Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2L3_LEIMA

TriTrypDb:

LmjF.34.3310 , LMJLV39_340038900 , LMJSD75_340039200

Length:

523

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11

Expansion

Sequence features

Q4Q2L3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2L3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	81	85	PF00656	0.498
CLV_NRD_NRD_1	172	174	PF00675	0.565
CLV_NRD_NRD_1	250	252	PF00675	0.387
CLV_NRD_NRD_1	339	341	PF00675	0.351
CLV_NRD_NRD_1	464	466	PF00675	0.643
CLV_NRD_NRD_1	57	59	PF00675	0.495
CLV_PCSK_FUR_1	143	147	PF00082	0.384
CLV_PCSK_KEX2_1	145	147	PF00082	0.411
CLV_PCSK_KEX2_1	172	174	PF00082	0.565
CLV_PCSK_KEX2_1	250	252	PF00082	0.387
CLV_PCSK_KEX2_1	339	341	PF00082	0.351
CLV_PCSK_KEX2_1	57	59	PF00082	0.608
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.411
CLV_PCSK_SKI1_1	156	160	PF00082	0.635
CLV_PCSK_SKI1_1	392	396	PF00082	0.422
CLV_PCSK_SKI1_1	397	401	PF00082	0.353
CLV_PCSK_SKI1_1	466	470	PF00082	0.536
CLV_PCSK_SKI1_1	5	9	PF00082	0.679
DEG_APCC_DBOX_1	179	187	PF00400	0.508
DEG_COP1_1	402	409	PF00400	0.332
DEG_Nend_UBRbox_2	1	3	PF02207	0.663
DOC_ANK_TNKS_1	110	117	PF00023	0.288
DOC_CDC14_PxL_1	387	395	PF14671	0.374
DOC_CKS1_1	195	200	PF01111	0.634
DOC_CYCLIN_RxL_1	392	403	PF00134	0.377
DOC_MAPK_gen_1	392	401	PF00069	0.422
DOC_MAPK_MEF2A_6	392	400	PF00069	0.366
DOC_MAPK_MEF2A_6	420	428	PF00069	0.433
DOC_PP4_FxxP_1	134	137	PF00568	0.461
DOC_PP4_FxxP_1	235	238	PF00568	0.375
DOC_PP4_FxxP_1	31	34	PF00568	0.608
DOC_PP4_FxxP_1	429	432	PF00568	0.395
DOC_SPAK_OSR1_1	104	108	PF12202	0.293
DOC_USP7_MATH_1	115	119	PF00917	0.316
DOC_USP7_MATH_1	151	155	PF00917	0.580
DOC_USP7_MATH_1	171	175	PF00917	0.442
DOC_USP7_MATH_1	261	265	PF00917	0.456
DOC_USP7_MATH_1	3	7	PF00917	0.556
DOC_USP7_MATH_1	381	385	PF00917	0.365
DOC_USP7_MATH_1	405	409	PF00917	0.341
DOC_WW_Pin1_4	194	199	PF00397	0.644
LIG_14-3-3_CanoR_1	172	176	PF00244	0.711
LIG_14-3-3_CanoR_1	339	344	PF00244	0.350
LIG_14-3-3_CanoR_1	74	80	PF00244	0.564
LIG_14-3-3_CanoR_1	93	103	PF00244	0.301
LIG_Actin_WH2_2	461	477	PF00022	0.375
LIG_Actin_WH2_2	95	113	PF00022	0.303
LIG_BRCT_BRCA1_1	231	235	PF00533	0.385
LIG_BRCT_BRCA1_1	95	99	PF00533	0.312
LIG_deltaCOP1_diTrp_1	127	134	PF00928	0.397
LIG_eIF4E_1	135	141	PF01652	0.447
LIG_FHA_1	153	159	PF00498	0.705
LIG_FHA_1	195	201	PF00498	0.637
LIG_FHA_1	221	227	PF00498	0.509
LIG_FHA_1	278	284	PF00498	0.386
LIG_FHA_1	296	302	PF00498	0.183
LIG_FHA_1	381	387	PF00498	0.433
LIG_FHA_1	419	425	PF00498	0.519
LIG_FHA_1	497	503	PF00498	0.506
LIG_FHA_2	347	353	PF00498	0.508
LIG_FHA_2	441	447	PF00498	0.422
LIG_FHA_2	79	85	PF00498	0.403
LIG_FHA_2	95	101	PF00498	0.433
LIG_LIR_Apic_2	118	122	PF02991	0.399
LIG_LIR_Apic_2	131	137	PF02991	0.402
LIG_LIR_Apic_2	232	238	PF02991	0.377
LIG_LIR_Gen_1	315	326	PF02991	0.389
LIG_LIR_Gen_1	332	343	PF02991	0.356
LIG_LIR_Gen_1	372	381	PF02991	0.371
LIG_LIR_Gen_1	478	488	PF02991	0.354
LIG_LIR_Gen_1	96	107	PF02991	0.410
LIG_LIR_Nem_3	193	199	PF02991	0.525
LIG_LIR_Nem_3	247	252	PF02991	0.441
LIG_LIR_Nem_3	315	321	PF02991	0.353
LIG_LIR_Nem_3	325	330	PF02991	0.320
LIG_LIR_Nem_3	332	338	PF02991	0.319
LIG_LIR_Nem_3	372	378	PF02991	0.404
LIG_LIR_Nem_3	408	414	PF02991	0.441
LIG_LIR_Nem_3	470	474	PF02991	0.434
LIG_LIR_Nem_3	478	483	PF02991	0.281
LIG_LIR_Nem_3	504	509	PF02991	0.539
LIG_LIR_Nem_3	96	102	PF02991	0.446
LIG_MAD2	397	405	PF02301	0.341
LIG_NRBOX	292	298	PF00104	0.296
LIG_NRBOX	355	361	PF00104	0.383
LIG_NRBOX	395	401	PF00104	0.340
LIG_Pex14_2	134	138	PF04695	0.466
LIG_Pex14_2	479	483	PF04695	0.320
LIG_PTB_Apo_2	473	480	PF02174	0.415
LIG_SH2_CRK	196	200	PF00017	0.557
LIG_SH2_CRK	375	379	PF00017	0.338
LIG_SH2_STAP1	440	444	PF00017	0.417
LIG_SH2_STAT5	196	199	PF00017	0.453
LIG_SH2_STAT5	302	305	PF00017	0.415
LIG_SH2_STAT5	375	378	PF00017	0.319
LIG_SH2_STAT5	389	392	PF00017	0.315
LIG_SH2_STAT5	471	474	PF00017	0.512
LIG_SH3_3	401	407	PF00018	0.328
LIG_SH3_4	191	198	PF00018	0.455
LIG_SUMO_SIM_par_1	197	202	PF11976	0.487
LIG_SUMO_SIM_par_1	279	285	PF11976	0.498
LIG_SUMO_SIM_par_1	292	298	PF11976	0.325
LIG_SUMO_SIM_par_1	397	403	PF11976	0.323
LIG_TRAF2_1	124	127	PF00917	0.460
LIG_TRAF2_1	20	23	PF00917	0.608
LIG_TRAF2_1	443	446	PF00917	0.373
LIG_TYR_ITIM	316	321	PF00017	0.318
LIG_TYR_ITIM	373	378	PF00017	0.311
LIG_UBA3_1	102	109	PF00899	0.384
LIG_UBA3_1	183	191	PF00899	0.497
LIG_UBA3_1	296	305	PF00899	0.309
LIG_UBA3_1	329	337	PF00899	0.237
LIG_UBA3_1	386	395	PF00899	0.428
MOD_CK1_1	154	160	PF00069	0.747
MOD_CK1_1	164	170	PF00069	0.505
MOD_CK1_1	276	282	PF00069	0.375
MOD_CK2_1	314	320	PF00069	0.312
MOD_CK2_1	352	358	PF00069	0.476
MOD_CK2_1	440	446	PF00069	0.422
MOD_CK2_1	80	86	PF00069	0.377
MOD_CK2_1	94	100	PF00069	0.451
MOD_GlcNHglycan	163	166	PF01048	0.555
MOD_GlcNHglycan	175	178	PF01048	0.446
MOD_GlcNHglycan	231	234	PF01048	0.444
MOD_GlcNHglycan	263	266	PF01048	0.594
MOD_GlcNHglycan	289	292	PF01048	0.410
MOD_GlcNHglycan	378	381	PF01048	0.458
MOD_GlcNHglycan	383	386	PF01048	0.423
MOD_GlcNHglycan	407	410	PF01048	0.406
MOD_GlcNHglycan	434	437	PF01048	0.449
MOD_GlcNHglycan	5	8	PF01048	0.631
MOD_GlcNHglycan	61	64	PF01048	0.463
MOD_GSK3_1	11	18	PF00069	0.705
MOD_GSK3_1	157	164	PF00069	0.736
MOD_GSK3_1	253	260	PF00069	0.504
MOD_GSK3_1	273	280	PF00069	0.589
MOD_GSK3_1	3	10	PF00069	0.735
MOD_GSK3_1	310	317	PF00069	0.469
MOD_GSK3_1	329	336	PF00069	0.502
MOD_GSK3_1	347	354	PF00069	0.302
MOD_GSK3_1	358	365	PF00069	0.457
MOD_GSK3_1	376	383	PF00069	0.285
MOD_GSK3_1	74	81	PF00069	0.476
MOD_GSK3_1	91	98	PF00069	0.357
MOD_N-GLC_1	475	480	PF02516	0.391
MOD_NEK2_1	110	115	PF00069	0.398
MOD_NEK2_1	159	164	PF00069	0.671
MOD_NEK2_1	229	234	PF00069	0.431
MOD_NEK2_1	277	282	PF00069	0.400
MOD_NEK2_1	314	319	PF00069	0.330
MOD_NEK2_1	329	334	PF00069	0.246
MOD_NEK2_1	371	376	PF00069	0.304
MOD_NEK2_1	484	489	PF00069	0.474
MOD_NEK2_1	495	500	PF00069	0.599
MOD_NEK2_2	7	12	PF00069	0.553
MOD_PIKK_1	157	163	PF00454	0.501
MOD_PKA_1	339	345	PF00069	0.355
MOD_PKA_2	110	116	PF00069	0.444
MOD_PKA_2	171	177	PF00069	0.550
MOD_PKA_2	339	345	PF00069	0.339
MOD_PKA_2	73	79	PF00069	0.575
MOD_Plk_1	201	207	PF00069	0.444
MOD_Plk_1	273	279	PF00069	0.493
MOD_Plk_1	314	320	PF00069	0.340
MOD_Plk_1	371	377	PF00069	0.441
MOD_Plk_1	475	481	PF00069	0.505
MOD_Plk_2-3	352	358	PF00069	0.432
MOD_Plk_2-3	78	84	PF00069	0.386
MOD_Plk_4	273	279	PF00069	0.505
MOD_Plk_4	322	328	PF00069	0.382
MOD_Plk_4	467	473	PF00069	0.489
MOD_Plk_4	475	481	PF00069	0.379
MOD_Plk_4	484	490	PF00069	0.389
MOD_ProDKin_1	194	200	PF00069	0.635
TRG_DiLeu_BaLyEn_6	195	200	PF01217	0.447
TRG_DiLeu_BaLyEn_6	389	394	PF01217	0.435
TRG_ENDOCYTIC_2	196	199	PF00928	0.475
TRG_ENDOCYTIC_2	318	321	PF00928	0.375
TRG_ENDOCYTIC_2	375	378	PF00928	0.326
TRG_ENDOCYTIC_2	471	474	PF00928	0.603
TRG_ENDOCYTIC_2	506	509	PF00928	0.483
TRG_ER_diArg_1	249	251	PF00400	0.384
TRG_ER_diArg_1	338	340	PF00400	0.350
TRG_ER_diArg_1	449	452	PF00400	0.406
TRG_ER_diArg_1	56	58	PF00400	0.500
TRG_NES_CRM1_1	388	403	PF08389	0.385
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.676
TRG_Pf-PMV_PEXEL_1	366	370	PF00026	0.376
TRG_Pf-PMV_PEXEL_1	397	402	PF00026	0.354

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4I9	Leptomonas seymouri	41%	96%
A0A1X0P9X1	Trypanosomatidae	28%	100%
A0A3R7RMD9	Trypanosoma rangeli	28%	100%
A0A3S7X887	Leishmania donovani	89%	100%
A4HB50	Leishmania braziliensis	64%	100%
A4IA98	Leishmania infantum	89%	100%
C9ZLZ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9B5C0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5BV51	Trypanosoma cruzi	29%	100%