Zeta_toxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AAA domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q2N3_LEIMA

TriTrypDb:

LmjF.34.3110 , LMJLV39_340036800 , LMJSD75_340037000

Length:

259

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4Q2N3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2N3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	56	60	PF00656	0.504
CLV_NRD_NRD_1	172	174	PF00675	0.507
CLV_NRD_NRD_1	66	68	PF00675	0.722
CLV_NRD_NRD_1	95	97	PF00675	0.763
CLV_PCSK_KEX2_1	122	124	PF00082	0.495
CLV_PCSK_KEX2_1	172	174	PF00082	0.507
CLV_PCSK_KEX2_1	20	22	PF00082	0.536
CLV_PCSK_KEX2_1	6	8	PF00082	0.481
CLV_PCSK_KEX2_1	61	63	PF00082	0.671
CLV_PCSK_KEX2_1	66	68	PF00082	0.737
CLV_PCSK_KEX2_1	95	97	PF00082	0.650
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.495
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.416
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.390
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.779
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.659
CLV_PCSK_PC7_1	62	68	PF00082	0.649
CLV_PCSK_SKI1_1	163	167	PF00082	0.458
CLV_PCSK_SKI1_1	203	207	PF00082	0.525
CLV_PCSK_SKI1_1	47	51	PF00082	0.305
CLV_PCSK_SKI1_1	69	73	PF00082	0.759
DEG_APCC_DBOX_1	188	196	PF00400	0.295
DEG_Nend_Nbox_1	1	3	PF02207	0.581
DEG_ODPH_VHL_1	195	207	PF01847	0.264
DOC_MAPK_DCC_7	98	108	PF00069	0.322
DOC_MAPK_gen_1	29	37	PF00069	0.525
DOC_MAPK_MEF2A_6	29	37	PF00069	0.502
DOC_PP1_RVXF_1	45	51	PF00149	0.304
DOC_USP7_MATH_1	139	143	PF00917	0.315
DOC_USP7_UBL2_3	75	79	PF12436	0.521
DOC_WW_Pin1_4	182	187	PF00397	0.345
LIG_14-3-3_CanoR_1	29	34	PF00244	0.582
LIG_14-3-3_CanoR_1	96	101	PF00244	0.421
LIG_Actin_WH2_2	158	174	PF00022	0.342
LIG_BRCT_BRCA1_1	184	188	PF00533	0.315
LIG_FHA_1	123	129	PF00498	0.300
LIG_FHA_1	14	20	PF00498	0.660
LIG_FHA_1	143	149	PF00498	0.315
LIG_FHA_1	150	156	PF00498	0.315
LIG_FHA_1	164	170	PF00498	0.284
LIG_FHA_1	30	36	PF00498	0.451
LIG_FHA_2	231	237	PF00498	0.280
LIG_FHA_2	248	254	PF00498	0.417
LIG_FHA_2	68	74	PF00498	0.408
LIG_LIR_Gen_1	131	140	PF02991	0.263
LIG_LIR_Gen_1	213	219	PF02991	0.295
LIG_LIR_Gen_1	36	46	PF02991	0.372
LIG_LIR_Nem_3	131	135	PF02991	0.263
LIG_LIR_Nem_3	36	41	PF02991	0.420
LIG_Pex14_1	120	124	PF04695	0.248
LIG_SH2_CRK	52	56	PF00017	0.393
LIG_SH2_PTP2	132	135	PF00017	0.279
LIG_SH2_STAP1	124	128	PF00017	0.295
LIG_SH2_STAP1	151	155	PF00017	0.248
LIG_SH2_STAT5	124	127	PF00017	0.259
LIG_SH2_STAT5	132	135	PF00017	0.285
LIG_SH2_STAT5	151	154	PF00017	0.365
LIG_SH3_1	98	104	PF00018	0.391
LIG_SH3_3	98	104	PF00018	0.391
LIG_SUMO_SIM_anti_2	105	111	PF11976	0.315
LIG_SUMO_SIM_par_1	233	238	PF11976	0.315
LIG_SUMO_SIM_par_1	31	36	PF11976	0.494
LIG_UBA3_1	108	117	PF00899	0.286
MOD_CDK_SPxxK_3	182	189	PF00069	0.326
MOD_CK1_1	102	108	PF00069	0.436
MOD_CK1_1	115	121	PF00069	0.292
MOD_CK1_1	142	148	PF00069	0.408
MOD_CK2_1	218	224	PF00069	0.369
MOD_CK2_1	230	236	PF00069	0.253
MOD_Cter_Amidation	64	67	PF01082	0.655
MOD_GlcNHglycan	11	14	PF01048	0.551
MOD_GlcNHglycan	114	117	PF01048	0.283
MOD_GlcNHglycan	63	66	PF01048	0.697
MOD_GSK3_1	206	213	PF00069	0.372
MOD_GSK3_1	25	32	PF00069	0.471
MOD_GSK3_1	61	68	PF00069	0.681
MOD_GSK3_1	77	84	PF00069	0.625
MOD_GSK3_1	9	16	PF00069	0.516
MOD_N-GLC_1	149	154	PF02516	0.398
MOD_N-GLC_1	182	187	PF02516	0.377
MOD_NEK2_1	144	149	PF00069	0.304
MOD_NEK2_1	171	176	PF00069	0.311
MOD_NEK2_1	247	252	PF00069	0.490
MOD_NEK2_1	25	30	PF00069	0.587
MOD_PK_1	206	212	PF00069	0.372
MOD_PKA_1	122	128	PF00069	0.348
MOD_PKA_1	61	67	PF00069	0.610
MOD_PKA_1	96	102	PF00069	0.477
MOD_PKA_2	122	128	PF00069	0.348
MOD_PKA_2	142	148	PF00069	0.377
MOD_PKA_2	171	177	PF00069	0.365
MOD_PKA_2	61	67	PF00069	0.577
MOD_PKB_1	7	15	PF00069	0.492
MOD_Plk_4	102	108	PF00069	0.420
MOD_Plk_4	115	121	PF00069	0.237
MOD_Plk_4	128	134	PF00069	0.276
MOD_Plk_4	230	236	PF00069	0.339
MOD_Plk_4	33	39	PF00069	0.422
MOD_ProDKin_1	182	188	PF00069	0.418
MOD_SUMO_rev_2	56	63	PF00179	0.514
TRG_DiLeu_BaLyEn_6	44	49	PF01217	0.396
TRG_ENDOCYTIC_2	124	127	PF00928	0.337
TRG_ENDOCYTIC_2	132	135	PF00928	0.293
TRG_ENDOCYTIC_2	214	217	PF00928	0.386
TRG_ENDOCYTIC_2	52	55	PF00928	0.513
TRG_ER_diArg_1	140	143	PF00400	0.377
TRG_ER_diArg_1	171	173	PF00400	0.365
TRG_ER_diArg_1	188	191	PF00400	0.222
TRG_ER_diArg_1	66	69	PF00400	0.563
TRG_ER_diArg_1	7	10	PF00400	0.622
TRG_NLS_MonoCore_2	94	99	PF00514	0.523
TRG_NLS_MonoExtC_3	94	100	PF00514	0.510
TRG_Pf-PMV_PEXEL_1	193	198	PF00026	0.390

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5F6	Leptomonas seymouri	57%	100%
A0A3R7RME9	Trypanosoma rangeli	30%	100%
A0A3S7X8C5	Leishmania donovani	92%	100%
A4HB30	Leishmania braziliensis	67%	100%
A4IA87	Leishmania infantum	93%	100%
E9B5A0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5B5B3	Trypanosoma cruzi	26%	100%