RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2J8_LEIMA

TriTrypDb:

LmjF.34.3460 , LMJLV39_340040300 , LMJSD75_340040600

Length:

475

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2J8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2J8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.575
CLV_NRD_NRD_1	238	240	PF00675	0.470
CLV_NRD_NRD_1	304	306	PF00675	0.511
CLV_PCSK_KEX2_1	237	239	PF00082	0.495
CLV_PCSK_KEX2_1	356	358	PF00082	0.677
CLV_PCSK_KEX2_1	38	40	PF00082	0.513
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.677
CLV_PCSK_PC1ET2_1	38	40	PF00082	0.513
CLV_PCSK_PC7_1	234	240	PF00082	0.473
CLV_PCSK_SKI1_1	101	105	PF00082	0.442
CLV_PCSK_SKI1_1	22	26	PF00082	0.414
CLV_PCSK_SKI1_1	384	388	PF00082	0.520
CLV_PCSK_SKI1_1	39	43	PF00082	0.547
CLV_PCSK_SKI1_1	67	71	PF00082	0.400
DEG_Nend_Nbox_1	1	3	PF02207	0.596
DOC_CKS1_1	263	268	PF01111	0.622
DOC_MAPK_MEF2A_6	333	340	PF00069	0.588
DOC_PP1_RVXF_1	424	430	PF00149	0.434
DOC_PP4_FxxP_1	185	188	PF00568	0.603
DOC_PP4_FxxP_1	9	12	PF00568	0.566
DOC_USP7_MATH_1	438	442	PF00917	0.492
DOC_USP7_MATH_2	209	215	PF00917	0.593
DOC_USP7_UBL2_3	247	251	PF12436	0.512
DOC_WW_Pin1_4	262	267	PF00397	0.512
DOC_WW_Pin1_4	366	371	PF00397	0.516
LIG_14-3-3_CanoR_1	22	27	PF00244	0.476
LIG_14-3-3_CanoR_1	357	365	PF00244	0.618
LIG_14-3-3_CanoR_1	39	47	PF00244	0.476
LIG_14-3-3_CanoR_1	67	73	PF00244	0.407
LIG_deltaCOP1_diTrp_1	127	133	PF00928	0.410
LIG_FHA_1	320	326	PF00498	0.499
LIG_FHA_1	348	354	PF00498	0.718
LIG_FHA_1	358	364	PF00498	0.565
LIG_FHA_1	408	414	PF00498	0.551
LIG_FHA_2	38	44	PF00498	0.460
LIG_FHA_2	414	420	PF00498	0.491
LIG_FHA_2	52	58	PF00498	0.426
LIG_IBAR_NPY_1	281	283	PF08397	0.587
LIG_LIR_Apic_2	184	188	PF02991	0.515
LIG_LIR_Apic_2	6	12	PF02991	0.571
LIG_LIR_Gen_1	127	137	PF02991	0.531
LIG_LIR_Gen_1	57	66	PF02991	0.405
LIG_LIR_LC3C_4	57	62	PF02991	0.385
LIG_LIR_Nem_3	127	132	PF02991	0.556
LIG_LIR_Nem_3	332	338	PF02991	0.645
LIG_LIR_Nem_3	444	449	PF02991	0.507
LIG_LIR_Nem_3	57	61	PF02991	0.406
LIG_PCNA_yPIPBox_3	70	82	PF02747	0.416
LIG_PDZ_Class_2	470	475	PF00595	0.571
LIG_Pex14_1	129	133	PF04695	0.399
LIG_Pex14_2	274	278	PF04695	0.561
LIG_PTB_Apo_2	230	237	PF02174	0.538
LIG_REV1ctd_RIR_1	443	451	PF16727	0.438
LIG_SH2_CRK	206	210	PF00017	0.487
LIG_SH2_NCK_1	113	117	PF00017	0.563
LIG_SH2_NCK_1	283	287	PF00017	0.382
LIG_SH2_SRC	113	116	PF00017	0.449
LIG_SH2_SRC	283	286	PF00017	0.568
LIG_SH2_STAP1	122	126	PF00017	0.387
LIG_SH2_STAP1	58	62	PF00017	0.482
LIG_SH2_STAT3	401	404	PF00017	0.485
LIG_SH2_STAT5	102	105	PF00017	0.391
LIG_SH2_STAT5	192	195	PF00017	0.395
LIG_SH2_STAT5	401	404	PF00017	0.485
LIG_SH2_STAT5	8	11	PF00017	0.559
LIG_SH2_STAT5	82	85	PF00017	0.357
LIG_SH2_STAT5	97	100	PF00017	0.363
LIG_SH3_3	149	155	PF00018	0.574
LIG_SH3_3	279	285	PF00018	0.581
LIG_SH3_3	318	324	PF00018	0.556
LIG_SH3_3	386	392	PF00018	0.440
LIG_SH3_4	247	254	PF00018	0.538
LIG_SH3_5	188	192	PF00018	0.410
LIG_SUMO_SIM_anti_2	372	378	PF11976	0.525
LIG_TRAF2_1	164	167	PF00917	0.672
LIG_TRAF2_1	170	173	PF00917	0.662
LIG_TRAF2_1	209	212	PF00917	0.509
LIG_TRAF2_1	300	303	PF00917	0.585
LIG_TRAF2_1	324	327	PF00917	0.546
LIG_TRAF2_1	342	345	PF00917	0.543
LIG_TYR_ITIM	56	61	PF00017	0.489
LIG_UBA3_1	65	70	PF00899	0.378
LIG_UBA3_1	83	89	PF00899	0.395
LIG_WRC_WIRS_1	23	28	PF05994	0.477
LIG_WRC_WIRS_1	442	447	PF05994	0.561
MOD_CK1_1	369	375	PF00069	0.498
MOD_CK1_1	441	447	PF00069	0.550
MOD_CK1_1	468	474	PF00069	0.558
MOD_CK2_1	121	127	PF00069	0.400
MOD_CK2_1	297	303	PF00069	0.613
MOD_CK2_1	37	43	PF00069	0.465
MOD_CK2_1	413	419	PF00069	0.453
MOD_Cter_Amidation	36	39	PF01082	0.473
MOD_GlcNHglycan	226	229	PF01048	0.542
MOD_GlcNHglycan	256	259	PF01048	0.635
MOD_GlcNHglycan	299	302	PF01048	0.566
MOD_GlcNHglycan	371	374	PF01048	0.416
MOD_GlcNHglycan	422	425	PF01048	0.456
MOD_GSK3_1	195	202	PF00069	0.557
MOD_GSK3_1	39	46	PF00069	0.462
MOD_LATS_1	68	74	PF00433	0.397
MOD_N-GLC_1	366	371	PF02516	0.579
MOD_N-GLC_1	413	418	PF02516	0.556
MOD_N-GLC_1	451	456	PF02516	0.531
MOD_NEK2_1	413	418	PF00069	0.486
MOD_NEK2_1	427	432	PF00069	0.400
MOD_NEK2_2	199	204	PF00069	0.582
MOD_OFUCOSY	197	203	PF10250	0.560
MOD_PIKK_1	413	419	PF00454	0.493
MOD_PKA_1	238	244	PF00069	0.473
MOD_PKA_2	16	22	PF00069	0.428
MOD_PKA_2	238	244	PF00069	0.473
MOD_PKB_1	357	365	PF00069	0.645
MOD_Plk_1	396	402	PF00069	0.542
MOD_Plk_4	121	127	PF00069	0.400
MOD_Plk_4	359	365	PF00069	0.541
MOD_Plk_4	441	447	PF00069	0.544
MOD_Plk_4	468	474	PF00069	0.486
MOD_Plk_4	51	57	PF00069	0.461
MOD_ProDKin_1	262	268	PF00069	0.514
MOD_ProDKin_1	366	372	PF00069	0.507
MOD_SUMO_for_1	144	147	PF00179	0.529
MOD_SUMO_rev_2	218	227	PF00179	0.479
MOD_SUMO_rev_2	257	263	PF00179	0.595
TRG_ENDOCYTIC_2	122	125	PF00928	0.409
TRG_ENDOCYTIC_2	23	26	PF00928	0.539
TRG_ENDOCYTIC_2	58	61	PF00928	0.486
TRG_ER_diArg_1	236	239	PF00400	0.577
TRG_ER_diArg_1	312	315	PF00400	0.481
TRG_NLS_Bipartite_1	237	255	PF00514	0.521
TRG_NLS_MonoExtC_3	355	361	PF00514	0.703
TRG_NLS_MonoExtN_4	248	255	PF00514	0.550
TRG_Pf-PMV_PEXEL_1	384	388	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	400	404	PF00026	0.572

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWZ1	Leptomonas seymouri	83%	100%
A0A0S4ILT1	Bodo saltans	49%	100%
A0A1X0PBC7	Trypanosomatidae	62%	100%
A0A3Q8IUU8	Leishmania donovani	99%	100%
A0A3R7NKC5	Trypanosoma rangeli	63%	100%
A4HB64	Leishmania braziliensis	93%	100%
A4IAB2	Leishmania infantum	99%	100%
C9ZLY4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9B5D5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5BKY3	Trypanosoma cruzi	64%	100%