LeishMANIAdb
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ATPase-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
ATPase-like protein
Gene product:
ATPase-like protein
Species:
Leishmania major
UniProt:
Q4Q2K9_LEIMA
TriTrypDb:
LmjF.34.3350 , LMJLV39_340039300 * , LMJSD75_340039600 *
Length:
536

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. no yes: 21
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 10
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 18
NetGPI no yes: 0, no: 18
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 7
GO:0010008 endosome membrane 5 11
GO:0012506 vesicle membrane 4 11
GO:0016020 membrane 2 11
GO:0030659 cytoplasmic vesicle membrane 5 11
GO:0031090 organelle membrane 3 11
GO:0031902 late endosome membrane 6 11
GO:0098588 bounding membrane of organelle 4 11
GO:0110165 cellular anatomical entity 1 16
GO:0000502 proteasome complex 3 6
GO:0032991 protein-containing complex 1 6
GO:0140535 intracellular protein-containing complex 2 6
GO:1902494 catalytic complex 2 6
GO:1905368 peptidase complex 3 6
GO:1905369 endopeptidase complex 4 6
GO:0008540 proteasome regulatory particle, base subcomplex 2 1
GO:0031597 cytosolic proteasome complex 4 1

Expansion

Sequence features

Q4Q2K9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2K9

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 5
GO:0006807 nitrogen compound metabolic process 2 6
GO:0008152 metabolic process 1 6
GO:0009056 catabolic process 2 6
GO:0009057 macromolecule catabolic process 4 6
GO:0019538 protein metabolic process 3 6
GO:0030163 protein catabolic process 4 6
GO:0043170 macromolecule metabolic process 3 6
GO:0044238 primary metabolic process 2 6
GO:0071704 organic substance metabolic process 2 6
GO:1901564 organonitrogen compound metabolic process 3 6
GO:1901565 organonitrogen compound catabolic process 4 6
GO:1901575 organic substance catabolic process 3 6
GO:0006355 regulation of DNA-templated transcription 6 1
GO:0006357 regulation of transcription by RNA polymerase II 7 1
GO:0006511 ubiquitin-dependent protein catabolic process 7 1
GO:0006950 response to stress 2 1
GO:0009889 regulation of biosynthetic process 4 1
GO:0009891 positive regulation of biosynthetic process 5 1
GO:0009893 positive regulation of metabolic process 4 1
GO:0009987 cellular process 1 1
GO:0010033 response to organic substance 3 1
GO:0010243 response to organonitrogen compound 4 1
GO:0010468 regulation of gene expression 5 1
GO:0010498 proteasomal protein catabolic process 5 1
GO:0010556 regulation of macromolecule biosynthetic process 5 1
GO:0010557 positive regulation of macromolecule biosynthetic process 6 1
GO:0010604 positive regulation of macromolecule metabolic process 5 1
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0019941 modification-dependent protein catabolic process 6 1
