Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tir chaperone protein (CesT) family, putative

Species:

Leishmania major

UniProt:

Q4Q2M7_LEIMA

TriTrypDb:

LmjF.34.3170 , LMJLV39_340037400 , LMJSD75_340037700

Length:

568

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2M7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2M7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	8
GO:0008104	protein localization	4	8
GO:0009306	protein secretion	4	8
GO:0009987	cellular process	1	8
GO:0015031	protein transport	4	8
GO:0030254	protein secretion by the type III secretion system	4	8
GO:0032940	secretion by cell	3	8
GO:0033036	macromolecule localization	2	8
GO:0035592	establishment of protein localization to extracellular region	4	8
GO:0045184	establishment of protein localization	3	8
GO:0046903	secretion	4	8
GO:0051179	localization	1	8
GO:0051234	establishment of localization	2	8
GO:0051641	cellular localization	2	8
GO:0055085	transmembrane transport	2	8
GO:0070727	cellular macromolecule localization	3	8
GO:0071692	protein localization to extracellular region	5	8
GO:0071702	organic substance transport	4	8
GO:0071705	nitrogen compound transport	4	8
GO:0071806	protein transmembrane transport	3	8
GO:0140352	export from cell	2	8

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.427
CLV_C14_Caspase3-7	235	239	PF00656	0.489
CLV_C14_Caspase3-7	300	304	PF00656	0.381
CLV_C14_Caspase3-7	385	389	PF00656	0.404
CLV_NRD_NRD_1	198	200	PF00675	0.601
CLV_NRD_NRD_1	331	333	PF00675	0.470
CLV_NRD_NRD_1	38	40	PF00675	0.457
CLV_NRD_NRD_1	391	393	PF00675	0.567
CLV_PCSK_KEX2_1	187	189	PF00082	0.601
CLV_PCSK_KEX2_1	198	200	PF00082	0.600
CLV_PCSK_KEX2_1	288	290	PF00082	0.564
CLV_PCSK_KEX2_1	330	332	PF00082	0.449
CLV_PCSK_KEX2_1	383	385	PF00082	0.466
CLV_PCSK_KEX2_1	391	393	PF00082	0.512
CLV_PCSK_KEX2_1	42	44	PF00082	0.388
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.554
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.473
CLV_PCSK_PC1ET2_1	383	385	PF00082	0.451
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.388
CLV_PCSK_PC7_1	327	333	PF00082	0.500
CLV_PCSK_SKI1_1	288	292	PF00082	0.562
CLV_PCSK_SKI1_1	356	360	PF00082	0.512
CLV_PCSK_SKI1_1	39	43	PF00082	0.404
DEG_APCC_DBOX_1	263	271	PF00400	0.464
DEG_APCC_DBOX_1	372	380	PF00400	0.433
DEG_APCC_DBOX_1	496	504	PF00400	0.465
DEG_Nend_UBRbox_2	1	3	PF02207	0.643
DEG_SPOP_SBC_1	87	91	PF00917	0.446
DOC_CYCLIN_RxL_1	315	329	PF00134	0.419
DOC_MAPK_gen_1	288	296	PF00069	0.414
DOC_MAPK_gen_1	497	505	PF00069	0.415
DOC_MAPK_MEF2A_6	475	484	PF00069	0.514
DOC_PP2B_LxvP_1	149	152	PF13499	0.538
DOC_PP4_FxxP_1	119	122	PF00568	0.528
DOC_USP7_MATH_1	100	104	PF00917	0.623
DOC_USP7_MATH_1	105	109	PF00917	0.658
DOC_USP7_MATH_1	297	301	PF00917	0.533
DOC_USP7_MATH_1	408	412	PF00917	0.579
DOC_USP7_MATH_1	443	447	PF00917	0.460
DOC_WW_Pin1_4	101	106	PF00397	0.633
DOC_WW_Pin1_4	131	136	PF00397	0.804
DOC_WW_Pin1_4	143	148	PF00397	0.702
DOC_WW_Pin1_4	163	168	PF00397	0.598
DOC_WW_Pin1_4	175	180	PF00397	0.557
DOC_WW_Pin1_4	206	211	PF00397	0.564
DOC_WW_Pin1_4	220	225	PF00397	0.612
DOC_WW_Pin1_4	445	450	PF00397	0.444
DOC_WW_Pin1_4	490	495	PF00397	0.469
DOC_WW_Pin1_4	519	524	PF00397	0.415
LIG_14-3-3_CanoR_1	148	152	PF00244	0.600
LIG_14-3-3_CanoR_1	373	377	PF00244	0.508
LIG_Actin_WH2_2	523	539	PF00022	0.523
LIG_BRCT_BRCA1_1	102	106	PF00533	0.513
LIG_BRCT_BRCA1_1	402	406	PF00533	0.517
LIG_Clathr_ClatBox_1	470	474	PF01394	0.465
LIG_CtBP_PxDLS_1	210	214	PF00389	0.622
LIG_eIF4E_1	481	487	PF01652	0.487
LIG_FHA_1	221	227	PF00498	0.590
LIG_FHA_1	385	391	PF00498	0.430
LIG_FHA_1	456	462	PF00498	0.454
LIG_FHA_1	475	481	PF00498	0.465
LIG_FHA_1	557	563	PF00498	0.545
LIG_FHA_1	9	15	PF00498	0.465
LIG_FHA_2	195	201	PF00498	0.551
LIG_FHA_2	336	342	PF00498	0.492
LIG_FHA_2	433	439	PF00498	0.393
LIG_FHA_2	446	452	PF00498	0.347
LIG_LIR_Apic_2	117	122	PF02991	0.527
LIG_LIR_Gen_1	478	487	PF02991	0.523
LIG_LIR_Gen_1	59	65	PF02991	0.481
LIG_LIR_Nem_3	478	484	PF02991	0.523
LIG_LIR_Nem_3	59	63	PF02991	0.488
LIG_SH2_CRK	207	211	PF00017	0.613
LIG_SH2_CRK	25	29	PF00017	0.363
LIG_SH2_NCK_1	207	211	PF00017	0.533
LIG_SH2_PTP2	483	486	PF00017	0.523
LIG_SH2_SRC	481	484	PF00017	0.487
LIG_SH2_STAP1	501	505	PF00017	0.585
LIG_SH2_STAP1	88	92	PF00017	0.396
LIG_SH2_STAT3	439	442	PF00017	0.424
LIG_SH2_STAT5	15	18	PF00017	0.392
LIG_SH2_STAT5	439	442	PF00017	0.424
LIG_SH2_STAT5	44	47	PF00017	0.399
LIG_SH2_STAT5	481	484	PF00017	0.519
LIG_SH3_3	402	408	PF00018	0.643
LIG_SH3_3	488	494	PF00018	0.469
LIG_SUMO_SIM_anti_2	322	329	PF11976	0.422
LIG_SUMO_SIM_anti_2	524	531	PF11976	0.498
LIG_SUMO_SIM_anti_2	561	566	PF11976	0.388
LIG_SUMO_SIM_par_1	448	453	PF11976	0.458
LIG_SUMO_SIM_par_1	469	474	PF11976	0.465
LIG_TRAF2_1	338	341	PF00917	0.465
LIG_TYR_ITIM	244	249	PF00017	0.450
LIG_WRC_WIRS_1	57	62	PF05994	0.469
LIG_WW_3	121	125	PF00397	0.553
MOD_CDK_SPK_2	131	136	PF00069	0.697
MOD_CDK_SPK_2	143	148	PF00069	0.627
MOD_CDK_SPxxK_3	490	497	PF00069	0.469
MOD_CK1_1	117	123	PF00069	0.737
MOD_CK1_1	232	238	PF00069	0.544
MOD_CK1_1	492	498	PF00069	0.445
MOD_CK1_1	522	528	PF00069	0.492
MOD_CK1_1	539	545	PF00069	0.424
MOD_CK2_1	206	212	PF00069	0.669
MOD_CK2_1	335	341	PF00069	0.436
MOD_CK2_1	372	378	PF00069	0.507
MOD_CK2_1	432	438	PF00069	0.436
MOD_CK2_1	445	451	PF00069	0.331
MOD_CK2_1	67	73	PF00069	0.318
MOD_GlcNHglycan	107	110	PF01048	0.647
MOD_GlcNHglycan	149	152	PF01048	0.759
MOD_GlcNHglycan	2	5	PF01048	0.593
MOD_GlcNHglycan	232	235	PF01048	0.599
MOD_GlcNHglycan	425	428	PF01048	0.438
MOD_GlcNHglycan	445	448	PF01048	0.444
MOD_GlcNHglycan	532	535	PF01048	0.317
MOD_GlcNHglycan	538	541	PF01048	0.282
MOD_GlcNHglycan	69	72	PF01048	0.563
MOD_GlcNHglycan	90	93	PF01048	0.584
MOD_GlcNHglycan	98	101	PF01048	0.594
MOD_GSK3_1	143	150	PF00069	0.751
MOD_GSK3_1	158	165	PF00069	0.516
MOD_GSK3_1	213	220	PF00069	0.670
MOD_GSK3_1	228	235	PF00069	0.579
MOD_GSK3_1	378	385	PF00069	0.489
MOD_GSK3_1	96	103	PF00069	0.602
MOD_N-GLC_1	137	142	PF02516	0.539
MOD_N-GLC_1	455	460	PF02516	0.281
MOD_NEK2_1	205	210	PF00069	0.598
MOD_NEK2_1	213	218	PF00069	0.613
MOD_NEK2_1	432	437	PF00069	0.508
MOD_NEK2_1	482	487	PF00069	0.487
MOD_NEK2_1	530	535	PF00069	0.523
MOD_NEK2_1	536	541	PF00069	0.528
MOD_NEK2_1	544	549	PF00069	0.425
MOD_NEK2_1	65	70	PF00069	0.473
MOD_NEK2_2	137	142	PF00069	0.614
MOD_NEK2_2	297	302	PF00069	0.380
MOD_PIKK_1	158	164	PF00454	0.569
MOD_PIKK_1	438	444	PF00454	0.488
MOD_PIKK_1	492	498	PF00454	0.415
MOD_PKA_2	147	153	PF00069	0.648
MOD_PKA_2	229	235	PF00069	0.685
MOD_PKA_2	372	378	PF00069	0.530
MOD_PKA_2	474	480	PF00069	0.523
MOD_PKA_2	536	542	PF00069	0.523
MOD_Plk_1	455	461	PF00069	0.507
MOD_Plk_1	65	71	PF00069	0.476
MOD_Plk_2-3	382	388	PF00069	0.411
MOD_Plk_4	137	143	PF00069	0.810
MOD_Plk_4	482	488	PF00069	0.508
MOD_ProDKin_1	101	107	PF00069	0.636
MOD_ProDKin_1	131	137	PF00069	0.803
MOD_ProDKin_1	143	149	PF00069	0.702
MOD_ProDKin_1	163	169	PF00069	0.597
MOD_ProDKin_1	175	181	PF00069	0.557
MOD_ProDKin_1	206	212	PF00069	0.568
MOD_ProDKin_1	220	226	PF00069	0.611
MOD_ProDKin_1	445	451	PF00069	0.446
MOD_ProDKin_1	490	496	PF00069	0.469
MOD_ProDKin_1	519	525	PF00069	0.415
MOD_SUMO_for_1	186	189	PF00179	0.530
MOD_SUMO_for_1	314	317	PF00179	0.418
MOD_SUMO_for_1	358	361	PF00179	0.518
MOD_SUMO_rev_2	280	290	PF00179	0.517
MOD_SUMO_rev_2	335	344	PF00179	0.517
TRG_DiLeu_BaEn_4	285	291	PF01217	0.447
TRG_DiLeu_BaLyEn_6	169	174	PF01217	0.503
TRG_ENDOCYTIC_2	246	249	PF00928	0.496
TRG_ENDOCYTIC_2	25	28	PF00928	0.366
TRG_ENDOCYTIC_2	481	484	PF00928	0.470
TRG_ENDOCYTIC_2	501	504	PF00928	0.402
TRG_ER_diArg_1	261	264	PF00400	0.507
TRG_ER_diArg_1	330	332	PF00400	0.529
TRG_ER_diArg_1	390	392	PF00400	0.466
TRG_ER_diArg_1	497	500	PF00400	0.415
TRG_NES_CRM1_1	248	259	PF08389	0.501
TRG_NES_CRM1_1	285	299	PF08389	0.367
TRG_NES_CRM1_1	55	67	PF08389	0.467
TRG_NLS_MonoExtC_3	38	43	PF00514	0.429
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	356	361	PF00026	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IIE0	Leishmania donovani	89%	100%
A0A422NNH6	Trypanosoma rangeli	33%	100%
A4HB36	Leishmania braziliensis	69%	99%
A4IAN3	Leishmania infantum	89%	100%
E9B5A6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5BKV7	Trypanosoma cruzi	30%	100%