Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2M9_LEIMA

TriTrypDb:

LmjF.34.3150 , LMJLV39_340037200 , LMJSD75_340037500

Length:

426

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q2M9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2M9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	366	370	PF00656	0.462
CLV_NRD_NRD_1	12	14	PF00675	0.708
CLV_NRD_NRD_1	305	307	PF00675	0.745
CLV_NRD_NRD_1	379	381	PF00675	0.575
CLV_PCSK_FUR_1	377	381	PF00082	0.530
CLV_PCSK_KEX2_1	12	14	PF00082	0.708
CLV_PCSK_KEX2_1	145	147	PF00082	0.705
CLV_PCSK_KEX2_1	307	309	PF00082	0.701
CLV_PCSK_KEX2_1	379	381	PF00082	0.575
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.705
CLV_PCSK_PC1ET2_1	307	309	PF00082	0.566
CLV_PCSK_SKI1_1	226	230	PF00082	0.660
CLV_PCSK_SKI1_1	265	269	PF00082	0.633
CLV_PCSK_SKI1_1	308	312	PF00082	0.617
CLV_PCSK_SKI1_1	359	363	PF00082	0.496
DEG_Nend_UBRbox_2	1	3	PF02207	0.581
DEG_SCF_FBW7_1	35	41	PF00400	0.441
DOC_CKS1_1	35	40	PF01111	0.433
DOC_MAPK_FxFP_2	187	190	PF00069	0.351
DOC_MAPK_gen_1	196	205	PF00069	0.457
DOC_MAPK_gen_1	306	312	PF00069	0.482
DOC_MAPK_gen_1	377	385	PF00069	0.402
DOC_MAPK_MEF2A_6	196	205	PF00069	0.430
DOC_MAPK_MEF2A_6	282	291	PF00069	0.439
DOC_PP2B_PxIxI_1	174	180	PF00149	0.398
DOC_PP4_FxxP_1	187	190	PF00568	0.351
DOC_USP7_MATH_1	148	152	PF00917	0.467
DOC_USP7_MATH_1	159	163	PF00917	0.527
DOC_USP7_MATH_1	166	170	PF00917	0.555
DOC_USP7_MATH_1	251	255	PF00917	0.606
DOC_USP7_MATH_1	52	56	PF00917	0.520
DOC_USP7_MATH_1	64	68	PF00917	0.389
DOC_USP7_MATH_1	76	80	PF00917	0.412
DOC_WW_Pin1_4	15	20	PF00397	0.486
DOC_WW_Pin1_4	171	176	PF00397	0.469
DOC_WW_Pin1_4	270	275	PF00397	0.335
DOC_WW_Pin1_4	316	321	PF00397	0.389
DOC_WW_Pin1_4	34	39	PF00397	0.348
DOC_WW_Pin1_4	340	345	PF00397	0.361
LIG_14-3-3_CanoR_1	136	142	PF00244	0.400
LIG_14-3-3_CanoR_1	263	268	PF00244	0.428
LIG_14-3-3_CanoR_1	353	363	PF00244	0.365
LIG_14-3-3_CanoR_1	63	73	PF00244	0.538
LIG_14-3-3_CanoR_1	94	99	PF00244	0.466
LIG_Actin_WH2_2	123	140	PF00022	0.349
LIG_Actin_WH2_2	81	96	PF00022	0.310
LIG_BRCT_BRCA1_1	399	403	PF00533	0.346
LIG_eIF4E_1	204	210	PF01652	0.422
LIG_EVH1_1	34	38	PF00568	0.367
LIG_FHA_1	360	366	PF00498	0.295
LIG_FHA_1	419	425	PF00498	0.514
LIG_FHA_1	68	74	PF00498	0.595
LIG_FHA_1	93	99	PF00498	0.395
LIG_FHA_2	159	165	PF00498	0.539
LIG_FHA_2	39	45	PF00498	0.586
LIG_GBD_Chelix_1	410	418	PF00786	0.429
LIG_LIR_Apic_2	18	23	PF02991	0.400
LIG_LIR_Apic_2	315	320	PF02991	0.398
LIG_LIR_Gen_1	381	390	PF02991	0.400
LIG_LIR_Nem_3	104	109	PF02991	0.377
LIG_LIR_Nem_3	261	267	PF02991	0.483
LIG_LIR_Nem_3	290	296	PF02991	0.380
LIG_LIR_Nem_3	311	317	PF02991	0.380
LIG_LIR_Nem_3	381	385	PF02991	0.379
LIG_NRBOX	385	391	PF00104	0.353
LIG_NRBOX	414	420	PF00104	0.436
LIG_PDZ_Class_2	421	426	PF00595	0.625
LIG_Pex14_1	184	188	PF04695	0.351
LIG_Pex14_1	264	268	PF04695	0.448
LIG_Pex14_2	384	388	PF04695	0.316
LIG_RPA_C_Fungi	51	63	PF08784	0.562
LIG_SH2_CRK	20	24	PF00017	0.656
LIG_SH2_CRK	317	321	PF00017	0.468
LIG_SH2_PTP2	382	385	PF00017	0.488
LIG_SH2_STAT3	141	144	PF00017	0.571
LIG_SH2_STAT5	185	188	PF00017	0.519
LIG_SH2_STAT5	204	207	PF00017	0.579
LIG_SH2_STAT5	270	273	PF00017	0.482
LIG_SH2_STAT5	317	320	PF00017	0.506
LIG_SH2_STAT5	382	385	PF00017	0.418
LIG_SH3_1	317	323	PF00018	0.500
LIG_SH3_1	32	38	PF00018	0.474
LIG_SH3_3	238	244	PF00018	0.704
LIG_SH3_3	268	274	PF00018	0.459
LIG_SH3_3	317	323	PF00018	0.424
LIG_SH3_3	32	38	PF00018	0.433
LIG_SH3_3	338	344	PF00018	0.443
LIG_SxIP_EBH_1	268	282	PF03271	0.338
LIG_TYR_ITIM	267	272	PF00017	0.491
LIG_UBA3_1	414	422	PF00899	0.357
MOD_CDC14_SPxK_1	18	21	PF00782	0.517
MOD_CDK_SPK_2	316	321	PF00069	0.505
MOD_CDK_SPxK_1	15	21	PF00069	0.505
MOD_CDK_SPxxK_3	171	178	PF00069	0.616
MOD_CK1_1	168	174	PF00069	0.660
MOD_CK1_1	254	260	PF00069	0.743
MOD_CK1_1	354	360	PF00069	0.564
MOD_CK1_1	5	11	PF00069	0.673
MOD_CK1_1	67	73	PF00069	0.690
MOD_CK2_1	107	113	PF00069	0.510
MOD_CK2_1	158	164	PF00069	0.721
MOD_CK2_1	166	172	PF00069	0.734
MOD_CK2_1	47	53	PF00069	0.692
MOD_GlcNHglycan	168	171	PF01048	0.717
MOD_GlcNHglycan	234	237	PF01048	0.543
MOD_GlcNHglycan	25	28	PF01048	0.496
MOD_GlcNHglycan	257	260	PF01048	0.697
MOD_GlcNHglycan	283	286	PF01048	0.501
MOD_GlcNHglycan	392	396	PF01048	0.572
MOD_GlcNHglycan	49	52	PF01048	0.730
MOD_GlcNHglycan	59	62	PF01048	0.709
MOD_GlcNHglycan	66	69	PF01048	0.662
MOD_GlcNHglycan	7	10	PF01048	0.783
MOD_GSK3_1	125	132	PF00069	0.454
MOD_GSK3_1	166	173	PF00069	0.660
MOD_GSK3_1	247	254	PF00069	0.749
MOD_GSK3_1	308	315	PF00069	0.529
MOD_GSK3_1	34	41	PF00069	0.636
MOD_N-GLC_1	308	313	PF02516	0.393
MOD_N-GLC_1	354	359	PF02516	0.367
MOD_N-GLC_2	131	133	PF02516	0.559
MOD_NEK2_1	126	131	PF00069	0.406
MOD_NEK2_1	245	250	PF00069	0.687
MOD_NEK2_1	292	297	PF00069	0.554
MOD_NEK2_1	3	8	PF00069	0.773
MOD_NEK2_1	397	402	PF00069	0.624
MOD_NEK2_1	92	97	PF00069	0.516
MOD_PIKK_1	258	264	PF00454	0.559
MOD_PKA_2	137	143	PF00069	0.511
MOD_PKA_2	245	251	PF00069	0.565
MOD_PKA_2	281	287	PF00069	0.564
MOD_PKA_2	93	99	PF00069	0.593
MOD_PKB_1	306	314	PF00069	0.463
MOD_Plk_1	308	314	PF00069	0.555
MOD_Plk_1	397	403	PF00069	0.662
MOD_Plk_4	263	269	PF00069	0.520
MOD_Plk_4	287	293	PF00069	0.474
MOD_Plk_4	308	314	PF00069	0.504
MOD_Plk_4	398	404	PF00069	0.401
MOD_Plk_4	94	100	PF00069	0.589
MOD_ProDKin_1	15	21	PF00069	0.618
MOD_ProDKin_1	171	177	PF00069	0.579
MOD_ProDKin_1	270	276	PF00069	0.411
MOD_ProDKin_1	316	322	PF00069	0.480
MOD_ProDKin_1	34	40	PF00069	0.439
MOD_ProDKin_1	340	346	PF00069	0.443
MOD_SUMO_rev_2	343	350	PF00179	0.602
MOD_SUMO_rev_2	366	373	PF00179	0.615
TRG_DiLeu_LyEn_5	172	177	PF01217	0.539
TRG_ENDOCYTIC_2	185	188	PF00928	0.470
TRG_ENDOCYTIC_2	269	272	PF00928	0.440
TRG_ENDOCYTIC_2	382	385	PF00928	0.502
TRG_ER_diArg_1	12	14	PF00400	0.757
TRG_ER_diArg_1	135	138	PF00400	0.461
TRG_ER_diArg_1	29	32	PF00400	0.435
TRG_ER_diArg_1	337	340	PF00400	0.553
TRG_ER_diArg_1	377	380	PF00400	0.454
TRG_Pf-PMV_PEXEL_1	178	182	PF00026	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHK0	Leptomonas seymouri	47%	96%
A0A1X0PA73	Trypanosomatidae	22%	100%
A0A3R7MRN0	Trypanosoma rangeli	23%	100%
A0A3S7X898	Leishmania donovani	86%	100%
A4HB34	Leishmania braziliensis	69%	100%
A4IAN5	Leishmania infantum	86%	100%
E9B5A4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5BQG2	Trypanosoma cruzi	23%	100%