Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2K5_LEIMA

TriTrypDb:

LmjF.34.3390 , LMJLV39_340039700 , LMJSD75_340040000

Length:

729

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2K5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2K5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	572	576	PF00656	0.609
CLV_C14_Caspase3-7	61	65	PF00656	0.367
CLV_NRD_NRD_1	241	243	PF00675	0.609
CLV_NRD_NRD_1	279	281	PF00675	0.474
CLV_NRD_NRD_1	623	625	PF00675	0.488
CLV_NRD_NRD_1	653	655	PF00675	0.549
CLV_NRD_NRD_1	71	73	PF00675	0.470
CLV_PCSK_KEX2_1	118	120	PF00082	0.403
CLV_PCSK_KEX2_1	241	243	PF00082	0.609
CLV_PCSK_KEX2_1	29	31	PF00082	0.465
CLV_PCSK_KEX2_1	525	527	PF00082	0.444
CLV_PCSK_KEX2_1	652	654	PF00082	0.538
CLV_PCSK_KEX2_1	71	73	PF00082	0.470
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.403
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.465
CLV_PCSK_PC1ET2_1	525	527	PF00082	0.424
CLV_PCSK_PC7_1	649	655	PF00082	0.538
CLV_PCSK_SKI1_1	138	142	PF00082	0.354
CLV_PCSK_SKI1_1	202	206	PF00082	0.466
CLV_PCSK_SKI1_1	307	311	PF00082	0.423
CLV_PCSK_SKI1_1	35	39	PF00082	0.447
CLV_PCSK_SKI1_1	42	46	PF00082	0.421
CLV_PCSK_SKI1_1	584	588	PF00082	0.513
CLV_PCSK_SKI1_1	642	646	PF00082	0.551
CLV_Separin_Metazoa	39	43	PF03568	0.607
CLV_Separin_Metazoa	608	612	PF03568	0.713
DEG_APCC_DBOX_1	34	42	PF00400	0.437
DEG_APCC_DBOX_1	651	659	PF00400	0.534
DEG_APCC_KENBOX_2	335	339	PF00400	0.509
DEG_Nend_Nbox_1	1	3	PF02207	0.528
DEG_SCF_FBW7_1	372	378	PF00400	0.587
DEG_SCF_FBW7_2	685	691	PF00400	0.563
DOC_CKS1_1	372	377	PF01111	0.581
DOC_CKS1_1	685	690	PF01111	0.550
DOC_CYCLIN_RxL_1	135	144	PF00134	0.409
DOC_MAPK_gen_1	642	650	PF00069	0.559
DOC_MAPK_gen_1	652	660	PF00069	0.436
DOC_MAPK_HePTP_8	650	662	PF00069	0.546
DOC_MAPK_MEF2A_6	653	662	PF00069	0.489
DOC_PP1_RVXF_1	482	489	PF00149	0.434
DOC_PP2B_LxvP_1	720	723	PF13499	0.618
DOC_PP4_FxxP_1	488	491	PF00568	0.395
DOC_PP4_FxxP_1	692	695	PF00568	0.561
DOC_PP4_FxxP_1	84	87	PF00568	0.324
DOC_USP7_MATH_1	173	177	PF00917	0.453
DOC_USP7_MATH_1	206	210	PF00917	0.339
DOC_USP7_MATH_1	251	255	PF00917	0.559
DOC_USP7_MATH_1	268	272	PF00917	0.550
DOC_USP7_MATH_1	273	277	PF00917	0.557
DOC_USP7_MATH_1	31	35	PF00917	0.430
DOC_USP7_MATH_1	375	379	PF00917	0.608
DOC_USP7_MATH_1	630	634	PF00917	0.564
DOC_USP7_MATH_1	65	69	PF00917	0.420
DOC_USP7_MATH_1	700	704	PF00917	0.592
DOC_USP7_MATH_1	723	727	PF00917	0.558
DOC_WW_Pin1_4	103	108	PF00397	0.359
DOC_WW_Pin1_4	152	157	PF00397	0.366
DOC_WW_Pin1_4	246	251	PF00397	0.630
DOC_WW_Pin1_4	296	301	PF00397	0.490
DOC_WW_Pin1_4	312	317	PF00397	0.323
DOC_WW_Pin1_4	371	376	PF00397	0.604
DOC_WW_Pin1_4	431	436	PF00397	0.577
DOC_WW_Pin1_4	602	607	PF00397	0.590
DOC_WW_Pin1_4	684	689	PF00397	0.571
DOC_WW_Pin1_4	709	714	PF00397	0.634
LIG_14-3-3_CanoR_1	223	228	PF00244	0.566
LIG_14-3-3_CanoR_1	30	38	PF00244	0.438
LIG_14-3-3_CanoR_1	611	617	PF00244	0.578
LIG_APCC_ABBAyCdc20_2	291	297	PF00400	0.511
LIG_BIR_III_4	383	387	PF00653	0.602
LIG_Clathr_ClatBox_1	195	199	PF01394	0.425
LIG_Clathr_ClatBox_1	207	211	PF01394	0.348
LIG_CtBP_PxDLS_1	705	709	PF00389	0.522
LIG_deltaCOP1_diTrp_1	674	680	PF00928	0.656
LIG_EVH1_2	688	692	PF00568	0.502
LIG_FAT_LD_1	15	23	PF03623	0.383
LIG_FHA_1	153	159	PF00498	0.411
LIG_FHA_1	184	190	PF00498	0.332
LIG_FHA_1	199	205	PF00498	0.405
LIG_FHA_1	264	270	PF00498	0.605
LIG_FHA_1	431	437	PF00498	0.599
LIG_FHA_1	508	514	PF00498	0.475
LIG_FHA_1	552	558	PF00498	0.641
LIG_FHA_1	594	600	PF00498	0.514
LIG_FHA_1	617	623	PF00498	0.570
LIG_FHA_1	685	691	PF00498	0.535
LIG_FHA_1	715	721	PF00498	0.632
LIG_FHA_2	273	279	PF00498	0.573
LIG_FHA_2	450	456	PF00498	0.527
LIG_FHA_2	475	481	PF00498	0.450
LIG_Integrin_isoDGR_2	338	340	PF01839	0.521
LIG_Integrin_isoDGR_2	502	504	PF01839	0.476
LIG_IRF3_LxIS_1	137	144	PF10401	0.348
LIG_LIR_Apic_2	186	190	PF02991	0.392
LIG_LIR_Apic_2	691	695	PF02991	0.540
LIG_LIR_Gen_1	111	120	PF02991	0.384
LIG_LIR_Gen_1	131	142	PF02991	0.303
LIG_LIR_Gen_1	177	188	PF02991	0.363
LIG_LIR_Gen_1	283	292	PF02991	0.483
LIG_LIR_Gen_1	293	303	PF02991	0.427
LIG_LIR_Gen_1	494	501	PF02991	0.444
LIG_LIR_Gen_1	646	655	PF02991	0.639
LIG_LIR_Gen_1	679	688	PF02991	0.650
LIG_LIR_Nem_3	131	137	PF02991	0.393
LIG_LIR_Nem_3	152	157	PF02991	0.430
LIG_LIR_Nem_3	177	183	PF02991	0.382
LIG_LIR_Nem_3	283	288	PF02991	0.617
LIG_LIR_Nem_3	302	308	PF02991	0.271
LIG_LIR_Nem_3	494	500	PF02991	0.437
LIG_LIR_Nem_3	565	571	PF02991	0.593
LIG_LIR_Nem_3	646	650	PF02991	0.560
LIG_LIR_Nem_3	679	683	PF02991	0.677
LIG_NRBOX	14	20	PF00104	0.381
LIG_NRBOX	226	232	PF00104	0.427
LIG_PCNA_yPIPBox_3	359	367	PF02747	0.401
LIG_PDZ_Class_2	724	729	PF00595	0.634
LIG_Pex14_1	5	9	PF04695	0.414
LIG_Pex14_1	617	621	PF04695	0.523
LIG_Pex14_2	324	328	PF04695	0.406
LIG_Pex14_2	9	13	PF04695	0.393
LIG_PTAP_UEV_1	701	706	PF05743	0.504
LIG_PTB_Apo_2	148	155	PF02174	0.379
LIG_PTB_Phospho_1	148	154	PF10480	0.445
LIG_RPA_C_Fungi	649	661	PF08784	0.544
LIG_SH2_CRK	120	124	PF00017	0.447
