Epimerase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NAD dependent epimerase/dehydratase family, putative

Species:

Leishmania major

UniProt:

Q4Q2M5_LEIMA

TriTrypDb:

LmjF.34.3190 , LMJLV39_340037600 , LMJSD75_340037900

Length:

510

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0005741	mitochondrial outer membrane	5	2
GO:0016020	membrane	2	10
GO:0019867	outer membrane	3	2
GO:0031090	organelle membrane	3	2
GO:0031966	mitochondrial membrane	4	2
GO:0031968	organelle outer membrane	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q2M5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2M5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016853	isomerase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	143	147	PF00656	0.311
CLV_C14_Caspase3-7	179	183	PF00656	0.303
CLV_C14_Caspase3-7	340	344	PF00656	0.355
CLV_NRD_NRD_1	417	419	PF00675	0.308
CLV_NRD_NRD_1	424	426	PF00675	0.315
CLV_NRD_NRD_1	472	474	PF00675	0.547
CLV_NRD_NRD_1	508	510	PF00675	0.723
CLV_PCSK_KEX2_1	229	231	PF00082	0.451
CLV_PCSK_KEX2_1	419	421	PF00082	0.341
CLV_PCSK_KEX2_1	424	426	PF00082	0.350
CLV_PCSK_KEX2_1	472	474	PF00082	0.538
CLV_PCSK_KEX2_1	508	510	PF00082	0.704
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.458
CLV_PCSK_PC1ET2_1	419	421	PF00082	0.355
CLV_PCSK_PC1ET2_1	472	474	PF00082	0.482
CLV_PCSK_PC1ET2_1	508	510	PF00082	0.742
CLV_PCSK_PC7_1	420	426	PF00082	0.401
CLV_PCSK_SKI1_1	108	112	PF00082	0.399
CLV_PCSK_SKI1_1	214	218	PF00082	0.478
CLV_PCSK_SKI1_1	230	234	PF00082	0.405
CLV_PCSK_SKI1_1	273	277	PF00082	0.508
CLV_PCSK_SKI1_1	373	377	PF00082	0.583
CLV_PCSK_SKI1_1	424	428	PF00082	0.360
CLV_PCSK_SKI1_1	450	454	PF00082	0.470
CLV_PCSK_SKI1_1	505	509	PF00082	0.703
CLV_Separin_Metazoa	42	46	PF03568	0.694
DEG_APCC_DBOX_1	441	449	PF00400	0.627
DEG_Nend_Nbox_1	1	3	PF02207	0.646
DOC_CKS1_1	261	266	PF01111	0.355
DOC_CKS1_1	381	386	PF01111	0.405
DOC_CYCLIN_RxL_1	211	218	PF00134	0.301
DOC_CYCLIN_yCln2_LP_2	484	490	PF00134	0.333
DOC_MAPK_gen_1	106	114	PF00069	0.566
DOC_MAPK_gen_1	282	291	PF00069	0.249
DOC_MAPK_gen_1	424	434	PF00069	0.559
DOC_MAPK_MEF2A_6	108	116	PF00069	0.604
DOC_MAPK_MEF2A_6	282	291	PF00069	0.252
DOC_MAPK_MEF2A_6	425	434	PF00069	0.542
DOC_MAPK_MEF2A_6	483	491	PF00069	0.526
DOC_PP1_RVXF_1	271	277	PF00149	0.254
DOC_PP2B_LxvP_1	382	385	PF13499	0.311
DOC_PP2B_PxIxI_1	295	301	PF00149	0.258
DOC_USP7_MATH_1	236	240	PF00917	0.302
DOC_USP7_MATH_1	319	323	PF00917	0.284
DOC_USP7_MATH_1	477	481	PF00917	0.741
DOC_USP7_MATH_1	497	501	PF00917	0.454
DOC_USP7_MATH_1	69	73	PF00917	0.777
DOC_USP7_UBL2_3	225	229	PF12436	0.269
DOC_WW_Pin1_4	196	201	PF00397	0.322
DOC_WW_Pin1_4	260	265	PF00397	0.355
DOC_WW_Pin1_4	380	385	PF00397	0.347
DOC_WW_Pin1_4	432	437	PF00397	0.531
DOC_WW_Pin1_4	483	488	PF00397	0.548
DOC_WW_Pin1_4	77	82	PF00397	0.745
LIG_14-3-3_CanoR_1	141	145	PF00244	0.269
LIG_Actin_WH2_2	167	183	PF00022	0.269
LIG_BRCT_BRCA1_1	249	253	PF00533	0.258
LIG_BRCT_BRCA1_1	321	325	PF00533	0.265
LIG_BRCT_BRCA1_1	331	335	PF00533	0.340
LIG_EH1_1	127	135	PF00400	0.329
LIG_FHA_1	208	214	PF00498	0.288
LIG_FHA_1	392	398	PF00498	0.305
LIG_FHA_1	77	83	PF00498	0.737
LIG_FHA_2	141	147	PF00498	0.269
LIG_FHA_2	242	248	PF00498	0.282
LIG_FHA_2	261	267	PF00498	0.355
LIG_FHA_2	438	444	PF00498	0.585
LIG_FHA_2	98	104	PF00498	0.651
LIG_LIR_Gen_1	255	264	PF02991	0.276
LIG_LIR_Gen_1	332	342	PF02991	0.302
LIG_LIR_Gen_1	388	398	PF02991	0.289
LIG_LIR_Gen_1	52	61	PF02991	0.715
LIG_LIR_LC3C_4	204	207	PF02991	0.188
LIG_LIR_LC3C_4	290	293	PF02991	0.269
LIG_LIR_Nem_3	255	261	PF02991	0.264
LIG_LIR_Nem_3	321	327	PF02991	0.335
LIG_LIR_Nem_3	332	338	PF02991	0.302
LIG_LIR_Nem_3	388	393	PF02991	0.282
LIG_LIR_Nem_3	52	56	PF02991	0.722
LIG_MLH1_MIPbox_1	321	325	PF16413	0.340
LIG_MYND_1	380	384	PF01753	0.333
LIG_Pex14_2	53	57	PF04695	0.740
LIG_Rb_pABgroove_1	211	219	PF01858	0.269
LIG_SH2_SRC	189	192	PF00017	0.242
LIG_SH2_STAP1	138	142	PF00017	0.258
LIG_SH2_STAP1	209	213	PF00017	0.321
LIG_SH2_STAT5	124	127	PF00017	0.313
LIG_SH2_STAT5	189	192	PF00017	0.258
LIG_SH2_STAT5	209	212	PF00017	0.340
LIG_SH2_STAT5	324	327	PF00017	0.317
LIG_SH2_STAT5	506	509	PF00017	0.536
LIG_SH3_1	323	329	PF00018	0.317
LIG_SH3_3	21	27	PF00018	0.641
LIG_SH3_3	258	264	PF00018	0.355
LIG_SH3_3	290	296	PF00018	0.249
LIG_SH3_3	323	329	PF00018	0.248
LIG_SH3_3	363	369	PF00018	0.366
LIG_SH3_3	40	46	PF00018	0.623
LIG_SH3_3	85	91	PF00018	0.709
LIG_SUMO_SIM_anti_2	204	210	PF11976	0.188
LIG_SUMO_SIM_anti_2	290	297	PF11976	0.258
LIG_SUMO_SIM_par_1	115	122	PF11976	0.419
LIG_SUMO_SIM_par_1	204	210	PF11976	0.332
LIG_SUMO_SIM_par_1	290	297	PF11976	0.249
LIG_SUMO_SIM_par_1	306	316	PF11976	0.247
LIG_SUMO_SIM_par_1	489	495	PF11976	0.416
LIG_TRAF2_1	72	75	PF00917	0.687
LIG_UBA3_1	216	225	PF00899	0.329
MOD_CDK_SPxxK_3	196	203	PF00069	0.430
MOD_CK1_1	196	202	PF00069	0.428
MOD_CK1_1	223	229	PF00069	0.428
MOD_CK1_1	260	266	PF00069	0.428
MOD_CK1_1	492	498	PF00069	0.399
MOD_CK1_1	8	14	PF00069	0.575
MOD_CK2_1	364	370	PF00069	0.353
MOD_CK2_1	69	75	PF00069	0.622
MOD_CK2_1	97	103	PF00069	0.505
MOD_Cter_Amidation	470	473	PF01082	0.690
MOD_GlcNHglycan	121	124	PF01048	0.400
MOD_GlcNHglycan	196	199	PF01048	0.426
MOD_GlcNHglycan	222	225	PF01048	0.361
MOD_GlcNHglycan	249	252	PF01048	0.314
MOD_GlcNHglycan	39	42	PF01048	0.650
MOD_GlcNHglycan	450	453	PF01048	0.556
MOD_GlcNHglycan	499	502	PF01048	0.216
MOD_GlcNHglycan	5	8	PF01048	0.598
MOD_GlcNHglycan	57	60	PF01048	0.594
MOD_GSK3_1	136	143	PF00069	0.308
MOD_GSK3_1	14	21	PF00069	0.666
MOD_GSK3_1	172	179	PF00069	0.329
MOD_GSK3_1	220	227	PF00069	0.379
MOD_GSK3_1	231	238	PF00069	0.329
MOD_GSK3_1	253	260	PF00069	0.310
MOD_GSK3_1	296	303	PF00069	0.305
MOD_GSK3_1	448	455	PF00069	0.521
MOD_N-GLC_1	319	324	PF02516	0.396
MOD_N-GLC_1	329	334	PF02516	0.396
MOD_N-GLC_2	363	365	PF02516	0.397
MOD_NEK2_1	253	258	PF00069	0.291
MOD_NEK2_1	318	323	PF00069	0.426
MOD_NEK2_1	402	407	PF00069	0.387
MOD_NEK2_1	411	416	PF00069	0.266
MOD_NEK2_1	430	435	PF00069	0.428
MOD_NEK2_1	437	442	PF00069	0.378
MOD_NEK2_1	448	453	PF00069	0.350
MOD_NEK2_1	5	10	PF00069	0.580
MOD_NEK2_1	57	62	PF00069	0.576
MOD_NEK2_2	136	141	PF00069	0.306
MOD_NEK2_2	224	229	PF00069	0.340
MOD_PKA_2	140	146	PF00069	0.314
MOD_PKA_2	165	171	PF00069	0.321
MOD_PKA_2	220	226	PF00069	0.352
MOD_Plk_1	329	335	PF00069	0.428
MOD_Plk_2-3	364	370	PF00069	0.478
MOD_Plk_4	14	20	PF00069	0.690
MOD_Plk_4	165	171	PF00069	0.344
MOD_Plk_4	236	242	PF00069	0.329
MOD_Plk_4	396	402	PF00069	0.338
MOD_Plk_4	489	495	PF00069	0.381
MOD_Plk_4	90	96	PF00069	0.535
MOD_ProDKin_1	196	202	PF00069	0.403
MOD_ProDKin_1	260	266	PF00069	0.450
MOD_ProDKin_1	380	386	PF00069	0.434
MOD_ProDKin_1	432	438	PF00069	0.420
MOD_ProDKin_1	483	489	PF00069	0.439
MOD_ProDKin_1	77	83	PF00069	0.710
TRG_DiLeu_BaEn_1	25	30	PF01217	0.669
TRG_DiLeu_BaEn_1	290	295	PF01217	0.428
TRG_ENDOCYTIC_2	324	327	PF00928	0.428
TRG_ER_diArg_1	281	284	PF00400	0.423
TRG_ER_diArg_1	417	420	PF00400	0.439
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.365

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P451	Leptomonas seymouri	82%	100%
A0A0S4ILP0	Bodo saltans	53%	100%
A0A0S4KPM4	Bodo saltans	30%	84%
A0A1X0PAG0	Trypanosomatidae	26%	100%
A0A1X0PAW0	Trypanosomatidae	53%	98%
A0A3S5IRZ5	Trypanosoma rangeli	24%	100%
A0A3S7X885	Leishmania donovani	98%	100%
A0A422NNP8	Trypanosoma rangeli	56%	100%
A4HB38	Leishmania braziliensis	91%	100%
A4IAN1	Leishmania infantum	98%	100%
C9ZM09	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9B5A8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
P53111	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P53183	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P83775	Candida albicans (strain SC5314 / ATCC MYA-2876)	22%	100%
Q12068	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
Q9S9N9	Arabidopsis thaliana	28%	100%
V5B687	Trypanosoma cruzi	26%	100%
V5DLY1	Trypanosoma cruzi	59%	100%