Glucose-6-phosphate 1-epimerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aldose 1-epimerase-like protein

Species:

Leishmania major

UniProt:

Q4Q2K6_LEIMA

TriTrypDb:

LmjF.34.3380 , LMJLV39_340039600 , LMJSD75_340039900

Length:

301

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005777	peroxisome	6	2
GO:0020015	glycosome	7	2
GO:0042579	microbody	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2K6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2K6

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0016853	isomerase activity	2	12
GO:0016854	racemase and epimerase activity	3	12
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	4	12
GO:0030246	carbohydrate binding	2	12
GO:0047938	glucose-6-phosphate 1-epimerase activity	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.532
CLV_PCSK_SKI1_1	270	274	PF00082	0.298
CLV_PCSK_SKI1_1	56	60	PF00082	0.360
DEG_APCC_DBOX_1	102	110	PF00400	0.532
DOC_MAPK_gen_1	39	47	PF00069	0.587
DOC_MAPK_gen_1	9	16	PF00069	0.553
DOC_MAPK_MEF2A_6	60	67	PF00069	0.494
DOC_MAPK_MEF2A_6	97	106	PF00069	0.504
DOC_PP2B_LxvP_1	102	105	PF13499	0.498
DOC_USP7_MATH_1	111	115	PF00917	0.532
DOC_USP7_MATH_1	244	248	PF00917	0.532
DOC_USP7_MATH_1	279	283	PF00917	0.542
DOC_USP7_MATH_1	296	300	PF00917	0.542
DOC_USP7_MATH_1	31	35	PF00917	0.532
DOC_USP7_UBL2_3	138	142	PF12436	0.568
DOC_USP7_UBL2_3	270	274	PF12436	0.547
DOC_WW_Pin1_4	116	121	PF00397	0.569
DOC_WW_Pin1_4	175	180	PF00397	0.541
DOC_WW_Pin1_4	192	197	PF00397	0.462
DOC_WW_Pin1_4	2	7	PF00397	0.611
DOC_WW_Pin1_4	230	235	PF00397	0.568
DOC_WW_Pin1_4	292	297	PF00397	0.635
DOC_WW_Pin1_4	45	50	PF00397	0.494
LIG_14-3-3_CanoR_1	84	89	PF00244	0.585
LIG_14-3-3_CanoR_1	97	103	PF00244	0.511
LIG_Actin_WH2_2	259	275	PF00022	0.543
LIG_APCC_ABBA_1	14	19	PF00400	0.560
LIG_BIR_III_2	191	195	PF00653	0.421
LIG_BRCT_BRCA1_1	150	154	PF00533	0.594
LIG_BRCT_BRCA1_1	78	82	PF00533	0.528
LIG_FHA_1	226	232	PF00498	0.491
LIG_FHA_1	284	290	PF00498	0.547
LIG_FHA_2	144	150	PF00498	0.571
LIG_FHA_2	23	29	PF00498	0.553
LIG_HCF-1_HBM_1	43	46	PF13415	0.568
LIG_LIR_Apic_2	43	49	PF02991	0.483
LIG_LIR_Gen_1	79	90	PF02991	0.560
LIG_LIR_Nem_3	160	164	PF02991	0.494
LIG_LIR_Nem_3	258	263	PF02991	0.480
LIG_LIR_Nem_3	79	85	PF02991	0.515
LIG_PDZ_Class_1	296	301	PF00595	0.681
LIG_Pex14_2	154	158	PF04695	0.483
LIG_SH2_CRK	73	77	PF00017	0.538
LIG_SH2_STAP1	128	132	PF00017	0.494
LIG_SH2_STAT3	211	214	PF00017	0.494
LIG_SH2_STAT5	128	131	PF00017	0.494
LIG_SH2_STAT5	161	164	PF00017	0.473
LIG_SH2_STAT5	46	49	PF00017	0.486
LIG_SH2_STAT6	259	263	PF00017	0.507