LIG_SH2_CRK	134	138	PF00017	0.311
LIG_SH2_CRK	154	158	PF00017	0.213
LIG_SH2_CRK	187	191	PF00017	0.397
LIG_SH2_CRK	497	501	PF00017	0.463
LIG_SH2_GRB2like	366	369	PF00017	0.398
LIG_SH2_GRB2like	629	632	PF00017	0.554
LIG_SH2_NCK_1	187	191	PF00017	0.397
LIG_SH2_NCK_1	497	501	PF00017	0.463
LIG_SH2_NCK_1	629	633	PF00017	0.599
LIG_SH2_SRC	629	632	PF00017	0.554
LIG_SH2_STAP1	55	59	PF00017	0.404
LIG_SH2_STAT5	154	157	PF00017	0.402
LIG_SH2_STAT5	2	5	PF00017	0.566
LIG_SH2_STAT5	216	219	PF00017	0.363
LIG_SH2_STAT5	308	311	PF00017	0.386
LIG_SH2_STAT5	366	369	PF00017	0.418
LIG_SH2_STAT5	519	522	PF00017	0.479
LIG_SH2_STAT5	647	650	PF00017	0.454
LIG_SH2_STAT5	83	86	PF00017	0.332
LIG_SH3_3	197	203	PF00018	0.454
LIG_SH3_3	391	397	PF00018	0.654
LIG_SH3_3	417	423	PF00018	0.686
LIG_SH3_3	635	641	PF00018	0.573
LIG_SH3_3	666	672	PF00018	0.629
LIG_SH3_3	679	685	PF00018	0.636
LIG_SH3_3	699	705	PF00018	0.512
LIG_SUMO_SIM_anti_2	369	374	PF11976	0.430
LIG_SUMO_SIM_par_1	585	591	PF11976	0.555
LIG_SxIP_EBH_1	261	273	PF03271	0.500
LIG_TRAF2_1	275	278	PF00917	0.523
LIG_TRAF2_1	605	608	PF00917	0.517
LIG_TRAF2_2	316	321	PF00917	0.439
LIG_TRFH_1	497	501	PF08558	0.463
LIG_WRC_WIRS_1	10	15	PF05994	0.438
LIG_WRC_WIRS_1	207	212	PF05994	0.325
LIG_WRC_WIRS_1	59	64	PF05994	0.365
LIG_WW_3	423	427	PF00397	0.635
MOD_CK1_1	152	158	PF00069	0.424
MOD_CK1_1	229	235	PF00069	0.536
MOD_CK1_1	249	255	PF00069	0.461
MOD_CK1_1	272	278	PF00069	0.534
MOD_CK1_1	296	302	PF00069	0.343
MOD_CK1_1	378	384	PF00069	0.653
MOD_CK1_1	430	436	PF00069	0.590
MOD_CK1_1	535	541	PF00069	0.506
MOD_CK1_1	602	608	PF00069	0.585
MOD_CK2_1	272	278	PF00069	0.583
MOD_CK2_1	296	302	PF00069	0.415
MOD_CK2_1	460	466	PF00069	0.585
MOD_CK2_1	474	480	PF00069	0.405
MOD_CK2_1	602	608	PF00069	0.563
MOD_CK2_1	700	706	PF00069	0.624
MOD_GlcNHglycan	143	146	PF01048	0.467
MOD_GlcNHglycan	251	254	PF01048	0.588
MOD_GlcNHglycan	271	274	PF01048	0.513
MOD_GlcNHglycan	389	393	PF01048	0.666
MOD_GlcNHglycan	530	533	PF01048	0.550
MOD_GlcNHglycan	536	540	PF01048	0.577
MOD_GlcNHglycan	702	705	PF01048	0.626
MOD_GSK3_1	198	205	PF00069	0.493
MOD_GSK3_1	225	232	PF00069	0.489
MOD_GSK3_1	268	275	PF00069	0.533
MOD_GSK3_1	371	378	PF00069	0.558
MOD_GSK3_1	427	434	PF00069	0.627
MOD_GSK3_1	456	463	PF00069	0.605
MOD_GSK3_1	5	12	PF00069	0.445
MOD_GSK3_1	528	535	PF00069	0.509
MOD_GSK3_1	547	554	PF00069	0.642
MOD_GSK3_1	588	595	PF00069	0.493
MOD_GSK3_1	616	623	PF00069	0.568
MOD_N-GLC_1	150	155	PF02516	0.453
MOD_N-GLC_1	378	383	PF02516	0.626
