TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tetratricopeptide repeat, putative

Species:

Leishmania major

UniProt:

Q4Q2J5_LEIMA

TriTrypDb:

LmjF.34.3490 , LMJLV39_340040600 , LMJSD75_340040900

Length:

425

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2J5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2J5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.449
CLV_C14_Caspase3-7	293	297	PF00656	0.432
CLV_NRD_NRD_1	137	139	PF00675	0.367
CLV_NRD_NRD_1	278	280	PF00675	0.387
CLV_PCSK_KEX2_1	194	196	PF00082	0.559
CLV_PCSK_KEX2_1	235	237	PF00082	0.476
CLV_PCSK_KEX2_1	278	280	PF00082	0.449
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.559
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.557
CLV_PCSK_SKI1_1	138	142	PF00082	0.413
CLV_PCSK_SKI1_1	182	186	PF00082	0.510
CLV_PCSK_SKI1_1	205	209	PF00082	0.382
CLV_PCSK_SKI1_1	308	312	PF00082	0.391
CLV_PCSK_SKI1_1	418	422	PF00082	0.552
DEG_APCC_DBOX_1	24	32	PF00400	0.681
DEG_Nend_Nbox_1	1	3	PF02207	0.741
DEG_SPOP_SBC_1	15	19	PF00917	0.509
DOC_ANK_TNKS_1	366	373	PF00023	0.558
DOC_CKS1_1	111	116	PF01111	0.612
DOC_MAPK_gen_1	202	210	PF00069	0.374
DOC_MAPK_MEF2A_6	202	210	PF00069	0.391
DOC_PP1_RVXF_1	2	8	PF00149	0.621
DOC_PP2B_LxvP_1	35	38	PF13499	0.592
DOC_USP7_MATH_1	15	19	PF00917	0.718
DOC_USP7_MATH_1	44	48	PF00917	0.719
DOC_USP7_UBL2_3	414	418	PF12436	0.587
DOC_WW_Pin1_4	110	115	PF00397	0.572
DOC_WW_Pin1_4	281	286	PF00397	0.500
DOC_WW_Pin1_4	404	409	PF00397	0.449
LIG_14-3-3_CanoR_1	27	32	PF00244	0.620
LIG_APCC_ABBA_1	175	180	PF00400	0.517
LIG_BIR_III_4	338	342	PF00653	0.385
LIG_eIF4E_1	305	311	PF01652	0.518
LIG_FHA_1	67	73	PF00498	0.717
LIG_FHA_1	7	13	PF00498	0.662
LIG_FHA_2	288	294	PF00498	0.412
LIG_LIR_Gen_1	101	107	PF02991	0.480
LIG_LIR_Gen_1	331	339	PF02991	0.329
LIG_LIR_Nem_3	101	106	PF02991	0.462
LIG_LIR_Nem_3	193	199	PF02991	0.350
LIG_LIR_Nem_3	228	234	PF02991	0.530
LIG_LIR_Nem_3	331	336	PF02991	0.329
LIG_SH2_CRK	161	165	PF00017	0.396
LIG_SH2_PTP2	333	336	PF00017	0.449
LIG_SH2_SRC	231	234	PF00017	0.558
LIG_SH2_SRC	353	356	PF00017	0.449
LIG_SH2_STAT3	273	276	PF00017	0.340
LIG_SH2_STAT5	333	336	PF00017	0.344
LIG_SH2_STAT5	353	356	PF00017	0.145
LIG_SH2_STAT5	382	385	PF00017	0.364
LIG_SH2_STAT5	74	77	PF00017	0.388
LIG_SH3_1	279	285	PF00018	0.449
LIG_SH3_3	111	117	PF00018	0.613
LIG_SH3_3	279	285	PF00018	0.449
LIG_SH3_3	405	411	PF00018	0.449
LIG_Sin3_3	391	398	PF02671	0.449
LIG_SUMO_SIM_par_1	290	296	PF11976	0.423
LIG_TRAF2_1	171	174	PF00917	0.410
LIG_TRAF2_1	274	277	PF00917	0.475
LIG_UBA3_1	80	85	PF00899	0.455
MOD_CK1_1	19	25	PF00069	0.633
MOD_CK1_1	39	45	PF00069	0.656
MOD_CK1_1	53	59	PF00069	0.758
MOD_CK1_1	66	72	PF00069	0.708
MOD_CK2_1	271	277	PF00069	0.449
MOD_CK2_1	287	293	PF00069	0.288
MOD_CK2_1	397	403	PF00069	0.345
MOD_CK2_1	95	101	PF00069	0.492
MOD_GlcNHglycan	41	44	PF01048	0.651
MOD_GlcNHglycan	54	58	PF01048	0.753
MOD_GlcNHglycan	97	100	PF01048	0.511
MOD_GSK3_1	106	113	PF00069	0.508
MOD_GSK3_1	15	22	PF00069	0.689
MOD_GSK3_1	49	56	PF00069	0.675
MOD_GSK3_1	59	66	PF00069	0.708
MOD_N-GLC_1	404	409	PF02516	0.413
MOD_NEK2_1	185	190	PF00069	0.430
MOD_NEK2_1	287	292	PF00069	0.449
MOD_NEK2_1	329	334	PF00069	0.344
MOD_NEK2_1	343	348	PF00069	0.319
MOD_PIKK_1	44	50	PF00454	0.686
MOD_PK_1	27	33	PF00069	0.528
MOD_PKB_1	25	33	PF00069	0.535
MOD_Plk_1	185	191	PF00069	0.505
MOD_Plk_2-3	397	403	PF00069	0.407
MOD_Plk_4	115	121	PF00069	0.519
MOD_Plk_4	287	293	PF00069	0.413
MOD_Plk_4	329	335	PF00069	0.418
MOD_Plk_4	36	42	PF00069	0.660
MOD_ProDKin_1	110	116	PF00069	0.563
MOD_ProDKin_1	281	287	PF00069	0.494
MOD_ProDKin_1	404	410	PF00069	0.449
MOD_SUMO_for_1	171	174	PF00179	0.495
MOD_SUMO_rev_2	174	184	PF00179	0.470
TRG_ENDOCYTIC_2	161	164	PF00928	0.392
TRG_ENDOCYTIC_2	178	181	PF00928	0.355
TRG_ENDOCYTIC_2	231	234	PF00928	0.549
TRG_ENDOCYTIC_2	333	336	PF00928	0.344
TRG_ER_diArg_1	25	28	PF00400	0.675
TRG_ER_diArg_1	278	280	PF00400	0.359
TRG_ER_diArg_1	361	364	PF00400	0.428
TRG_NES_CRM1_1	180	193	PF08389	0.397
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.465
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	399	403	PF00026	0.335
TRG_Pf-PMV_PEXEL_1	78	82	PF00026	0.563

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCA8	Leptomonas seymouri	72%	96%
A0A0S4IIG6	Bodo saltans	39%	100%
A0A1X0PAU4	Trypanosomatidae	58%	100%
A0A3R7KCS2	Trypanosoma rangeli	56%	100%
A0A3S7X8G8	Leishmania donovani	94%	100%
A4HB67	Leishmania braziliensis	84%	100%
A4IAB5	Leishmania infantum	94%	100%
C9ZLY1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9B5D8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5DM07	Trypanosoma cruzi	61%	100%