CAP_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2P0_LEIMA

TriTrypDb:

LmjF.34.3040 , LMJLV39_340035700 , LMJSD75_340036000

Length:

597

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2P0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2P0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	409	413	PF00656	0.519
CLV_C14_Caspase3-7	502	506	PF00656	0.413
CLV_C14_Caspase3-7	56	60	PF00656	0.476
CLV_C14_Caspase3-7	81	85	PF00656	0.632
CLV_NRD_NRD_1	107	109	PF00675	0.384
CLV_NRD_NRD_1	245	247	PF00675	0.478
CLV_NRD_NRD_1	357	359	PF00675	0.525
CLV_NRD_NRD_1	529	531	PF00675	0.390
CLV_PCSK_KEX2_1	107	109	PF00082	0.384
CLV_PCSK_KEX2_1	529	531	PF00082	0.436
CLV_PCSK_SKI1_1	14	18	PF00082	0.558
CLV_PCSK_SKI1_1	224	228	PF00082	0.641
CLV_PCSK_SKI1_1	288	292	PF00082	0.463
CLV_PCSK_SKI1_1	321	325	PF00082	0.405
CLV_PCSK_SKI1_1	359	363	PF00082	0.389
CLV_PCSK_SKI1_1	439	443	PF00082	0.402
DOC_ANK_TNKS_1	529	536	PF00023	0.395
DOC_CKS1_1	489	494	PF01111	0.507
DOC_CYCLIN_RxL_1	356	366	PF00134	0.353
DOC_CYCLIN_yCln2_LP_2	17	23	PF00134	0.627
DOC_CYCLIN_yCln2_LP_2	424	430	PF00134	0.517
DOC_MAPK_RevD_3	234	248	PF00069	0.574
DOC_MAPK_RevD_3	515	530	PF00069	0.399
DOC_PP2B_LxvP_1	206	209	PF13499	0.597
DOC_PP2B_LxvP_1	72	75	PF13499	0.519
DOC_PP4_FxxP_1	276	279	PF00568	0.490
DOC_PP4_FxxP_1	292	295	PF00568	0.395
DOC_PP4_FxxP_1	339	342	PF00568	0.307
DOC_USP7_MATH_1	10	14	PF00917	0.639
DOC_USP7_MATH_1	217	221	PF00917	0.703
DOC_USP7_MATH_1	301	305	PF00917	0.387
DOC_USP7_MATH_1	349	353	PF00917	0.412
DOC_USP7_MATH_1	385	389	PF00917	0.602
DOC_USP7_MATH_1	443	447	PF00917	0.415
DOC_USP7_MATH_1	47	51	PF00917	0.409
DOC_USP7_UBL2_3	223	227	PF12436	0.616
DOC_USP7_UBL2_3	229	233	PF12436	0.583
DOC_USP7_UBL2_3	486	490	PF12436	0.531
DOC_USP7_UBL2_3	5	9	PF12436	0.622
DOC_WW_Pin1_4	234	239	PF00397	0.612
DOC_WW_Pin1_4	376	381	PF00397	0.516
DOC_WW_Pin1_4	403	408	PF00397	0.622
DOC_WW_Pin1_4	488	493	PF00397	0.536
LIG_14-3-3_CanoR_1	288	293	PF00244	0.403
LIG_14-3-3_CanoR_1	300	306	PF00244	0.422
LIG_14-3-3_CanoR_1	529	533	PF00244	0.388
LIG_APCC_ABBA_1	147	152	PF00400	0.548
LIG_BIR_III_4	57	61	PF00653	0.562
LIG_BRCT_BRCA1_1	27	31	PF00533	0.470
LIG_BRCT_BRCA1_1	505	509	PF00533	0.344
LIG_FHA_1	158	164	PF00498	0.476
LIG_FHA_1	27	33	PF00498	0.648
LIG_FHA_1	364	370	PF00498	0.371
LIG_FHA_1	418	424	PF00498	0.485
LIG_FHA_1	477	483	PF00498	0.568
LIG_FHA_1	560	566	PF00498	0.485
LIG_FHA_1	67	73	PF00498	0.454
LIG_FHA_2	315	321	PF00498	0.556
LIG_FHA_2	500	506	PF00498	0.434
LIG_FHA_2	54	60	PF00498	0.465
LIG_IBAR_NPY_1	148	150	PF08397	0.530
LIG_LIR_Apic_2	275	279	PF02991	0.545
LIG_LIR_Apic_2	291	295	PF02991	0.439
LIG_LIR_Apic_2	338	342	PF02991	0.305
LIG_LIR_Apic_2	585	591	PF02991	0.481
LIG_LIR_Gen_1	280	290	PF02991	0.377
LIG_LIR_Gen_1	36	44	PF02991	0.487
LIG_LIR_Gen_1	464	473	PF02991	0.342
LIG_LIR_Gen_1	506	517	PF02991	0.381
LIG_LIR_Gen_1	577	583	PF02991	0.463
LIG_LIR_Nem_3	280	285	PF02991	0.356
LIG_LIR_Nem_3	327	332	PF02991	0.436
LIG_LIR_Nem_3	36	41	PF02991	0.511
LIG_LIR_Nem_3	464	468	PF02991	0.340
LIG_LIR_Nem_3	477	481	PF02991	0.535
LIG_LIR_Nem_3	506	512	PF02991	0.394
LIG_LIR_Nem_3	577	581	PF02991	0.493
LIG_MYND_1	234	238	PF01753	0.540
LIG_MYND_1	591	595	PF01753	0.431
LIG_Pex14_2	31	35	PF04695	0.601
LIG_PTB_Apo_2	304	311	PF02174	0.523
LIG_SH2_CRK	329	333	PF00017	0.430
LIG_SH2_CRK	348	352	PF00017	0.243
LIG_SH2_CRK	588	592	PF00017	0.486
LIG_SH2_GRB2like	588	591	PF00017	0.428
LIG_SH2_NCK_1	348	352	PF00017	0.434
LIG_SH2_NCK_1	38	42	PF00017	0.556
LIG_SH2_SRC	150	153	PF00017	0.492
LIG_SH2_SRC	532	535	PF00017	0.389
LIG_SH2_SRC	588	591	PF00017	0.428
LIG_SH2_STAP1	150	154	PF00017	0.523
LIG_SH2_STAP1	159	163	PF00017	0.505
LIG_SH2_STAP1	478	482	PF00017	0.579
LIG_SH2_STAT3	255	258	PF00017	0.514
LIG_SH2_STAT5	159	162	PF00017	0.486
LIG_SH2_STAT5	272	275	PF00017	0.654
LIG_SH2_STAT5	329	332	PF00017	0.377
LIG_SH2_STAT5	473	476	PF00017	0.433
LIG_SH2_STAT5	478	481	PF00017	0.575
LIG_SH2_STAT5	532	535	PF00017	0.432
LIG_SH2_STAT5	556	559	PF00017	0.409
LIG_SH3_1	486	492	PF00018	0.560
LIG_SH3_2	193	198	PF14604	0.500
LIG_SH3_3	121	127	PF00018	0.616
LIG_SH3_3	134	140	PF00018	0.556
LIG_SH3_3	187	193	PF00018	0.441
LIG_SH3_3	401	407	PF00018	0.603
LIG_SH3_3	486	492	PF00018	0.589
LIG_SH3_3	59	65	PF00018	0.489
LIG_Sin3_3	90	97	PF02671	0.326
LIG_SUMO_SIM_anti_2	69	78	PF11976	0.485
LIG_SUMO_SIM_par_1	319	327	PF11976	0.410
LIG_SUMO_SIM_par_1	69	78	PF11976	0.513
LIG_SUMO_SIM_par_1	90	95	PF11976	0.506
LIG_TRAF2_1	142	145	PF00917	0.587
LIG_TRAF2_1	266	269	PF00917	0.438
LIG_TRAF2_1	75	78	PF00917	0.580
LIG_WRC_WIRS_1	273	278	PF05994	0.550
MOD_CK1_1	25	31	PF00069	0.517
MOD_CK1_1	37	43	PF00069	0.485
MOD_CK1_1	503	509	PF00069	0.349
MOD_CK2_1	528	534	PF00069	0.393
