Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2M6_LEIMA

TriTrypDb:

LmjF.34.3180 , LMJLV39_340037500 , LMJSD75_340037800

Length:

404

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2M6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2M6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	341	345	PF00656	0.736
CLV_C14_Caspase3-7	65	69	PF00656	0.500
CLV_NRD_NRD_1	217	219	PF00675	0.804
CLV_NRD_NRD_1	259	261	PF00675	0.751
CLV_NRD_NRD_1	336	338	PF00675	0.700
CLV_NRD_NRD_1	346	348	PF00675	0.749
CLV_NRD_NRD_1	385	387	PF00675	0.792
CLV_PCSK_KEX2_1	217	219	PF00082	0.699
CLV_PCSK_KEX2_1	259	261	PF00082	0.748
CLV_PCSK_KEX2_1	313	315	PF00082	0.733
CLV_PCSK_KEX2_1	318	320	PF00082	0.699
CLV_PCSK_KEX2_1	336	338	PF00082	0.706
CLV_PCSK_KEX2_1	346	348	PF00082	0.761
CLV_PCSK_KEX2_1	385	387	PF00082	0.700
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.754
CLV_PCSK_PC1ET2_1	318	320	PF00082	0.718
CLV_PCSK_PC7_1	314	320	PF00082	0.716
CLV_PCSK_PC7_1	332	338	PF00082	0.751
CLV_PCSK_PC7_1	381	387	PF00082	0.690
CLV_PCSK_SKI1_1	21	25	PF00082	0.662
CLV_PCSK_SKI1_1	262	266	PF00082	0.731
CLV_PCSK_SKI1_1	336	340	PF00082	0.741
CLV_PCSK_SKI1_1	45	49	PF00082	0.439
DOC_ANK_TNKS_1	339	346	PF00023	0.735
DOC_MAPK_gen_1	259	269	PF00069	0.738
DOC_MAPK_gen_1	70	79	PF00069	0.712
DOC_MAPK_HePTP_8	257	269	PF00069	0.544
DOC_MAPK_MEF2A_6	260	269	PF00069	0.544
DOC_MAPK_NFAT4_5	262	270	PF00069	0.541
DOC_USP7_MATH_1	100	104	PF00917	0.685
DOC_USP7_MATH_1	179	183	PF00917	0.745
DOC_USP7_MATH_1	285	289	PF00917	0.742
DOC_WW_Pin1_4	140	145	PF00397	0.725
DOC_WW_Pin1_4	210	215	PF00397	0.605
DOC_WW_Pin1_4	306	311	PF00397	0.793
DOC_WW_Pin1_4	96	101	PF00397	0.686
LIG_14-3-3_CanoR_1	278	286	PF00244	0.725
LIG_14-3-3_CanoR_1	314	318	PF00244	0.748
LIG_14-3-3_CanoR_1	87	95	PF00244	0.769
LIG_Clathr_ClatBox_1	242	246	PF01394	0.636
LIG_deltaCOP1_diTrp_1	15	22	PF00928	0.545
LIG_FHA_1	51	57	PF00498	0.642
LIG_FHA_2	227	233	PF00498	0.652
LIG_FHA_2	268	274	PF00498	0.688
LIG_FHA_2	378	384	PF00498	0.680
LIG_FHA_2	87	93	PF00498	0.733
LIG_LIR_Gen_1	15	23	PF02991	0.531
LIG_LIR_Nem_3	15	19	PF02991	0.528
LIG_PALB2_WD40_1	5	13	PF16756	0.471
LIG_PTAP_UEV_1	203	208	PF05743	0.766
LIG_SH2_STAP1	107	111	PF00017	0.544
LIG_SH2_STAP1	14	18	PF00017	0.562
LIG_SH2_STAT5	244	247	PF00017	0.480
LIG_SH3_3	184	190	PF00018	0.654
LIG_SH3_3	201	207	PF00018	0.716
LIG_SUMO_SIM_anti_2	263	273	PF11976	0.527
LIG_SUMO_SIM_par_1	263	273	PF11976	0.527
LIG_TRAF2_1	112	115	PF00917	0.816
LIG_TRAF2_1	281	284	PF00917	0.705
LIG_TRAF2_1	392	395	PF00917	0.708
LIG_TRAF2_1	89	92	PF00917	0.582
MOD_CDK_SPxxK_3	210	217	PF00069	0.569
MOD_CDK_SPxxK_3	306	313	PF00069	0.738
MOD_CK1_1	110	116	PF00069	0.554
MOD_CK1_1	143	149	PF00069	0.685
MOD_CK1_1	164	170	PF00069	0.753
MOD_CK1_1	195	201	PF00069	0.746
MOD_CK1_1	226	232	PF00069	0.630
MOD_CK1_1	66	72	PF00069	0.772
MOD_CK2_1	226	232	PF00069	0.661
MOD_CK2_1	277	283	PF00069	0.709
MOD_CK2_1	52	58	PF00069	0.643
MOD_CK2_1	86	92	PF00069	0.796
MOD_Cter_Amidation	344	347	PF01082	0.762
MOD_GlcNHglycan	109	112	PF01048	0.736
MOD_GlcNHglycan	15	19	PF01048	0.631
MOD_GlcNHglycan	163	166	PF01048	0.809
MOD_GlcNHglycan	168	171	PF01048	0.768
MOD_GlcNHglycan	271	277	PF01048	0.636
MOD_GlcNHglycan	280	283	PF01048	0.640
MOD_GlcNHglycan	287	290	PF01048	0.613
MOD_GlcNHglycan	332	335	PF01048	0.787
MOD_GlcNHglycan	40	44	PF01048	0.429
MOD_GSK3_1	106	113	PF00069	0.686
MOD_GSK3_1	140	147	PF00069	0.777
MOD_GSK3_1	219	226	PF00069	0.740
MOD_GSK3_1	274	281	PF00069	0.647
MOD_GSK3_1	309	316	PF00069	0.779
MOD_GSK3_1	50	57	PF00069	0.590
MOD_GSK3_1	82	89	PF00069	0.805
MOD_GSK3_1	96	103	PF00069	0.673
MOD_NEK2_1	105	110	PF00069	0.580
MOD_NEK2_1	22	27	PF00069	0.585
MOD_NEK2_1	274	279	PF00069	0.646
MOD_NEK2_1	362	367	PF00069	0.719
MOD_NEK2_1	72	77	PF00069	0.540
MOD_NEK2_2	220	225	PF00069	0.677
MOD_OFUCOSY	353	358	PF10250	0.522
MOD_PIKK_1	124	130	PF00454	0.736
MOD_PIKK_1	185	191	PF00454	0.753
MOD_PIKK_1	287	293	PF00454	0.808
MOD_PIKK_1	394	400	PF00454	0.721
MOD_PKA_1	313	319	PF00069	0.732
MOD_PKA_1	346	352	PF00069	0.782
MOD_PKA_2	202	208	PF00069	0.808
MOD_PKA_2	277	283	PF00069	0.823
MOD_PKA_2	313	319	PF00069	0.714
MOD_PKA_2	328	334	PF00069	0.650
MOD_PKA_2	346	352	PF00069	0.782
MOD_PKA_2	72	78	PF00069	0.567
MOD_PKA_2	86	92	PF00069	0.687
MOD_PKB_1	61	69	PF00069	0.543
MOD_Plk_1	14	20	PF00069	0.528
MOD_Plk_1	39	45	PF00069	0.432
MOD_Plk_1	394	400	PF00069	0.704
MOD_Plk_2-3	52	58	PF00069	0.605
MOD_Plk_4	135	141	PF00069	0.727
MOD_Plk_4	173	179	PF00069	0.733
MOD_Plk_4	220	226	PF00069	0.744
MOD_Plk_4	32	38	PF00069	0.559
MOD_ProDKin_1	140	146	PF00069	0.685
MOD_ProDKin_1	210	216	PF00069	0.604
MOD_ProDKin_1	306	312	PF00069	0.794
MOD_ProDKin_1	96	102	PF00069	0.685
MOD_SUMO_rev_2	231	238	PF00179	0.622
MOD_SUMO_rev_2	65	72	PF00179	0.506
TRG_DiLeu_BaEn_1	261	266	PF01217	0.514
TRG_DiLeu_BaEn_1	91	96	PF01217	0.582
TRG_ER_diArg_1	336	338	PF00400	0.699
TRG_ER_diArg_1	346	348	PF00400	0.779
TRG_ER_diArg_1	384	386	PF00400	0.701
TRG_ER_diArg_1	61	64	PF00400	0.682
TRG_Pf-PMV_PEXEL_1	26	30	PF00026	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB80	Leptomonas seymouri	35%	75%
A0A3Q8IFR9	Leishmania donovani	85%	100%
A4HB37	Leishmania braziliensis	57%	100%
A4IAN2	Leishmania infantum	86%	100%
E9B5A7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%