Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2J6_LEIMA

TriTrypDb:

LmjF.34.3480 , LMJLV39_340040500 , LMJSD75_340040800

Length:

237

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	6
GO:0120025	plasma membrane bounded cell projection	3	6

Expansion

Sequence features

Q4Q2J6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2J6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	52	56	PF00656	0.600
CLV_NRD_NRD_1	16	18	PF00675	0.612
CLV_NRD_NRD_1	216	218	PF00675	0.616
CLV_NRD_NRD_1	48	50	PF00675	0.415
CLV_PCSK_KEX2_1	16	18	PF00082	0.612
CLV_PCSK_KEX2_1	216	218	PF00082	0.616
CLV_PCSK_KEX2_1	48	50	PF00082	0.415
CLV_PCSK_PC7_1	12	18	PF00082	0.727
CLV_PCSK_SKI1_1	12	16	PF00082	0.732
CLV_PCSK_SKI1_1	192	196	PF00082	0.567
CLV_PCSK_SKI1_1	96	100	PF00082	0.589
DEG_SCF_FBW7_1	33	40	PF00400	0.523
DOC_CYCLIN_RxL_1	114	124	PF00134	0.572
DOC_CYCLIN_RxL_1	9	18	PF00134	0.726
DOC_MAPK_MEF2A_6	128	136	PF00069	0.551
DOC_PP1_RVXF_1	115	122	PF00149	0.601
DOC_PP1_RVXF_1	126	132	PF00149	0.396
DOC_USP7_MATH_1	103	107	PF00917	0.574
DOC_USP7_MATH_1	233	237	PF00917	0.816
DOC_USP7_MATH_1	37	41	PF00917	0.595
DOC_USP7_MATH_1	65	69	PF00917	0.675
DOC_WW_Pin1_4	194	199	PF00397	0.590
DOC_WW_Pin1_4	20	25	PF00397	0.577
DOC_WW_Pin1_4	227	232	PF00397	0.728
DOC_WW_Pin1_4	33	38	PF00397	0.616
LIG_14-3-3_CanoR_1	16	26	PF00244	0.597
LIG_14-3-3_CanoR_1	192	198	PF00244	0.590
LIG_14-3-3_CanoR_1	66	70	PF00244	0.551
LIG_14-3-3_CanoR_1	77	86	PF00244	0.541
LIG_14-3-3_CanoR_1	96	101	PF00244	0.511
LIG_BIR_II_1	1	5	PF00653	0.658
LIG_CSL_BTD_1	130	133	PF09270	0.545
LIG_FHA_1	213	219	PF00498	0.610
LIG_FHA_1	9	15	PF00498	0.729
LIG_FHA_1	93	99	PF00498	0.411
LIG_FHA_2	1	7	PF00498	0.761
LIG_FHA_2	135	141	PF00498	0.511
LIG_GBD_Chelix_1	158	166	PF00786	0.516
LIG_LIR_Gen_1	40	51	PF02991	0.473
LIG_LIR_Gen_1	95	105	PF02991	0.489
LIG_LIR_Nem_3	40	46	PF02991	0.435
LIG_LIR_Nem_3	73	78	PF02991	0.601
LIG_LIR_Nem_3	87	93	PF02991	0.537
LIG_LIR_Nem_3	95	100	PF02991	0.504
LIG_NRBOX	157	163	PF00104	0.554
LIG_Pex14_1	131	135	PF04695	0.540
LIG_SH2_CRK	43	47	PF00017	0.519
LIG_SH2_PTP2	50	53	PF00017	0.578
LIG_SH2_PTP2	97	100	PF00017	0.350
LIG_SH2_SRC	50	53	PF00017	0.345
LIG_SH2_STAP1	43	47	PF00017	0.597
LIG_SH2_STAT5	125	128	PF00017	0.629
LIG_SH2_STAT5	50	53	PF00017	0.418
LIG_SH2_STAT5	75	78	PF00017	0.598
LIG_SH2_STAT5	90	93	PF00017	0.567
LIG_SH2_STAT5	97	100	PF00017	0.468
LIG_SH3_3	36	42	PF00018	0.627
LIG_SUMO_SIM_anti_2	155	163	PF11976	0.558
LIG_SUMO_SIM_par_1	23	29	PF11976	0.707
LIG_TRAF2_1	2	5	PF00917	0.769
LIG_TYR_ITIM	41	46	PF00017	0.608
LIG_TYR_ITSM	93	100	PF00017	0.463
LIG_UBA3_1	190	195	PF00899	0.494
MOD_CK1_1	148	154	PF00069	0.418
MOD_CK1_1	196	202	PF00069	0.589
MOD_CK1_1	20	26	PF00069	0.541
MOD_GlcNHglycan	105	108	PF01048	0.600
MOD_GlcNHglycan	176	180	PF01048	0.575
MOD_GlcNHglycan	61	64	PF01048	0.706
MOD_GSK3_1	143	150	PF00069	0.565
MOD_GSK3_1	171	178	PF00069	0.415
MOD_GSK3_1	194	201	PF00069	0.583
MOD_GSK3_1	229	236	PF00069	0.779
MOD_GSK3_1	31	38	PF00069	0.660
MOD_GSK3_1	92	99	PF00069	0.423
MOD_NEK2_1	143	148	PF00069	0.430
MOD_NEK2_1	15	20	PF00069	0.710
MOD_NEK2_1	162	167	PF00069	0.236
MOD_NEK2_1	175	180	PF00069	0.571
MOD_NEK2_1	193	198	PF00069	0.290
MOD_NEK2_1	78	83	PF00069	0.558
MOD_PIKK_1	148	154	PF00454	0.445
MOD_PIKK_1	198	204	PF00454	0.590
MOD_PKA_2	15	21	PF00069	0.607
MOD_PKA_2	65	71	PF00069	0.527
MOD_Plk_4	121	127	PF00069	0.633
MOD_Plk_4	71	77	PF00069	0.606
MOD_ProDKin_1	194	200	PF00069	0.584
MOD_ProDKin_1	20	26	PF00069	0.580
MOD_ProDKin_1	227	233	PF00069	0.737
MOD_ProDKin_1	33	39	PF00069	0.612
TRG_DiLeu_BaLyEn_6	21	26	PF01217	0.572
TRG_DiLeu_BaLyEn_6	9	14	PF01217	0.705
TRG_ENDOCYTIC_2	43	46	PF00928	0.475
TRG_ENDOCYTIC_2	50	53	PF00928	0.381
TRG_ENDOCYTIC_2	75	78	PF00928	0.598
TRG_ENDOCYTIC_2	97	100	PF00928	0.584
TRG_ER_diArg_1	15	17	PF00400	0.622
TRG_ER_diArg_1	216	218	PF00400	0.616
TRG_ER_diArg_1	47	49	PF00400	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X8B4	Leishmania donovani	92%	100%
A4HB66	Leishmania braziliensis	77%	100%
A4IAB4	Leishmania infantum	92%	100%
E9B5D7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%