MOD_CK2_1	9	15	PF00069	0.682
MOD_DYRK1A_RPxSP_1	403	407	PF00069	0.580
MOD_GlcNHglycan	24	27	PF01048	0.566
MOD_GlcNHglycan	351	354	PF01048	0.405
MOD_GlcNHglycan	395	400	PF01048	0.619
MOD_GlcNHglycan	444	448	PF01048	0.402
MOD_GlcNHglycan	534	538	PF01048	0.486
MOD_GlcNHglycan	84	87	PF01048	0.557
MOD_GSK3_1	112	119	PF00069	0.538
MOD_GSK3_1	157	164	PF00069	0.580
MOD_GSK3_1	22	29	PF00069	0.474
MOD_GSK3_1	225	232	PF00069	0.567
MOD_GSK3_1	33	40	PF00069	0.544
MOD_GSK3_1	476	483	PF00069	0.609
MOD_GSK3_1	499	506	PF00069	0.397
MOD_GSK3_1	5	12	PF00069	0.684
MOD_GSK3_1	520	527	PF00069	0.403
MOD_N-GLC_1	10	15	PF02516	0.606
MOD_N-GLC_1	412	417	PF02516	0.519
MOD_NEK2_1	225	230	PF00069	0.506
MOD_NEK2_1	324	329	PF00069	0.419
MOD_NEK2_1	519	524	PF00069	0.478
MOD_NEK2_2	26	31	PF00069	0.603
MOD_NEK2_2	476	481	PF00069	0.476
MOD_NEK2_2	559	564	PF00069	0.414
MOD_PIKK_1	324	330	PF00454	0.350
MOD_PIKK_1	363	369	PF00454	0.468
MOD_PK_1	161	167	PF00069	0.316
MOD_PK_1	524	530	PF00069	0.385
MOD_PKA_1	229	235	PF00069	0.594
MOD_PKA_1	4	10	PF00069	0.621
MOD_PKA_2	157	163	PF00069	0.485
MOD_PKA_2	520	526	PF00069	0.399
MOD_PKA_2	528	534	PF00069	0.336
MOD_Plk_1	161	167	PF00069	0.479
MOD_Plk_1	500	506	PF00069	0.427
MOD_Plk_1	559	565	PF00069	0.409
MOD_Plk_1	584	590	PF00069	0.477
MOD_Plk_2-3	202	208	PF00069	0.589
MOD_Plk_4	112	118	PF00069	0.462
MOD_Plk_4	26	32	PF00069	0.633
MOD_Plk_4	476	482	PF00069	0.537
MOD_Plk_4	546	552	PF00069	0.374
MOD_ProDKin_1	234	240	PF00069	0.607
MOD_ProDKin_1	376	382	PF00069	0.526
MOD_ProDKin_1	403	409	PF00069	0.621
MOD_ProDKin_1	488	494	PF00069	0.539
MOD_SUMO_for_1	142	145	PF00179	0.554
MOD_SUMO_for_1	266	269	PF00179	0.455
TRG_DiLeu_BaEn_1	269	274	PF01217	0.460
TRG_DiLeu_BaLyEn_6	319	324	PF01217	0.435
TRG_ENDOCYTIC_2	329	332	PF00928	0.337
TRG_ENDOCYTIC_2	38	41	PF00928	0.497
TRG_ER_diArg_1	528	530	PF00400	0.435
TRG_ER_diArg_1	563	566	PF00400	0.399
TRG_NLS_MonoExtC_3	228	233	PF00514	0.669
TRG_NLS_MonoExtN_4	2	8	PF00514	0.623
TRG_NLS_MonoExtN_4	227	234	PF00514	0.647

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5J9	Leptomonas seymouri	58%	100%
A0A1X0PAQ0	Trypanosomatidae	30%	100%
A0A3S5H7X4	Leishmania donovani	92%	100%
A4HB23	Leishmania braziliensis	75%	99%
A4IA80	Leishmania infantum	91%	100%
C9ZM29	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B593	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%