Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2M8_LEIMA

TriTrypDb:

LmjF.34.3160 , LMJLV39_340037300 , LMJSD75_340037600

Length:

588

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2M8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2M8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.720
CLV_C14_Caspase3-7	179	183	PF00656	0.675
CLV_C14_Caspase3-7	375	379	PF00656	0.458
CLV_C14_Caspase3-7	64	68	PF00656	0.673
CLV_NRD_NRD_1	100	102	PF00675	0.627
CLV_NRD_NRD_1	278	280	PF00675	0.561
CLV_NRD_NRD_1	35	37	PF00675	0.603
CLV_NRD_NRD_1	388	390	PF00675	0.455
CLV_NRD_NRD_1	444	446	PF00675	0.523
CLV_NRD_NRD_1	575	577	PF00675	0.751
CLV_PCSK_KEX2_1	388	390	PF00082	0.438
CLV_PCSK_SKI1_1	164	168	PF00082	0.583
CLV_PCSK_SKI1_1	24	28	PF00082	0.609
CLV_PCSK_SKI1_1	280	284	PF00082	0.469
CLV_PCSK_SKI1_1	391	395	PF00082	0.434
CLV_PCSK_SKI1_1	405	409	PF00082	0.471
CLV_PCSK_SKI1_1	523	527	PF00082	0.584
CLV_PCSK_SKI1_1	84	88	PF00082	0.701
DEG_APCC_DBOX_1	163	171	PF00400	0.597
DEG_APCC_DBOX_1	388	396	PF00400	0.550
DEG_MDM2_SWIB_1	423	431	PF02201	0.539
DEG_SPOP_SBC_1	140	144	PF00917	0.718
DOC_CYCLIN_RxL_1	388	396	PF00134	0.525
DOC_CYCLIN_RxL_1	401	412	PF00134	0.441
DOC_MAPK_gen_1	388	395	PF00069	0.481
DOC_MAPK_gen_1	401	410	PF00069	0.417
DOC_MAPK_gen_1	44	53	PF00069	0.681
DOC_MAPK_gen_1	84	92	PF00069	0.664
DOC_PP1_RVXF_1	403	410	PF00149	0.445
DOC_PP2B_LxvP_1	381	384	PF13499	0.551
DOC_PP4_FxxP_1	69	72	PF00568	0.670
DOC_USP7_MATH_1	14	18	PF00917	0.676
DOC_USP7_MATH_1	176	180	PF00917	0.653
DOC_USP7_MATH_1	236	240	PF00917	0.679
DOC_USP7_MATH_1	250	254	PF00917	0.777
DOC_USP7_MATH_1	260	264	PF00917	0.745
DOC_USP7_MATH_1	384	388	PF00917	0.555
DOC_USP7_MATH_1	61	65	PF00917	0.583
DOC_USP7_UBL2_3	80	84	PF12436	0.649
DOC_WW_Pin1_4	200	205	PF00397	0.540
DOC_WW_Pin1_4	243	248	PF00397	0.811
DOC_WW_Pin1_4	415	420	PF00397	0.491
DOC_WW_Pin1_4	473	478	PF00397	0.674
LIG_14-3-3_CanoR_1	175	181	PF00244	0.659
LIG_14-3-3_CanoR_1	200	204	PF00244	0.545
LIG_14-3-3_CanoR_1	308	312	PF00244	0.603
LIG_14-3-3_CanoR_1	321	325	PF00244	0.534
LIG_Actin_WH2_2	187	202	PF00022	0.526
LIG_Actin_WH2_2	50	68	PF00022	0.695
LIG_BIR_II_1	1	5	PF00653	0.659
LIG_BRCT_BRCA1_1	381	385	PF00533	0.540
LIG_BRCT_BRCA1_1	432	436	PF00533	0.480
LIG_BRCT_BRCA1_1	450	454	PF00533	0.490
LIG_BRCT_BRCA1_1	580	584	PF00533	0.745
LIG_CaM_NSCaTE_8	427	434	PF13499	0.465
LIG_Clathr_ClatBox_1	342	346	PF01394	0.504
LIG_Clathr_ClatBox_1	392	396	PF01394	0.546
LIG_deltaCOP1_diTrp_1	414	423	PF00928	0.489
LIG_deltaCOP1_diTrp_1	534	539	PF00928	0.514
LIG_EH1_1	436	444	PF00400	0.371
LIG_eIF4E_1	277	283	PF01652	0.514
LIG_FHA_1	175	181	PF00498	0.626
LIG_FHA_1	225	231	PF00498	0.616
LIG_FHA_1	262	268	PF00498	0.623
LIG_FHA_1	308	314	PF00498	0.608
LIG_FHA_1	416	422	PF00498	0.483
LIG_FHA_1	492	498	PF00498	0.520
LIG_FHA_1	60	66	PF00498	0.710
LIG_FHA_2	111	117	PF00498	0.706
LIG_FHA_2	131	137	PF00498	0.764
LIG_FHA_2	238	244	PF00498	0.791
LIG_FHA_2	345	351	PF00498	0.513
LIG_FHA_2	366	372	PF00498	0.538
LIG_FHA_2	373	379	PF00498	0.420
LIG_FHA_2	547	553	PF00498	0.638
LIG_LIR_Apic_2	67	72	PF02991	0.666
LIG_LIR_Gen_1	2	11	PF02991	0.716
LIG_LIR_Gen_1	206	215	PF02991	0.442
LIG_LIR_Gen_1	316	326	PF02991	0.534
LIG_LIR_Gen_1	336	345	PF02991	0.443
LIG_LIR_Gen_1	433	443	PF02991	0.445
LIG_LIR_Gen_1	457	468	PF02991	0.540
LIG_LIR_Gen_1	489	497	PF02991	0.531
LIG_LIR_Gen_1	498	506	PF02991	0.453
LIG_LIR_Nem_3	2	8	PF02991	0.641
LIG_LIR_Nem_3	206	210	PF02991	0.434
LIG_LIR_Nem_3	316	322	PF02991	0.544
LIG_LIR_Nem_3	336	341	PF02991	0.446
LIG_LIR_Nem_3	350	355	PF02991	0.355
LIG_LIR_Nem_3	433	439	PF02991	0.469
LIG_LIR_Nem_3	457	463	PF02991	0.498
LIG_LIR_Nem_3	489	493	PF02991	0.531
LIG_LIR_Nem_3	498	502	PF02991	0.459
LIG_LIR_Nem_3	530	536	PF02991	0.609
LIG_MYND_1	77	81	PF01753	0.684
LIG_NRBOX	365	371	PF00104	0.511
LIG_Pex14_1	298	302	PF04695	0.429
LIG_Pex14_2	423	427	PF04695	0.496
LIG_Pex14_2	533	537	PF04695	0.646
LIG_SH2_CRK	287	291	PF00017	0.487
LIG_SH2_CRK	5	9	PF00017	0.768
LIG_SH2_NCK_1	302	306	PF00017	0.516
LIG_SH2_NCK_1	460	464	PF00017	0.628
LIG_SH2_NCK_1	490	494	PF00017	0.597
LIG_SH2_SRC	70	73	PF00017	0.696
LIG_SH2_STAP1	22	26	PF00017	0.659
LIG_SH2_STAP1	302	306	PF00017	0.432
LIG_SH2_STAP1	460	464	PF00017	0.569
LIG_SH2_STAT5	277	280	PF00017	0.437
LIG_SH2_STAT5	302	305	PF00017	0.421
LIG_SH2_STAT5	306	309	PF00017	0.439
LIG_SH2_STAT5	524	527	PF00017	0.638
LIG_SH2_STAT5	70	73	PF00017	0.729
LIG_SH3_3	105	111	PF00018	0.717
LIG_SH3_3	227	233	PF00018	0.518
LIG_SH3_3	244	250	PF00018	0.727
LIG_SH3_3	474	480	PF00018	0.653
LIG_SH3_3	72	78	PF00018	0.692
LIG_SH3_4	80	87	PF00018	0.667
LIG_SUMO_SIM_anti_2	320	326	PF11976	0.565
LIG_SUMO_SIM_anti_2	390	396	PF11976	0.523
LIG_SUMO_SIM_anti_2	88	94	PF11976	0.482
LIG_SUMO_SIM_par_1	339	347	PF11976	0.509
LIG_SUMO_SIM_par_1	390	396	PF11976	0.511
LIG_TRAF2_1	193	196	PF00917	0.613
LIG_TRAF2_1	548	551	PF00917	0.657
LIG_TYR_ITIM	488	493	PF00017	0.592
LIG_UBA3_1	341	348	PF00899	0.504
LIG_UBA3_1	86	94	PF00899	0.660
LIG_WW_1	19	22	PF00397	0.677
MOD_CDK_SPxxK_3	415	422	PF00069	0.376
MOD_CK1_1	144	150	PF00069	0.712
MOD_CK1_1	174	180	PF00069	0.710
MOD_CK1_1	203	209	PF00069	0.530
MOD_CK1_1	246	252	PF00069	0.798
MOD_CK1_1	261	267	PF00069	0.691
MOD_CK1_1	3	9	PF00069	0.755
MOD_CK1_1	344	350	PF00069	0.514
MOD_CK1_1	387	393	PF00069	0.486
MOD_CK1_1	580	586	PF00069	0.666
MOD_CK1_1	60	66	PF00069	0.637
MOD_CK2_1	110	116	PF00069	0.801
MOD_CK2_1	344	350	PF00069	0.482
MOD_CK2_1	455	461	PF00069	0.539
MOD_CK2_1	546	552	PF00069	0.648
MOD_Cter_Amidation	99	102	PF01082	0.516
MOD_GlcNHglycan	104	108	PF01048	0.781
MOD_GlcNHglycan	252	255	PF01048	0.813
MOD_GlcNHglycan	258	261	PF01048	0.753
MOD_GlcNHglycan	381	384	PF01048	0.539
MOD_GlcNHglycan	432	435	PF01048	0.459
MOD_GlcNHglycan	551	556	PF01048	0.603
MOD_GlcNHglycan	59	62	PF01048	0.679
MOD_GSK3_1	139	146	PF00069	0.735
MOD_GSK3_1	170	177	PF00069	0.663
MOD_GSK3_1	199	206	PF00069	0.548
MOD_GSK3_1	246	253	PF00069	0.805
MOD_GSK3_1	256	263	PF00069	0.737
MOD_GSK3_1	337	344	PF00069	0.515
MOD_GSK3_1	491	498	PF00069	0.559
MOD_GSK3_1	542	549	PF00069	0.567
MOD_GSK3_1	566	573	PF00069	0.693
MOD_GSK3_1	57	64	PF00069	0.715
MOD_GSK3_1	579	586	PF00069	0.665
MOD_N-GLC_1	157	162	PF02516	0.628
MOD_N-GLC_1	336	341	PF02516	0.551
MOD_NEK2_1	103	108	PF00069	0.716
MOD_NEK2_1	141	146	PF00069	0.722
MOD_NEK2_1	170	175	PF00069	0.638
MOD_NEK2_1	199	204	PF00069	0.613
MOD_NEK2_1	210	215	PF00069	0.475
MOD_NEK2_1	258	263	PF00069	0.647
MOD_NEK2_1	300	305	PF00069	0.440
MOD_NEK2_1	307	312	PF00069	0.475
MOD_NEK2_1	432	437	PF00069	0.516
MOD_NEK2_1	448	453	PF00069	0.346
MOD_NEK2_1	526	531	PF00069	0.637
MOD_NEK2_1	57	62	PF00069	0.641
MOD_NEK2_2	176	181	PF00069	0.629
MOD_NEK2_2	61	66	PF00069	0.622
MOD_PIKK_1	546	552	PF00454	0.654
MOD_PKA_2	170	176	PF00069	0.659
MOD_PKA_2	199	205	PF00069	0.541
MOD_PKA_2	307	313	PF00069	0.597
MOD_PKA_2	320	326	PF00069	0.533
MOD_PKA_2	387	393	PF00069	0.541
MOD_PKA_2	466	472	PF00069	0.596
MOD_PKA_2	570	576	PF00069	0.737
MOD_Plk_1	103	109	PF00069	0.718
MOD_Plk_1	3	9	PF00069	0.673
MOD_Plk_1	336	342	PF00069	0.529
MOD_Plk_1	373	379	PF00069	0.492
MOD_Plk_1	413	419	PF00069	0.461
MOD_Plk_1	455	461	PF00069	0.507
MOD_Plk_1	551	557	PF00069	0.577
MOD_Plk_2-3	157	163	PF00069	0.551
MOD_Plk_2-3	237	243	PF00069	0.776
MOD_Plk_4	320	326	PF00069	0.569
MOD_Plk_4	337	343	PF00069	0.456
MOD_Plk_4	365	371	PF00069	0.468
MOD_Plk_4	455	461	PF00069	0.507
MOD_Plk_4	508	514	PF00069	0.588
MOD_Plk_4	580	586	PF00069	0.702
MOD_ProDKin_1	200	206	PF00069	0.537
MOD_ProDKin_1	243	249	PF00069	0.813
MOD_ProDKin_1	415	421	PF00069	0.482
MOD_ProDKin_1	473	479	PF00069	0.666
MOD_SUMO_for_1	79	82	PF00179	0.678
MOD_SUMO_rev_2	82	87	PF00179	0.513
TRG_DiLeu_BaLyEn_6	213	218	PF01217	0.489
TRG_DiLeu_BaLyEn_6	327	332	PF01217	0.465
TRG_DiLeu_BaLyEn_6	388	393	PF01217	0.544
TRG_ENDOCYTIC_2	287	290	PF00928	0.495
TRG_ENDOCYTIC_2	352	355	PF00928	0.414
TRG_ENDOCYTIC_2	460	463	PF00928	0.527
TRG_ENDOCYTIC_2	490	493	PF00928	0.595
TRG_ENDOCYTIC_2	5	8	PF00928	0.676
TRG_ER_diArg_1	388	391	PF00400	0.516
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	164	169	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	330	334	PF00026	0.392
TRG_Pf-PMV_PEXEL_1	391	396	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.726
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.676

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P314	Leptomonas seymouri	55%	93%
A0A1X0P9X4	Trypanosomatidae	31%	100%
A0A3Q8IIR9	Leishmania donovani	93%	100%
A4HB35	Leishmania braziliensis	71%	100%
A4IAN4	Leishmania infantum	93%	100%
C9ZM12	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9B5A5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BV34	Trypanosoma cruzi	30%	100%