Putative pyruvate/indole-pyruvate carboxylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Alpha-keto-acid decarboxylase, putative

Species:

Leishmania major

UniProt:

Q4Q2L9_LEIMA

TriTrypDb:

LmjF.34.3250 , LMJLV39_340038200 , LMJSD75_340038500

Length:

550

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2L9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2L9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000287	magnesium ion binding	5	6
GO:0003824	catalytic activity	1	6
GO:0005488	binding	1	6
GO:0016829	lyase activity	2	6
GO:0016830	carbon-carbon lyase activity	3	6
GO:0016831	carboxy-lyase activity	4	6
GO:0019842	vitamin binding	3	6
GO:0030976	thiamine pyrophosphate binding	3	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0047434	indolepyruvate decarboxylase activity	5	5
GO:0050997	quaternary ammonium group binding	2	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6
GO:1901681	sulfur compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.384
CLV_C14_Caspase3-7	518	522	PF00656	0.506
CLV_NRD_NRD_1	186	188	PF00675	0.531
CLV_PCSK_KEX2_1	186	188	PF00082	0.600
CLV_PCSK_SKI1_1	112	116	PF00082	0.363
CLV_PCSK_SKI1_1	152	156	PF00082	0.384
CLV_PCSK_SKI1_1	458	462	PF00082	0.336
DOC_CKS1_1	140	145	PF01111	0.384
DOC_CYCLIN_yCln2_LP_2	537	543	PF00134	0.376
DOC_MAPK_DCC_7	183	193	PF00069	0.451
DOC_MAPK_DCC_7	297	305	PF00069	0.384
DOC_MAPK_gen_1	161	168	PF00069	0.384
DOC_MAPK_gen_1	183	193	PF00069	0.451
DOC_MAPK_gen_1	454	462	PF00069	0.384
DOC_MAPK_HePTP_8	516	528	PF00069	0.385
DOC_MAPK_MEF2A_6	186	193	PF00069	0.450
DOC_MAPK_MEF2A_6	376	385	PF00069	0.363
DOC_MAPK_MEF2A_6	519	528	PF00069	0.382
DOC_PP2B_LxvP_1	395	398	PF13499	0.384
DOC_PP2B_PxIxI_1	95	101	PF00149	0.384
DOC_PP4_FxxP_1	25	28	PF00568	0.384
DOC_USP7_MATH_1	189	193	PF00917	0.439
DOC_USP7_MATH_1	268	272	PF00917	0.370
DOC_USP7_MATH_1	425	429	PF00917	0.354
DOC_USP7_UBL2_3	454	458	PF12436	0.336
DOC_USP7_UBL2_3	546	550	PF12436	0.623
DOC_WW_Pin1_4	139	144	PF00397	0.487
DOC_WW_Pin1_4	355	360	PF00397	0.642
DOC_WW_Pin1_4	536	541	PF00397	0.376
LIG_14-3-3_CanoR_1	152	159	PF00244	0.384
LIG_14-3-3_CanoR_1	206	215	PF00244	0.336
LIG_Actin_WH2_2	288	306	PF00022	0.384
LIG_CtBP_PxDLS_1	324	328	PF00389	0.336
LIG_FHA_1	153	159	PF00498	0.384
LIG_FHA_1	183	189	PF00498	0.363
LIG_FHA_1	215	221	PF00498	0.384
LIG_FHA_1	359	365	PF00498	0.488
LIG_FHA_1	389	395	PF00498	0.384
LIG_FHA_1	501	507	PF00498	0.463
LIG_FHA_1	73	79	PF00498	0.406
LIG_FHA_2	146	152	PF00498	0.336
LIG_FHA_2	441	447	PF00498	0.384
LIG_FHA_2	48	54	PF00498	0.360
LIG_FHA_2	513	519	PF00498	0.451
LIG_LIR_Apic_2	22	28	PF02991	0.384
LIG_LIR_Apic_2	344	350	PF02991	0.530
LIG_LIR_Apic_2	411	417	PF02991	0.457
LIG_LIR_Gen_1	477	485	PF02991	0.475
LIG_LIR_Nem_3	317	323	PF02991	0.384
LIG_LIR_Nem_3	477	483	PF02991	0.469
LIG_MYND_1	540	544	PF01753	0.413
LIG_Pex14_1	343	347	PF04695	0.518
LIG_Pex14_1	476	480	PF04695	0.469
