ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies)/Ankyrin repeats (many copies), putative

Species:

Leishmania major

UniProt:

Q4Q2I8_LEIMA

TriTrypDb:

LmjF.34.3560 , LMJLV39_340041800 , LMJSD75_340042100

Length:

341

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 14
NetGPI	no	yes: 0, no: 15

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2I8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2I8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.343
CLV_NRD_NRD_1	235	237	PF00675	0.536
CLV_NRD_NRD_1	262	264	PF00675	0.595
CLV_NRD_NRD_1	90	92	PF00675	0.428
CLV_PCSK_KEX2_1	234	236	PF00082	0.538
CLV_PCSK_KEX2_1	262	264	PF00082	0.595
CLV_PCSK_SKI1_1	16	20	PF00082	0.463
CLV_PCSK_SKI1_1	196	200	PF00082	0.501
DEG_COP1_1	250	259	PF00400	0.681
DOC_CKS1_1	136	141	PF01111	0.323
DOC_MAPK_gen_1	132	142	PF00069	0.336
DOC_MAPK_gen_1	179	188	PF00069	0.251
DOC_MAPK_MEF2A_6	148	156	PF00069	0.382
DOC_MAPK_MEF2A_6	179	188	PF00069	0.251
DOC_MAPK_MEF2A_6	247	256	PF00069	0.555
DOC_USP7_MATH_1	212	216	PF00917	0.492
DOC_USP7_MATH_1	274	278	PF00917	0.495
DOC_WW_Pin1_4	135	140	PF00397	0.284
DOC_WW_Pin1_4	168	173	PF00397	0.312
DOC_WW_Pin1_4	282	287	PF00397	0.719
DOC_WW_Pin1_4	45	50	PF00397	0.346
DOC_WW_Pin1_4	68	73	PF00397	0.290
LIG_14-3-3_CanoR_1	16	26	PF00244	0.396
LIG_14-3-3_CanoR_1	234	244	PF00244	0.662
LIG_Actin_WH2_2	180	198	PF00022	0.360
LIG_BIR_II_1	1	5	PF00653	0.505
LIG_FHA_1	149	155	PF00498	0.379
LIG_FHA_1	305	311	PF00498	0.603
LIG_FHA_2	189	195	PF00498	0.226
LIG_FHA_2	311	317	PF00498	0.574
LIG_FHA_2	65	71	PF00498	0.238
LIG_LIR_Apic_2	280	286	PF02991	0.499
LIG_LIR_Apic_2	334	339	PF02991	0.552
LIG_LIR_Gen_1	150	160	PF02991	0.323
LIG_LIR_Gen_1	71	82	PF02991	0.394
LIG_LIR_Nem_3	150	156	PF02991	0.289
LIG_LIR_Nem_3	178	184	PF02991	0.350
LIG_LIR_Nem_3	32	38	PF02991	0.303
LIG_LIR_Nem_3	71	77	PF02991	0.389
LIG_NRBOX	118	124	PF00104	0.327
LIG_SH2_CRK	283	287	PF00017	0.592
LIG_SH2_CRK	336	340	PF00017	0.650
LIG_SH2_NCK_1	283	287	PF00017	0.535
LIG_SH2_NCK_1	336	340	PF00017	0.531
LIG_SH2_PTP2	35	38	PF00017	0.298
LIG_SH2_PTP2	74	77	PF00017	0.382
LIG_SH2_SRC	336	339	PF00017	0.594
LIG_SH2_SRC	87	90	PF00017	0.262
LIG_SH2_STAT5	141	144	PF00017	0.356
LIG_SH2_STAT5	153	156	PF00017	0.323
LIG_SH2_STAT5	174	177	PF00017	0.224
LIG_SH2_STAT5	35	38	PF00017	0.302
LIG_SH2_STAT5	39	42	PF00017	0.270
LIG_SH2_STAT5	74	77	PF00017	0.243
LIG_SH2_STAT5	87	90	PF00017	0.252
LIG_SH3_3	253	259	PF00018	0.576
LIG_SH3_3	284	290	PF00018	0.567
LIG_SH3_3	95	101	PF00018	0.262
LIG_TRAF2_1	134	137	PF00917	0.359
LIG_TRAF2_1	277	280	PF00917	0.503
MOD_CK1_1	285	291	PF00069	0.676
MOD_CK1_1	45	51	PF00069	0.292
MOD_CK1_1	68	74	PF00069	0.194
MOD_CK2_1	174	180	PF00069	0.262
MOD_CK2_1	274	280	PF00069	0.523
MOD_CK2_1	310	316	PF00069	0.691
MOD_CK2_1	64	70	PF00069	0.300
MOD_GlcNHglycan	123	126	PF01048	0.323
MOD_GlcNHglycan	19	22	PF01048	0.436
MOD_GlcNHglycan	215	218	PF01048	0.499
MOD_GlcNHglycan	237	240	PF01048	0.595
MOD_GlcNHglycan	67	70	PF01048	0.374
MOD_GSK3_1	117	124	PF00069	0.360
MOD_GSK3_1	197	204	PF00069	0.588
MOD_GSK3_1	64	71	PF00069	0.273
MOD_NEK2_1	188	193	PF00069	0.214
MOD_NEK2_1	213	218	PF00069	0.488
MOD_NEK2_1	43	48	PF00069	0.328
MOD_NEK2_1	73	78	PF00069	0.390
MOD_PK_1	324	330	PF00069	0.544
MOD_PKA_1	234	240	PF00069	0.530
MOD_PKA_2	102	108	PF00069	0.400
MOD_PKA_2	234	240	PF00069	0.664
MOD_PKA_2	299	305	PF00069	0.580
MOD_PKA_2	64	70	PF00069	0.391
MOD_Plk_4	148	154	PF00069	0.402
MOD_Plk_4	305	311	PF00069	0.599
MOD_ProDKin_1	135	141	PF00069	0.284
MOD_ProDKin_1	168	174	PF00069	0.312
MOD_ProDKin_1	282	288	PF00069	0.723
MOD_ProDKin_1	45	51	PF00069	0.346
MOD_ProDKin_1	68	74	PF00069	0.290
MOD_SUMO_rev_2	167	172	PF00179	0.252
MOD_SUMO_rev_2	177	184	PF00179	0.254
TRG_DiLeu_BaEn_4	53	59	PF01217	0.346
TRG_ENDOCYTIC_2	153	156	PF00928	0.282
TRG_ENDOCYTIC_2	181	184	PF00928	0.382
TRG_ENDOCYTIC_2	35	38	PF00928	0.303
TRG_ENDOCYTIC_2	74	77	PF00928	0.393
TRG_ER_diArg_1	206	209	PF00400	0.528
TRG_ER_diArg_1	233	236	PF00400	0.519
TRG_ER_diArg_1	261	263	PF00400	0.768
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB55	Leptomonas seymouri	67%	100%
A0A0S4IZ37	Bodo saltans	28%	93%
A0A1X0PAB8	Trypanosomatidae	47%	100%
A0A3Q8IFT3	Leishmania donovani	93%	100%
A0A3R7RA24	Trypanosoma rangeli	44%	100%
A0A3S7WRN0	Leishmania donovani	27%	100%
A4HB74	Leishmania braziliensis	86%	100%
A4HUX9	Leishmania infantum	27%	100%
A4IAC2	Leishmania infantum	93%	100%
C9ZLX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B1A1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	83%
E9B5E5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QH09	Leishmania major	27%	100%
V5B6C0	Trypanosoma cruzi	49%	93%