PDCD2_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Programmed cell death protein 2, C-terminal putative domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q2I9_LEIMA

TriTrypDb:

LmjF.34.3550 , LMJLV39_340041700 , LMJSD75_340042000

Length:

408

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4Q2I9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2I9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	95	97	PF00675	0.564
CLV_PCSK_KEX2_1	95	97	PF00082	0.487
CLV_PCSK_SKI1_1	16	20	PF00082	0.466
CLV_PCSK_SKI1_1	197	201	PF00082	0.660
CLV_PCSK_SKI1_1	232	236	PF00082	0.506
DEG_SCF_FBW7_1	318	325	PF00400	0.307
DOC_CKS1_1	11	16	PF01111	0.372
DOC_CYCLIN_yCln2_LP_2	354	360	PF00134	0.257
DOC_PP2B_LxvP_1	337	340	PF13499	0.455
DOC_PP2B_LxvP_1	354	357	PF13499	0.234
DOC_PP4_FxxP_1	57	60	PF00568	0.314
DOC_USP7_MATH_1	125	129	PF00917	0.537
DOC_USP7_MATH_1	135	139	PF00917	0.281
DOC_USP7_MATH_1	228	232	PF00917	0.580
DOC_USP7_MATH_1	26	30	PF00917	0.428
DOC_USP7_MATH_1	271	275	PF00917	0.553
DOC_USP7_MATH_1	66	70	PF00917	0.440
DOC_USP7_MATH_1	99	103	PF00917	0.638
DOC_WW_Pin1_4	10	15	PF00397	0.356
DOC_WW_Pin1_4	199	204	PF00397	0.736
DOC_WW_Pin1_4	217	222	PF00397	0.653
DOC_WW_Pin1_4	306	311	PF00397	0.429
DOC_WW_Pin1_4	318	323	PF00397	0.179
DOC_WW_Pin1_4	325	330	PF00397	0.278
LIG_14-3-3_CanoR_1	127	133	PF00244	0.528
LIG_14-3-3_CanoR_1	232	237	PF00244	0.545
LIG_14-3-3_CanoR_1	324	329	PF00244	0.293
LIG_14-3-3_CanoR_1	98	104	PF00244	0.521
LIG_Actin_WH2_2	311	326	PF00022	0.176
LIG_APCC_ABBA_1	249	254	PF00400	0.387
LIG_BIR_II_1	1	5	PF00653	0.555
LIG_BRCT_BRCA1_1	130	134	PF00533	0.297
LIG_BRCT_BRCA1_1	137	141	PF00533	0.308
LIG_BRCT_BRCA1_1	53	57	PF00533	0.433
LIG_deltaCOP1_diTrp_1	179	189	PF00928	0.659
LIG_FHA_1	233	239	PF00498	0.496
LIG_FHA_1	242	248	PF00498	0.375
LIG_FHA_1	258	264	PF00498	0.567
LIG_FHA_1	26	32	PF00498	0.327
LIG_FHA_1	325	331	PF00498	0.298
LIG_FHA_1	353	359	PF00498	0.254
LIG_FHA_1	361	367	PF00498	0.227
LIG_FHA_1	63	69	PF00498	0.401
LIG_FHA_2	159	165	PF00498	0.598
LIG_FHA_2	17	23	PF00498	0.484
LIG_FHA_2	218	224	PF00498	0.657
LIG_LIR_Apic_2	250	255	PF02991	0.422
LIG_LIR_Apic_2	54	60	PF02991	0.330
LIG_LIR_Gen_1	144	153	PF02991	0.514
LIG_LIR_Gen_1	400	408	PF02991	0.277
LIG_LIR_Gen_1	79	88	PF02991	0.328
LIG_LIR_Nem_3	144	149	PF02991	0.474
LIG_LIR_Nem_3	400	404	PF02991	0.277
LIG_LIR_Nem_3	79	84	PF02991	0.343
LIG_MLH1_MIPbox_1	53	57	PF16413	0.456
LIG_PDZ_Class_3	403	408	PF00595	0.388
LIG_SH2_CRK	81	85	PF00017	0.287
LIG_SH2_NCK_1	252	256	PF00017	0.485
LIG_SH2_PTP2	401	404	PF00017	0.387
LIG_SH2_SRC	252	255	PF00017	0.553
LIG_SH2_STAP1	27	31	PF00017	0.347
LIG_SH2_STAP1	81	85	PF00017	0.287
LIG_SH2_STAT5	243	246	PF00017	0.493
LIG_SH2_STAT5	27	30	PF00017	0.355
LIG_SH2_STAT5	361	364	PF00017	0.308
LIG_SH2_STAT5	37	40	PF00017	0.347
LIG_SH2_STAT5	382	385	PF00017	0.297
LIG_SH2_STAT5	397	400	PF00017	0.191
LIG_SH2_STAT5	401	404	PF00017	0.138
LIG_SH2_STAT5	56	59	PF00017	0.465
LIG_SH2_STAT5	86	89	PF00017	0.277
LIG_SH3_1	200	206	PF00018	0.617
LIG_SH3_3	104	110	PF00018	0.558
LIG_SH3_3	200	206	PF00018	0.725
LIG_SH3_3	222	228	PF00018	0.585
LIG_SH3_3	336	342	PF00018	0.273
LIG_SH3_3	393	399	PF00018	0.387
LIG_SH3_3	71	77	PF00018	0.378
LIG_SUMO_SIM_par_1	247	254	PF11976	0.415
LIG_SUMO_SIM_par_1	76	82	PF11976	0.319
LIG_TRAF2_1	264	267	PF00917	0.595
LIG_TRAF2_1	293	296	PF00917	0.456
MOD_CDK_SPxK_1	10	16	PF00069	0.434
MOD_CDK_SPxK_1	318	324	PF00069	0.307
MOD_CK1_1	117	123	PF00069	0.721
MOD_CK1_1	128	134	PF00069	0.412
MOD_CK2_1	158	164	PF00069	0.639
MOD_CK2_1	199	205	PF00069	0.558
MOD_CK2_1	217	223	PF00069	0.613
MOD_CK2_1	261	267	PF00069	0.568
MOD_CK2_1	282	288	PF00069	0.560
MOD_CK2_1	40	46	PF00069	0.494
MOD_GlcNHglycan	1	4	PF01048	0.613
MOD_GlcNHglycan	119	122	PF01048	0.741
MOD_GlcNHglycan	244	247	PF01048	0.417
MOD_GlcNHglycan	278	281	PF01048	0.618
MOD_GlcNHglycan	283	287	PF01048	0.622
MOD_GlcNHglycan	48	51	PF01048	0.580
MOD_GSK3_1	110	117	PF00069	0.558
MOD_GSK3_1	135	142	PF00069	0.382
MOD_GSK3_1	16	23	PF00069	0.431
MOD_GSK3_1	228	235	PF00069	0.490
MOD_GSK3_1	238	245	PF00069	0.505
MOD_GSK3_1	257	264	PF00069	0.381
MOD_GSK3_1	271	278	PF00069	0.597
MOD_GSK3_1	318	325	PF00069	0.367
MOD_GSK3_1	62	69	PF00069	0.399
MOD_GSK3_1	99	106	PF00069	0.656
MOD_N-GLC_1	139	144	PF02516	0.466
MOD_N-GLC_1	332	337	PF02516	0.263
MOD_NEK2_1	103	108	PF00069	0.647
MOD_NEK2_1	238	243	PF00069	0.399
MOD_NEK2_1	275	280	PF00069	0.614
MOD_NEK2_1	282	287	PF00069	0.660
MOD_NEK2_1	323	328	PF00069	0.276
MOD_NEK2_1	352	357	PF00069	0.238
MOD_NEK2_1	374	379	PF00069	0.274
MOD_NEK2_1	380	385	PF00069	0.258
MOD_NEK2_1	40	45	PF00069	0.482
MOD_NEK2_2	271	276	PF00069	0.485
MOD_PIKK_1	135	141	PF00454	0.311
MOD_PIKK_1	308	314	PF00454	0.242
MOD_PK_1	261	267	PF00069	0.626
MOD_PKA_2	158	164	PF00069	0.482
MOD_PKA_2	323	329	PF00069	0.291
MOD_Plk_1	261	267	PF00069	0.613
MOD_Plk_2-3	188	194	PF00069	0.577
MOD_Plk_4	238	244	PF00069	0.414
MOD_Plk_4	271	277	PF00069	0.544
MOD_Plk_4	66	72	PF00069	0.296
MOD_ProDKin_1	10	16	PF00069	0.374
MOD_ProDKin_1	199	205	PF00069	0.735
MOD_ProDKin_1	217	223	PF00069	0.652
MOD_ProDKin_1	306	312	PF00069	0.429
MOD_ProDKin_1	318	324	PF00069	0.179
MOD_ProDKin_1	325	331	PF00069	0.278
MOD_SUMO_rev_2	192	202	PF00179	0.592
MOD_SUMO_rev_2	365	372	PF00179	0.304
TRG_ENDOCYTIC_2	37	40	PF00928	0.515
TRG_ENDOCYTIC_2	401	404	PF00928	0.276
TRG_ENDOCYTIC_2	75	78	PF00928	0.345
TRG_ENDOCYTIC_2	81	84	PF00928	0.324
TRG_ER_diArg_1	95	98	PF00400	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYV7	Leptomonas seymouri	63%	100%
A0A0S4JQH8	Bodo saltans	30%	100%
A0A1X0PA07	Trypanosomatidae	35%	100%
A0A3R7N1R1	Trypanosoma rangeli	35%	100%
A0A3S7X8B9	Leishmania donovani	91%	100%
A4HB73	Leishmania braziliensis	76%	100%
A4IAC1	Leishmania infantum	91%	100%
C9ZLX1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B5E4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
P87156	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q5ZID2	Gallus gallus	24%	100%
Q8C5N5	Mus musculus	24%	100%
V5DMW4	Trypanosoma cruzi	34%	100%