rRNA maturation RNase YbeY

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterized protein family UPF0054, putative

Species:

Leishmania major

UniProt:

Q4Q2L4_LEIMA

TriTrypDb:

LmjF.34.3300 , LMJLV39_340038800 , LMJSD75_340039100

Length:

213

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2L4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2L4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016072	rRNA metabolic process	7	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004175	endopeptidase activity	4	11
GO:0004222	metalloendopeptidase activity	5	11
GO:0004518	nuclease activity	4	11
GO:0004519	endonuclease activity	5	11
GO:0005488	binding	1	11
GO:0008233	peptidase activity	3	11
GO:0008237	metallopeptidase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	88	92	PF00656	0.534
CLV_NRD_NRD_1	144	146	PF00675	0.336
CLV_NRD_NRD_1	17	19	PF00675	0.282
CLV_NRD_NRD_1	184	186	PF00675	0.278
CLV_PCSK_FUR_1	142	146	PF00082	0.336
CLV_PCSK_KEX2_1	144	146	PF00082	0.303
CLV_PCSK_KEX2_1	17	19	PF00082	0.282
CLV_PCSK_KEX2_1	184	186	PF00082	0.273
CLV_PCSK_PC7_1	140	146	PF00082	0.296
CLV_PCSK_SKI1_1	176	180	PF00082	0.323
CLV_PCSK_SKI1_1	5	9	PF00082	0.383
DEG_APCC_DBOX_1	122	130	PF00400	0.442
DEG_APCC_DBOX_1	175	183	PF00400	0.562
DEG_APCC_DBOX_1	37	45	PF00400	0.496
DEG_Nend_UBRbox_1	1	4	PF02207	0.461
DOC_CDC14_PxL_1	151	159	PF14671	0.536
DOC_MAPK_gen_1	17	28	PF00069	0.351
DOC_MAPK_HePTP_8	14	30	PF00069	0.210
DOC_MAPK_MEF2A_6	202	209	PF00069	0.452
DOC_MAPK_MEF2A_6	21	30	PF00069	0.521
DOC_MAPK_NFAT4_5	21	29	PF00069	0.496
DOC_MAPK_RevD_3	132	145	PF00069	0.496
DOC_WW_Pin1_4	100	105	PF00397	0.583
LIG_14-3-3_CanoR_1	145	155	PF00244	0.496
LIG_Clathr_ClatBox_1	27	31	PF01394	0.536
LIG_EH1_1	21	29	PF00400	0.536
LIG_eIF4E_1	156	162	PF01652	0.498
LIG_FHA_1	11	17	PF00498	0.489
LIG_FHA_1	116	122	PF00498	0.562
LIG_FHA_1	148	154	PF00498	0.542
LIG_FHA_1	61	67	PF00498	0.442
LIG_G3BP_FGDF_1	81	86	PF02136	0.444
LIG_Integrin_RGD_1	89	91	PF01839	0.262
LIG_LIR_Gen_1	135	146	PF02991	0.510
LIG_LIR_Gen_1	3	14	PF02991	0.396
LIG_LIR_Gen_1	42	49	PF02991	0.493
LIG_LIR_Nem_3	135	141	PF02991	0.467
LIG_LIR_Nem_3	3	9	PF02991	0.502
LIG_LIR_Nem_3	42	46	PF02991	0.501
LIG_LIR_Nem_3	80	86	PF02991	0.537
LIG_SH2_CRK	138	142	PF00017	0.496
LIG_SH2_SRC	156	159	PF00017	0.498
LIG_SH2_STAP1	35	39	PF00017	0.550
LIG_SH2_STAT5	156	159	PF00017	0.498
LIG_SH2_STAT5	6	9	PF00017	0.265
LIG_SH3_3	149	155	PF00018	0.536
LIG_SUMO_SIM_par_1	26	31	PF11976	0.536
LIG_TYR_ITIM	136	141	PF00017	0.355
LIG_WRC_WIRS_1	1	6	PF05994	0.423
LIG_WRC_WIRS_1	65	70	PF05994	0.406
MOD_GSK3_1	60	67	PF00069	0.283
MOD_GSK3_1	96	103	PF00069	0.306
MOD_NEK2_1	117	122	PF00069	0.417
MOD_PIKK_1	115	121	PF00454	0.412
MOD_PKA_2	60	66	PF00069	0.353
MOD_Plk_4	117	123	PF00069	0.390
MOD_Plk_4	73	79	PF00069	0.429
MOD_ProDKin_1	100	106	PF00069	0.476
TRG_DiLeu_BaEn_2	72	78	PF01217	0.282
TRG_ENDOCYTIC_2	138	141	PF00928	0.347
TRG_ENDOCYTIC_2	56	59	PF00928	0.312
TRG_ENDOCYTIC_2	6	9	PF00928	0.431
TRG_ER_diArg_1	139	142	PF00400	0.421
TRG_ER_diArg_1	144	146	PF00400	0.398
TRG_ER_diArg_1	16	18	PF00400	0.353
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1C3	Leptomonas seymouri	51%	99%
A0A0S4ILL3	Bodo saltans	37%	89%
A0A1X0PA77	Trypanosomatidae	35%	98%
A0A3R7KIB7	Trypanosoma rangeli	37%	100%
A0A3S7X8C1	Leishmania donovani	90%	100%
A4HB49	Leishmania braziliensis	77%	100%
A4IA97	Leishmania infantum	90%	100%
C9ZLZ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9B5B9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%