LeishMANIAdb
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HECT domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
HECT domain-containing protein
Gene product:
HECT-domain (ubiquitin-transferase), putative
Species:
Leishmania major
UniProt:
Q4Q2K4_LEIMA
TriTrypDb:
LmjF.34.3400 , LMJLV39_340039800 * , LMJSD75_340040100 *
Length:
325

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2K4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2K4

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0004842 ubiquitin-protein transferase activity 4 7
GO:0016740 transferase activity 2 7
GO:0019787 ubiquitin-like protein transferase activity 3 7
GO:0140096 catalytic activity, acting on a protein 2 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 289 291 PF00675 0.593
CLV_NRD_NRD_1 293 295 PF00675 0.613
CLV_PCSK_KEX2_1 289 291 PF00082 0.593
CLV_PCSK_KEX2_1 293 295 PF00082 0.613
CLV_PCSK_PC7_1 289 295 PF00082 0.572
CLV_PCSK_SKI1_1 115 119 PF00082 0.572
CLV_Separin_Metazoa 167 171 PF03568 0.587
DEG_Nend_UBRbox_3 1 3 PF02207 0.626
DOC_ANK_TNKS_1 182 189 PF00023 0.612
DOC_MAPK_gen_1 176 184 PF00069 0.609
DOC_PP2B_LxvP_1 316 319 PF13499 0.644
DOC_PP4_FxxP_1 192 195 PF00568 0.601
DOC_PP4_FxxP_1 269 272 PF00568 0.493
DOC_USP7_MATH_1 121 125 PF00917 0.706
DOC_USP7_MATH_1 252 256 PF00917 0.605
DOC_WW_Pin1_4 305 310 PF00397 0.669
LIG_14-3-3_CanoR_1 129 137 PF00244 0.567
LIG_14-3-3_CanoR_1 151 158 PF00244 0.576
LIG_14-3-3_CanoR_1 20 29 PF00244 0.430
LIG_14-3-3_CanoR_1 214 219 PF00244 0.580
LIG_14-3-3_CanoR_1 261 270 PF00244 0.663
LIG_14-3-3_CanoR_1 289 293 PF00244 0.612
LIG_14-3-3_CanoR_1 294 300 PF00244 0.492
LIG_14-3-3_CanoR_1 92 99 PF00244 0.382
LIG_APCC_ABBA_1 198 203 PF00400 0.553
LIG_APCC_ABBA_1 317 322 PF00400 0.578
LIG_BRCT_BRCA1_1 176 180 PF00533 0.530
LIG_BRCT_BRCA1_1 259 263 PF00533 0.516
LIG_deltaCOP1_diTrp_1 148 152 PF00928 0.499
LIG_FHA_1 142 148 PF00498 0.633
LIG_FHA_1 197 203 PF00498 0.560
LIG_FHA_1 311 317 PF00498 0.606
LIG_FHA_1 69 75 PF00498 0.298
LIG_FHA_2 138 144 PF00498 0.522
LIG_FHA_2 189 195 PF00498 0.682
LIG_FHA_2 208 214 PF00498 0.401
LIG_Integrin_isoDGR_2 87 89 PF01839 0.369
LIG_LIR_Apic_2 189 195 PF02991 0.612
LIG_LIR_Gen_1 100 109 PF02991 0.311
LIG_LIR_Gen_1 199 209 PF02991 0.497
LIG_LIR_Gen_1 260 271 PF02991 0.508
LIG_LIR_Gen_1 43 51 PF02991 0.308
LIG_LIR_Gen_1 63 72 PF02991 0.183
LIG_LIR_Gen_1 80 86 PF02991 0.327
LIG_LIR_Nem_3 100 105 PF02991 0.335
LIG_LIR_Nem_3 217 222 PF02991 0.529
LIG_LIR_Nem_3 236 241 PF02991 0.573
LIG_LIR_Nem_3 260 266 PF02991 0.512
LIG_LIR_Nem_3 63 68 PF02991 0.329
LIG_LIR_Nem_3 71 75 PF02991 0.376
LIG_LIR_Nem_3 80 85 PF02991 0.433
LIG_NRBOX 204 210 PF00104 0.482
LIG_REV1ctd_RIR_1 99 108 PF16727 0.369
LIG_SH2_CRK 82 86 PF00017 0.317
LIG_SH2_GRB2like 109 112 PF00017 0.466
LIG_SH2_NCK_1 82 86 PF00017 0.304
LIG_SH2_STAT5 241 244 PF00017 0.528
LIG_SH3_2 165 170 PF14604 0.595
LIG_SH3_3 162 168 PF00018 0.702
LIG_SUMO_SIM_anti_2 203 211 PF11976 0.540
LIG_TRAF2_1 319 322 PF00917 0.577
LIG_TRFH_1 82 86 PF08558 0.304
MOD_CK1_1 239 245 PF00069 0.635
MOD_CK2_1 207 213 PF00069 0.479
MOD_CK2_1 46 52 PF00069 0.237
MOD_CMANNOS 149 152 PF00535 0.501
MOD_GlcNHglycan 132 135 PF01048 0.626
MOD_GlcNHglycan 227 230 PF01048 0.712
MOD_GlcNHglycan 263 266 PF01048 0.764
MOD_GlcNHglycan 296 299 PF01048 0.674
MOD_GSK3_1 137 144 PF00069 0.635
MOD_GSK3_1 236 243 PF00069 0.590
MOD_GSK3_1 257 264 PF00069 0.779
MOD_GSK3_1 46 53 PF00069 0.237
MOD_GSK3_1 73 80 PF00069 0.339
MOD_N-GLC_1 77 82 PF02516 0.355
MOD_NEK2_1 130 135 PF00069 0.599
MOD_NEK2_1 137 142 PF00069 0.565
MOD_NEK2_1 68 73 PF00069 0.304
MOD_PIKK_1 119 125 PF00454 0.633
MOD_PIKK_1 21 27 PF00454 0.429
MOD_PIKK_1 252 258 PF00454 0.616
MOD_PIKK_1 46 52 PF00454 0.237
MOD_PIKK_1 91 97 PF00454 0.369
MOD_PK_1 214 220 PF00069 0.574
MOD_PKA_1 293 299 PF00069 0.537
MOD_PKA_2 130 136 PF00069 0.599
MOD_PKA_2 137 143 PF00069 0.553
MOD_PKA_2 150 156 PF00069 0.567
MOD_PKA_2 246 252 PF00069 0.579
MOD_PKA_2 288 294 PF00069 0.608
MOD_PKA_2 91 97 PF00069 0.304
MOD_PKB_1 127 135 PF00069 0.571
MOD_Plk_1 188 194 PF00069 0.611
MOD_Plk_1 236 242 PF00069 0.602
MOD_Plk_1 58 64 PF00069 0.306
MOD_Plk_1 77 83 PF00069 0.254
MOD_Plk_2-3 143 149 PF00069 0.480
MOD_Plk_4 188 194 PF00069 0.641
MOD_Plk_4 196 202 PF00069 0.542
MOD_Plk_4 236 242 PF00069 0.528
MOD_ProDKin_1 305 311 PF00069 0.669
TRG_ENDOCYTIC_2 109 112 PF00928 0.441
TRG_ENDOCYTIC_2 82 85 PF00928 0.331
TRG_ER_diArg_1 127 130 PF00400 0.583
TRG_ER_diArg_1 136 139 PF00400 0.575
TRG_ER_diArg_1 175 178 PF00400 0.585
TRG_ER_diArg_1 292 294 PF00400 0.660
TRG_NES_CRM1_1 196 211 PF08389 0.485
TRG_NES_CRM1_1 66 79 PF08389 0.369

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HYK9 Leptomonas seymouri 48% 99%
A0A3Q8INP3 Leishmania donovani 93% 100%
A4HB59 Leishmania braziliensis 80% 100%
A4IAA6 Leishmania infantum 93% 100%
E9B5C9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS