AA_TRNA_LIGASE_II domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amidinotransferase, putative

Species:

Leishmania major

UniProt:

Q4Q2J7_LEIMA

TriTrypDb:

LmjF.34.3470 , LMJLV39_340040400 , LMJSD75_340040700

Length:

358

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	2
GO:0030863	cortical cytoskeleton	6	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2J7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2J7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016740	transferase activity	2	2
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	120	122	PF00675	0.422
CLV_NRD_NRD_1	320	322	PF00675	0.350
CLV_PCSK_KEX2_1	320	322	PF00082	0.350
CLV_PCSK_SKI1_1	197	201	PF00082	0.279
CLV_PCSK_SKI1_1	298	302	PF00082	0.419
CLV_Separin_Metazoa	350	354	PF03568	0.519
DEG_APCC_KENBOX_2	306	310	PF00400	0.357
DOC_CYCLIN_RxL_1	295	303	PF00134	0.348
DOC_CYCLIN_yCln2_LP_2	265	271	PF00134	0.411
DOC_CYCLIN_yCln2_LP_2	6	12	PF00134	0.448
DOC_MAPK_gen_1	67	76	PF00069	0.548
DOC_MAPK_JIP1_4	186	192	PF00069	0.411
DOC_PP2B_LxvP_1	190	193	PF13499	0.299
DOC_PP2B_LxvP_1	265	268	PF13499	0.411
DOC_USP7_MATH_1	223	227	PF00917	0.479
DOC_USP7_MATH_1	341	345	PF00917	0.621
DOC_WW_Pin1_4	159	164	PF00397	0.388
LIG_14-3-3_CanoR_1	321	327	PF00244	0.369
LIG_APCC_ABBA_1	143	148	PF00400	0.411
LIG_BIR_II_1	1	5	PF00653	0.262
LIG_BRCT_BRCA1_1	157	161	PF00533	0.436
LIG_BRCT_BRCA1_1	225	229	PF00533	0.436
LIG_FHA_1	207	213	PF00498	0.293
LIG_FHA_1	346	352	PF00498	0.495
LIG_FHA_1	58	64	PF00498	0.435
LIG_FHA_2	44	50	PF00498	0.493
LIG_IBAR_NPY_1	112	114	PF08397	0.284
LIG_LIR_Gen_1	243	252	PF02991	0.363
LIG_LIR_Nem_3	243	249	PF02991	0.350
LIG_LIR_Nem_3	312	317	PF02991	0.409
LIG_LIR_Nem_3	49	54	PF02991	0.508
LIG_REV1ctd_RIR_1	49	57	PF16727	0.473
LIG_SH2_CRK	169	173	PF00017	0.323
LIG_SH2_CRK	246	250	PF00017	0.323
LIG_SH2_CRK	72	76	PF00017	0.422
LIG_SH2_NCK_1	169	173	PF00017	0.316
LIG_SH2_PTP2	281	284	PF00017	0.411
LIG_SH2_SRC	152	155	PF00017	0.397
LIG_SH2_STAP1	246	250	PF00017	0.334
LIG_SH2_STAT5	152	155	PF00017	0.395
LIG_SH2_STAT5	167	170	PF00017	0.355
LIG_SH2_STAT5	281	284	PF00017	0.467
LIG_SH2_STAT5	334	337	PF00017	0.512
LIG_SH3_2	110	115	PF14604	0.366
LIG_SH3_3	104	110	PF00018	0.370
LIG_SH3_3	265	271	PF00018	0.444
LIG_SH3_3	337	343	PF00018	0.523
LIG_SUMO_SIM_anti_2	179	185	PF11976	0.287
LIG_SUMO_SIM_anti_2	2	8	PF11976	0.435
LIG_SUMO_SIM_anti_2	347	353	PF11976	0.512
LIG_SUMO_SIM_par_1	247	254	PF11976	0.436
LIG_SUMO_SIM_par_1	281	288	PF11976	0.411
LIG_TRAF2_1	131	134	PF00917	0.482
LIG_TRAF2_1	145	148	PF00917	0.298
LIG_TRAF2_1	75	78	PF00917	0.520
LIG_TYR_ITSM	310	317	PF00017	0.482
LIG_WRC_WIRS_1	310	315	PF05994	0.436
LIG_WRC_WIRS_1	48	53	PF05994	0.453
LIG_WW_2	340	343	PF00397	0.487
MOD_CDK_SPxxK_3	159	166	PF00069	0.397
MOD_CK1_1	173	179	PF00069	0.300
MOD_CK1_1	325	331	PF00069	0.403
MOD_CK1_1	344	350	PF00069	0.344
MOD_CK2_1	250	256	PF00069	0.393
MOD_CK2_1	260	266	PF00069	0.355
MOD_CK2_1	344	350	PF00069	0.511
MOD_CK2_1	43	49	PF00069	0.464
MOD_GlcNHglycan	154	158	PF01048	0.397
MOD_GlcNHglycan	242	245	PF01048	0.470
MOD_GlcNHglycan	262	265	PF01048	0.423
MOD_GlcNHglycan	272	275	PF01048	0.403
MOD_GSK3_1	155	162	PF00069	0.387
MOD_GSK3_1	240	247	PF00069	0.380
MOD_GSK3_1	321	328	PF00069	0.445
MOD_GSK3_1	341	348	PF00069	0.328
MOD_GSK3_1	43	50	PF00069	0.403
MOD_NEK2_1	153	158	PF00069	0.321
MOD_NEK2_1	23	28	PF00069	0.510
MOD_NEK2_1	260	265	PF00069	0.427
MOD_NEK2_1	36	41	PF00069	0.471
MOD_OFUCOSY	322	329	PF10250	0.439
MOD_PIKK_1	170	176	PF00454	0.381
MOD_PIKK_1	341	347	PF00454	0.567
MOD_PIKK_1	36	42	PF00454	0.419
MOD_PK_1	79	85	PF00069	0.484
MOD_Plk_1	36	42	PF00069	0.478
MOD_Plk_4	155	161	PF00069	0.444
MOD_Plk_4	223	229	PF00069	0.467
MOD_Plk_4	309	315	PF00069	0.485
MOD_Plk_4	47	53	PF00069	0.452
MOD_ProDKin_1	159	165	PF00069	0.388
MOD_SUMO_rev_2	147	153	PF00179	0.397
MOD_SUMO_rev_2	66	71	PF00179	0.491
TRG_DiLeu_BaEn_4	148	154	PF01217	0.415
TRG_ENDOCYTIC_2	169	172	PF00928	0.307
TRG_ENDOCYTIC_2	239	242	PF00928	0.348
TRG_ENDOCYTIC_2	246	249	PF00928	0.234
TRG_ENDOCYTIC_2	281	284	PF00928	0.407
TRG_ENDOCYTIC_2	314	317	PF00928	0.424
TRG_Pf-PMV_PEXEL_1	298	303	PF00026	0.381

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Q5	Leptomonas seymouri	66%	100%
A0A0N1IKG5	Leptomonas seymouri	38%	99%
A0A0S4JAZ5	Bodo saltans	27%	93%
A0A1X0PAA5	Trypanosomatidae	38%	95%
A0A3R7KYJ2	Trypanosoma rangeli	38%	95%
A0A3S7X8B2	Leishmania donovani	95%	100%
A4HB65	Leishmania braziliensis	85%	100%
A4IAB3	Leishmania infantum	95%	100%
C9ZLY3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	96%
E9B5D6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5B5E2	Trypanosoma cruzi	38%	95%