	0.490
LIG_LIR_Gen_1	295	304	PF02991	0.490
LIG_LIR_Nem_3	258	262	PF02991	0.490
LIG_LIR_Nem_3	295	299	PF02991	0.490
LIG_Pex14_2	131	135	PF04695	0.686
LIG_SH2_CRK	231	235	PF00017	0.490
LIG_SH2_NCK_1	145	149	PF00017	0.721
LIG_SH2_STAT3	290	293	PF00017	0.490
LIG_SH2_STAT5	249	252	PF00017	0.476
LIG_SH2_STAT5	290	293	PF00017	0.499
LIG_SH3_3	130	136	PF00018	0.613
LIG_UBA3_1	7	15	PF00899	0.580
LIG_WRC_WIRS_1	45	50	PF05994	0.593
MOD_CDK_SPxxK_3	155	162	PF00069	0.628
MOD_CK1_1	118	124	PF00069	0.704
MOD_CK1_1	141	147	PF00069	0.733
MOD_CK1_1	149	155	PF00069	0.575
MOD_CK1_1	182	188	PF00069	0.508
MOD_CK1_1	295	301	PF00069	0.485
MOD_CK1_1	63	69	PF00069	0.709
MOD_CK1_1	74	80	PF00069	0.655
MOD_CK2_1	136	142	PF00069	0.665
MOD_CK2_1	64	70	PF00069	0.699
MOD_CK2_1	85	91	PF00069	0.694
MOD_GlcNHglycan	116	120	PF01048	0.727
MOD_GlcNHglycan	127	130	PF01048	0.642
MOD_GlcNHglycan	138	141	PF01048	0.586
MOD_GlcNHglycan	21	24	PF01048	0.716
MOD_GlcNHglycan	243	246	PF01048	0.224
MOD_GlcNHglycan	263	266	PF01048	0.391
MOD_GlcNHglycan	284	287	PF01048	0.287
MOD_GlcNHglycan	300	303	PF01048	0.267
MOD_GlcNHglycan	73	76	PF01048	0.713
MOD_GSK3_1	121	128	PF00069	0.745
MOD_GSK3_1	134	141	PF00069	0.690
MOD_GSK3_1	151	158	PF00069	0.364
MOD_GSK3_1	179	186	PF00069	0.424
MOD_GSK3_1	26	33	PF00069	0.724
MOD_GSK3_1	276	283	PF00069	0.483
MOD_GSK3_1	59	66	PF00069	0.727
MOD_GSK3_1	69	76	PF00069	0.676
MOD_GSK3_1	81	88	PF00069	0.661
MOD_N-GLC_2	18	20	PF02516	0.681
MOD_N-GLC_2	206	208	PF02516	0.331
MOD_NEK2_1	125	130	PF00069	0.743
MOD_NEK2_1	183	188	PF00069	0.536
MOD_NEK2_1	248	253	PF00069	0.490
MOD_NEK2_1	281	286	PF00069	0.548
MOD_NEK2_1	305	310	PF00069	0.570
MOD_NEK2_1	334	339	PF00069	0.676
MOD_PKA_1	30	36	PF00069	0.771
MOD_PKA_2	149	155	PF00069	0.474
MOD_PKA_2	281	287	PF00069	0.591
MOD_PKA_2	30	36	PF00069	0.698
MOD_PKA_2	308	314	PF00069	0.707
MOD_PKA_2	81	87	PF00069	0.721
MOD_Plk_1	183	189	PF00069	0.562
MOD_Plk_1	213	219	PF00069	0.591
MOD_Plk_1	311	317	PF00069	0.765
MOD_Plk_2-3	179	185	PF00069	0.481
MOD_Plk_2-3	3	9	PF00069	0.688
MOD_Plk_4	292	298	PF00069	0.529
MOD_Plk_4	3	9	PF00069	0.646
MOD_ProDKin_1	155	161	PF00069	0.621
MOD_ProDKin_1	263	269	PF00069	0.531
TRG_DiLeu_BaEn_1	3	8	PF01217	0.687
TRG_DiLeu_BaLyEn_6	156	161	PF01217	0.579
TRG_ENDOCYTIC_2	231	234	PF00928	0.490
TRG_ENDOCYTIC_2	249	252	PF00928	0.478
TRG_ER_diArg_1	30	32	PF00400	0.777
TRG_ER_diArg_1	338	340	PF00400	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P513	Leptomonas seymouri	52%	95%
A0A1X0P9U1	Trypanosomatidae	38%	100%
A0A3S7X892	Leishmania donovani	92%	100%
A0A422N4K3	Trypanosoma rangeli	41%	100%
A4HB22	Leishmania braziliensis	71%	100%
A4IA79	Leishmania infantum	91%	100%
C9ZM30	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9B592	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%