DRBM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 28

Species:

Leishmania major

UniProt:

Q4Q2N1_LEIMA

TriTrypDb:

LmjF.34.3130 , LMJLV39_340037000 , LMJSD75_340037300

Length:

385

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	2
GO:0016020	membrane	2	2
GO:0019867	outer membrane	3	2
GO:0031090	organelle membrane	3	2
GO:0031966	mitochondrial membrane	4	2
GO:0031968	organelle outer membrane	4	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2N1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2N1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	85	89	PF00656	0.476
CLV_C14_Caspase3-7	9	13	PF00656	0.714
CLV_NRD_NRD_1	30	32	PF00675	0.511
CLV_PCSK_FUR_1	380	384	PF00082	0.400
CLV_PCSK_KEX2_1	128	130	PF00082	0.533
CLV_PCSK_KEX2_1	29	31	PF00082	0.504
CLV_PCSK_KEX2_1	382	384	PF00082	0.624
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.561
CLV_PCSK_PC1ET2_1	382	384	PF00082	0.600
CLV_PCSK_SKI1_1	173	177	PF00082	0.386
CLV_PCSK_SKI1_1	313	317	PF00082	0.482
CLV_PCSK_SKI1_1	73	77	PF00082	0.620
CLV_Separin_Metazoa	68	72	PF03568	0.490
DEG_APCC_DBOX_1	20	28	PF00400	0.558
DEG_Nend_UBRbox_2	1	3	PF02207	0.474
DOC_CDC14_PxL_1	180	188	PF14671	0.530
DOC_MAPK_DCC_7	251	261	PF00069	0.397
DOC_MAPK_gen_1	279	288	PF00069	0.513
DOC_MAPK_gen_1	29	40	PF00069	0.577
DOC_MAPK_gen_1	313	323	PF00069	0.509
DOC_MAPK_MEF2A_6	232	239	PF00069	0.393
DOC_MAPK_MEF2A_6	281	290	PF00069	0.298
DOC_MAPK_MEF2A_6	316	325	PF00069	0.325
DOC_MAPK_MEF2A_6	34	42	PF00069	0.596
DOC_PP2B_LxvP_1	94	97	PF13499	0.414
DOC_PP4_FxxP_1	62	65	PF00568	0.386
DOC_SPAK_OSR1_1	366	370	PF12202	0.556
DOC_USP7_MATH_1	114	118	PF00917	0.733
DOC_USP7_MATH_1	249	253	PF00917	0.472
DOC_USP7_MATH_1	275	279	PF00917	0.531
DOC_USP7_MATH_1	355	359	PF00917	0.575
DOC_USP7_UBL2_3	281	285	PF12436	0.552
DOC_WW_Pin1_4	164	169	PF00397	0.427
DOC_WW_Pin1_4	240	245	PF00397	0.390
DOC_WW_Pin1_4	88	93	PF00397	0.407
LIG_14-3-3_CanoR_1	232	238	PF00244	0.412
LIG_14-3-3_CanoR_1	341	348	PF00244	0.456
LIG_14-3-3_CanoR_1	71	80	PF00244	0.578
LIG_Actin_WH2_2	219	234	PF00022	0.421
LIG_Actin_WH2_2	303	318	PF00022	0.460
LIG_FHA_1	17	23	PF00498	0.644
LIG_FHA_1	363	369	PF00498	0.431
LIG_FHA_1	89	95	PF00498	0.416
LIG_FHA_2	275	281	PF00498	0.568
LIG_FHA_2	344	350	PF00498	0.514
LIG_LIR_Gen_1	130	140	PF02991	0.541
LIG_LIR_Gen_1	48	54	PF02991	0.506
LIG_LIR_Nem_3	130	136	PF02991	0.512
LIG_LIR_Nem_3	46	52	PF02991	0.441
LIG_LIR_Nem_3	88	93	PF02991	0.504
LIG_Pex14_2	290	294	PF04695	0.477
LIG_PTB_Apo_2	185	192	PF02174	0.457
LIG_PTB_Phospho_1	185	191	PF10480	0.459
LIG_REV1ctd_RIR_1	287	297	PF16727	0.441
LIG_SH2_GRB2like	216	219	PF00017	0.340
LIG_SH2_PTP2	308	311	PF00017	0.447
LIG_SH2_SRC	216	219	PF00017	0.378