LIG_SH3_1	187	193	PF00018	0.448
LIG_SH3_3	187	193	PF00018	0.528
LIG_SH3_3	272	278	PF00018	0.506
LIG_SH3_3	72	78	PF00018	0.543
LIG_SUMO_SIM_anti_2	288	295	PF11976	0.592
LIG_TRAF2_1	146	149	PF00917	0.580
LIG_WRC_WIRS_1	1	6	PF05994	0.536
MOD_CDK_SPxxK_3	2	9	PF00069	0.524
MOD_CK1_1	114	120	PF00069	0.557
MOD_CK1_1	165	171	PF00069	0.592
MOD_CK1_1	22	28	PF00069	0.506
MOD_CK1_1	281	287	PF00069	0.568
MOD_CK1_1	35	41	PF00069	0.542
MOD_CK2_1	130	136	PF00069	0.524
MOD_CK2_1	143	149	PF00069	0.464
MOD_CK2_1	192	198	PF00069	0.587
MOD_CK2_1	22	28	PF00069	0.559
MOD_CK2_1	292	298	PF00069	0.682
MOD_GlcNHglycan	148	153	PF01048	0.364
MOD_GlcNHglycan	172	175	PF01048	0.332
MOD_GlcNHglycan	94	97	PF01048	0.281
MOD_GSK3_1	112	119	PF00069	0.490
MOD_GSK3_1	126	133	PF00069	0.507
MOD_GSK3_1	144	151	PF00069	0.440
MOD_GSK3_1	15	22	PF00069	0.556
MOD_GSK3_1	225	232	PF00069	0.494
MOD_GSK3_1	279	286	PF00069	0.528
MOD_GSK3_1	292	299	PF00069	0.585
MOD_GSK3_1	31	38	PF00069	0.524
MOD_GSK3_1	92	99	PF00069	0.493
MOD_N-GLC_1	144	149	PF02516	0.337
MOD_N-GLC_1	175	180	PF02516	0.287
MOD_N-GLC_1	234	239	PF02516	0.332
MOD_NEK2_1	126	131	PF00069	0.494
MOD_NEK2_1	141	146	PF00069	0.494
MOD_NEK2_1	229	234	PF00069	0.580
MOD_NEK2_2	98	103	PF00069	0.532
MOD_PIKK_1	283	289	PF00454	0.507
MOD_PKA_2	96	102	PF00069	0.536
MOD_Plk_1	112	118	PF00069	0.585
MOD_Plk_1	54	60	PF00069	0.532
MOD_Plk_4	157	163	PF00069	0.482
MOD_ProDKin_1	116	122	PF00069	0.569
MOD_ProDKin_1	175	181	PF00069	0.541
MOD_ProDKin_1	192	198	PF00069	0.462
MOD_ProDKin_1	2	8	PF00069	0.617
MOD_ProDKin_1	230	236	PF00069	0.568
MOD_ProDKin_1	292	298	PF00069	0.643
MOD_ProDKin_1	45	51	PF00069	0.494
MOD_SUMO_rev_2	133	139	PF00179	0.549
TRG_DiLeu_BaLyEn_6	61	66	PF01217	0.568
TRG_ENDOCYTIC_2	161	164	PF00928	0.482
TRG_ENDOCYTIC_2	260	263	PF00928	0.482
TRG_ENDOCYTIC_2	73	76	PF00928	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6S8	Leptomonas seymouri	70%	100%
A0A0S4IIG2	Bodo saltans	34%	100%
A0A1X0P9Y8	Trypanosomatidae	50%	100%
A0A3S5H7X6	Leishmania donovani	95%	100%
A0A422NEP9	Trypanosoma rangeli	48%	100%
A4HB57	Leishmania braziliensis	77%	100%
A4IAA4	Leishmania infantum	95%	100%
C9ZLY9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B5C7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
P39173	Escherichia coli (strain K12)	33%	100%
P44160	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	27%	100%
Q03161	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
Q40784	Cenchrus ciliaris	30%	91%
Q8ZPV9	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	33%	100%
V5BV57	Trypanosoma cruzi	49%	100%