LIG_Pex14_2	31	35	PF04695	0.442
LIG_Pex14_2	339	343	PF04695	0.341
LIG_PTB_Apo_2	461	468	PF02174	0.384
LIG_PTB_Phospho_1	461	467	PF10480	0.384
LIG_REV1ctd_RIR_1	309	318	PF16727	0.384
LIG_SH2_CRK	321	325	PF00017	0.336
LIG_SH2_CRK	414	418	PF00017	0.505
LIG_SH2_NCK_1	414	418	PF00017	0.384
LIG_SH2_NCK_1	480	484	PF00017	0.445
LIG_SH2_PTP2	165	168	PF00017	0.426
LIG_SH2_PTP2	459	462	PF00017	0.384
LIG_SH2_SRC	241	244	PF00017	0.336
LIG_SH2_STAT3	63	66	PF00017	0.384
LIG_SH2_STAT5	165	168	PF00017	0.426
LIG_SH2_STAT5	258	261	PF00017	0.481
LIG_SH2_STAT5	262	265	PF00017	0.464
LIG_SH2_STAT5	414	417	PF00017	0.384
LIG_SH2_STAT5	459	462	PF00017	0.384
LIG_SH2_STAT5	467	470	PF00017	0.323
LIG_SH2_STAT5	472	475	PF00017	0.383
LIG_SH2_STAT5	6	9	PF00017	0.384
LIG_SH3_3	163	169	PF00018	0.319
LIG_SH3_3	174	180	PF00018	0.437
LIG_SH3_3	237	243	PF00018	0.396
LIG_SH3_3	353	359	PF00018	0.476
LIG_SH3_3	538	544	PF00018	0.536
LIG_SUMO_SIM_anti_2	379	384	PF11976	0.413
LIG_SUMO_SIM_par_1	379	384	PF11976	0.516
LIG_TRAF2_1	331	334	PF00917	0.386
LIG_TRAF2_1	443	446	PF00917	0.384
LIG_TRFH_1	453	457	PF08558	0.384
MOD_CK1_1	105	111	PF00069	0.404
MOD_CK1_1	192	198	PF00069	0.457
MOD_CK1_1	358	364	PF00069	0.481
MOD_CK1_1	388	394	PF00069	0.409
MOD_CK2_1	270	276	PF00069	0.384
MOD_CK2_1	440	446	PF00069	0.384
MOD_CK2_1	47	53	PF00069	0.360
MOD_CK2_1	512	518	PF00069	0.392
MOD_CK2_1	87	93	PF00069	0.384
MOD_GlcNHglycan	130	133	PF01048	0.384
MOD_GlcNHglycan	196	199	PF01048	0.452
MOD_GlcNHglycan	208	211	PF01048	0.336
MOD_GlcNHglycan	276	279	PF01048	0.336
MOD_GlcNHglycan	391	394	PF01048	0.444
MOD_GlcNHglycan	80	84	PF01048	0.384
MOD_GSK3_1	202	209	PF00069	0.384
MOD_GSK3_1	270	277	PF00069	0.336
MOD_GSK3_1	338	345	PF00069	0.469
MOD_GSK3_1	384	391	PF00069	0.384
MOD_GSK3_1	408	415	PF00069	0.384
MOD_GSK3_1	87	94	PF00069	0.433
MOD_N-GLC_1	128	133	PF02516	0.312
MOD_N-GLC_1	341	346	PF02516	0.582
MOD_N-GLC_1	486	491	PF02516	0.432
MOD_N-GLC_2	494	496	PF02516	0.458
MOD_NEK2_1	115	120	PF00069	0.360
MOD_NEK2_1	199	204	PF00069	0.454
MOD_NEK2_1	288	293	PF00069	0.411
MOD_NEK2_1	385	390	PF00069	0.312
MOD_NEK2_1	40	45	PF00069	0.239
MOD_NEK2_1	408	413	PF00069	0.384
MOD_NEK2_1	91	96	PF00069	0.426
MOD_PIKK_1	105	111	PF00454	0.384
MOD_Plk_1	189	195	PF00069	0.446
MOD_Plk_1	476	482	PF00069	0.458
MOD_Plk_1	512	518	PF00069	0.320
MOD_Plk_1	79	85	PF00069	0.384
MOD_Plk_2-3	465	471	PF00069	0.384
MOD_Plk_4	258	264	PF00069	0.384
MOD_Plk_4	270	276	PF00069	0.261
MOD_Plk_4	291	297	PF00069	0.312
MOD_ProDKin_1	139	145	PF00069	0.487
MOD_ProDKin_1	355	361	PF00069	0.634
MOD_ProDKin_1	536	542	PF00069	0.390
TRG_ENDOCYTIC_2	165	168	PF00928	0.384
TRG_ENDOCYTIC_2	459	462	PF00928	0.487
TRG_ENDOCYTIC_2	480	483	PF00928	0.498
TRG_ER_diArg_1	186	188	PF00400	0.510
TRG_ER_diArg_1	352	355	PF00400	0.421
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	186	190	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.384

