LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4Q2L0_LEIMA
TriTrypDb:
LmjF.34.3340 * , LMJLV39_340039200 * , LMJSD75_340039500 *
Length:
729

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2L0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2L0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 132 136 PF00656 0.582
CLV_C14_Caspase3-7 504 508 PF00656 0.721
CLV_NRD_NRD_1 162 164 PF00675 0.668
CLV_NRD_NRD_1 200 202 PF00675 0.699
CLV_NRD_NRD_1 436 438 PF00675 0.776
CLV_NRD_NRD_1 457 459 PF00675 0.589
CLV_NRD_NRD_1 543 545 PF00675 0.711
CLV_NRD_NRD_1 563 565 PF00675 0.453
CLV_NRD_NRD_1 573 575 PF00675 0.613
CLV_NRD_NRD_1 644 646 PF00675 0.798
CLV_PCSK_FUR_1 434 438 PF00082 0.581
CLV_PCSK_KEX2_1 162 164 PF00082 0.745
CLV_PCSK_KEX2_1 182 184 PF00082 0.383
CLV_PCSK_KEX2_1 35 37 PF00082 0.829
CLV_PCSK_KEX2_1 436 438 PF00082 0.776
CLV_PCSK_KEX2_1 457 459 PF00082 0.744
CLV_PCSK_KEX2_1 543 545 PF00082 0.785
CLV_PCSK_KEX2_1 563 565 PF00082 0.453
CLV_PCSK_KEX2_1 573 575 PF00082 0.613
CLV_PCSK_KEX2_1 644 646 PF00082 0.726
CLV_PCSK_PC1ET2_1 182 184 PF00082 0.597
CLV_PCSK_PC1ET2_1 35 37 PF00082 0.802
CLV_PCSK_SKI1_1 102 106 PF00082 0.604
CLV_PCSK_SKI1_1 182 186 PF00082 0.707
CLV_PCSK_SKI1_1 320 324 PF00082 0.796
CLV_PCSK_SKI1_1 437 441 PF00082 0.773
CLV_PCSK_SKI1_1 458 462 PF00082 0.615
CLV_PCSK_SKI1_1 563 567 PF00082 0.587
DEG_Nend_UBRbox_3 1 3 PF02207 0.634
DEG_SPOP_SBC_1 74 78 PF00917 0.589
DOC_CKS1_1 559 564 PF01111 0.693
DOC_CYCLIN_RxL_1 561 571 PF00134 0.707
DOC_CYCLIN_RxL_1 98 109 PF00134 0.590
DOC_CYCLIN_yCln2_LP_2 66 69 PF00134 0.703
DOC_MAPK_gen_1 457 463 PF00069 0.727
DOC_MAPK_gen_1 98 107 PF00069 0.628
DOC_MAPK_MEF2A_6 235 242 PF00069 0.453
DOC_MAPK_MEF2A_6 610 618 PF00069 0.777
DOC_PP1_RVXF_1 562 569 PF00149 0.629
DOC_PP2B_LxvP_1 478 481 PF13499 0.700
DOC_PP2B_LxvP_1 66 69 PF13499 0.681
DOC_USP7_MATH_1 206 210 PF00917 0.822
DOC_USP7_MATH_1 27 31 PF00917 0.729
DOC_USP7_MATH_1 390 394 PF00917 0.690
DOC_USP7_MATH_1 420 424 PF00917 0.748
DOC_USP7_MATH_1 495 499 PF00917 0.687
DOC_WW_Pin1_4 114 119 PF00397 0.752
DOC_WW_Pin1_4 168 173 PF00397 0.748
DOC_WW_Pin1_4 202 207 PF00397 0.676
DOC_WW_Pin1_4 273 278 PF00397 0.498
DOC_WW_Pin1_4 348 353 PF00397 0.658
DOC_WW_Pin1_4 41 46 PF00397 0.730
DOC_WW_Pin1_4 481 486 PF00397 0.702
DOC_WW_Pin1_4 521 526 PF00397 0.694
DOC_WW_Pin1_4 558 563 PF00397 0.689
DOC_WW_Pin1_4 605 610 PF00397 0.711
DOC_WW_Pin1_4 665 670 PF00397 0.644
LIG_14-3-3_CanoR_1 108 118 PF00244 0.726
LIG_14-3-3_CanoR_1 20 27 PF00244 0.740
LIG_14-3-3_CanoR_1 229 238 PF00244 0.458
LIG_14-3-3_CanoR_1 376 382 PF00244 0.798
LIG_14-3-3_CanoR_1 543 551 PF00244 0.746
LIG_14-3-3_CanoR_1 644 650 PF00244 0.711
LIG_14-3-3_CanoR_1 662 667 PF00244 0.569
LIG_Actin_WH2_2 169 184 PF00022 0.638
LIG_Actin_WH2_2 5 22 PF00022 0.743
LIG_BIR_III_2 264 268 PF00653 0.737
LIG_BIR_III_4 326 330 PF00653 0.566
LIG_BRCT_BRCA1_1 688 692 PF00533 0.662
LIG_BRCT_BRCA1_2 688 694 PF00533 0.662
LIG_Clathr_ClatBox_1 81 85 PF01394 0.716
LIG_deltaCOP1_diTrp_1 219 227 PF00928 0.657
LIG_FHA_1 183 189 PF00498 0.679
LIG_FHA_1 219 225 PF00498 0.750
LIG_FHA_1 50 56 PF00498 0.641
LIG_FHA_1 546 552 PF00498 0.524
LIG_FHA_1 589 595 PF00498 0.629
LIG_FHA_1 634 640 PF00498 0.830
LIG_FHA_1 69 75 PF00498 0.702
LIG_FHA_1 76 82 PF00498 0.691
LIG_FHA_1 9 15 PF00498 0.692
LIG_FHA_2 231 237 PF00498 0.531
LIG_FHA_2 259 265 PF00498 0.668
LIG_FHA_2 537 543 PF00498 0.737
LIG_FHA_2 646 652 PF00498 0.543
LIG_LIR_Apic_2 380 385 PF02991 0.730
LIG_LIR_Apic_2 664 669 PF02991 0.580
LIG_LIR_Gen_1 147 154 PF02991 0.630
LIG_LIR_Gen_1 456 467 PF02991 0.652
LIG_LIR_Gen_1 647 657 PF02991 0.762
LIG_LIR_Gen_1 689 699 PF02991 0.658
LIG_LIR_Nem_3 147 151 PF02991 0.625
LIG_LIR_Nem_3 456 462 PF02991 0.735
LIG_LIR_Nem_3 580 586 PF02991 0.518
LIG_LIR_Nem_3 647 652 PF02991 0.673
LIG_LIR_Nem_3 689 695 PF02991 0.733
LIG_MYND_1 605 609 PF01753 0.598
LIG_SH2_CRK 459 463 PF00017 0.715
LIG_SH2_STAP1 254 258 PF00017 0.745
LIG_SH2_STAP1 459 463 PF00017 0.715
LIG_SH2_STAT3 640 643 PF00017 0.824
LIG_SH2_STAT5 241 244 PF00017 0.467
LIG_SH2_STAT5 446 449 PF00017 0.685
LIG_SH3_3 591 597 PF00018 0.754
LIG_SH3_3 606 612 PF00018 0.534
LIG_SUMO_SIM_anti_2 171 177 PF11976 0.675
LIG_SUMO_SIM_par_1 103 109 PF11976 0.661
LIG_SUMO_SIM_par_1 76 85 PF11976 0.708
MOD_CDC14_SPxK_1 351 354 PF00782 0.602
MOD_CDK_SPK_2 481 486 PF00069 0.577
MOD_CDK_SPK_2 558 563 PF00069 0.611
MOD_CDK_SPK_2 605 610 PF00069 0.791
