Putative exosome subunit rrp6p homologue

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

exosome subunit rrp6p homologue, putative

Species:

Leishmania major

UniProt:

Q4Q2N6_LEIMA

TriTrypDb:

LmjF.34.3080 , LMJLV39_340036200 , LMJSD75_340036400

Length:

742

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000176	nuclear exosome (RNase complex)	3	12
GO:0000178	exosome (RNase complex)	4	12
GO:0005730	nucleolus	5	2
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	12
GO:1902494	catalytic complex	2	12
GO:1905354	exoribonuclease complex	3	12

Expansion

Sequence features

Q4Q2N6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2N6

Function

Biological processes
Term	Name	Level	Count
GO:0000459	exonucleolytic trimming involved in rRNA processing	8	12
GO:0000467	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	12
GO:0000469	cleavage involved in rRNA processing	7	12
GO:0000956	nuclear-transcribed mRNA catabolic process	7	2
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006399	tRNA metabolic process	7	2
GO:0006401	RNA catabolic process	5	2
GO:0006402	mRNA catabolic process	6	2
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008334	histone mRNA metabolic process	7	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009892	negative regulation of metabolic process	4	2
GO:0009987	cellular process	1	12
GO:0010468	regulation of gene expression	5	2
GO:0010605	negative regulation of macromolecule metabolic process	5	2
GO:0010629	negative regulation of gene expression	6	2
GO:0016070	RNA metabolic process	5	12
GO:0016071	mRNA metabolic process	6	2
GO:0016072	rRNA metabolic process	7	12
GO:0016073	snRNA metabolic process	7	2
GO:0016074	sno(s)RNA metabolic process	7	2
GO:0016075	rRNA catabolic process	7	2
GO:0016076	snRNA catabolic process	7	2
GO:0016077	sno(s)RNA catabolic process	7	2
GO:0016078	tRNA catabolic process	7	2
GO:0019222	regulation of metabolic process	3	2
GO:0019439	aromatic compound catabolic process	4	2
GO:0031123	RNA 3'-end processing	7	12
GO:0031125	rRNA 3'-end processing	9	12
GO:0031126	sno(s)RNA 3'-end processing	9	2
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034655	nucleobase-containing compound catabolic process	4	2
GO:0034660	ncRNA metabolic process	6	12
GO:0034661	ncRNA catabolic process	6	2
GO:0042868	antisense RNA metabolic process	7	2
GO:0043144	sno(s)RNA processing	8	2
GO:0043170	macromolecule metabolic process	3	12
GO:0043628	regulatory ncRNA 3'-end processing	8	12
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0043633	polyadenylation-dependent RNA catabolic process	6	2
GO:0043634	polyadenylation-dependent ncRNA catabolic process	7	2
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0044270	cellular nitrogen compound catabolic process	4	2
GO:0046483	heterocycle metabolic process	3	12
GO:0046700	heterocycle catabolic process	4	2
GO:0048519	negative regulation of biological process	3	2
GO:0050789	regulation of biological process	2	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0071025	RNA surveillance	6	2
GO:0071027	nuclear RNA surveillance	7	2
GO:0071029	nuclear ncRNA surveillance	7	2
GO:0071034	CUT catabolic process	7	2
GO:0071035	nuclear polyadenylation-dependent rRNA catabolic process	8	2
GO:0071036	nuclear polyadenylation-dependent snoRNA catabolic process	8	2
GO:0071037	nuclear polyadenylation-dependent snRNA catabolic process	8	2
GO:0071038	nuclear polyadenylation-dependent tRNA catabolic process	8	2
GO:0071039	nuclear polyadenylation-dependent CUT catabolic process	8	2
GO:0071040	nuclear polyadenylation-dependent antisense transcript catabolic process	8	2
GO:0071041	antisense RNA transcript catabolic process	7	2
GO:0071043	CUT metabolic process	7	2
GO:0071044	histone mRNA catabolic process	8	2
GO:0071046	nuclear polyadenylation-dependent ncRNA catabolic process	8	2
GO:0071051	polyadenylation-dependent snoRNA 3'-end processing	10	2
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	12
GO:0090501	RNA phosphodiester bond hydrolysis	6	12
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	7	12
GO:0106354	tRNA surveillance	7	2
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901361	organic cyclic compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0000175	3'-5'-RNA exonuclease activity	7	12
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	2
GO:0003727	single-stranded RNA binding	5	2
GO:0003824	catalytic activity	1	12
GO:0004518	nuclease activity	4	12
GO:0004527	exonuclease activity	5	12
GO:0004532	RNA exonuclease activity	5	12
GO:0004540	RNA nuclease activity	4	12
GO:0005488	binding	1	12
GO:0008408	3'-5' exonuclease activity	6	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	12
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	12
GO:0036094	small molecule binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.266
CLV_C14_Caspase3-7	108	112	PF00656	0.266
CLV_C14_Caspase3-7	690	694	PF00656	0.654
CLV_NRD_NRD_1	119	121	PF00675	0.555
CLV_NRD_NRD_1	164	166	PF00675	0.494
CLV_NRD_NRD_1	48	50	PF00675	0.368
CLV_NRD_NRD_1	74	76	PF00675	0.266
CLV_PCSK_KEX2_1	164	166	PF00082	0.494
CLV_PCSK_KEX2_1	540	542	PF00082	0.411
CLV_PCSK_KEX2_1	72	74	PF00082	0.325
CLV_PCSK_PC1ET2_1	540	542	PF00082	0.411
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.303
CLV_PCSK_SKI1_1	247	251	PF00082	0.319
CLV_PCSK_SKI1_1	395	399	PF00082	0.222
CLV_PCSK_SKI1_1	438	442	PF00082	0.383
CLV_PCSK_SKI1_1	457	461	PF00082	0.152
CLV_PCSK_SKI1_1	495	499	PF00082	0.288
CLV_PCSK_SKI1_1	535	539	PF00082	0.597
CLV_PCSK_SKI1_1	572	576	PF00082	0.607
CLV_PCSK_SKI1_1	598	602	PF00082	0.650
CLV_PCSK_SKI1_1	713	717	PF00082	0.652
DEG_ODPH_VHL_1	296	308	PF01847	0.448
DEG_SIAH_1	217	225	PF03145	0.495
DOC_CKS1_1	170	175	PF01111	0.474
DOC_CKS1_1	2	7	PF01111	0.661
DOC_CYCLIN_RxL_1	244	253	PF00134	0.508
DOC_CYCLIN_RxL_1	391	402	PF00134	0.423
DOC_CYCLIN_yCln2_LP_2	340	346	PF00134	0.498
DOC_MAPK_DCC_7	219	227	PF00069	0.485
DOC_MAPK_gen_1	164	170	PF00069	0.510
DOC_MAPK_MEF2A_6	14	21	PF00069	0.482
DOC_MAPK_MEF2A_6	219	227	PF00069	0.404
DOC_MAPK_MEF2A_6	509	518	PF00069	0.538
DOC_PP1_SILK_1	303	308	PF00149	0.509
DOC_PP2B_LxvP_1	340	343	PF13499	0.422
DOC_PP4_FxxP_1	170	173	PF00568	0.391
DOC_PP4_FxxP_1	209	212	PF00568	0.432
DOC_PP4_FxxP_1	300	303	PF00568	0.434
DOC_USP7_MATH_1	102	106	PF00917	0.282
DOC_USP7_MATH_1	138	142	PF00917	0.572
DOC_USP7_MATH_1	201	205	PF00917	0.465
DOC_USP7_MATH_1	522	526	PF00917	0.475
DOC_USP7_MATH_1	591	595	PF00917	0.640
DOC_USP7_MATH_1	647	651	PF00917	0.599
DOC_USP7_MATH_1	654	658	PF00917	0.592
DOC_USP7_MATH_1	694	698	PF00917	0.583
DOC_USP7_UBL2_3	357	361	PF12436	0.434
DOC_USP7_UBL2_3	450	454	PF12436	0.386
DOC_USP7_UBL2_3	727	731	PF12436	0.679
DOC_USP7_UBL2_3	737	741	PF12436	0.700
DOC_WW_Pin1_4	1	6	PF00397	0.672
DOC_WW_Pin1_4	136	141	PF00397	0.528
DOC_WW_Pin1_4	169	174	PF00397	0.431
DOC_WW_Pin1_4	470	475	PF00397	0.422
DOC_WW_Pin1_4	603	608	PF00397	0.606
LIG_14-3-3_CanoR_1	29	36	PF00244	0.329
LIG_14-3-3_CanoR_1	290	294	PF00244	0.433
LIG_14-3-3_CanoR_1	370	379	PF00244	0.508
LIG_14-3-3_CanoR_1	674	679	PF00244	0.755
LIG_14-3-3_CanoR_1	73	79	PF00244	0.328
LIG_14-3-3_CanoR_1	96	100	PF00244	0.396
LIG_APCC_ABBA_1	412	417	PF00400	0.381
LIG_BIR_III_2	228	232	PF00653	0.421
LIG_BIR_III_4	187	191	PF00653	0.502
LIG_BRCT_BRCA1_1	128	132	PF00533	0.551
LIG_BRCT_BRCA1_1	17	21	PF00533	0.551
LIG_BRCT_BRCA1_1	344	348	PF00533	0.434
LIG_BRCT_BRCA1_1	607	611	PF00533	0.461
LIG_deltaCOP1_diTrp_1	314	323	PF00928	0.422
LIG_deltaCOP1_diTrp_1	558	561	PF00928	0.636
LIG_FHA_1	11	17	PF00498	0.460
LIG_FHA_1	382	388	PF00498	0.422
LIG_FHA_1	473	479	PF00498	0.514
LIG_FHA_1	503	509	PF00498	0.501
LIG_FHA_1	511	517	PF00498	0.484
LIG_FHA_1	573	579	PF00498	0.568
LIG_FHA_1	65	71	PF00498	0.399
LIG_FHA_2	170	176	PF00498	0.464
LIG_FHA_2	2	8	PF00498	0.594
LIG_FHA_2	231	237	PF00498	0.286
LIG_FHA_2	275	281	PF00498	0.443
LIG_FHA_2	537	543	PF00498	0.662
LIG_FHA_2	657	663	PF00498	0.604
LIG_FHA_2	96	102	PF00498	0.376
LIG_LIR_Gen_1	26	35	PF02991	0.299
LIG_LIR_Gen_1	351	358	PF02991	0.446
LIG_LIR_Gen_1	608	617	PF02991	0.482
LIG_LIR_Nem_3	18	24	PF02991	0.435
LIG_LIR_Nem_3	26	30	PF02991	0.230
LIG_LIR_Nem_3	262	266	PF02991	0.422
LIG_LIR_Nem_3	322	326	PF02991	0.432
LIG_LIR_Nem_3	351	356	PF02991	0.431
LIG_LIR_Nem_3	383	389	PF02991	0.429
LIG_LIR_Nem_3	556	562	PF02991	0.643
LIG_NRBOX	393	399	PF00104	0.422
LIG_PCNA_yPIPBox_3	242	252	PF02747	0.367
LIG_PCNA_yPIPBox_3	302	313	PF02747	0.488
LIG_Rb_pABgroove_1	325	333	PF01858	0.388
LIG_RPA_C_Fungi	635	647	PF08784	0.510
LIG_SH2_CRK	27	31	PF00017	0.282
LIG_SH2_CRK	562	566	PF00017	0.672
LIG_SH2_NCK_1	344	348	PF00017	0.372
LIG_SH2_NCK_1	426	430	PF00017	0.382
LIG_SH2_SRC	39	42	PF00017	0.282
LIG_SH2_STAP1	344	348	PF00017	0.372
LIG_SH2_STAP1	39	43	PF00017	0.308
LIG_SH2_STAP1	55	59	PF00017	0.282
LIG_SH2_STAT3	264	267	PF00017	0.282
LIG_SH2_STAT3	379	382	PF00017	0.266
LIG_SH2_STAT5	326	329	PF00017	0.266
LIG_SH2_STAT5	389	392	PF00017	0.268
LIG_SH3_3	17	23	PF00018	0.461
LIG_SH3_3	177	183	PF00018	0.511
LIG_SH3_3	220	226	PF00018	0.422
LIG_SH3_3	567	573	PF00018	0.577
LIG_SH3_3	626	632	PF00018	0.541
LIG_SH3_5	35	39	PF00018	0.302
LIG_SUMO_SIM_anti_2	15	21	PF11976	0.477
LIG_SUMO_SIM_anti_2	510	517	PF11976	0.423
LIG_SUMO_SIM_anti_2	56	64	PF11976	0.403
LIG_SUMO_SIM_par_1	481	488	PF11976	0.282
LIG_SUMO_SIM_par_1	512	517	PF11976	0.365
LIG_SUMO_SIM_par_1	56	64	PF11976	0.300
LIG_TRAF2_1	277	280	PF00917	0.401
LIG_TRAF2_1	594	597	PF00917	0.617
LIG_TRAF2_1	660	663	PF00917	0.658
LIG_UBA3_1	514	520	PF00899	0.390
LIG_UBA3_1	708	713	PF00899	0.600
LIG_Vh1_VBS_1	99	117	PF01044	0.260
MOD_CDC14_SPxK_1	139	142	PF00782	0.468
MOD_CDK_SPxK_1	136	142	PF00069	0.462
MOD_CK1_1	109	115	PF00069	0.326
MOD_CK1_1	28	34	PF00069	0.368
MOD_CK1_1	406	412	PF00069	0.427
MOD_CK1_1	482	488	PF00069	0.351
MOD_CK1_1	580	586	PF00069	0.652
MOD_CK1_1	603	609	PF00069	0.624
MOD_CK1_1	679	685	PF00069	0.713
MOD_CK2_1	102	108	PF00069	0.263
MOD_CK2_1	273	279	PF00069	0.302
MOD_CK2_1	536	542	PF00069	0.630
MOD_CK2_1	591	597	PF00069	0.661
MOD_CK2_1	656	662	PF00069	0.631
MOD_CK2_1	674	680	PF00069	0.648
MOD_CK2_1	95	101	PF00069	0.301
MOD_Cter_Amidation	118	121	PF01082	0.507
MOD_GlcNHglycan	175	179	PF01048	0.487
MOD_GlcNHglycan	187	191	PF01048	0.505
MOD_GlcNHglycan	236	240	PF01048	0.401
MOD_GlcNHglycan	30	33	PF01048	0.415
MOD_GlcNHglycan	372	375	PF01048	0.396
MOD_GlcNHglycan	445	448	PF01048	0.526
MOD_GlcNHglycan	464	467	PF01048	0.170
MOD_GlcNHglycan	524	527	PF01048	0.471
MOD_GlcNHglycan	542	545	PF01048	0.525
MOD_GlcNHglycan	596	601	PF01048	0.585
MOD_GlcNHglycan	666	669	PF01048	0.700
MOD_GlcNHglycan	696	699	PF01048	0.623
MOD_GlcNHglycan	78	81	PF01048	0.377
MOD_GlcNHglycan	85	88	PF01048	0.316
MOD_GSK3_1	102	109	PF00069	0.250
MOD_GSK3_1	207	214	PF00069	0.512
MOD_GSK3_1	230	237	PF00069	0.426
MOD_GSK3_1	415	422	PF00069	0.329
MOD_GSK3_1	478	485	PF00069	0.281
MOD_GSK3_1	536	543	PF00069	0.529
MOD_GSK3_1	580	587	PF00069	0.664
MOD_GSK3_1	596	603	PF00069	0.583
MOD_GSK3_1	605	612	PF00069	0.473
MOD_GSK3_1	670	677	PF00069	0.689
MOD_GSK3_1	688	695	PF00069	0.716
MOD_GSK3_1	700	707	PF00069	0.529
MOD_LATS_1	51	57	PF00433	0.280
MOD_N-GLC_1	415	420	PF02516	0.331
MOD_N-GLC_1	510	515	PF02516	0.311
MOD_N-GLC_1	664	669	PF02516	0.487