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ILD2	Leishmania donovani	94%	94%
A0PL16	Mycobacterium ulcerans (strain Agy99)	43%	97%
A0QBE6	Mycobacterium avium (strain 104)	43%	98%
A0R480	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	43%	99%
A0REB6	Bacillus thuringiensis (strain Al Hakam)	23%	85%
A1KGY5	Mycobacterium bovis (strain BCG / Pasteur 1173P2)	43%	98%
A2XFI3	Oryza sativa subsp. indica	32%	91%
A2Y5L9	Oryza sativa subsp. indica	32%	91%
A2YQ76	Oryza sativa subsp. indica	31%	94%
A4HB43	Leishmania braziliensis	86%	100%
A4IA92	Leishmania infantum	94%	94%
A4IPB6	Geobacillus thermodenitrificans (strain NG80-2)	24%	86%
A5U0P1	Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)	43%	98%
A5YBJ6	Lactobacillus casei	20%	86%
C1EVJ3	Bacillus cereus (strain 03BB102)	23%	85%
E9B5B4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O06335	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	24%	100%
O08353	Methanococcus aeolicus	26%	92%
O19929	Cyanidium caldarium	24%	94%
O33112	Mycobacterium leprae (strain TN)	26%	88%
O42873	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	96%
O78518	Guillardia theta	24%	96%
O82647	Arabidopsis thaliana	33%	91%
O85293	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	23%	96%
P00893	Escherichia coli (strain K12)	25%	96%
P06169	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	98%
P06672	Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)	31%	97%
P07003	Escherichia coli (strain K12)	23%	96%
P07342	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	80%
P08142	Escherichia coli (strain K12)	22%	98%
P09114	Nicotiana tabacum	23%	83%
P09342	Nicotiana tabacum	24%	82%
P0A623	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	26%	89%
P0AEP7	Escherichia coli (strain K12)	22%	93%
P0AEP8	Escherichia coli O157:H7	22%	93%
P0CH62	Azoarcus sp.	22%	93%
P0DP90	Escherichia coli (strain K12)	24%	100%
P0DUV9	Actinomycetospora chiangmaiensis (strain DSM 45062 / JCM 15998 / NBRC 104400 / YIM 0006)	23%	93%
P14874	Brassica napus	23%	86%
P16467	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	98%
P17597	Arabidopsis thaliana	23%	82%
P20906	Pseudomonas putida	23%	100%
P23234	Enterobacter cloacae	40%	100%
P26263	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	98%
P27696	Klebsiella pneumoniae	23%	98%
P27818	Brassica napus	24%	84%
P27819	Brassica napus	24%	84%
P27868	Arthrospira platensis	25%	95%
P28516	Zea mays	32%	90%
P33149	Kluyveromyces marxianus	35%	98%
P33287	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	30%	96%
P34734	Hanseniaspora uvarum	34%	98%
P36620	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	82%
P37063	Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)	22%	91%
P37251	Bacillus subtilis (strain 168)	26%	96%
P40811	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	25%	96%
P42463	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	25%	88%
P45261	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	25%	96%
P51844	Aspergillus parasiticus	33%	95%
