DUF4379 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4379), putative

Species:

Leishmania major

UniProt:

Q4Q2L7_LEIMA

TriTrypDb:

LmjF.34.3270 , LMJLV39_340038500 , LMJSD75_340038800

Length:

184

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0020023	kinetoplast	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2L7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2L7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	45	47	PF00675	0.490
CLV_PCSK_FUR_1	171	175	PF00082	0.575
CLV_PCSK_KEX2_1	113	115	PF00082	0.344
CLV_PCSK_KEX2_1	173	175	PF00082	0.572
CLV_PCSK_KEX2_1	55	57	PF00082	0.517
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.344
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.572
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.517
DOC_CKS1_1	30	35	PF01111	0.678
DOC_CYCLIN_yCln2_LP_2	30	36	PF00134	0.617
DOC_MAPK_gen_1	171	180	PF00069	0.577
DOC_MAPK_gen_1	35	43	PF00069	0.499
DOC_MAPK_gen_1	46	53	PF00069	0.446
DOC_MAPK_RevD_3	159	174	PF00069	0.642
DOC_USP7_MATH_1	16	20	PF00917	0.634
DOC_WW_Pin1_4	155	160	PF00397	0.602
DOC_WW_Pin1_4	29	34	PF00397	0.639
LIG_14-3-3_CanoR_1	101	111	PF00244	0.458
LIG_14-3-3_CanoR_1	11	15	PF00244	0.646
LIG_14-3-3_CanoR_1	171	180	PF00244	0.654
LIG_14-3-3_CanoR_1	35	43	PF00244	0.495
LIG_APCC_ABBA_1	81	86	PF00400	0.366
LIG_BIR_II_1	1	5	PF00653	0.418
LIG_BRCT_BRCA1_1	131	135	PF00533	0.558
LIG_FHA_1	156	162	PF00498	0.710
LIG_FHA_1	173	179	PF00498	0.626
LIG_FHA_1	38	44	PF00498	0.535
LIG_LIR_Apic_2	89	95	PF02991	0.429
LIG_LYPXL_S_1	83	87	PF13949	0.344
LIG_LYPXL_yS_3	84	87	PF13949	0.344
LIG_MAD2	114	122	PF02301	0.344
LIG_MYND_1	159	163	PF01753	0.603
LIG_SH2_STAT5	58	61	PF00017	0.338
LIG_SH3_3	157	163	PF00018	0.648
LIG_SH3_3	62	68	PF00018	0.567
LIG_TRAF2_1	163	166	PF00917	0.669
LIG_UBA3_1	177	183	PF00899	0.563
MOD_CDK_SPxK_1	29	35	PF00069	0.620
MOD_CK1_1	17	23	PF00069	0.593
MOD_Cter_Amidation	53	56	PF01082	0.491
MOD_GlcNHglycan	1	4	PF01048	0.588
MOD_GlcNHglycan	143	146	PF01048	0.700
MOD_GSK3_1	103	110	PF00069	0.343
MOD_GSK3_1	14	21	PF00069	0.549
MOD_GSK3_1	6	13	PF00069	0.594
MOD_N-GLC_1	166	171	PF02516	0.658
MOD_NEK2_1	129	134	PF00069	0.523
MOD_NEK2_1	22	27	PF00069	0.620
MOD_NEK2_2	6	11	PF00069	0.632
MOD_PIKK_1	23	29	PF00454	0.603
MOD_PKA_1	173	179	PF00069	0.677
MOD_PKA_2	10	16	PF00069	0.599
MOD_PKA_2	173	179	PF00069	0.665
MOD_Plk_1	166	172	PF00069	0.660
MOD_Plk_4	173	179	PF00069	0.672
MOD_ProDKin_1	155	161	PF00069	0.596
MOD_ProDKin_1	29	35	PF00069	0.641
TRG_DiLeu_BaEn_4	165	171	PF01217	0.611
TRG_DiLeu_BaLyEn_6	157	162	PF01217	0.663
TRG_ENDOCYTIC_2	84	87	PF00928	0.344
TRG_ER_diArg_1	62	65	PF00400	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU88	Leptomonas seymouri	65%	91%
A0A1X0PA15	Trypanosomatidae	51%	100%
A0A3R7NSK5	Trypanosoma rangeli	56%	100%
A0A3S7X894	Leishmania donovani	91%	99%
A4HB45	Leishmania braziliensis	78%	100%
A4IA94	Leishmania infantum	91%	99%
C9ZM00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9B5B6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	99%