MOD_NEK2_1	128	133	PF00069	0.560
MOD_NEK2_1	234	239	PF00069	0.345
MOD_NEK2_1	273	278	PF00069	0.274
MOD_NEK2_1	289	294	PF00069	0.266
MOD_NEK2_1	330	335	PF00069	0.266
MOD_NEK2_1	441	446	PF00069	0.408
MOD_NEK2_1	478	483	PF00069	0.279
MOD_NEK2_1	536	541	PF00069	0.513
MOD_NEK2_1	561	566	PF00069	0.602
MOD_NEK2_1	574	579	PF00069	0.467
MOD_NEK2_1	602	607	PF00069	0.634
MOD_NEK2_1	704	709	PF00069	0.621
MOD_NEK2_2	336	341	PF00069	0.302
MOD_NEK2_2	714	719	PF00069	0.646
MOD_PIKK_1	211	217	PF00454	0.477
MOD_PIKK_1	591	597	PF00454	0.670
MOD_PIKK_1	64	70	PF00454	0.356
MOD_PIKK_1	679	685	PF00454	0.620
MOD_PK_1	207	213	PF00069	0.428
MOD_PK_1	674	680	PF00069	0.608
MOD_PKA_1	540	546	PF00069	0.416
MOD_PKA_1	73	79	PF00069	0.304
MOD_PKA_2	28	34	PF00069	0.189
MOD_PKA_2	289	295	PF00069	0.305
MOD_PKA_2	403	409	PF00069	0.409
MOD_PKA_2	462	468	PF00069	0.368
MOD_PKA_2	540	546	PF00069	0.438
MOD_PKA_2	73	79	PF00069	0.356
MOD_PKA_2	95	101	PF00069	0.390
MOD_PKB_1	368	376	PF00069	0.386
MOD_Plk_1	25	31	PF00069	0.189
MOD_Plk_1	321	327	PF00069	0.378
MOD_Plk_1	433	439	PF00069	0.387
MOD_Plk_1	510	516	PF00069	0.329
MOD_Plk_1	596	602	PF00069	0.602
MOD_Plk_1	94	100	PF00069	0.326
MOD_Plk_2-3	95	101	PF00069	0.326
MOD_Plk_4	102	108	PF00069	0.239
MOD_Plk_4	109	115	PF00069	0.222
MOD_Plk_4	15	21	PF00069	0.477
MOD_Plk_4	201	207	PF00069	0.526
MOD_Plk_4	230	236	PF00069	0.386
MOD_Plk_4	301	307	PF00069	0.324
MOD_Plk_4	406	412	PF00069	0.522
MOD_Plk_4	479	485	PF00069	0.371
MOD_Plk_4	510	516	PF00069	0.260
MOD_Plk_4	55	61	PF00069	0.287
MOD_Plk_4	704	710	PF00069	0.709
MOD_Plk_4	95	101	PF00069	0.297
MOD_ProDKin_1	1	7	PF00069	0.669
MOD_ProDKin_1	136	142	PF00069	0.530
MOD_ProDKin_1	169	175	PF00069	0.429
MOD_ProDKin_1	470	476	PF00069	0.266
MOD_ProDKin_1	603	609	PF00069	0.604
MOD_SUMO_for_1	718	721	PF00179	0.600
TRG_DiLeu_BaEn_1	597	602	PF01217	0.641
TRG_ENDOCYTIC_2	266	269	PF00928	0.282
TRG_ENDOCYTIC_2	27	30	PF00928	0.266
TRG_ENDOCYTIC_2	562	565	PF00928	0.642
TRG_ER_diArg_1	163	165	PF00400	0.517
TRG_ER_diArg_1	367	370	PF00400	0.266
TRG_ER_diArg_1	73	75	PF00400	0.304
TRG_NLS_MonoCore_2	71	76	PF00514	0.358
TRG_NLS_MonoExtN_4	71	76	PF00514	0.326
TRG_Pf-PMV_PEXEL_1	120	125	PF00026	0.650
TRG_Pf-PMV_PEXEL_1	317	322	PF00026	0.266
TRG_Pf-PMV_PEXEL_1	370	375	PF00026	0.401

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2R9	Leptomonas seymouri	70%	100%
A0A0S4JND8	Bodo saltans	48%	100%
A0A1X0P9Z3	Trypanosomatidae	54%	100%
A0A381MTM9	Leishmania infantum	93%	100%
A0A3R7LLL0	Trypanosoma rangeli	54%	100%
A0A3S7X869	Leishmania donovani	93%	100%
A4HB27	Leishmania braziliensis	79%	100%
C9ZM21	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9B597	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
P56960	Mus musculus	32%	84%
Q01780	Homo sapiens	33%	84%
V5BQF7	Trypanosoma cruzi	52%	100%