LeishMANIAdb
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DRMBL domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
DRMBL domain-containing protein
Gene product:
DNA repair metallo-beta-lactamase, putative
Species:
Leishmania major
UniProt:
Q4Q2L8_LEIMA
TriTrypDb:
LmjF.34.3260 * , LMJLV39_340038300 * , LMJSD75_340038600 *
Length:
664

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0031974 membrane-enclosed lumen 2 2
GO:0031981 nuclear lumen 5 2
GO:0043233 organelle lumen 3 2
GO:0070013 intracellular organelle lumen 4 2
GO:0110165 cellular anatomical entity 1 11
GO:0005634 nucleus 5 9
GO:0043226 organelle 2 9
GO:0043227 membrane-bounded organelle 3 9
GO:0043229 intracellular organelle 3 9
GO:0043231 intracellular membrane-bounded organelle 4 9

Expansion

Sequence features

Q4Q2L8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2L8

Function

Biological processes
Term Name Level Count
GO:0000723 telomere maintenance 5 2
GO:0006139 nucleobase-containing compound metabolic process 3 2
GO:0006259 DNA metabolic process 4 2
GO:0006281 DNA repair 5 2
GO:0006302 double-strand break repair 6 2
GO:0006303 double-strand break repair via nonhomologous end joining 7 2
GO:0006725 cellular aromatic compound metabolic process 3 2
GO:0006807 nitrogen compound metabolic process 2 2
GO:0006950 response to stress 2 11
GO:0006974 DNA damage response 4 11
GO:0006996 organelle organization 4 2
GO:0008152 metabolic process 1 2
GO:0009987 cellular process 1 11
GO:0016043 cellular component organization 3 2
GO:0031848 protection from non-homologous end joining at telomere 6 2
GO:0032200 telomere organization 6 2
GO:0033554 cellular response to stress 3 11
GO:0034641 cellular nitrogen compound metabolic process 3 2
GO:0036297 interstrand cross-link repair 6 2
GO:0043170 macromolecule metabolic process 3 2
GO:0043247 telomere maintenance in response to DNA damage 5 2
GO:0044237 cellular metabolic process 2 2
GO:0044238 primary metabolic process 2 2
GO:0044260 obsolete cellular macromolecule metabolic process 3 2
GO:0046483 heterocycle metabolic process 3 2
GO:0050896 response to stimulus 1 11
GO:0051276 chromosome organization 5 2
GO:0051716 cellular response to stimulus 2 11
GO:0071704 organic substance metabolic process 2 2
GO:0071840 cellular component organization or biogenesis 2 2
GO:0090304 nucleic acid metabolic process 4 2
GO:1901360 organic cyclic compound metabolic process 3 2
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 2
GO:0003677 DNA binding 4 2
GO:0003684 damaged DNA binding 5 2
GO:0003824 catalytic activity 1 2
GO:0004518 nuclease activity 4 2
GO:0004527 exonuclease activity 5 2
GO:0004529 DNA exonuclease activity 5 2
GO:0004536 DNA nuclease activity 4 2
GO:0005488 binding 1 2
GO:0008409 5'-3' exonuclease activity 6 2
GO:0016787 hydrolase activity 2 2
GO:0016788 hydrolase activity, acting on ester bonds 3 2
GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 6 2
GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 6 2
GO:0035312 5'-3' DNA exonuclease activity 7 2
GO:0097159 organic cyclic compound binding 2 2
GO:0140097 catalytic activity, acting on DNA 3 2
GO:0140640 catalytic activity, acting on a nucleic acid 2 2
GO:1901363 heterocyclic compound binding 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 369 373 PF00656 0.646
CLV_MEL_PAP_1 506 512 PF00089 0.578
CLV_NRD_NRD_1 103 105 PF00675 0.520
CLV_NRD_NRD_1 337 339 PF00675 0.686
CLV_NRD_NRD_1 535 537 PF00675 0.705
CLV_NRD_NRD_1 583 585 PF00675 0.725
CLV_PCSK_KEX2_1 103 105 PF00082 0.558
CLV_PCSK_KEX2_1 116 118 PF00082 0.738
CLV_PCSK_KEX2_1 444 446 PF00082 0.316
CLV_PCSK_KEX2_1 535 537 PF00082 0.697
CLV_PCSK_KEX2_1 585 587 PF00082 0.788
CLV_PCSK_KEX2_1 624 626 PF00082 0.674
CLV_PCSK_PC1ET2_1 116 118 PF00082 0.642
CLV_PCSK_PC1ET2_1 444 446 PF00082 0.311
CLV_PCSK_PC1ET2_1 585 587 PF00082 0.787
CLV_PCSK_PC1ET2_1 624 626 PF00082 0.700
CLV_PCSK_PC7_1 99 105 PF00082 0.510
CLV_PCSK_SKI1_1 149 153 PF00082 0.503
CLV_PCSK_SKI1_1 183 187 PF00082 0.426
CLV_PCSK_SKI1_1 223 227 PF00082 0.374
CLV_PCSK_SKI1_1 229 233 PF00082 0.420
CLV_PCSK_SKI1_1 270 274 PF00082 0.429
CLV_PCSK_SKI1_1 295 299 PF00082 0.696
CLV_PCSK_SKI1_1 549 553 PF00082 0.595
CLV_Separin_Metazoa 180 184 PF03568 0.488
DEG_APCC_DBOX_1 148 156 PF00400 0.472
DEG_APCC_DBOX_1 633 641 PF00400 0.742
DEG_Nend_UBRbox_2 1 3 PF02207 0.403
DEG_SPOP_SBC_1 598 602 PF00917 0.655
DEG_SPOP_SBC_1 607 611 PF00917 0.612
DOC_CKS1_1 21 26 PF01111 0.437
DOC_CKS1_1 296 301 PF01111 0.538
DOC_CYCLIN_RxL_1 144 153 PF00134 0.473
DOC_MAPK_gen_1 206 214 PF00069 0.430
DOC_MAPK_gen_1 221 228 PF00069 0.254
DOC_MAPK_gen_1 584 593 PF00069 0.673
DOC_MAPK_MEF2A_6 149 156 PF00069 0.490
DOC_MAPK_MEF2A_6 221 228 PF00069 0.392
DOC_MAPK_MEF2A_6 361 368 PF00069 0.648
DOC_PP2B_LxvP_1 33 36 PF13499 0.601
DOC_PP2B_LxvP_1 458 461 PF13499 0.458
DOC_PP4_FxxP_1 161 164 PF00568 0.381
DOC_PP4_FxxP_1 394 397 PF00568 0.494
DOC_PP4_FxxP_1 477 480 PF00568 0.458
DOC_PP4_FxxP_1 71 74 PF00568 0.361
DOC_USP7_MATH_1 196 200 PF00917 0.729
DOC_USP7_MATH_1 254 258 PF00917 0.730
DOC_USP7_MATH_1 289 293 PF00917 0.629
DOC_USP7_MATH_1 36 40 PF00917 0.683
DOC_USP7_MATH_1 397 401 PF00917 0.494
DOC_USP7_MATH_1 485 489 PF00917 0.472
DOC_USP7_MATH_1 607 611 PF00917 0.791
DOC_USP7_MATH_2 349 355 PF00917 0.537
DOC_WW_Pin1_4 108 113 PF00397 0.436
DOC_WW_Pin1_4 20 25 PF00397 0.502
DOC_WW_Pin1_4 264 269 PF00397 0.369
DOC_WW_Pin1_4 295 300 PF00397 0.762
DOC_WW_Pin1_4 31 36 PF00397 0.603
DOC_WW_Pin1_4 500 505 PF00397 0.519
DOC_WW_Pin1_4 628 633 PF00397 0.803
DOC_WW_Pin1_4 70 75 PF00397 0.364
LIG_14-3-3_CanoR_1 103 108 PF00244 0.539
LIG_14-3-3_CanoR_1 252 262 PF00244 0.733
LIG_14-3-3_CanoR_1 338 342 PF00244 0.570
LIG_14-3-3_CanoR_1 353 360 PF00244 0.677
LIG_14-3-3_CanoR_1 459 468 PF00244 0.500
LIG_14-3-3_CanoR_1 518 523 PF00244 0.551
LIG_BIR_III_2 230 234 PF00653 0.511
LIG_BRCT_BRCA1_1 275 279 PF00533 0.501
LIG_BRCT_BRCA1_1 5 9 PF00533 0.265
LIG_BRCT_BRCA1_1 72 76 PF00533 0.368
LIG_deltaCOP1_diTrp_1 92 97 PF00928 0.468
LIG_FHA_1 173 179 PF00498 0.416
LIG_FHA_1 312 318 PF00498 0.562
LIG_FHA_1 593 599 PF00498 0.703
LIG_FHA_1 607 613 PF00498 0.689
LIG_FHA_2 296 302 PF00498 0.755
LIG_FHA_2 484 490 PF00498 0.548
LIG_LIR_Apic_2 106 110 PF02991 0.515
LIG_LIR_Apic_2 158 164 PF02991 0.363
LIG_LIR_Apic_2 392 397 PF02991 0.522
LIG_LIR_Gen_1 269 279 PF02991 0.396
LIG_LIR_Gen_1 429 439 PF02991 0.587
LIG_LIR_Gen_1 452 462 PF02991 0.506
LIG_LIR_Gen_1 473 481 PF02991 0.505
LIG_LIR_Gen_1 517 528 PF02991 0.677
LIG_LIR_Gen_1 617 628 PF02991 0.721
LIG_LIR_Gen_1 92 98 PF02991 0.504
LIG_LIR_Nem_3 230 235 PF02991 0.438
LIG_LIR_Nem_3 269 274 PF02991 0.403
LIG_LIR_Nem_3 281 287 PF02991 0.369
LIG_LIR_Nem_3 400 406 PF02991 0.475
LIG_LIR_Nem_3 429 434 PF02991 0.543
LIG_LIR_Nem_3 452 458 PF02991 0.506
LIG_LIR_Nem_3 473 477 PF02991 0.505
LIG_LIR_Nem_3 489 495 PF02991 0.417
LIG_LIR_Nem_3 517 523 PF02991 0.630
LIG_LIR_Nem_3 617 623 PF02991 0.706
LIG_LIR_Nem_3 73 79 PF02991 0.356
LIG_LIR_Nem_3 92 97 PF02991 0.414
LIG_MYND_1 321 325 PF01753 0.517
LIG_NRBOX 151 157 PF00104 0.389
LIG_PCNA_yPIPBox_3 144 155 PF02747 0.468
LIG_Pex14_2 168 172 PF04695 0.482
LIG_Pex14_2 280 284 PF04695 0.450
LIG_SH2_CRK 166 170 PF00017 0.471
LIG_SH2_CRK 271 275 PF00017 0.462
LIG_SH2_CRK 403 407 PF00017 0.514
LIG_SH2_CRK 431 435 PF00017 0.548
LIG_SH2_CRK 455 459 PF00017 0.475
LIG_SH2_PTP2 107 110 PF00017 0.581
LIG_SH2_SRC 107 110 PF00017 0.570
LIG_SH2_STAP1 133 137 PF00017 0.498
LIG_SH2_STAP1 431 435 PF00017 0.548
LIG_SH2_STAP1 495 499 PF00017 0.438
LIG_SH2_STAT5 107 110 PF00017 0.581
LIG_SH2_STAT5 217 220 PF00017 0.384
LIG_SH2_STAT5 455 458 PF00017 0.531
LIG_SH2_STAT5 7 10 PF00017 0.335
LIG_SH3_3 106 112 PF00018 0.568
LIG_SH3_3 125 131 PF00018 0.469
LIG_SH3_3 18 24 PF00018 0.505
LIG_SH3_3 192 198 PF00018 0.584
LIG_SH3_3 293 299 PF00018 0.635
LIG_SH3_3 319 325 PF00018 0.414
LIG_SH3_3 356 362 PF00018 0.776
LIG_SH3_3 562 568 PF00018 0.650
LIG_SH3_3 593 599 PF00018 0.670
LIG_SUMO_SIM_anti_2 153 158 PF11976 0.385
LIG_SUMO_SIM_par_1 153 158 PF11976 0.385
LIG_SUMO_SIM_par_1 324 330 PF11976 0.517
LIG_SUMO_SIM_par_1 432 438 PF11976 0.533
LIG_SUMO_SIM_par_1 594 606 PF11976 0.601
LIG_SUMO_SIM_par_1 656 664 PF11976 0.621
LIG_TRAF2_1 564 567 PF00917 0.546
LIG_TRAF2_1 636 639 PF00917 0.656
LIG_TYR_ITIM 401 406 PF00017 0.367
MOD_CDC14_SPxK_1 267 270 PF00782 0.390
MOD_CDC14_SPxK_1 631 634 PF00782 0.654
MOD_CDK_SPK_2 295 300 PF00069 0.598
MOD_CDK_SPK_2 500 505 PF00069 0.322
MOD_CDK_SPxK_1 264 270 PF00069 0.364
MOD_CDK_SPxK_1 628 634 PF00069 0.652
MOD_CDK_SPxxK_3 500 507 PF00069 0.326
MOD_CK1_1 10 16 PF00069 0.515
MOD_CK1_1 238 244 PF00069 0.655
MOD_CK1_1 290 296 PF00069 0.676
MOD_CK1_1 340 346 PF00069 0.646
MOD_CK1_1 508 514 PF00069 0.636
MOD_CK1_1 555 561 PF00069 0.706
MOD_CK1_1 601 607 PF00069 0.684
MOD_CK1_1 610 616 PF00069 0.560
MOD_CK1_1 90 96 PF00069 0.502
MOD_CK2_1 167 173 PF00069 0.388
MOD_CK2_1 375 381 PF00069 0.666
MOD_CK2_1 483 489 PF00069 0.419
MOD_GlcNHglycan 198 201 PF01048 0.574
MOD_GlcNHglycan 292 295 PF01048 0.690
MOD_GlcNHglycan 342 345 PF01048 0.668
MOD_GlcNHglycan 354 357 PF01048 0.792
MOD_GlcNHglycan 377 380 PF01048 0.717
MOD_GlcNHglycan 545 548 PF01048 0.721
MOD_GlcNHglycan 579 582 PF01048 0.696
MOD_GSK3_1 234 241 PF00069 0.572
MOD_GSK3_1 254 261 PF00069 0.412
MOD_GSK3_1 3 10 PF00069 0.381
MOD_GSK3_1 305 312 PF00069 0.671
MOD_GSK3_1 449 456 PF00069 0.376
MOD_GSK3_1 514 521 PF00069 0.523
MOD_GSK3_1 539 546 PF00069 0.686
MOD_GSK3_1 597 604 PF00069 0.729
MOD_GSK3_1 606 613 PF00069 0.704
MOD_GSK3_1 75 82 PF00069 0.349
MOD_N-GLC_1 254 259 PF02516 0.543
MOD_N-GLC_1 375 380 PF02516 0.655
MOD_N-GLC_1 87 92 PF02516 0.446
MOD_N-GLC_2 61 63 PF02516 0.377
MOD_NEK2_1 157 162 PF00069 0.325
MOD_NEK2_1 247 252 PF00069 0.641
MOD_NEK2_1 273 278 PF00069 0.551
MOD_NEK2_1 287 292 PF00069 0.491
MOD_NEK2_1 3 8 PF00069 0.356
MOD_NEK2_1 552 557 PF00069 0.701
MOD_NEK2_1 9 14 PF00069 0.375
MOD_NEK2_1 97 102 PF00069 0.493
MOD_PIKK_1 167 173 PF00454 0.497
MOD_PIKK_1 247 253 PF00454 0.735
MOD_PK_1 518 524 PF00069 0.647
MOD_PKA_1 103 109 PF00069 0.383
MOD_PKA_2 235 241 PF00069 0.629
MOD_PKA_2 290 296 PF00069 0.612
MOD_PKA_2 337 343 PF00069 0.570
MOD_PKA_2 352 358 PF00069 0.740
MOD_PKA_2 360 366 PF00069 0.751
MOD_PKA_2 508 514 PF00069 0.545
MOD_PKA_2 90 96 PF00069 0.480
MOD_PKA_2 98 104 PF00069 0.497
MOD_Plk_1 157 163 PF00069 0.327
MOD_Plk_4 103 109 PF00069 0.590
MOD_Plk_4 3 9 PF00069 0.361
MOD_Plk_4 389 395 PF00069 0.346
MOD_Plk_4 453 459 PF00069 0.305
MOD_Plk_4 75 81 PF00069 0.363
MOD_ProDKin_1 108 114 PF00069 0.445
MOD_ProDKin_1 20 26 PF00069 0.507
MOD_ProDKin_1 264 270 PF00069 0.364
MOD_ProDKin_1 295 301 PF00069 0.764
MOD_ProDKin_1 31 37 PF00069 0.614
MOD_ProDKin_1 500 506 PF00069 0.514
MOD_ProDKin_1 628 634 PF00069 0.805
MOD_ProDKin_1 70 76 PF00069 0.368
MOD_SUMO_for_1 115 118 PF00179 0.508
TRG_DiLeu_BaEn_1 386 391 PF01217 0.510
TRG_DiLeu_BaEn_1 453 458 PF01217 0.429
TRG_DiLeu_BaEn_2 469 475 PF01217 0.302
TRG_DiLeu_BaLyEn_6 53 58 PF01217 0.423
TRG_ENDOCYTIC_2 133 136 PF00928 0.504
TRG_ENDOCYTIC_2 271 274 PF00928 0.396
TRG_ENDOCYTIC_2 403 406 PF00928 0.355
TRG_ENDOCYTIC_2 431 434 PF00928 0.419
TRG_ENDOCYTIC_2 455 458 PF00928 0.403
TRG_ENDOCYTIC_2 495 498 PF00928 0.439
TRG_ER_diArg_1 192 195 PF00400 0.503
TRG_ER_diArg_1 504 507 PF00400 0.413
TRG_NES_CRM1_1 514 529 PF08389 0.539
TRG_NLS_MonoExtC_3 583 588 PF00514 0.792
TRG_NLS_MonoExtN_4 584 589 PF00514 0.787
TRG_Pf-PMV_PEXEL_1 149 153 PF00026 0.480

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PB91 Leptomonas seymouri 42% 76%
A0A1X0P9Y1 Trypanosomatidae 30% 90%
A0A3Q8IHR3 Leishmania donovani 90% 100%
A0A3R7MJM0 Trypanosoma rangeli 31% 94%
A4HB44 Leishmania braziliensis 66% 100%
A4IA93 Leishmania infantum 90% 82%
C9ZM02 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 92%
E9B5B5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 99%
V5BQH0 Trypanosoma cruzi 32% 93%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS