D-aminoacyl-tRNA deacylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

D-Tyr-tRNA(Tyr) deacylase, putative

Species:

Leishmania major

UniProt:

Q4Q2K8_LEIMA

TriTrypDb:

LmjF.34.3360 , LMJLV39_340039400 , LMJSD75_340039700

Length:

211

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	11
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q2K8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2K8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006399	tRNA metabolic process	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0002161	aminoacyl-tRNA editing activity	5	11
GO:0003824	catalytic activity	1	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0051499	D-aminoacyl-tRNA deacylase activity	6	11
GO:0051500	D-tyrosyl-tRNA(Tyr) deacylase activity	7	2
GO:0052689	carboxylic ester hydrolase activity	4	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140101	catalytic activity, acting on a tRNA	4	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	159	163	PF00656	0.537
CLV_C14_Caspase3-7	169	173	PF00656	0.537
CLV_C14_Caspase3-7	63	67	PF00656	0.533
CLV_PCSK_SKI1_1	29	33	PF00082	0.299
CLV_PCSK_SKI1_1	86	90	PF00082	0.318
DEG_APCC_DBOX_1	28	36	PF00400	0.358
DEG_Nend_UBRbox_1	1	4	PF02207	0.593
DOC_MAPK_gen_1	122	130	PF00069	0.499
DOC_MAPK_gen_1	47	57	PF00069	0.534
DOC_MAPK_HePTP_8	20	32	PF00069	0.562
DOC_MAPK_MEF2A_6	23	32	PF00069	0.643
DOC_MAPK_MEF2A_6	50	59	PF00069	0.492
DOC_MAPK_MEF2A_6	76	83	PF00069	0.537
DOC_PP1_RVXF_1	124	131	PF00149	0.513
DOC_PP2B_LxvP_1	112	115	PF13499	0.485
DOC_USP7_MATH_1	115	119	PF00917	0.536
DOC_WW_Pin1_4	89	94	PF00397	0.565
LIG_BIR_III_4	162	166	PF00653	0.516
LIG_BRCT_BRCA1_1	126	130	PF00533	0.565
LIG_BRCT_BRCA1_1	187	191	PF00533	0.557
LIG_EH1_1	76	84	PF00400	0.533
LIG_FHA_1	25	31	PF00498	0.600
LIG_LIR_Gen_1	127	138	PF02991	0.542
LIG_LIR_Gen_1	144	153	PF02991	0.411
LIG_LIR_Gen_1	202	211	PF02991	0.509
LIG_LIR_Gen_1	85	96	PF02991	0.565
LIG_LIR_Nem_3	127	133	PF02991	0.542
LIG_LIR_Nem_3	144	149	PF02991	0.411
LIG_LIR_Nem_3	177	182	PF02991	0.566
LIG_LIR_Nem_3	85	91	PF02991	0.565
LIG_PDZ_Class_2	206	211	PF00595	0.485
LIG_Pex14_2	205	209	PF04695	0.561
LIG_SH2_CRK	16	20	PF00017	0.606
LIG_SH2_STAT5	48	51	PF00017	0.484
LIG_SH2_STAT5	58	61	PF00017	0.472
LIG_SUMO_SIM_anti_2	110	115	PF11976	0.485
LIG_TRAF2_1	102	105	PF00917	0.533
LIG_TYR_ITIM	14	19	PF00017	0.560
MOD_CDC14_SPxK_1	92	95	PF00782	0.565
MOD_CDK_SPxK_1	89	95	PF00069	0.565
MOD_CK2_1	99	105	PF00069	0.538
MOD_GlcNHglycan	187	190	PF01048	0.335
MOD_GlcNHglycan	66	69	PF01048	0.394
MOD_GSK3_1	181	188	PF00069	0.561
MOD_GSK3_1	60	67	PF00069	0.586
MOD_GSK3_1	82	89	PF00069	0.529
MOD_LATS_1	84	90	PF00433	0.422
MOD_NEK2_1	82	87	PF00069	0.565
MOD_PK_1	124	130	PF00069	0.565
MOD_PKA_2	64	70	PF00069	0.533
MOD_Plk_1	156	162	PF00069	0.509
MOD_ProDKin_1	89	95	PF00069	0.565
MOD_SUMO_for_1	174	177	PF00179	0.556
TRG_DiLeu_BaEn_1	108	113	PF01217	0.589
TRG_ENDOCYTIC_2	143	146	PF00928	0.485
TRG_ENDOCYTIC_2	16	19	PF00928	0.604
TRG_ENDOCYTIC_2	58	61	PF00928	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKW6	Leptomonas seymouri	78%	100%
A0A0S4JLF2	Bodo saltans	38%	100%
A0A1X0P9Y0	Trypanosomatidae	51%	100%
A0A3S7X8A0	Leishmania donovani	96%	100%
A0A422NEP7	Trypanosoma rangeli	49%	100%
A4HB55	Leishmania braziliensis	80%	81%
A4IAA2	Leishmania infantum	96%	100%
C9ZLZ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E1C762	Gallus gallus	32%	100%
E9B5C5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
P84066	Leishmania major	100%	100%
Q68EL2	Danio rerio	30%	100%
Q8BHA3	Mus musculus	30%	100%
Q96FN9	Homo sapiens	31%	100%