SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2J3_LEIMA

TriTrypDb:

LmjF.34.3510 , LMJLV39_340040800 , LMJSD75_340041100

Length:

329

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2J3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2J3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.593
CLV_C14_Caspase3-7	165	169	PF00656	0.548
CLV_NRD_NRD_1	12	14	PF00675	0.481
CLV_NRD_NRD_1	209	211	PF00675	0.420
CLV_NRD_NRD_1	291	293	PF00675	0.456
CLV_NRD_NRD_1	46	48	PF00675	0.440
CLV_NRD_NRD_1	99	101	PF00675	0.645
CLV_PCSK_KEX2_1	12	14	PF00082	0.479
CLV_PCSK_KEX2_1	209	211	PF00082	0.421
CLV_PCSK_KEX2_1	291	293	PF00082	0.456
CLV_PCSK_KEX2_1	46	48	PF00082	0.474
CLV_PCSK_PC7_1	42	48	PF00082	0.481
CLV_PCSK_SKI1_1	291	295	PF00082	0.468
CLV_PCSK_SKI1_1	307	311	PF00082	0.370
DEG_APCC_DBOX_1	129	137	PF00400	0.398
DEG_Nend_Nbox_1	1	3	PF02207	0.581
DOC_CYCLIN_RxL_1	287	298	PF00134	0.376
DOC_MAPK_gen_1	156	164	PF00069	0.349
DOC_PP1_RVXF_1	196	202	PF00149	0.370
DOC_PP1_RVXF_1	271	278	PF00149	0.608
DOC_USP7_MATH_1	110	114	PF00917	0.370
DOC_USP7_MATH_1	172	176	PF00917	0.597
DOC_USP7_MATH_1	219	223	PF00917	0.360
DOC_USP7_MATH_1	278	282	PF00917	0.576
DOC_WW_Pin1_4	124	129	PF00397	0.504
DOC_WW_Pin1_4	59	64	PF00397	0.644
DOC_WW_Pin1_4	93	98	PF00397	0.636
LIG_14-3-3_CanoR_1	107	114	PF00244	0.505
LIG_14-3-3_CanoR_1	307	317	PF00244	0.409
LIG_14-3-3_CanoR_1	68	74	PF00244	0.409
LIG_14-3-3_CanoR_1	81	87	PF00244	0.349
LIG_BIR_III_4	238	242	PF00653	0.413
LIG_deltaCOP1_diTrp_1	316	322	PF00928	0.332
LIG_eIF4E_1	24	30	PF01652	0.487
LIG_FHA_1	142	148	PF00498	0.612
LIG_FHA_1	270	276	PF00498	0.396
LIG_FHA_1	288	294	PF00498	0.436
LIG_FHA_1	72	78	PF00498	0.385
LIG_FHA_2	309	315	PF00498	0.418
LIG_LIR_Apic_2	21	27	PF02991	0.497
LIG_LIR_Gen_1	112	122	PF02991	0.483
LIG_LIR_Gen_1	19	30	PF02991	0.467
LIG_LIR_Gen_1	200	207	PF02991	0.363
LIG_LIR_Nem_3	112	117	PF02991	0.441
LIG_LIR_Nem_3	19	25	PF02991	0.407
LIG_LIR_Nem_3	200	204	PF02991	0.363
LIG_LIR_Nem_3	243	248	PF02991	0.371
LIG_LYPXL_S_1	244	248	PF13949	0.321
LIG_LYPXL_yS_3	245	248	PF13949	0.322
LIG_Pex14_1	26	30	PF04695	0.384
LIG_Pex14_1	318	322	PF04695	0.479
LIG_SH2_NCK_1	157	161	PF00017	0.460
LIG_SH2_PTP2	260	263	PF00017	0.450
LIG_SH2_STAP1	157	161	PF00017	0.448
LIG_SH2_STAT3	324	327	PF00017	0.338
LIG_SH2_STAT5	132	135	PF00017	0.397
LIG_SH2_STAT5	22	25	PF00017	0.443
