Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2L5_LEIMA

TriTrypDb:

LmjF.34.3290 , LMJLV39_340038700 , LMJSD75_340039000

Length:

478

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2L5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2L5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.485
CLV_MEL_PAP_1	267	273	PF00089	0.572
CLV_NRD_NRD_1	166	168	PF00675	0.635
CLV_NRD_NRD_1	21	23	PF00675	0.675
CLV_PCSK_KEX2_1	166	168	PF00082	0.591
CLV_PCSK_KEX2_1	21	23	PF00082	0.685
CLV_PCSK_KEX2_1	470	472	PF00082	0.551
CLV_PCSK_PC1ET2_1	470	472	PF00082	0.522
CLV_PCSK_SKI1_1	109	113	PF00082	0.591
CLV_PCSK_SKI1_1	124	128	PF00082	0.560
CLV_PCSK_SKI1_1	167	171	PF00082	0.586
CLV_PCSK_SKI1_1	180	184	PF00082	0.564
CLV_PCSK_SKI1_1	257	261	PF00082	0.563
DEG_APCC_DBOX_1	179	187	PF00400	0.472
DOC_ANK_TNKS_1	324	331	PF00023	0.403
DOC_CYCLIN_yCln2_LP_2	182	185	PF00134	0.362
DOC_MAPK_DCC_7	180	188	PF00069	0.442
DOC_MAPK_MEF2A_6	180	188	PF00069	0.451
DOC_MAPK_RevD_3	7	22	PF00069	0.416
DOC_PP1_RVXF_1	234	241	PF00149	0.501
DOC_PP1_RVXF_1	263	270	PF00149	0.432
DOC_PP1_RVXF_1	361	367	PF00149	0.463
DOC_PP2B_LxvP_1	127	130	PF13499	0.413
DOC_PP2B_LxvP_1	182	185	PF13499	0.362
DOC_PP2B_LxvP_1	473	476	PF13499	0.680
DOC_USP7_MATH_1	156	160	PF00917	0.420
DOC_USP7_MATH_1	296	300	PF00917	0.366
DOC_USP7_MATH_1	41	45	PF00917	0.420
DOC_USP7_MATH_1	415	419	PF00917	0.696
DOC_USP7_MATH_1	453	457	PF00917	0.593
DOC_USP7_MATH_1	88	92	PF00917	0.542
DOC_WW_Pin1_4	84	89	PF00397	0.521
LIG_14-3-3_CanoR_1	201	208	PF00244	0.452
LIG_14-3-3_CanoR_1	291	296	PF00244	0.338
LIG_14-3-3_CanoR_1	304	311	PF00244	0.419
LIG_14-3-3_CanoR_1	325	329	PF00244	0.336
LIG_14-3-3_CanoR_1	348	358	PF00244	0.334
LIG_14-3-3_CanoR_1	363	369	PF00244	0.370
LIG_14-3-3_CanoR_1	37	45	PF00244	0.477
LIG_14-3-3_CanoR_1	388	397	PF00244	0.633
LIG_14-3-3_CanoR_1	460	468	PF00244	0.588
LIG_14-3-3_CanoR_1	77	81	PF00244	0.377
LIG_Actin_WH2_2	252	267	PF00022	0.377
LIG_Actin_WH2_2	383	400	PF00022	0.624
LIG_BRCT_BRCA1_1	306	310	PF00533	0.480
LIG_Clathr_ClatBox_1	111	115	PF01394	0.436
LIG_CtBP_PxDLS_1	439	443	PF00389	0.639
LIG_deltaCOP1_diTrp_1	105	110	PF00928	0.354
LIG_deltaCOP1_diTrp_1	420	430	PF00928	0.553
LIG_FHA_1	254	260	PF00498	0.406
LIG_FHA_1	26	32	PF00498	0.527
LIG_FHA_1	350	356	PF00498	0.417
LIG_FHA_1	426	432	PF00498	0.624
LIG_FHA_1	447	453	PF00498	0.612
LIG_FHA_1	64	70	PF00498	0.338
LIG_FHA_2	422	428	PF00498	0.689
LIG_FHA_2	50	56	PF00498	0.479
LIG_LIR_Gen_1	190	198	PF02991	0.434
LIG_LIR_Gen_1	200	208	PF02991	0.308
LIG_LIR_Gen_1	367	376	PF02991	0.447
LIG_LIR_Gen_1	427	438	PF02991	0.660
LIG_LIR_Nem_3	190	195	PF02991	0.369
LIG_LIR_Nem_3	200	205	PF02991	0.287
LIG_LIR_Nem_3	237	243	PF02991	0.379
LIG_LIR_Nem_3	367	371	PF02991	0.377
LIG_LIR_Nem_3	427	433	PF02991	0.686
LIG_MLH1_MIPbox_1	307	311	PF16413	0.469
LIG_MYND_3	380	384	PF01753	0.619
LIG_Pex14_1	454	458	PF04695	0.589
LIG_Pex14_2	195	199	PF04695	0.366
LIG_Pex14_2	285	289	PF04695	0.273
LIG_SH2_STAP1	45	49	PF00017	0.481
LIG_SH2_STAT5	45	48	PF00017	0.480
LIG_SH3_3	375	381	PF00018	0.393
LIG_SUMO_SIM_par_1	115	123	PF11976	0.447
LIG_SUMO_SIM_par_1	184	191	PF11976	0.305
LIG_SUMO_SIM_par_1	27	32	PF11976	0.525
LIG_SUMO_SIM_par_1	357	362	PF11976	0.325
LIG_TRAF2_1	424	427	PF00917	0.674
LIG_TRAF2_1	62	65	PF00917	0.447
LIG_UBA3_1	111	117	PF00899	0.302
LIG_UBA3_1	260	265	PF00899	0.383
LIG_UBA3_1	38	47	PF00899	0.459
LIG_WRC_WIRS_1	157	162	PF05994	0.418
MOD_CK1_1	200	206	PF00069	0.403
MOD_CK1_1	226	232	PF00069	0.494
MOD_CK1_1	263	269	PF00069	0.355
MOD_CK1_1	305	311	PF00069	0.475
MOD_CK1_1	91	97	PF00069	0.546
MOD_CK2_1	419	425	PF00069	0.719
MOD_CK2_1	438	444	PF00069	0.459
MOD_CK2_1	91	97	PF00069	0.435
MOD_CMANNOS	107	110	PF00535	0.541
MOD_CMANNOS	365	368	PF00535	0.453
MOD_GlcNHglycan	139	142	PF01048	0.697
MOD_GlcNHglycan	146	149	PF01048	0.638
MOD_GlcNHglycan	272	275	PF01048	0.520
MOD_GlcNHglycan	314	318	PF01048	0.601
MOD_GlcNHglycan	39	42	PF01048	0.677
MOD_GlcNHglycan	416	420	PF01048	0.553
MOD_GlcNHglycan	446	449	PF01048	0.447
MOD_GlcNHglycan	47	50	PF01048	0.632
MOD_GlcNHglycan	93	96	PF01048	0.716
MOD_GSK3_1	167	174	PF00069	0.483
MOD_GSK3_1	298	305	PF00069	0.446
MOD_GSK3_1	37	44	PF00069	0.482
MOD_GSK3_1	415	422	PF00069	0.741
MOD_GSK3_1	440	447	PF00069	0.666
MOD_GSK3_1	45	52	PF00069	0.406
MOD_GSK3_1	63	70	PF00069	0.476
MOD_GSK3_1	84	91	PF00069	0.521
MOD_NEK2_1	188	193	PF00069	0.319
MOD_NEK2_1	260	265	PF00069	0.408
MOD_NEK2_1	364	369	PF00069	0.517
MOD_NEK2_1	383	388	PF00069	0.435
MOD_NEK2_1	390	395	PF00069	0.621
MOD_NEK2_1	8	13	PF00069	0.428
MOD_NEK2_2	156	161	PF00069	0.417
MOD_PIKK_1	298	304	PF00454	0.436
MOD_PKA_2	200	206	PF00069	0.401
MOD_PKA_2	303	309	PF00069	0.471
MOD_PKA_2	324	330	PF00069	0.346
MOD_PKA_2	459	465	PF00069	0.591
MOD_PKA_2	76	82	PF00069	0.365
MOD_Plk_1	16	22	PF00069	0.525
MOD_Plk_1	383	389	PF00069	0.621
MOD_Plk_1	419	425	PF00069	0.610
MOD_Plk_2-3	27	33	PF00069	0.472
MOD_Plk_4	156	162	PF00069	0.397
MOD_Plk_4	390	396	PF00069	0.502
MOD_Plk_4	425	431	PF00069	0.646
MOD_Plk_4	67	73	PF00069	0.380
MOD_Plk_4	76	82	PF00069	0.391
MOD_Plk_4	8	14	PF00069	0.412
MOD_ProDKin_1	84	90	PF00069	0.523
TRG_DiLeu_BaEn_1	469	474	PF01217	0.654
TRG_DiLeu_BaLyEn_6	34	39	PF01217	0.462
TRG_ENDOCYTIC_2	192	195	PF00928	0.420
TRG_ER_diArg_1	20	22	PF00400	0.488
TRG_ER_diArg_1	290	293	PF00400	0.342
TRG_NES_CRM1_1	322	336	PF08389	0.409
TRG_Pf-PMV_PEXEL_1	385	389	PF00026	0.367

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P448	Leptomonas seymouri	32%	96%
A0A3S7X8E6	Leishmania donovani	89%	100%
A4HB48	Leishmania braziliensis	68%	100%
A4IA96	Leishmania infantum	88%	100%
E9B5B8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%