GO:0030433 ubiquitin-dependent ERAD pathway 6 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031325 positive regulation of cellular metabolic process 5 1
GO:0031326 regulation of cellular biosynthetic process 5 1
GO:0031328 positive regulation of cellular biosynthetic process 6 1
GO:0031334 positive regulation of protein-containing complex assembly 6 1
GO:0033554 cellular response to stress 3 1
GO:0034976 response to endoplasmic reticulum stress 4 1
GO:0036503 ERAD pathway 5 1
GO:0042221 response to chemical 2 1
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 6 1
GO:0043254 regulation of protein-containing complex assembly 5 1
GO:0043632 modification-dependent macromolecule catabolic process 5 1
GO:0044087 regulation of cellular component biogenesis 4 1
GO:0044089 positive regulation of cellular component biogenesis 5 1
GO:0044237 cellular metabolic process 2 1
GO:0044248 cellular catabolic process 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0044265 obsolete cellular macromolecule catabolic process 4 1
GO:0045893 positive regulation of DNA-templated transcription 7 1
GO:0045898 regulation of RNA polymerase II transcription preinitiation complex assembly 6 1
GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly 7 1
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 6 1
GO:0045944 positive regulation of transcription by RNA polymerase II 8 1
GO:0048518 positive regulation of biological process 3 1
GO:0048522 positive regulation of cellular process 4 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0050896 response to stimulus 1 1
GO:0051128 regulation of cellular component organization 4 1
GO:0051130 positive regulation of cellular component organization 5 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051173 positive regulation of nitrogen compound metabolic process 5 1
GO:0051252 regulation of RNA metabolic process 5 1
GO:0051254 positive regulation of RNA metabolic process 6 1
GO:0051603 proteolysis involved in protein catabolic process 5 1
GO:0051716 cellular response to stimulus 2 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0060260 regulation of transcription initiation by RNA polymerase II 8 1
GO:0060261 positive regulation of transcription initiation by RNA polymerase II 9 1
GO:0065007 biological regulation 1 1
GO:0080090 regulation of primary metabolic process 4 1
GO:1901698 response to nitrogen compound 3 1
GO:1902680 positive regulation of RNA biosynthetic process 7 1
GO:1903506 regulation of nucleic acid-templated transcription 7 1
GO:1903508 positive regulation of nucleic acid-templated transcription 8 1
GO:2000142 regulation of DNA-templated transcription initiation 7 1
GO:2000144 positive regulation of DNA-templated transcription initiation 8 1
GO:2001141 regulation of RNA biosynthetic process 6 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 19
GO:0003824 catalytic activity 1 19
GO:0005488 binding 1 19
GO:0005524 ATP binding 5 19
GO:0016462 pyrophosphatase activity 5 19
GO:0016787 hydrolase activity 2 19
GO:0016817 hydrolase activity, acting on acid anhydrides 3 19
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 19
GO:0016887 ATP hydrolysis activity 7 19
GO:0017076 purine nucleotide binding 4 19
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 19
GO:0030554 adenyl nucleotide binding 5 19
GO:0032553 ribonucleotide binding 3 19
GO:0032555 purine ribonucleotide binding 4 19
GO:0032559 adenyl ribonucleotide binding 5 19
GO:0035639 purine ribonucleoside triphosphate binding 4 19
GO:0036094 small molecule binding 2 19
GO:0043167 ion binding 2 19
GO:0043168 anion binding 3 19
GO:0097159 organic cyclic compound binding 2 19
GO:0097367 carbohydrate derivative binding 2 19
GO:1901265 nucleoside phosphate binding 3 19
GO:1901363 heterocyclic compound binding 2 19
GO:0008233 peptidase activity 3 5
GO:0036402 proteasome-activating activity 2 6
GO:0140096 catalytic activity, acting on a protein 2 5
GO:0140657 ATP-dependent activity 1 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 258 262 PF00656 0.320
CLV_NRD_NRD_1 114 116 PF00675 0.683
CLV_NRD_NRD_1 192 194 PF00675 0.356
CLV_NRD_NRD_1 277 279 PF00675 0.228
CLV_NRD_NRD_1 312 314 PF00675 0.313
CLV_NRD_NRD_1 329 331 PF00675 0.423
CLV_NRD_NRD_1 364 366 PF00675 0.437
CLV_PCSK_KEX2_1 192 194 PF00082 0.339
CLV_PCSK_KEX2_1 277 279 PF00082 0.263
CLV_PCSK_KEX2_1 312 314 PF00082 0.269
CLV_PCSK_KEX2_1 328 330 PF00082 0.507
CLV_PCSK_KEX2_1 364 366 PF00082 0.445
CLV_PCSK_PC1ET2_1 328 330 PF00082 0.388
CLV_PCSK_PC7_1 188 194 PF00082 0.380
CLV_PCSK_SKI1_1 171 175 PF00082 0.348
CLV_PCSK_SKI1_1 192 196 PF00082 0.331
CLV_PCSK_SKI1_1 240 244 PF00082 0.299
CLV_PCSK_SKI1_1 252 256 PF00082 0.299
CLV_PCSK_SKI1_1 26 30 PF00082 0.417
CLV_PCSK_SKI1_1 277 281 PF00082 0.271
CLV_PCSK_SKI1_1 329 333 PF00082 0.395
CLV_PCSK_SKI1_1 364 368 PF00082 0.502
CLV_PCSK_SKI1_1 451 455 PF00082 0.509
CLV_PCSK_SKI1_1 50 54 PF00082 0.375
CLV_PCSK_SKI1_1 525 529 PF00082 0.566
DEG_APCC_DBOX_1 364 372 PF00400 0.250
DEG_APCC_DBOX_1 49 57 PF00400 0.483
DEG_Nend_UBRbox_1 1 4 PF02207 0.488
DOC_CKS1_1 126 131 PF01111 0.502
DOC_CYCLIN_RxL_1 326 335 PF00134 0.438
DOC_CYCLIN_yClb5_NLxxxL_5 297 306 PF00134 0.306
DOC_MAPK_gen_1 277 287 PF00069 0.233
DOC_MAPK_gen_1 312 322 PF00069 0.322
DOC_MAPK_HePTP_8 275 287 PF00069 0.231
DOC_MAPK_MEF2A_6 278 287 PF00069 0.299
DOC_MAPK_MEF2A_6 313 322 PF00069 0.294
DOC_MAPK_NFAT4_5 280 288 PF00069 0.249
DOC_PP1_RVXF_1 250 257 PF00149 0.242
DOC_PP4_FxxP_1 184 187 PF00568 0.439
DOC_SPAK_OSR1_1 357 361 PF12202 0.293
DOC_USP7_MATH_1 120 124 PF00917 0.745
DOC_USP7_MATH_1 150 154 PF00917 0.485
DOC_USP7_MATH_1 246 250 PF00917 0.459
DOC_USP7_MATH_1 262 266 PF00917 0.299
DOC_USP7_MATH_1 467 471 PF00917 0.717
DOC_USP7_MATH_1 516 520 PF00917 0.485
DOC_WW_Pin1_4 116 121 PF00397 0.692
DOC_WW_Pin1_4 125 130 PF00397 0.597
DOC_WW_Pin1_4 421 426 PF00397 0.718
DOC_WW_Pin1_4 459 464 PF00397 0.701
DOC_WW_Pin1_4 468 473 PF00397 0.736
LIG_14-3-3_CanoR_1 171 177 PF00244 0.358
LIG_14-3-3_CanoR_1 277 287 PF00244 0.233
LIG_14-3-3_CanoR_1 357 361 PF00244 0.544
LIG_14-3-3_CanoR_1 383 387 PF00244 0.407
LIG_14-3-3_CanoR_1 451 460 PF00244 0.472
LIG_14-3-3_CanoR_1 494 502 PF00244 0.446
LIG_14-3-3_CanoR_1 525 530 PF00244 0.554
LIG_Actin_WH2_1 364 382 PF00022 0.264
LIG_Actin_WH2_2 324 339 PF00022 0.520
LIG_APCC_ABBAyCdc20_2 252 258 PF00400 0.233
LIG_FHA_1 128 134 PF00498 0.641
LIG_FHA_1 16 22 PF00498 0.484
LIG_FHA_1 173 179 PF00498 0.361
LIG_FHA_1 279 285 PF00498 0.252
LIG_FHA_1 374 380 PF00498 0.476
LIG_FHA_1 4 10 PF00498 0.619
LIG_FHA_1 441 447 PF00498 0.503
LIG_FHA_1 455 461 PF00498 0.476
LIG_FHA_1 73 79 PF00498 0.417
LIG_FHA_2 209 215 PF00498 0.271
LIG_FHA_2 340 346 PF00498 0.500
LIG_FHA_2 383 389 PF00498 0.528
LIG_FHA_2 426 432 PF00498 0.690
LIG_FHA_2 516 522 PF00498 0.540
LIG_GBD_Chelix_1 275 283 PF00786 0.382
LIG_LIR_Apic_2 182 187 PF02991 0.350
LIG_LIR_Gen_1 315 323 PF02991 0.327
LIG_LIR_Gen_1 355 366 PF02991 0.395
LIG_LIR_Gen_1 376 386 PF02991 0.532
LIG_LIR_Gen_1 67 78 PF02991 0.519
LIG_LIR_Nem_3 315 320 PF02991 0.327
LIG_LIR_Nem_3 355 361 PF02991 0.397
LIG_LIR_Nem_3 376 381 PF02991 0.519
LIG_LIR_Nem_3 498 504 PF02991 0.556
LIG_LIR_Nem_3 67 73 PF02991 0.524
LIG_Pex14_1 157 161 PF04695 0.456
LIG_Pex14_2 310 314 PF04695 0.271
LIG_PTAP_UEV_1 128 133 PF05743 0.476
LIG_SH2_CRK 197 201 PF00017 0.336
LIG_SH2_CRK 31 35 PF00017 0.547
LIG_SH2_CRK 70 74 PF00017 0.420
LIG_SH2_STAP1 66 70 PF00017 0.582
LIG_SH2_STAP1 76 80 PF00017 0.524
LIG_SH2_STAT5 438 441 PF00017 0.474
LIG_SH2_STAT5 70 73 PF00017 0.620
LIG_SH3_2 187 192 PF14604 0.432
LIG_SH3_2 472 477 PF14604 0.526
LIG_SH3_3 126 132 PF00018 0.520
LIG_SH3_3 184 190 PF00018 0.425
LIG_SH3_3 31 37 PF00018 0.503
LIG_SH3_3 317 323 PF00018 0.276
LIG_SH3_3 368 374 PF00018 0.369
LIG_SH3_3 466 472 PF00018 0.526
LIG_SUMO_SIM_anti_2 401 409 PF11976 0.499
LIG_TRAF2_1 519 522 PF00917 0.452
LIG_TYR_ITIM 29 34 PF00017 0.399
MOD_CDC14_SPxK_1 424 427 PF00782 0.536
MOD_CDC14_SPxK_1 474 477 PF00782 0.486
MOD_CDK_SPK_2 463 468 PF00069 0.520
MOD_CDK_SPxK_1 421 427 PF00069 0.543
MOD_CDK_SPxK_1 471 477 PF00069 0.483
MOD_CK1_1 127 133 PF00069 0.617
MOD_CK1_1 153 159 PF00069 0.340
MOD_CK1_1 182 188 PF00069 0.409
MOD_CK1_1 321 327 PF00069 0.279
MOD_CK1_1 390 396 PF00069 0.672
MOD_CK1_1 452 458 PF00069 0.668
MOD_CK1_1 459 465 PF00069 0.696
MOD_CK1_1 471 477 PF00069 0.497
MOD_CK1_1 480 486 PF00069 0.669
MOD_CK2_1 208 214 PF00069 0.271
MOD_CK2_1 425 431 PF00069 0.694
MOD_CK2_1 452 458 PF00069 0.534
MOD_CK2_1 515 521 PF00069 0.490
MOD_CK2_1 71 77 PF00069 0.445
MOD_DYRK1A_RPxSP_1 468 472 PF00069 0.514
MOD_GlcNHglycan 121 125 PF01048 0.601
MOD_GlcNHglycan 222 225 PF01048 0.252
MOD_GlcNHglycan 248 251 PF01048 0.365
MOD_GlcNHglycan 264 267 PF01048 0.350
MOD_GlcNHglycan 395 398 PF01048 0.702
MOD_GlcNHglycan 454 457 PF01048 0.530
MOD_GlcNHglycan 508 511 PF01048 0.603
MOD_GlcNHglycan 518 521 PF01048 0.520
MOD_GlcNHglycan 80 83 PF01048 0.444
MOD_GSK3_1 116 123 PF00069 0.612
MOD_GSK3_1 153 160 PF00069 0.382
MOD_GSK3_1 352 359 PF00069 0.378
MOD_GSK3_1 421 428 PF00069 0.652
MOD_GSK3_1 452 459 PF00069 0.535
MOD_GSK3_1 463 470 PF00069 0.685
MOD_GSK3_1 477 484 PF00069 0.583
MOD_GSK3_1 512 519 PF00069 0.663
MOD_GSK3_1 58 65 PF00069 0.449
MOD_GSK3_1 68 75 PF00069 0.564
MOD_NEK2_1 218 223 PF00069 0.278
MOD_NEK2_1 297 302 PF00069 0.368
MOD_NEK2_1 379 384 PF00069 0.373
MOD_NEK2_1 420 425 PF00069 0.617
MOD_NEK2_1 78 83 PF00069 0.381
MOD_PK_1 433 439 PF00069 0.514
MOD_PKA_2 356 362 PF00069 0.469
MOD_PKA_2 379 385 PF00069 0.489
MOD_PKA_2 388 394 PF00069 0.618
MOD_PKA_2 467 473 PF00069 0.526
MOD_Plk_1 68 74 PF00069 0.435
MOD_Plk_1 76 82 PF00069 0.377
MOD_Plk_2-3 356 362 PF00069 0.432
MOD_Plk_4 179 185 PF00069 0.470
MOD_Plk_4 292 298 PF00069 0.320
MOD_Plk_4 58 64 PF00069 0.427
MOD_Plk_4 68 74 PF00069 0.505
MOD_ProDKin_1 116 122 PF00069 0.692
MOD_ProDKin_1 125 131 PF00069 0.592
MOD_ProDKin_1 421 427 PF00069 0.718
MOD_ProDKin_1 459 465 PF00069 0.703
MOD_ProDKin_1 468 474 PF00069 0.738
MOD_SUMO_for_1 279 282 PF00179 0.233
MOD_SUMO_rev_2 8 15 PF00179 0.514
TRG_DiLeu_BaEn_1 100 105 PF01217 0.443
TRG_DiLeu_BaEn_1 17 22 PF01217 0.437
TRG_DiLeu_BaLyEn_6 190 195 PF01217 0.322
TRG_DiLeu_BaLyEn_6 327 332 PF01217 0.435
TRG_DiLeu_BaLyEn_6 362 367 PF01217 0.423
TRG_DiLeu_BaLyEn_6 415 420 PF01217 0.527
TRG_ENDOCYTIC_2 215 218 PF00928 0.231
TRG_ENDOCYTIC_2 31 34 PF00928 0.486
TRG_ENDOCYTIC_2 504 507 PF00928 0.480
TRG_ENDOCYTIC_2 70 73 PF00928 0.504
TRG_ER_diArg_1 191 193 PF00400 0.395
TRG_ER_diArg_1 277 279 PF00400 0.228
TRG_ER_diArg_1 311 313 PF00400 0.261
TRG_ER_diArg_1 329 331 PF00400 0.227
TRG_ER_diArg_1 363 365 PF00400 0.529
TRG_ER_diArg_1 529 532 PF00400 0.515
TRG_NES_CRM1_1 274 288 PF08389 0.365
TRG_NLS_Bipartite_1 312 332 PF00514 0.301
TRG_Pf-PMV_PEXEL_1 277 282 PF00026 0.429
TRG_Pf-PMV_PEXEL_1 330 335 PF00026 0.452
TRG_Pf-PMV_PEXEL_1 39 44 PF00026 0.564

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P643 Leptomonas seymouri 49% 100%
A0A0S4JAU3 Bodo saltans 30% 80%
A0A1X0P9Z1 Trypanosomatidae 40% 100%
A0A3Q8IIF1 Leishmania donovani 94% 99%
A0A3S5H547 Leishmania donovani 34% 100%
A0A422NNS9 Trypanosoma rangeli 45% 100%
A4H3L6 Leishmania braziliensis 33% 100%
A4H6T6 Leishmania braziliensis 30% 100%
A4HB54 Leishmania braziliensis 75% 100%
A4HME8 Leishmania braziliensis 36% 100%
A4IAA1 Leishmania infantum 94% 99%
C9ZLZ3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
E9ACJ9 Leishmania major 34% 100%
E9AG43 Leishmania infantum 34% 100%
E9AJT7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9B5C4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
O17071 Caenorhabditis elegans 29% 100%
P62333 Homo sapiens 28% 100%
P62334 Mus musculus 28% 100%
P62335 Ictidomys tridecemlineatus 28% 100%
V5B5D2 Trypanosoma cruzi 42% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS