Mitochondrial carrier protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial carrier protein-like protein

Species:

Leishmania major

UniProt:

Q4Q2N8_LEIMA

TriTrypDb:

LmjF.34.3060 , LMJLV39_340035900 , LMJSD75_340036200

Length:

358

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0016020	membrane	2	7
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4Q2N8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2N8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0009987	cellular process	1	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1

Molecular functions
Term	Name	Level	Count
GO:0000295	adenine nucleotide transmembrane transporter activity	6	2
GO:0005215	transporter activity	1	2
GO:0005346	purine ribonucleotide transmembrane transporter activity	4	2
GO:0005347	ATP transmembrane transporter activity	5	2
GO:0008509	monoatomic anion transmembrane transporter activity	4	2
GO:0008514	organic anion transmembrane transporter activity	5	2
GO:0015075	monoatomic ion transmembrane transporter activity	3	2
GO:0015215	nucleotide transmembrane transporter activity	4	2
GO:0015216	purine nucleotide transmembrane transporter activity	5	2
GO:0015605	organophosphate ester transmembrane transporter activity	3	2
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	2
GO:0022857	transmembrane transporter activity	2	2
GO:1901505	carbohydrate derivative transmembrane transporter activity	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	63	67	PF00656	0.462
CLV_NRD_NRD_1	33	35	PF00675	0.487
CLV_NRD_NRD_1	49	51	PF00675	0.503
CLV_PCSK_KEX2_1	258	260	PF00082	0.595
CLV_PCSK_KEX2_1	33	35	PF00082	0.487
CLV_PCSK_PC1ET2_1	258	260	PF00082	0.595
CLV_PCSK_SKI1_1	255	259	PF00082	0.569
CLV_PCSK_SKI1_1	320	324	PF00082	0.486
CLV_PCSK_SKI1_1	51	55	PF00082	0.550
CLV_Separin_Metazoa	204	208	PF03568	0.436
DEG_APCC_DBOX_1	32	40	PF00400	0.565
DEG_Nend_Nbox_1	1	3	PF02207	0.688
DEG_SCF_FBW7_1	123	128	PF00400	0.608
DOC_AGCK_PIF_2	344	349	PF00069	0.211
DOC_CDC14_PxL_1	156	164	PF14671	0.523
DOC_CKS1_1	145	150	PF01111	0.617
DOC_MAPK_gen_1	133	141	PF00069	0.627
DOC_MAPK_gen_1	46	55	PF00069	0.534
DOC_MAPK_gen_1	71	81	PF00069	0.396
DOC_PP2B_LxvP_1	146	149	PF13499	0.591
DOC_USP7_MATH_1	116	120	PF00917	0.663
DOC_USP7_MATH_1	243	247	PF00917	0.388
DOC_WW_Pin1_4	112	117	PF00397	0.663
DOC_WW_Pin1_4	121	126	PF00397	0.749
DOC_WW_Pin1_4	144	149	PF00397	0.612
LIG_14-3-3_CanoR_1	137	142	PF00244	0.590
LIG_14-3-3_CanoR_1	34	40	PF00244	0.471
LIG_Actin_WH2_2	322	337	PF00022	0.388
LIG_deltaCOP1_diTrp_1	5	12	PF00928	0.527
LIG_eIF4E_1	349	355	PF01652	0.211
LIG_FHA_1	122	128	PF00498	0.661
LIG_FHA_1	186	192	PF00498	0.377
LIG_FHA_1	341	347	PF00498	0.388
LIG_FHA_2	126	132	PF00498	0.714
LIG_GBD_Chelix_1	28	36	PF00786	0.564
LIG_Integrin_isoDGR_2	300	302	PF01839	0.388
LIG_LIR_Gen_1	147	156	PF02991	0.594
LIG_LIR_Gen_1	25	32	PF02991	0.412
LIG_LIR_Gen_1	343	350	PF02991	0.388
LIG_LIR_Gen_1	75	86	PF02991	0.575
LIG_LIR_Nem_3	104	109	PF02991	0.524
LIG_LIR_Nem_3	147	153	PF02991	0.610
LIG_LIR_Nem_3	217	222	PF02991	0.388
LIG_LIR_Nem_3	25	29	PF02991	0.239
LIG_LIR_Nem_3	323	329	PF02991	0.370
LIG_LIR_Nem_3	343	347	PF02991	0.161
LIG_LIR_Nem_3	5	11	PF02991	0.527
LIG_LIR_Nem_3	75	81	PF02991	0.553
LIG_PCNA_yPIPBox_3	315	326	PF02747	0.388
LIG_Pex14_2	218	222	PF04695	0.346
LIG_Pex14_2	26	30	PF04695	0.471