MOD_CDK_SPxK_1 348 354 PF00069 0.635
MOD_CDK_SPxK_1 558 564 PF00069 0.692
MOD_CK1_1 109 115 PF00069 0.795
MOD_CK1_1 116 122 PF00069 0.537
MOD_CK1_1 165 171 PF00069 0.705
MOD_CK1_1 361 367 PF00069 0.761
MOD_CK1_1 386 392 PF00069 0.807
MOD_CK1_1 40 46 PF00069 0.718
MOD_CK1_1 502 508 PF00069 0.600
MOD_CK1_1 546 552 PF00069 0.758
MOD_CK1_1 621 627 PF00069 0.683
MOD_CK1_1 668 674 PF00069 0.699
MOD_CK1_1 70 76 PF00069 0.745
MOD_CK2_1 257 263 PF00069 0.592
MOD_CK2_1 413 419 PF00069 0.757
MOD_CK2_1 469 475 PF00069 0.557
MOD_CK2_1 536 542 PF00069 0.737
MOD_CK2_1 77 83 PF00069 0.754
MOD_Cter_Amidation 160 163 PF01082 0.654
MOD_Cter_Amidation 33 36 PF01082 0.721
MOD_GlcNHglycan 108 111 PF01048 0.787
MOD_GlcNHglycan 140 144 PF01048 0.771
MOD_GlcNHglycan 164 167 PF01048 0.558
MOD_GlcNHglycan 331 334 PF01048 0.720
MOD_GlcNHglycan 360 363 PF01048 0.710
MOD_GlcNHglycan 388 391 PF01048 0.674
MOD_GlcNHglycan 402 405 PF01048 0.777
MOD_GlcNHglycan 450 453 PF01048 0.749
MOD_GlcNHglycan 465 468 PF01048 0.593
MOD_GlcNHglycan 497 500 PF01048 0.755
MOD_GlcNHglycan 504 507 PF01048 0.741
MOD_GlcNHglycan 620 623 PF01048 0.676
MOD_GlcNHglycan 631 634 PF01048 0.725
MOD_GSK3_1 109 116 PF00069 0.711
MOD_GSK3_1 149 156 PF00069 0.687
MOD_GSK3_1 161 168 PF00069 0.604
MOD_GSK3_1 202 209 PF00069 0.754
MOD_GSK3_1 21 28 PF00069 0.646
MOD_GSK3_1 243 250 PF00069 0.565
MOD_GSK3_1 254 261 PF00069 0.627
MOD_GSK3_1 357 364 PF00069 0.777
MOD_GSK3_1 37 44 PF00069 0.682
MOD_GSK3_1 386 393 PF00069 0.752
MOD_GSK3_1 476 483 PF00069 0.769
MOD_GSK3_1 490 497 PF00069 0.566
MOD_GSK3_1 517 524 PF00069 0.717
MOD_GSK3_1 529 536 PF00069 0.579
MOD_GSK3_1 58 65 PF00069 0.682
MOD_GSK3_1 620 627 PF00069 0.739
MOD_GSK3_1 629 636 PF00069 0.726
MOD_GSK3_1 661 668 PF00069 0.668
MOD_GSK3_1 672 679 PF00069 0.753
MOD_GSK3_1 70 77 PF00069 0.608
MOD_LATS_1 23 29 PF00433 0.630
MOD_LATS_1 572 578 PF00433 0.623
MOD_N-GLC_1 386 391 PF02516 0.756
MOD_N-GLC_1 588 593 PF02516 0.506
MOD_NEK2_1 106 111 PF00069 0.672
MOD_NEK2_1 19 24 PF00069 0.728
MOD_NEK2_1 568 573 PF00069 0.625
MOD_NEK2_1 618 623 PF00069 0.674
MOD_NEK2_1 8 13 PF00069 0.684
MOD_NEK2_2 243 248 PF00069 0.582
MOD_NEK2_2 254 259 PF00069 0.516
MOD_NEK2_2 420 425 PF00069 0.750
MOD_PIKK_1 206 212 PF00454 0.660
MOD_PIKK_1 27 33 PF00454 0.757
MOD_PIKK_1 37 43 PF00454 0.689
MOD_PKA_1 162 168 PF00069 0.669
MOD_PKA_1 182 188 PF00069 0.361
MOD_PKA_1 543 549 PF00069 0.688
MOD_PKA_1 644 650 PF00069 0.783
MOD_PKA_2 138 144 PF00069 0.705
MOD_PKA_2 149 155 PF00069 0.485
MOD_PKA_2 161 167 PF00069 0.555
MOD_PKA_2 182 188 PF00069 0.536
MOD_PKA_2 19 25 PF00069 0.820
MOD_PKA_2 247 253 PF00069 0.615
MOD_PKA_2 293 299 PF00069 0.552
MOD_PKA_2 543 549 PF00069 0.688
MOD_PKA_2 644 650 PF00069 0.784
MOD_PKA_2 661 667 PF00069 0.494
MOD_PKB_1 137 145 PF00069 0.704
MOD_Plk_1 139 145 PF00069 0.712
MOD_Plk_1 218 224 PF00069 0.751
MOD_Plk_1 302 308 PF00069 0.753
MOD_Plk_4 171 177 PF00069 0.707
MOD_Plk_4 302 308 PF00069 0.753
MOD_Plk_4 377 383 PF00069 0.774
MOD_Plk_4 546 552 PF00069 0.763
MOD_Plk_4 62 68 PF00069 0.628
MOD_Plk_4 655 661 PF00069 0.751
MOD_Plk_4 672 678 PF00069 0.675
MOD_Plk_4 77 83 PF00069 0.677
MOD_ProDKin_1 114 120 PF00069 0.753
MOD_ProDKin_1 168 174 PF00069 0.742
MOD_ProDKin_1 202 208 PF00069 0.676
MOD_ProDKin_1 273 279 PF00069 0.493
MOD_ProDKin_1 348 354 PF00069 0.661
MOD_ProDKin_1 41 47 PF00069 0.728
MOD_ProDKin_1 481 487 PF00069 0.702
MOD_ProDKin_1 521 527 PF00069 0.698
MOD_ProDKin_1 558 564 PF00069 0.692
MOD_ProDKin_1 605 611 PF00069 0.706
MOD_ProDKin_1 665 671 PF00069 0.645
TRG_DiLeu_BaEn_1 51 56 PF01217 0.581
TRG_DiLeu_BaEn_2 426 432 PF01217 0.722
TRG_DiLeu_BaLyEn_6 212 217 PF01217 0.608
TRG_DiLeu_BaLyEn_6 602 607 PF01217 0.722
TRG_DiLeu_BaLyEn_6 611 616 PF01217 0.656
TRG_ENDOCYTIC_2 459 462 PF00928 0.712
TRG_ER_diArg_1 457 459 PF00400 0.589
TRG_ER_diArg_1 562 564 PF00400 0.597
TRG_NES_CRM1_1 417 427 PF08389 0.558
TRG_NES_CRM1_1 5 18 PF08389 0.681
TRG_NES_CRM1_1 715 729 PF08389 0.475
TRG_Pf-PMV_PEXEL_1 563 567 PF00026 0.634
TRG_Pf-PMV_PEXEL_1 637 642 PF00026 0.751
TRG_Pf-PMV_PEXEL_1 708 712 PF00026 0.729

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5Q0 Leptomonas seymouri 34% 89%
A0A3S7X8B8 Leishmania donovani 87% 100%
A4HB53 Leishmania braziliensis 63% 100%
E9AHT9 Leishmania infantum 87% 100%
E9B5C3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 89%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS