LicD family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

LicD family protein

Gene product:

LicD family, putative

Species:

Leishmania major

UniProt:

Q4Q2J0_LEIMA

TriTrypDb:

LmjF.34.3540 , LMJLV39_340041600 , LMJSD75_340041900

Length:

224

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q2J0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2J0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	151	153	PF00675	0.487
CLV_PCSK_KEX2_1	140	142	PF00082	0.530
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.618
CLV_PCSK_PC7_1	136	142	PF00082	0.574
CLV_PCSK_SKI1_1	101	105	PF00082	0.503
CLV_PCSK_SKI1_1	141	145	PF00082	0.591
CLV_PCSK_SKI1_1	77	81	PF00082	0.593
DEG_SCF_FBW7_1	1	8	PF00400	0.632
DOC_PP1_RVXF_1	99	106	PF00149	0.292
DOC_PP2B_LxvP_1	216	219	PF13499	0.361
DOC_USP7_MATH_1	116	120	PF00917	0.396
DOC_USP7_MATH_1	143	147	PF00917	0.450
DOC_USP7_MATH_1	186	190	PF00917	0.416
DOC_WW_Pin1_4	1	6	PF00397	0.772
DOC_WW_Pin1_4	114	119	PF00397	0.396
LIG_14-3-3_CanoR_1	188	193	PF00244	0.320
LIG_BIR_II_1	1	5	PF00653	0.741
LIG_BRCT_BRCA1_1	181	185	PF00533	0.346
LIG_FHA_1	153	159	PF00498	0.283
LIG_FHA_1	163	169	PF00498	0.293
LIG_FHA_1	215	221	PF00498	0.302
LIG_FHA_2	11	17	PF00498	0.725
LIG_LIR_Gen_1	214	223	PF02991	0.345
LIG_LIR_Gen_1	50	56	PF02991	0.368
LIG_LIR_Nem_3	214	218	PF02991	0.340
LIG_LIR_Nem_3	50	54	PF02991	0.330
LIG_SH2_STAP1	163	167	PF00017	0.295
LIG_SH2_STAT3	206	209	PF00017	0.368
LIG_SH2_STAT5	206	209	PF00017	0.323
LIG_SH2_STAT5	56	59	PF00017	0.395
LIG_SH2_STAT5	61	64	PF00017	0.343
LIG_SH3_3	110	116	PF00018	0.361
LIG_SH3_3	18	24	PF00018	0.729
MOD_CDK_SPK_2	1	6	PF00069	0.634
MOD_CK1_1	117	123	PF00069	0.408
MOD_CK1_1	179	185	PF00069	0.341
MOD_CK1_1	50	56	PF00069	0.410
MOD_GlcNHglycan	124	127	PF01048	0.575
MOD_GlcNHglycan	192	195	PF01048	0.575
MOD_GlcNHglycan	65	68	PF01048	0.557
MOD_GSK3_1	1	8	PF00069	0.672
MOD_GSK3_1	186	193	PF00069	0.435
MOD_GSK3_1	89	96	PF00069	0.297
MOD_N-GLC_1	168	173	PF02516	0.471
MOD_N-GLC_1	89	94	PF02516	0.493
MOD_NEK2_1	162	167	PF00069	0.277
MOD_NEK2_1	35	40	PF00069	0.339
MOD_NEK2_1	89	94	PF00069	0.338
MOD_PKA_1	152	158	PF00069	0.339
MOD_PKA_2	63	69	PF00069	0.370
MOD_Plk_1	163	169	PF00069	0.297
MOD_Plk_1	28	34	PF00069	0.612
MOD_Plk_4	163	169	PF00069	0.329
MOD_Plk_4	89	95	PF00069	0.270
MOD_ProDKin_1	1	7	PF00069	0.772
MOD_ProDKin_1	114	120	PF00069	0.394
TRG_DiLeu_BaLyEn_6	216	221	PF01217	0.348
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P990	Leptomonas seymouri	62%	100%
A0A0S4JMC1	Bodo saltans	38%	100%
A0A1X0PAV6	Trypanosomatidae	55%	100%
A0A3S7X8D8	Leishmania donovani	95%	100%
A0A422MZF8	Trypanosoma rangeli	51%	100%
A4HB72	Leishmania braziliensis	77%	100%
A4IAC0	Leishmania infantum	95%	100%
C9ZLX2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9B5E3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%