LIG_SH2_CRK	106	110	PF00017	0.486
LIG_SH2_NCK_1	240	244	PF00017	0.388
LIG_SH2_STAP1	349	353	PF00017	0.211
LIG_SH2_STAP1	40	44	PF00017	0.497
LIG_SH2_STAT3	250	253	PF00017	0.509
LIG_SH2_STAT5	333	336	PF00017	0.388
LIG_SH2_STAT5	35	38	PF00017	0.498
LIG_SH3_3	280	286	PF00018	0.388
LIG_TYR_ITIM	230	235	PF00017	0.388
LIG_UBA3_1	179	187	PF00899	0.329
LIG_UBA3_1	248	256	PF00899	0.612
MOD_CK1_1	115	121	PF00069	0.690
MOD_CK1_1	144	150	PF00069	0.614
MOD_CK1_1	263	269	PF00069	0.557
MOD_CK1_1	324	330	PF00069	0.388
MOD_CK1_1	340	346	PF00069	0.267
MOD_CK2_1	125	131	PF00069	0.625
MOD_CK2_1	35	41	PF00069	0.473
MOD_GlcNHglycan	118	121	PF01048	0.580
MOD_GlcNHglycan	241	244	PF01048	0.392
MOD_GlcNHglycan	265	268	PF01048	0.565
MOD_GlcNHglycan	306	309	PF01048	0.486
MOD_GlcNHglycan	326	329	PF01048	0.388
MOD_GlcNHglycan	339	342	PF01048	0.388
MOD_GSK3_1	112	119	PF00069	0.624
MOD_GSK3_1	121	128	PF00069	0.700
MOD_GSK3_1	137	144	PF00069	0.573
MOD_GSK3_1	239	246	PF00069	0.388
MOD_GSK3_1	275	282	PF00069	0.388
MOD_GSK3_1	289	296	PF00069	0.267
MOD_GSK3_1	320	327	PF00069	0.388
MOD_N-GLC_1	164	169	PF02516	0.388
MOD_N-GLC_1	64	69	PF02516	0.400
MOD_NEK2_1	239	244	PF00069	0.388
MOD_NEK2_1	274	279	PF00069	0.370
MOD_NEK2_2	321	326	PF00069	0.388
MOD_NEK2_2	35	40	PF00069	0.466
MOD_PIKK_1	293	299	PF00454	0.381
MOD_PK_1	137	143	PF00069	0.633
MOD_PK_1	64	70	PF00069	0.574
MOD_PKA_1	304	310	PF00069	0.411
MOD_PKB_1	135	143	PF00069	0.585
MOD_PKB_1	291	299	PF00069	0.388
MOD_Plk_1	141	147	PF00069	0.621
MOD_Plk_1	164	170	PF00069	0.388
MOD_Plk_1	260	266	PF00069	0.479
MOD_Plk_1	64	70	PF00069	0.370
MOD_Plk_4	109	115	PF00069	0.543
MOD_Plk_4	141	147	PF00069	0.621
MOD_Plk_4	243	249	PF00069	0.388
MOD_Plk_4	321	327	PF00069	0.388
MOD_Plk_4	340	346	PF00069	0.388
MOD_Plk_4	35	41	PF00069	0.473
MOD_Plk_4	94	100	PF00069	0.696
MOD_ProDKin_1	112	118	PF00069	0.663
MOD_ProDKin_1	121	127	PF00069	0.741
MOD_ProDKin_1	144	150	PF00069	0.614
TRG_DiLeu_BaLyEn_6	349	354	PF01217	0.367
TRG_ENDOCYTIC_2	106	109	PF00928	0.485
TRG_ENDOCYTIC_2	219	222	PF00928	0.388
TRG_ENDOCYTIC_2	232	235	PF00928	0.388
TRG_ENDOCYTIC_2	306	309	PF00928	0.388
TRG_ER_diArg_1	132	135	PF00400	0.623
TRG_ER_diArg_1	290	293	PF00400	0.388
TRG_ER_diArg_1	32	34	PF00400	0.472
TRG_NLS_Bipartite_1	33	54	PF00514	0.588
TRG_NLS_MonoExtC_3	254	259	PF00514	0.565
TRG_NLS_MonoExtN_4	48	54	PF00514	0.534
TRG_Pf-PMV_PEXEL_1	352	356	PF00026	0.367

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXG6	Leptomonas seymouri	70%	68%
A0A1X0NTK9	Trypanosomatidae	23%	100%
A0A3Q8INL3	Leishmania donovani	94%	100%
A2ASZ8	Mus musculus	23%	76%
A2CEQ0	Danio rerio	28%	76%
A4H8E6	Leishmania braziliensis	24%	100%
A4HB25	Leishmania braziliensis	78%	100%
A4IA82	Leishmania infantum	94%	100%
B2VSU4	Pyrenophora tritici-repentis (strain Pt-1C-BFP)	22%	100%
E9B595	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
O97649	Sus scrofa	27%	100%
P32331	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P55916	Homo sapiens	26%	100%
P56501	Mus musculus	25%	100%
Q0V7M4	Bos taurus	22%	76%
Q5XH95	Xenopus tropicalis	29%	70%
Q6FR88	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	23%	100%
Q6KCM7	Homo sapiens	22%	76%
Q86AV5	Dictyostelium discoideum	25%	100%
Q8K3P6	Rattus norvegicus	23%	76%
Q9N2I9	Canis lupus familiaris	27%	100%
Q9P6L7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	99%