LIG_SH2_STAT5	260	263	PF00017	0.496
LIG_SH2_STAT5	28	31	PF00017	0.386
LIG_SH2_STAT5	324	327	PF00017	0.393
LIG_SH2_STAT5	70	73	PF00017	0.470
LIG_SH3_2	125	130	PF14604	0.519
LIG_SH3_3	122	128	PF00018	0.470
LIG_SH3_3	70	76	PF00018	0.446
LIG_SH3_3	91	97	PF00018	0.533
LIG_WRC_WIRS_1	111	116	PF05994	0.255
MOD_CDC14_SPxK_1	127	130	PF00782	0.460
MOD_CDK_SPxK_1	124	130	PF00069	0.476
MOD_CDK_SPxxK_3	93	100	PF00069	0.476
MOD_CK1_1	93	99	PF00069	0.525
MOD_CK2_1	106	112	PF00069	0.507
MOD_CK2_1	277	283	PF00069	0.621
MOD_CK2_1	92	98	PF00069	0.469
MOD_GlcNHglycan	108	111	PF01048	0.456
MOD_GlcNHglycan	141	144	PF01048	0.512
MOD_GlcNHglycan	193	196	PF01048	0.533
MOD_GlcNHglycan	279	283	PF01048	0.594
MOD_GSK3_1	106	113	PF00069	0.536
MOD_GSK3_1	141	148	PF00069	0.573
MOD_GSK3_1	225	232	PF00069	0.332
MOD_GSK3_1	4	11	PF00069	0.567
MOD_GSK3_1	88	95	PF00069	0.450
MOD_GSK3_1	96	103	PF00069	0.624
MOD_NEK2_1	139	144	PF00069	0.551
MOD_NEK2_1	229	234	PF00069	0.452
MOD_NEK2_1	4	9	PF00069	0.579
MOD_NEK2_1	71	76	PF00069	0.407
MOD_NEK2_1	90	95	PF00069	0.281
MOD_PIKK_1	193	199	PF00454	0.360
MOD_PIKK_1	5	11	PF00454	0.588
MOD_PKA_1	100	106	PF00069	0.626
MOD_PKA_2	106	112	PF00069	0.463
MOD_Plk_1	18	24	PF00069	0.485
MOD_Plk_4	100	106	PF00069	0.574
MOD_Plk_4	18	24	PF00069	0.531
MOD_Plk_4	240	246	PF00069	0.402
MOD_ProDKin_1	124	130	PF00069	0.507
MOD_ProDKin_1	59	65	PF00069	0.641
MOD_ProDKin_1	93	99	PF00069	0.647
TRG_DiLeu_BaLyEn_6	243	248	PF01217	0.400
TRG_DiLeu_BaLyEn_6	281	286	PF01217	0.452
TRG_DiLeu_BaLyEn_6	289	294	PF01217	0.379
TRG_ENDOCYTIC_2	108	111	PF00928	0.487
TRG_ENDOCYTIC_2	132	135	PF00928	0.397
TRG_ENDOCYTIC_2	22	25	PF00928	0.404
TRG_ENDOCYTIC_2	245	248	PF00928	0.319
TRG_ENDOCYTIC_2	260	263	PF00928	0.468
TRG_ENDOCYTIC_2	70	73	PF00928	0.470
TRG_ER_diArg_1	12	14	PF00400	0.465
TRG_ER_diArg_1	209	211	PF00400	0.412
TRG_ER_diArg_1	291	293	PF00400	0.482
TRG_Pf-PMV_PEXEL_1	209	213	PF00026	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6T7	Leptomonas seymouri	71%	97%
A0A0S4KKV6	Bodo saltans	32%	95%
A0A1X0PAA6	Trypanosomatidae	44%	100%
A0A3S5IR23	Trypanosoma rangeli	50%	100%
A0A3S7X8A6	Leishmania donovani	95%	100%
A4HB69	Leishmania braziliensis	87%	100%
A4IAB7	Leishmania infantum	95%	100%
C9ZLX9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	99%
E9B5E0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BV68	Trypanosoma cruzi	50%	95%