Protein Abitram

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Protein Abitram

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2M3_LEIMA

TriTrypDb:

LmjF.34.3210 , LMJLV39_340037800 , LMJSD75_340038100

Length:

211

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005730	nucleolus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2M3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2M3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.613
CLV_NRD_NRD_1	88	90	PF00675	0.550
CLV_PCSK_KEX2_1	88	90	PF00082	0.550
CLV_PCSK_SKI1_1	101	105	PF00082	0.533
CLV_PCSK_SKI1_1	124	128	PF00082	0.538
CLV_PCSK_SKI1_1	59	63	PF00082	0.567
CLV_Separin_Metazoa	85	89	PF03568	0.499
DOC_CYCLIN_yCln2_LP_2	164	170	PF00134	0.532
DOC_PP1_RVXF_1	99	105	PF00149	0.492
DOC_USP7_MATH_1	10	14	PF00917	0.713
DOC_USP7_MATH_1	25	29	PF00917	0.436
LIG_BIR_II_1	1	5	PF00653	0.683
LIG_BIR_III_4	204	208	PF00653	0.659
LIG_BRCT_BRCA1_1	38	42	PF00533	0.574
LIG_FHA_1	107	113	PF00498	0.518
LIG_FHA_2	160	166	PF00498	0.481
LIG_FHA_2	199	205	PF00498	0.477
LIG_FHA_2	38	44	PF00498	0.603
LIG_LIR_Apic_2	144	149	PF02991	0.380
LIG_LIR_Gen_1	177	185	PF02991	0.359
LIG_LIR_Gen_1	192	200	PF02991	0.385
LIG_LIR_Gen_1	28	37	PF02991	0.603
LIG_LIR_Gen_1	39	50	PF02991	0.445
LIG_LIR_Nem_3	177	182	PF02991	0.367
LIG_LIR_Nem_3	190	194	PF02991	0.408
LIG_LIR_Nem_3	28	34	PF02991	0.595
LIG_LIR_Nem_3	39	45	PF02991	0.455
LIG_LIR_Nem_3	47	53	PF02991	0.349
LIG_REV1ctd_RIR_1	102	112	PF16727	0.518
LIG_SH2_CRK	146	150	PF00017	0.361
LIG_SH2_NCK_1	146	150	PF00017	0.418
LIG_SH2_PTP2	33	36	PF00017	0.636
LIG_SH2_STAP1	194	198	PF00017	0.536
LIG_SH2_STAT3	49	52	PF00017	0.360
LIG_SH2_STAT5	146	149	PF00017	0.498
LIG_SH2_STAT5	179	182	PF00017	0.364
LIG_SH2_STAT5	33	36	PF00017	0.536
LIG_SH2_STAT5	44	47	PF00017	0.395
MOD_CK1_1	141	147	PF00069	0.409
MOD_CK1_1	38	44	PF00069	0.607
MOD_CK1_1	8	14	PF00069	0.684
MOD_CK2_1	159	165	PF00069	0.473
MOD_CK2_1	189	195	PF00069	0.571
MOD_Cter_Amidation	119	122	PF01082	0.483
MOD_GlcNHglycan	12	15	PF01048	0.692
MOD_GlcNHglycan	190	194	PF01048	0.495
MOD_GSK3_1	25	32	PF00069	0.544
MOD_N-GLC_1	159	164	PF02516	0.464
MOD_N-GLC_2	64	66	PF02516	0.365
MOD_NEK2_1	159	164	PF00069	0.433
MOD_NEK2_1	36	41	PF00069	0.394
MOD_NEK2_1	5	10	PF00069	0.671
MOD_NEK2_1	69	74	PF00069	0.366
MOD_Plk_1	144	150	PF00069	0.471
MOD_Plk_1	159	165	PF00069	0.486
MOD_Plk_1	29	35	PF00069	0.602
MOD_Plk_4	159	165	PF00069	0.382
MOD_SUMO_rev_2	54	61	PF00179	0.556
TRG_DiLeu_BaLyEn_6	32	37	PF01217	0.642
TRG_ENDOCYTIC_2	179	182	PF00928	0.356
TRG_ENDOCYTIC_2	194	197	PF00928	0.348
TRG_ENDOCYTIC_2	33	36	PF00928	0.649
TRG_ENDOCYTIC_2	50	53	PF00928	0.483
TRG_ER_diArg_1	87	89	PF00400	0.559
TRG_NLS_MonoCore_2	120	125	PF00514	0.474
TRG_NLS_MonoExtN_4	121	126	PF00514	0.462
TRG_NLS_MonoExtN_4	56	63	PF00514	0.579

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4J2	Leptomonas seymouri	71%	100%
A0A0S4ILQ4	Bodo saltans	37%	98%
A0A1X0PA68	Trypanosomatidae	51%	100%
A0A3S7X8B1	Leishmania donovani	93%	100%
A0A422NNR6	Trypanosoma rangeli	48%	100%
A4HB40	Leishmania braziliensis	82%	100%
A4IAM9	Leishmania infantum	93%	100%
C9ZM07	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9B5B0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q1LU93	Danio rerio	29%	100%
Q28G67	Xenopus tropicalis	32%	100%
Q29S16	Bos taurus	32%	100%
Q54TD9	Dictyostelium discoideum	31%	100%
Q5RFS0	Pongo abelii	31%	100%
Q5ZHW7	Gallus gallus	32%	100%
Q6GR35	Xenopus laevis	31%	100%
Q80ZQ9	Mus musculus	32%	100%
Q9NX38	Homo sapiens	31%	100%
Q9VFR1	Drosophila melanogaster	30%	99%