P51845	Nicotiana tabacum	30%	100%
P51846	Nicotiana tabacum	31%	90%
P51850	Pisum sativum	32%	93%
P51852	Azospirillum brasilense	27%	100%
P57321	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	23%	96%
P69683	Porphyra purpurea	26%	93%
P69684	Porphyra umbilicalis	26%	93%
P83779	Candida albicans (strain SC5314 / ATCC MYA-2876)	34%	97%
P87208	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	36%	97%
P96591	Bacillus subtilis (strain 168)	24%	96%
P9WG36	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	43%	98%
P9WG37	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	43%	98%
P9WG40	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	26%	89%
P9WG41	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	26%	89%
Q02137	Lactococcus lactis subsp. lactis (strain IL1403)	24%	96%
Q04524	Raoultella terrigena	25%	98%
Q04789	Bacillus subtilis (strain 168)	21%	96%
Q06408	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	87%
Q07471	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	90%
Q09737	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	96%
Q0CNV1	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	35%	97%
Q0D3D2	Oryza sativa subsp. japonica	31%	94%
Q0DHF6	Oryza sativa subsp. japonica	32%	91%
Q10MW3	Oryza sativa subsp. japonica	32%	91%
Q12629	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	34%	98%
Q1XDF6	Neopyropia yezoensis	25%	93%
Q2UKV4	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	35%	96%
Q41768	Zea mays	23%	86%
Q4V1F5	Bacillus cereus (strain ZK / E33L)	23%	85%
Q4WXX9	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	36%	97%
Q54DA9	Dictyostelium discoideum	23%	95%
Q57725	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	28%	93%
Q59498	Mycobacterium avium	24%	89%
Q5KPJ5	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	23%	77%
Q5KYR0	Geobacillus kaustophilus (strain HTA426)	22%	85%
Q6FJA3	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	35%	98%
Q6K2E8	Oryza sativa subsp. japonica	21%	85%
Q6SSJ3	Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487)	23%	77%
Q723S8	Listeria monocytogenes serotype 4b (strain F2365)	22%	86%
Q742Q2	Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)	43%	98%
Q7U140	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	43%	98%
Q7U5G1	Parasynechococcus marenigrum (strain WH8102)	24%	89%
Q89AP7	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	23%	95%
Q8CHM7	Rattus norvegicus	22%	95%
Q92345	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	97%
Q9CBD6	Mycobacterium leprae (strain TN)	42%	97%
Q9FFT4	Arabidopsis thaliana	33%	91%
Q9HUI8	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	23%	98%
Q9HUR2	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	22%	100%
Q9LCV9	Streptomyces clavuligerus	25%	96%
Q9M039	Arabidopsis thaliana	32%	93%
Q9M040	Arabidopsis thaliana	32%	91%
Q9P7P6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	96%
Q9QXE0	Mus musculus	24%	95%
Q9RQ65	Buchnera aphidicola subsp. Schlechtendalia chinensis	23%	96%
Q9UJ83	Homo sapiens	21%	95%