CCHC-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2N0_LEIMA

TriTrypDb:

LmjF.34.3140 , LMJLV39_340037100 , LMJSD75_340037400

Length:

255

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q2N0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2N0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0005488	binding	1	7
GO:0008270	zinc ion binding	6	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	199	203	PF00656	0.788
CLV_C14_Caspase3-7	232	236	PF00656	0.711
CLV_NRD_NRD_1	13	15	PF00675	0.727
CLV_NRD_NRD_1	16	18	PF00675	0.730
CLV_NRD_NRD_1	9	11	PF00675	0.723
CLV_PCSK_FUR_1	14	18	PF00082	0.745
CLV_PCSK_KEX2_1	13	15	PF00082	0.707
CLV_PCSK_KEX2_1	16	18	PF00082	0.706
CLV_PCSK_KEX2_1	243	245	PF00082	0.568
CLV_PCSK_KEX2_1	9	11	PF00082	0.731
CLV_PCSK_PC1ET2_1	243	245	PF00082	0.568
CLV_PCSK_PC7_1	5	11	PF00082	0.735
DOC_PP4_FxxP_1	131	134	PF00568	0.491
DOC_USP7_MATH_1	231	235	PF00917	0.713
LIG_14-3-3_CanoR_1	21	25	PF00244	0.760
LIG_BIR_II_1	1	5	PF00653	0.731
LIG_BRCT_BRCA1_1	172	176	PF00533	0.575
LIG_deltaCOP1_diTrp_1	126	131	PF00928	0.481
LIG_FHA_1	134	140	PF00498	0.532
LIG_FHA_1	153	159	PF00498	0.364
LIG_FHA_1	216	222	PF00498	0.702
LIG_LIR_Apic_2	130	134	PF02991	0.479
LIG_LIR_Gen_1	118	129	PF02991	0.537
LIG_LIR_Nem_3	118	124	PF02991	0.570
LIG_LIR_Nem_3	126	132	PF02991	0.485
LIG_LIR_Nem_3	62	67	PF02991	0.605
LIG_LYPXL_yS_3	78	81	PF13949	0.605
LIG_PCNA_PIPBox_1	99	108	PF02747	0.576
LIG_PCNA_yPIPBox_3	99	108	PF02747	0.602
LIG_Pex14_1	128	132	PF04695	0.479
LIG_SH2_GRB2like	141	144	PF00017	0.503
LIG_SH2_SRC	141	144	PF00017	0.503
LIG_SH2_STAT5	105	108	PF00017	0.564
LIG_SH2_STAT5	164	167	PF00017	0.492
LIG_SH2_STAT5	67	70	PF00017	0.559
MOD_CK1_1	144	150	PF00069	0.569
MOD_CK1_1	20	26	PF00069	0.602
MOD_CK1_1	201	207	PF00069	0.713
MOD_CK1_1	208	214	PF00069	0.709
MOD_CK1_1	215	221	PF00069	0.768
MOD_CK1_1	222	228	PF00069	0.706
MOD_CK1_1	230	236	PF00069	0.566
MOD_CK1_1	33	39	PF00069	0.732
MOD_CK1_1	4	10	PF00069	0.817
MOD_CK2_1	9	15	PF00069	0.779
MOD_GlcNHglycan	172	175	PF01048	0.492
MOD_GlcNHglycan	227	230	PF01048	0.772
MOD_GlcNHglycan	244	247	PF01048	0.597
MOD_GlcNHglycan	32	35	PF01048	0.729
MOD_GlcNHglycan	95	98	PF01048	0.607
MOD_GSK3_1	194	201	PF00069	0.732
MOD_GSK3_1	202	209	PF00069	0.759
MOD_GSK3_1	211	218	PF00069	0.560
MOD_GSK3_1	219	226	PF00069	0.666
MOD_GSK3_1	227	234	PF00069	0.517
MOD_GSK3_1	29	36	PF00069	0.793
MOD_NEK2_1	1	6	PF00069	0.831
MOD_NEK2_1	181	186	PF00069	0.567
MOD_PIKK_1	144	150	PF00454	0.569
MOD_PIKK_1	95	101	PF00454	0.586
MOD_PKA_1	17	23	PF00069	0.705
MOD_PKA_1	9	15	PF00069	0.732
MOD_PKA_2	20	26	PF00069	0.550
MOD_PKA_2	222	228	PF00069	0.620
MOD_PKA_2	30	36	PF00069	0.622
MOD_PKA_2	4	10	PF00069	0.752
MOD_Plk_1	144	150	PF00069	0.569
MOD_Plk_1	216	222	PF00069	0.702
MOD_Plk_4	157	163	PF00069	0.488
MOD_SUMO_rev_2	127	136	PF00179	0.569
MOD_SUMO_rev_2	235	245	PF00179	0.561
TRG_ENDOCYTIC_2	78	81	PF00928	0.605
TRG_NLS_Bipartite_1	9	29	PF00514	0.665

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2M7	Leptomonas seymouri	71%	99%
A0A3S7X890	Leishmania donovani	89%	100%
A4HB33	Leishmania braziliensis	87%	100%
A4IAN6	Leishmania infantum	90%	100%
E9B5A3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%