Lactamase_B domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo-beta-lactamase superfamily, putative

Species:

Leishmania major

UniProt:

Q4Q2K2_LEIMA

TriTrypDb:

LmjF.34.3420 , LMJLV39_340039900 , LMJSD75_340040200

Length:

518

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4Q2K2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2K2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0004416	hydroxyacylglutathione hydrolase activity	5	4
GO:0016787	hydrolase activity	2	5
GO:0016788	hydrolase activity, acting on ester bonds	3	4
GO:0016790	thiolester hydrolase activity	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	287	291	PF00656	0.356
CLV_C14_Caspase3-7	421	425	PF00656	0.593
CLV_C14_Caspase3-7	434	438	PF00656	0.584
CLV_NRD_NRD_1	511	513	PF00675	0.381
CLV_PCSK_KEX2_1	510	512	PF00082	0.368
CLV_PCSK_SKI1_1	427	431	PF00082	0.322
DOC_CKS1_1	127	132	PF01111	0.293
DOC_CKS1_1	253	258	PF01111	0.356
DOC_CKS1_1	513	518	PF01111	0.512
DOC_CYCLIN_yClb3_PxF_3	63	71	PF00134	0.578
DOC_CYCLIN_yCln2_LP_2	206	212	PF00134	0.507
DOC_MAPK_DCC_7	158	167	PF00069	0.471
DOC_MAPK_MEF2A_6	158	167	PF00069	0.471
DOC_MAPK_MEF2A_6	203	212	PF00069	0.507
DOC_MAPK_MEF2A_6	471	479	PF00069	0.430
DOC_PP1_RVXF_1	259	265	PF00149	0.418
DOC_PP2B_LxvP_1	206	209	PF13499	0.507
DOC_PP4_FxxP_1	456	459	PF00568	0.589
DOC_USP7_MATH_1	20	24	PF00917	0.242
DOC_USP7_MATH_1	495	499	PF00917	0.617
DOC_USP7_MATH_1	69	73	PF00917	0.663
DOC_USP7_MATH_2	343	349	PF00917	0.579
DOC_USP7_UBL2_3	488	492	PF12436	0.532
DOC_WW_Pin1_4	115	120	PF00397	0.372
DOC_WW_Pin1_4	126	131	PF00397	0.387
DOC_WW_Pin1_4	252	257	PF00397	0.448
DOC_WW_Pin1_4	280	285	PF00397	0.507
DOC_WW_Pin1_4	320	325	PF00397	0.569
DOC_WW_Pin1_4	406	411	PF00397	0.565
DOC_WW_Pin1_4	512	517	PF00397	0.487
LIG_14-3-3_CanoR_1	356	360	PF00244	0.514
LIG_14-3-3_CanoR_1	364	369	PF00244	0.504
LIG_14-3-3_CanoR_1	402	410	PF00244	0.666
LIG_Actin_WH2_2	107	125	PF00022	0.388
LIG_Actin_WH2_2	425	442	PF00022	0.460
LIG_Actin_WH2_2	472	490	PF00022	0.482
LIG_APCC_ABBA_1	165	170	PF00400	0.538
LIG_APCC_ABBA_1	241	246	PF00400	0.402
LIG_BIR_II_1	1	5	PF00653	0.594
LIG_BIR_III_2	281	285	PF00653	0.449
LIG_BRCT_BRCA1_1	282	286	PF00533	0.507
LIG_BRCT_BRCA1_1	306	310	PF00533	0.403
LIG_BRCT_BRCA1_1	66	70	PF00533	0.613
LIG_BRCT_BRCA1_1	71	75	PF00533	0.594
LIG_Clathr_ClatBox_1	476	480	PF01394	0.544
LIG_EH_1	61	65	PF12763	0.548
LIG_eIF4E_1	85	91	PF01652	0.171
LIG_FHA_1	151	157	PF00498	0.412
LIG_FHA_1	179	185	PF00498	0.459
LIG_FHA_1	211	217	PF00498	0.429
LIG_FHA_1	253	259	PF00498	0.378
LIG_FHA_1	344	350	PF00498	0.537
LIG_FHA_1	387	393	PF00498	0.510
LIG_FHA_1	6	12	PF00498	0.356
LIG_FHA_2	356	362	PF00498	0.488
LIG_FHA_2	369	375	PF00498	0.556
LIG_FHA_2	407	413	PF00498	0.692
LIG_FHA_2	432	438	PF00498	0.615
LIG_LIR_Apic_2	35	40	PF02991	0.441
LIG_LIR_Apic_2	6	10	PF02991	0.449
LIG_LIR_Gen_1	170	179	PF02991	0.404
LIG_LIR_Gen_1	283	293	PF02991	0.449
LIG_LIR_Gen_1	86	96	PF02991	0.351
LIG_LIR_Nem_3	170	175	PF02991	0.438
LIG_LIR_Nem_3	43	49	PF02991	0.320
LIG_LIR_Nem_3	72	78	PF02991	0.451
LIG_LIR_Nem_3	86	92	PF02991	0.331
LIG_MYND_1	256	260	PF01753	0.449
LIG_MYND_1	455	459	PF01753	0.474
LIG_Pex14_2	135	139	PF04695	0.347
LIG_Pex14_2	64	68	PF04695	0.562
LIG_SH2_CRK	172	176	PF00017	0.445
LIG_SH2_CRK	37	41	PF00017	0.500
LIG_SH2_CRK	46	50	PF00017	0.323
LIG_SH2_NCK_1	140	144	PF00017	0.302
LIG_SH2_SRC	174	177	PF00017	0.502
LIG_SH2_SRC	19	22	PF00017	0.302
LIG_SH2_STAP1	172	176	PF00017	0.412
LIG_SH2_STAP1	388	392	PF00017	0.459
LIG_SH2_STAT5	174	177	PF00017	0.424
LIG_SH2_STAT5	383	386	PF00017	0.434
LIG_SH2_STAT5	388	391	PF00017	0.458
LIG_SH2_STAT5	418	421	PF00017	0.520
LIG_SH2_STAT5	46	49	PF00017	0.389
LIG_SH2_STAT5	506	509	PF00017	0.529
LIG_SH2_STAT5	82	85	PF00017	0.240
LIG_SH2_STAT5	89	92	PF00017	0.253
LIG_SH3_1	121	127	PF00018	0.430
LIG_SH3_1	237	243	PF00018	0.514
LIG_SH3_3	121	127	PF00018	0.349
LIG_SH3_3	160	166	PF00018	0.431
LIG_SH3_3	186	192	PF00018	0.430
LIG_SH3_3	236	242	PF00018	0.480
LIG_SH3_3	250	256	PF00018	0.392
LIG_SH3_3	407	413	PF00018	0.585
LIG_SH3_3	57	63	PF00018	0.583
LIG_SH3_3	88	94	PF00018	0.415
LIG_SH3_3	97	103	PF00018	0.347
LIG_SH3_5	103	107	PF00018	0.227
LIG_SUMO_SIM_anti_2	395	401	PF11976	0.554
LIG_SUMO_SIM_par_1	395	401	PF11976	0.579
LIG_SUMO_SIM_par_1	475	480	PF11976	0.482
LIG_TRAF2_1	243	246	PF00917	0.418
LIG_TRAF2_1	314	317	PF00917	0.451
LIG_TRAF2_1	371	374	PF00917	0.593
LIG_TYR_ITIM	44	49	PF00017	0.302
LIG_TYR_ITIM	87	92	PF00017	0.272
LIG_UBA3_1	175	183	PF00899	0.507
LIG_UBA3_1	74	80	PF00899	0.383
LIG_WRC_WIRS_1	65	70	PF05994	0.573
MOD_CDC14_SPxK_1	118	121	PF00782	0.416
MOD_CDK_SPxK_1	115	121	PF00069	0.410
MOD_CDK_SPxK_1	320	326	PF00069	0.557
MOD_CDK_SPxK_1	512	518	PF00069	0.504
MOD_CK1_1	178	184	PF00069	0.403
MOD_CK1_1	3	9	PF00069	0.518
MOD_CK2_1	232	238	PF00069	0.457
MOD_CK2_1	311	317	PF00069	0.457
MOD_CK2_1	355	361	PF00069	0.508
MOD_CK2_1	368	374	PF00069	0.646
MOD_DYRK1A_RPxSP_1	406	410	PF00069	0.576
MOD_GlcNHglycan	26	29	PF01048	0.652
MOD_GlcNHglycan	266	269	PF01048	0.209
MOD_GlcNHglycan	313	316	PF01048	0.301
MOD_GlcNHglycan	32	35	PF01048	0.651
MOD_GlcNHglycan	55	58	PF01048	0.297
MOD_GSK3_1	20	27	PF00069	0.433
MOD_GSK3_1	210	217	PF00069	0.400
MOD_GSK3_1	364	371	PF00069	0.533
MOD_GSK3_1	398	405	PF00069	0.600
MOD_GSK3_1	459	466	PF00069	0.485
MOD_NEK2_1	175	180	PF00069	0.414
MOD_NEK2_1	5	10	PF00069	0.542
MOD_NEK2_2	40	45	PF00069	0.302
MOD_PIKK_1	364	370	PF00454	0.639
MOD_PKA_2	355	361	PF00069	0.569
MOD_PKA_2	401	407	PF00069	0.605
MOD_PKB_1	406	414	PF00069	0.536
MOD_Plk_4	152	158	PF00069	0.497
MOD_Plk_4	304	310	PF00069	0.427
MOD_Plk_4	331	337	PF00069	0.534
MOD_Plk_4	355	361	PF00069	0.563
MOD_Plk_4	395	401	PF00069	0.519
MOD_ProDKin_1	115	121	PF00069	0.380
MOD_ProDKin_1	126	132	PF00069	0.380
MOD_ProDKin_1	252	258	PF00069	0.448
MOD_ProDKin_1	280	286	PF00069	0.507
MOD_ProDKin_1	320	326	PF00069	0.558
MOD_ProDKin_1	406	412	PF00069	0.557
MOD_ProDKin_1	512	518	PF00069	0.504
TRG_DiLeu_BaEn_1	395	400	PF01217	0.609
TRG_DiLeu_BaLyEn_6	253	258	PF01217	0.449
TRG_DiLeu_BaLyEn_6	388	393	PF01217	0.510
TRG_DiLeu_BaLyEn_6	472	477	PF01217	0.454
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.507
TRG_ENDOCYTIC_2	172	175	PF00928	0.445
TRG_ENDOCYTIC_2	46	49	PF00928	0.383
TRG_ENDOCYTIC_2	89	92	PF00928	0.253
TRG_ER_diArg_1	363	366	PF00400	0.539
TRG_ER_diArg_1	510	512	PF00400	0.493
TRG_Pf-PMV_PEXEL_1	391	395	PF00026	0.317

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD83	Leptomonas seymouri	67%	99%
A0A0S4IM37	Bodo saltans	35%	100%
A0A1X0PA00	Trypanosomatidae	37%	100%
A0A3R7K9K9	Trypanosoma rangeli	41%	100%
A0A3S7X8A7	Leishmania donovani	92%	100%
A4HB60	Leishmania braziliensis	82%	100%
A4IAA8	Leishmania infantum	92%	100%
C9ZLY8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B5D1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q8N490	Homo sapiens	28%	100%
V5B5D7	Trypanosoma cruzi	42%	100%