Cytochrome b5 heme-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome b5-like Heme/Steroid binding domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q2N9_LEIMA

TriTrypDb:

LmjF.34.3050 , LMJLV39_340035800 , LMJSD75_340036100

Length:

178

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 40

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	2
GO:0012505	endomembrane system	2	3
GO:0016020	membrane	2	10
GO:0019867	outer membrane	3	2
GO:0031090	organelle membrane	3	2
GO:0031966	mitochondrial membrane	4	2
GO:0031968	organelle outer membrane	4	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q2N9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2N9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	50	52	PF00082	0.716
CLV_PCSK_KEX2_1	6	8	PF00082	0.366
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.681
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.319
CLV_PCSK_SKI1_1	7	11	PF00082	0.209
DOC_MAPK_gen_1	6	14	PF00069	0.432
DOC_MAPK_gen_1	87	95	PF00069	0.285
DOC_MAPK_MEF2A_6	6	14	PF00069	0.445
DOC_MAPK_MEF2A_6	90	97	PF00069	0.255
DOC_PP4_FxxP_1	106	109	PF00568	0.314
DOC_USP7_MATH_1	13	17	PF00917	0.305
DOC_USP7_MATH_1	20	24	PF00917	0.319
DOC_USP7_UBL2_3	156	160	PF12436	0.340
DOC_USP7_UBL2_3	31	35	PF12436	0.422
LIG_14-3-3_CanoR_1	51	60	PF00244	0.433
LIG_14-3-3_CanoR_1	90	96	PF00244	0.280
LIG_BIR_II_1	1	5	PF00653	0.647
LIG_FHA_1	19	25	PF00498	0.352
LIG_LIR_Gen_1	89	100	PF02991	0.314
LIG_LIR_Nem_3	159	164	PF02991	0.334
LIG_LIR_Nem_3	170	176	PF02991	0.377
LIG_LIR_Nem_3	81	86	PF02991	0.298
LIG_LIR_Nem_3	89	95	PF02991	0.331
LIG_LYPXL_yS_3	161	164	PF13949	0.323
LIG_SH2_CRK	83	87	PF00017	0.251
LIG_SH2_GRB2like	134	137	PF00017	0.280
LIG_SH2_NCK_1	100	104	PF00017	0.251
LIG_SH2_STAT3	134	137	PF00017	0.291
LIG_SH2_STAT5	134	137	PF00017	0.280
LIG_SH2_STAT5	153	156	PF00017	0.179
LIG_SH2_STAT5	167	170	PF00017	0.306
LIG_SH2_STAT5	26	29	PF00017	0.544
LIG_SH2_STAT5	75	78	PF00017	0.329
LIG_SUMO_SIM_anti_2	143	152	PF11976	0.316
LIG_SUMO_SIM_par_1	10	16	PF11976	0.270
LIG_TRAF2_1	143	146	PF00917	0.333
MOD_CK2_1	140	146	PF00069	0.310
MOD_CK2_1	52	58	PF00069	0.531
MOD_Cter_Amidation	4	7	PF01082	0.313
MOD_GlcNHglycan	15	18	PF01048	0.283
MOD_GlcNHglycan	54	57	PF01048	0.696
MOD_GlcNHglycan	61	64	PF01048	0.660
MOD_GlcNHglycan	67	70	PF01048	0.536
MOD_LATS_1	49	55	PF00433	0.399
MOD_N-GLC_1	140	145	PF02516	0.516
MOD_NEK2_2	20	25	PF00069	0.311
MOD_PIKK_1	78	84	PF00454	0.304
MOD_PKA_1	50	56	PF00069	0.476
MOD_PKA_2	50	56	PF00069	0.524
MOD_Plk_4	20	26	PF00069	0.393
MOD_SUMO_for_1	86	89	PF00179	0.316
TRG_DiLeu_BaEn_4	145	151	PF01217	0.273
TRG_ENDOCYTIC_2	113	116	PF00928	0.363
TRG_ENDOCYTIC_2	161	164	PF00928	0.323
TRG_ENDOCYTIC_2	83	86	PF00928	0.251

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I427	Leptomonas seymouri	73%	95%
A0A0S4IWT4	Bodo saltans	38%	100%
A0A0S4KHZ8	Bodo saltans	38%	100%
A0A3Q8IGX1	Leishmania donovani	41%	100%
A0A3R7RC54	Trypanosoma rangeli	42%	99%
A0A3S7X865	Leishmania donovani	96%	100%
A4H7Y9	Leishmania braziliensis	40%	100%
A4HB24	Leishmania braziliensis	84%	100%
A4HQJ0	Leishmania braziliensis	34%	100%
A4IA81	Leishmania infantum	96%	100%
E9AHZ9	Leishmania infantum	41%	100%
E9AUA3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9B594	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O00264	Homo sapiens	31%	91%
Q1JQA5	Bos taurus	33%	100%
Q4Q088	Leishmania major	40%	100%
Q5RED0	Pongo abelii	31%	91%
Q5ZKN2	Gallus gallus	36%	93%
Q9UMX5	Homo sapiens	33%	100%
Q9XFM6	Arabidopsis thaliana	39%	81%
V5DM24	Trypanosoma cruzi	46%	99%