UBP-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zn-finger in ubiquitin-hydrolases and other protein, putative

Species:

Leishmania major

UniProt:

Q4Q2L6_LEIMA

TriTrypDb:

LmjF.34.3280 , LMJLV39_340038600 , LMJSD75_340038900

Length:

477

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2L6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2L6

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	2
GO:0007165	signal transduction	2	2
GO:0007264	small GTPase mediated signal transduction	4	2
GO:0007265	Ras protein signal transduction	5	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016567	protein ubiquitination	7	2
GO:0019538	protein metabolic process	3	2
GO:0032446	protein modification by small protein conjugation	6	2
GO:0035556	intracellular signal transduction	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0065007	biological regulation	1	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0004842	ubiquitin-protein transferase activity	4	2
GO:0005488	binding	1	12
GO:0008270	zinc ion binding	6	12
GO:0016740	transferase activity	2	2
GO:0019787	ubiquitin-like protein transferase activity	3	2
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12
GO:0061630	ubiquitin protein ligase activity	5	2
GO:0061659	ubiquitin-like protein ligase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	282	286	PF00656	0.545
CLV_C14_Caspase3-7	67	71	PF00656	0.628
CLV_NRD_NRD_1	127	129	PF00675	0.552
CLV_NRD_NRD_1	352	354	PF00675	0.583
CLV_NRD_NRD_1	426	428	PF00675	0.567
CLV_NRD_NRD_1	464	466	PF00675	0.699
CLV_PCSK_KEX2_1	127	129	PF00082	0.552
CLV_PCSK_KEX2_1	287	289	PF00082	0.504
CLV_PCSK_KEX2_1	351	353	PF00082	0.590
CLV_PCSK_KEX2_1	426	428	PF00082	0.599
CLV_PCSK_KEX2_1	464	466	PF00082	0.721
CLV_PCSK_PC1ET2_1	287	289	PF00082	0.556
CLV_PCSK_PC1ET2_1	351	353	PF00082	0.578
CLV_PCSK_SKI1_1	267	271	PF00082	0.600
CLV_PCSK_SKI1_1	287	291	PF00082	0.260
CLV_PCSK_SKI1_1	363	367	PF00082	0.554
CLV_PCSK_SKI1_1	409	413	PF00082	0.571
CLV_PCSK_SKI1_1	439	443	PF00082	0.714
DEG_Nend_UBRbox_2	1	3	PF02207	0.532
DEG_SPOP_SBC_1	49	53	PF00917	0.550
DOC_CYCLIN_yClb5_NLxxxL_5	363	369	PF00134	0.543
DOC_MAPK_MEF2A_6	153	161	PF00069	0.514
DOC_USP7_MATH_1	12	16	PF00917	0.621
DOC_USP7_MATH_1	25	29	PF00917	0.461
DOC_USP7_MATH_1	340	344	PF00917	0.606
DOC_USP7_MATH_1	389	393	PF00917	0.579
DOC_USP7_UBL2_3	255	259	PF12436	0.545
DOC_USP7_UBL2_3	264	268	PF12436	0.502
DOC_WW_Pin1_4	247	252	PF00397	0.704
DOC_WW_Pin1_4	98	103	PF00397	0.569
LIG_14-3-3_CanoR_1	352	362	PF00244	0.506
LIG_14-3-3_CanoR_1	403	411	PF00244	0.475
LIG_14-3-3_CanoR_1	50	55	PF00244	0.567
LIG_Actin_WH2_2	376	393	PF00022	0.504
LIG_AP2alpha_2	156	158	PF02296	0.464
LIG_EH1_1	205	213	PF00400	0.624
LIG_FHA_1	114	120	PF00498	0.584
LIG_FHA_1	191	197	PF00498	0.453
LIG_FHA_1	353	359	PF00498	0.597
LIG_FHA_1	374	380	PF00498	0.542
LIG_FHA_1	385	391	PF00498	0.476
LIG_FHA_2	310	316	PF00498	0.741
LIG_FHA_2	319	325	PF00498	0.630
LIG_FHA_2	334	340	PF00498	0.600
LIG_FHA_2	369	375	PF00498	0.573
LIG_FHA_2	412	418	PF00498	0.449
LIG_FHA_2	65	71	PF00498	0.654
LIG_LIR_Apic_2	76	81	PF02991	0.530
LIG_LIR_Gen_1	156	166	PF02991	0.444
LIG_LIR_Gen_1	169	176	PF02991	0.444
LIG_LIR_Gen_1	218	225	PF02991	0.690
LIG_LIR_Gen_1	330	338	PF02991	0.630
LIG_LIR_Nem_3	156	161	PF02991	0.444
LIG_LIR_Nem_3	218	224	PF02991	0.686
LIG_LIR_Nem_3	330	334	PF02991	0.612
LIG_LIR_Nem_3	336	341	PF02991	0.583
LIG_LIR_Nem_3	76	80	PF02991	0.523
LIG_PTAP_UEV_1	139	144	PF05743	0.360
LIG_SH2_CRK	276	280	PF00017	0.572
LIG_SH2_STAP1	265	269	PF00017	0.530
LIG_SH2_STAP1	276	280	PF00017	0.441
LIG_SH2_STAP1	291	295	PF00017	0.464
LIG_SH2_STAT3	135	138	PF00017	0.526
LIG_SH2_STAT3	291	294	PF00017	0.579
LIG_SH2_STAT3	97	100	PF00017	0.627
LIG_SH2_STAT5	165	168	PF00017	0.492
LIG_SH2_STAT5	55	58	PF00017	0.573
LIG_SH2_STAT5	79	82	PF00017	0.499
LIG_SH3_1	78	84	PF00018	0.591
LIG_SH3_3	137	143	PF00018	0.361
LIG_SH3_3	78	84	PF00018	0.591
LIG_SUMO_SIM_anti_2	31	37	PF11976	0.517
LIG_SUMO_SIM_anti_2	438	444	PF11976	0.629
LIG_SUMO_SIM_par_1	207	216	PF11976	0.518
LIG_UBA3_1	345	351	PF00899	0.500
MOD_CK1_1	113	119	PF00069	0.644
MOD_CK1_1	215	221	PF00069	0.556
MOD_CK1_1	385	391	PF00069	0.556
MOD_CK1_1	446	452	PF00069	0.685
MOD_CK2_1	318	324	PF00069	0.588
MOD_CK2_1	333	339	PF00069	0.604
MOD_CK2_1	368	374	PF00069	0.521
MOD_CK2_1	404	410	PF00069	0.497
MOD_Cter_Amidation	462	465	PF01082	0.667
MOD_GlcNHglycan	108	111	PF01048	0.557
MOD_GlcNHglycan	16	19	PF01048	0.502
MOD_GlcNHglycan	261	264	PF01048	0.651
MOD_GlcNHglycan	300	303	PF01048	0.685
MOD_GlcNHglycan	445	448	PF01048	0.668
MOD_GSK3_1	102	109	PF00069	0.503
MOD_GSK3_1	211	218	PF00069	0.622
MOD_GSK3_1	309	316	PF00069	0.718
MOD_GSK3_1	385	392	PF00069	0.459
MOD_GSK3_1	92	99	PF00069	0.551
MOD_NEK2_1	118	123	PF00069	0.545
MOD_NEK2_1	211	216	PF00069	0.564
MOD_NEK2_1	269	274	PF00069	0.575
MOD_NEK2_1	290	295	PF00069	0.557
MOD_NEK2_1	402	407	PF00069	0.478
MOD_NEK2_1	411	416	PF00069	0.398
MOD_NEK2_1	90	95	PF00069	0.577
MOD_OFUCOSY	117	123	PF10250	0.474
MOD_PIKK_1	110	116	PF00454	0.331
MOD_PIKK_1	190	196	PF00454	0.453
MOD_PIKK_1	290	296	PF00454	0.588
MOD_PIKK_1	421	427	PF00454	0.585
MOD_PIKK_1	96	102	PF00454	0.623
MOD_PKA_1	267	273	PF00069	0.625
MOD_PKA_1	352	358	PF00069	0.570
MOD_PKA_2	352	358	PF00069	0.517
MOD_PKA_2	402	408	PF00069	0.497
MOD_PKA_2	463	469	PF00069	0.773
MOD_PKA_2	49	55	PF00069	0.596
MOD_Plk_1	374	380	PF00069	0.504
MOD_Plk_1	90	96	PF00069	0.591
MOD_Plk_4	217	223	PF00069	0.682
MOD_Plk_4	31	37	PF00069	0.487
MOD_Plk_4	340	346	PF00069	0.551
MOD_Plk_4	50	56	PF00069	0.599
MOD_Plk_4	73	79	PF00069	0.656
MOD_ProDKin_1	247	253	PF00069	0.700
MOD_ProDKin_1	98	104	PF00069	0.563
MOD_SUMO_for_1	146	149	PF00179	0.506
MOD_SUMO_for_1	280	283	PF00179	0.542
MOD_SUMO_for_1	365	368	PF00179	0.509
MOD_SUMO_rev_2	252	261	PF00179	0.637
MOD_SUMO_rev_2	262	270	PF00179	0.567
MOD_SUMO_rev_2	282	289	PF00179	0.245
MOD_SUMO_rev_2	405	414	PF00179	0.524
TRG_DiLeu_BaEn_4	374	380	PF01217	0.587
TRG_ENDOCYTIC_2	171	174	PF00928	0.514
TRG_ENDOCYTIC_2	276	279	PF00928	0.563
TRG_ENDOCYTIC_2	331	334	PF00928	0.602
TRG_ENDOCYTIC_2	77	80	PF00928	0.518
TRG_ER_diArg_1	127	129	PF00400	0.552
TRG_ER_diArg_1	426	428	PF00400	0.570
TRG_NES_CRM1_1	27	41	PF08389	0.486
TRG_Pf-PMV_PEXEL_1	288	292	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	409	413	PF00026	0.538
TRG_Pf-PMV_PEXEL_1	426	431	PF00026	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAV0	Leptomonas seymouri	68%	79%
A0A0S4ILW6	Bodo saltans	32%	83%
A0A1X0PAX0	Trypanosomatidae	35%	94%
A0A3Q8IEL0	Leishmania donovani	92%	100%
A0A422NNH1	Trypanosoma rangeli	36%	96%
A4HB46	Leishmania braziliensis	79%	100%
A4IA95	Leishmania infantum	92%	81%
C9ZLZ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	96%
E5KGE0	Arabidopsis thaliana	28%	98%
E9B5B7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
O13747	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	87%
Q7Z569	Homo sapiens	23%	81%
Q95QN6	Caenorhabditis elegans	24%	81%
Q99MP8	Mus musculus	23%	81%
V5DLZ1	Trypanosoma cruzi	35%	94%