LIG_SH2_STAP1	10	14	PF00017	0.521
LIG_SH2_STAP1	36	40	PF00017	0.525
LIG_SH2_STAT3	296	299	PF00017	0.506
LIG_SH2_STAT5	191	194	PF00017	0.455
LIG_SH2_STAT5	216	219	PF00017	0.400
LIG_SH2_STAT5	272	275	PF00017	0.549
LIG_SH2_STAT5	308	311	PF00017	0.397
LIG_SH3_1	308	314	PF00018	0.468
LIG_SH3_2	311	316	PF14604	0.479
LIG_SH3_3	308	314	PF00018	0.412
LIG_SH3_3	322	328	PF00018	0.416
LIG_SUMO_SIM_par_1	91	99	PF11976	0.405
LIG_TRAF2_1	359	362	PF00917	0.556
LIG_UBA3_1	175	182	PF00899	0.498
MOD_CK1_1	112	118	PF00069	0.735
MOD_CK1_1	16	22	PF00069	0.649
MOD_CK1_1	167	173	PF00069	0.435
MOD_CK1_1	200	206	PF00069	0.490
MOD_CK1_1	240	246	PF00069	0.399
MOD_CK1_1	343	349	PF00069	0.487
MOD_CK1_1	350	356	PF00069	0.494
MOD_CK1_1	8	14	PF00069	0.685
MOD_CK2_1	331	337	PF00069	0.524
MOD_CK2_1	343	349	PF00069	0.435
MOD_GlcNHglycan	113	117	PF01048	0.675
MOD_GlcNHglycan	280	284	PF01048	0.511
MOD_GlcNHglycan	353	356	PF01048	0.527
MOD_GlcNHglycan	357	360	PF01048	0.508
MOD_GlcNHglycan	73	76	PF01048	0.628
MOD_GSK3_1	108	115	PF00069	0.663
MOD_GSK3_1	135	142	PF00069	0.564
MOD_GSK3_1	156	163	PF00069	0.381
MOD_GSK3_1	178	185	PF00069	0.532
MOD_GSK3_1	233	240	PF00069	0.374
MOD_GSK3_1	275	282	PF00069	0.507
MOD_GSK3_1	343	350	PF00069	0.527
MOD_GSK3_1	351	358	PF00069	0.489
MOD_GSK3_1	6	13	PF00069	0.729
MOD_N-GLC_1	200	205	PF02516	0.597
MOD_NEK2_1	150	155	PF00069	0.401
MOD_NEK2_1	239	244	PF00069	0.387
MOD_NEK2_1	38	43	PF00069	0.598
MOD_PKA_2	275	281	PF00069	0.483
MOD_PKA_2	340	346	PF00069	0.439
MOD_Plk_1	200	206	PF00069	0.560
MOD_Plk_1	38	44	PF00069	0.519
MOD_Plk_2-3	331	337	PF00069	0.621
MOD_Plk_4	347	353	PF00069	0.573
MOD_Plk_4	38	44	PF00069	0.559
MOD_Plk_4	45	51	PF00069	0.468
MOD_ProDKin_1	164	170	PF00069	0.434
MOD_ProDKin_1	240	246	PF00069	0.399
MOD_ProDKin_1	88	94	PF00069	0.404
MOD_SUMO_for_1	127	130	PF00179	0.628
TRG_DiLeu_BaLyEn_6	380	385	PF01217	0.411
TRG_DiLeu_BaLyEn_6	89	94	PF01217	0.397
TRG_ENDOCYTIC_2	49	52	PF00928	0.405
TRG_ER_diArg_1	29	31	PF00400	0.524
TRG_ER_diArg_1	70	73	PF00400	0.396
TRG_NES_CRM1_1	145	160	PF08389	0.483
TRG_Pf-PMV_PEXEL_1	173	178	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	30	35	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	366	370	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1E1	Leptomonas seymouri	74%	82%
A0A0S4INK9	Bodo saltans	49%	88%
A0A1X0PAR0	Trypanosomatidae	61%	91%
A0A3S7X876	Leishmania donovani	94%	89%
A0A422NNH0	Trypanosoma rangeli	59%	77%
A4HB32	Leishmania braziliensis	86%	96%
A4IAN7	Leishmania infantum	94%	89%
C9ZM15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	90%
E9B5A2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	88%
V5DLX6	Trypanosoma cruzi	59%	100%