MOD_N-GLC_1	5	10	PF02516	0.457
MOD_N-GLC_1	630	635	PF02516	0.566
MOD_N-GLC_1	706	711	PF02516	0.531
MOD_NEK2_1	149	154	PF00069	0.520
MOD_NEK2_1	183	188	PF00069	0.507
MOD_NEK2_1	230	235	PF00069	0.476
MOD_NEK2_1	599	604	PF00069	0.517
MOD_NEK2_1	9	14	PF00069	0.397
MOD_NEK2_2	449	454	PF00069	0.551
MOD_NEK2_2	55	60	PF00069	0.409
MOD_NEK2_2	723	728	PF00069	0.492
MOD_PIKK_1	126	132	PF00454	0.486
MOD_PIKK_1	167	173	PF00454	0.455
MOD_PIKK_1	314	320	PF00454	0.495
MOD_PIKK_1	44	50	PF00454	0.445
MOD_PIKK_1	466	472	PF00454	0.548
MOD_PIKK_1	610	616	PF00454	0.583
MOD_PIKK_1	721	727	PF00454	0.585
MOD_PK_1	654	660	PF00069	0.639
MOD_PKA_2	474	480	PF00069	0.466
MOD_PKA_2	610	616	PF00069	0.597
MOD_PKB_1	223	231	PF00069	0.407
MOD_PKB_1	652	660	PF00069	0.542
MOD_Plk_1	150	156	PF00069	0.445
MOD_Plk_1	320	326	PF00069	0.622
MOD_Plk_1	456	462	PF00069	0.552
MOD_Plk_1	5	11	PF00069	0.454
MOD_Plk_1	706	712	PF00069	0.531
MOD_Plk_2-3	588	594	PF00069	0.582
MOD_Plk_4	14	20	PF00069	0.342
MOD_Plk_4	175	181	PF00069	0.453
MOD_Plk_4	226	232	PF00069	0.492
MOD_Plk_4	456	462	PF00069	0.544
MOD_Plk_4	5	11	PF00069	0.502
MOD_Plk_4	643	649	PF00069	0.629
MOD_Plk_4	706	712	PF00069	0.531
MOD_Plk_4	723	729	PF00069	0.445
MOD_ProDKin_1	103	109	PF00069	0.355
MOD_ProDKin_1	152	158	PF00069	0.359
MOD_ProDKin_1	246	252	PF00069	0.633
MOD_ProDKin_1	296	302	PF00069	0.480
MOD_ProDKin_1	312	318	PF00069	0.328
MOD_ProDKin_1	371	377	PF00069	0.613
MOD_ProDKin_1	431	437	PF00069	0.577
MOD_ProDKin_1	602	608	PF00069	0.585
MOD_ProDKin_1	684	690	PF00069	0.574
MOD_ProDKin_1	709	715	PF00069	0.632
MOD_SUMO_rev_2	521	527	PF00179	0.448
TRG_DiLeu_BaEn_2	336	342	PF01217	0.526
TRG_DiLeu_BaLyEn_6	646	651	PF01217	0.534
TRG_ENDOCYTIC_2	110	113	PF00928	0.364
TRG_ENDOCYTIC_2	120	123	PF00928	0.387
TRG_ENDOCYTIC_2	134	137	PF00928	0.307
TRG_ENDOCYTIC_2	154	157	PF00928	0.216
TRG_ENDOCYTIC_2	216	219	PF00928	0.363
TRG_ENDOCYTIC_2	497	500	PF00928	0.446
TRG_ENDOCYTIC_2	568	571	PF00928	0.570
TRG_ENDOCYTIC_2	647	650	PF00928	0.472
TRG_ENDOCYTIC_2	83	86	PF00928	0.332
TRG_ER_diArg_1	240	242	PF00400	0.583
TRG_ER_diArg_1	310	313	PF00400	0.409
TRG_ER_diArg_1	651	654	PF00400	0.532
TRG_Pf-PMV_PEXEL_1	365	369	PF00026	0.442
TRG_Pf-PMV_PEXEL_1	462	466	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I561	Leptomonas seymouri	45%	99%
A0A3S7X8F7	Leishmania donovani	93%	100%
A4HB58	Leishmania braziliensis	79%	100%
A4IAA5	Leishmania infantum	93%	100%
E9B5C8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%