Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2I6_LEIMA

TriTrypDb:

LmjF.34.3580 , LMJLV39_340042000 , LMJSD75_340042300

Length:

870

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	3
GO:0120025	plasma membrane bounded cell projection	3	2
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q2I6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2I6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.414
CLV_C14_Caspase3-7	537	541	PF00656	0.653
CLV_C14_Caspase3-7	572	576	PF00656	0.593
CLV_NRD_NRD_1	244	246	PF00675	0.491
CLV_NRD_NRD_1	732	734	PF00675	0.561
CLV_NRD_NRD_1	783	785	PF00675	0.533
CLV_NRD_NRD_1	795	797	PF00675	0.513
CLV_PCSK_KEX2_1	732	734	PF00082	0.523
CLV_PCSK_KEX2_1	785	787	PF00082	0.571
CLV_PCSK_KEX2_1	795	797	PF00082	0.528
CLV_PCSK_PC1ET2_1	785	787	PF00082	0.560
CLV_PCSK_SKI1_1	10	14	PF00082	0.488
CLV_PCSK_SKI1_1	263	267	PF00082	0.409
CLV_PCSK_SKI1_1	343	347	PF00082	0.343
CLV_PCSK_SKI1_1	376	380	PF00082	0.536
CLV_PCSK_SKI1_1	556	560	PF00082	0.470
CLV_PCSK_SKI1_1	796	800	PF00082	0.616
CLV_Separin_Metazoa	21	25	PF03568	0.459
DEG_APCC_DBOX_1	654	662	PF00400	0.349
DEG_MDM2_SWIB_1	468	475	PF02201	0.581
DEG_SCF_FBW7_1	550	557	PF00400	0.490
DEG_SCF_FBW7_1	614	621	PF00400	0.480
DOC_CDC14_PxL_1	773	781	PF14671	0.526
DOC_CKS1_1	551	556	PF01111	0.485
DOC_CYCLIN_RxL_1	729	740	PF00134	0.537
DOC_MAPK_gen_1	732	738	PF00069	0.503
DOC_MAPK_MEF2A_6	394	402	PF00069	0.424
DOC_MAPK_MEF2A_6	556	564	PF00069	0.460
DOC_PP1_RVXF_1	641	648	PF00149	0.485
DOC_PP1_RVXF_1	8	14	PF00149	0.497
DOC_PP2B_LxvP_1	447	450	PF13499	0.473
DOC_PP2B_LxvP_1	513	516	PF13499	0.482
DOC_PP2B_LxvP_1	605	608	PF13499	0.386
DOC_PP2B_LxvP_1	809	812	PF13499	0.645
DOC_PP2B_LxvP_1	863	866	PF13499	0.661
DOC_PP4_FxxP_1	195	198	PF00568	0.402
DOC_USP7_MATH_1	113	117	PF00917	0.611
DOC_USP7_MATH_1	366	370	PF00917	0.507
DOC_USP7_MATH_1	422	426	PF00917	0.584
DOC_USP7_MATH_1	489	493	PF00917	0.490
DOC_USP7_MATH_1	554	558	PF00917	0.463
DOC_USP7_MATH_1	618	622	PF00917	0.532
DOC_USP7_MATH_1	625	629	PF00917	0.526
DOC_USP7_MATH_1	692	696	PF00917	0.737
DOC_USP7_MATH_1	737	741	PF00917	0.482
DOC_USP7_MATH_1	80	84	PF00917	0.697
DOC_USP7_MATH_2	2	8	PF00917	0.486
DOC_WW_Pin1_4	301	306	PF00397	0.618
DOC_WW_Pin1_4	550	555	PF00397	0.382
DOC_WW_Pin1_4	592	597	PF00397	0.431
DOC_WW_Pin1_4	614	619	PF00397	0.459
DOC_WW_Pin1_4	683	688	PF00397	0.500
DOC_WW_Pin1_4	759	764	PF00397	0.634
DOC_WW_Pin1_4	810	815	PF00397	0.687
LIG_14-3-3_CanoR_1	145	155	PF00244	0.375
LIG_14-3-3_CanoR_1	197	205	PF00244	0.377
LIG_14-3-3_CanoR_1	252	258	PF00244	0.457
LIG_14-3-3_CanoR_1	27	35	PF00244	0.426
LIG_14-3-3_CanoR_1	343	352	PF00244	0.331
LIG_14-3-3_CanoR_1	376	381	PF00244	0.479
LIG_14-3-3_CanoR_1	423	430	PF00244	0.487
LIG_14-3-3_CanoR_1	486	492	PF00244	0.547
LIG_14-3-3_CanoR_1	556	561	PF00244	0.469
LIG_14-3-3_CanoR_1	60	64	PF00244	0.405
LIG_14-3-3_CanoR_1	795	803	PF00244	0.610
LIG_14-3-3_CanoR_1	85	90	PF00244	0.598
LIG_Actin_WH2_2	350	365	PF00022	0.352
LIG_Actin_WH2_2	47	62	PF00022	0.290
LIG_Actin_WH2_2	8	26	PF00022	0.495
LIG_APCC_ABBA_1	330	335	PF00400	0.568
LIG_BIR_III_2	264	268	PF00653	0.385
LIG_BRCT_BRCA1_1	128	132	PF00533	0.437
LIG_BRCT_BRCA1_1	430	434	PF00533	0.617
LIG_BRCT_BRCA1_1	83	87	PF00533	0.610
LIG_BRCT_BRCA1_1	99	103	PF00533	0.468
LIG_CaM_IQ_9	146	162	PF13499	0.334
LIG_CaM_NSCaTE_8	33	40	PF13499	0.475
LIG_deltaCOP1_diTrp_1	31	36	PF00928	0.474
LIG_deltaCOP1_diTrp_1	4	13	PF00928	0.409
LIG_deltaCOP1_diTrp_1	471	474	PF00928	0.386
LIG_EH1_1	229	237	PF00400	0.391
LIG_EVH1_1	817	821	PF00568	0.693
LIG_FHA_1	183	189	PF00498	0.528
LIG_FHA_1	191	197	PF00498	0.489
LIG_FHA_1	236	242	PF00498	0.434
LIG_FHA_1	273	279	PF00498	0.474
LIG_FHA_1	317	323	PF00498	0.425
LIG_FHA_1	327	333	PF00498	0.407
LIG_FHA_1	344	350	PF00498	0.254
LIG_FHA_1	557	563	PF00498	0.425
LIG_FHA_1	593	599	PF00498	0.444
LIG_FHA_1	609	615	PF00498	0.385
LIG_FHA_1	704	710	PF00498	0.365
LIG_FHA_1	795	801	PF00498	0.631
LIG_FHA_2	437	443	PF00498	0.753
LIG_FHA_2	506	512	PF00498	0.368
LIG_FHA_2	535	541	PF00498	0.551
LIG_FHA_2	570	576	PF00498	0.690
LIG_FHA_2	778	784	PF00498	0.510
LIG_GBD_Chelix_1	227	235	PF00786	0.400
LIG_LIR_Apic_2	193	198	PF02991	0.443
LIG_LIR_Gen_1	133	142	PF02991	0.360
LIG_LIR_Gen_1	149	157	PF02991	0.325
LIG_LIR_Gen_1	31	40	PF02991	0.432
LIG_LIR_Gen_1	315	326	PF02991	0.379
LIG_LIR_Gen_1	374	385	PF02991	0.535
LIG_LIR_Gen_1	399	407	PF02991	0.412
LIG_LIR_Gen_1	470	476	PF02991	0.600
LIG_LIR_Gen_1	671	680	PF02991	0.582
LIG_LIR_Gen_1	704	713	PF02991	0.370
LIG_LIR_Gen_1	840	851	PF02991	0.632
LIG_LIR_Nem_3	129	135	PF02991	0.365
LIG_LIR_Nem_3	149	155	PF02991	0.245
LIG_LIR_Nem_3	255	261	PF02991	0.374
LIG_LIR_Nem_3	264	269	PF02991	0.332
LIG_LIR_Nem_3	31	36	PF02991	0.382
LIG_LIR_Nem_3	315	321	PF02991	0.386
LIG_LIR_Nem_3	374	380	PF02991	0.529
LIG_LIR_Nem_3	386	391	PF02991	0.421
LIG_LIR_Nem_3	399	404	PF02991	0.375
LIG_LIR_Nem_3	47	53	PF02991	0.304
LIG_LIR_Nem_3	470	475	PF02991	0.593
LIG_LIR_Nem_3	553	558	PF02991	0.426
LIG_LIR_Nem_3	6	12	PF02991	0.392
LIG_LIR_Nem_3	671	675	PF02991	0.547
LIG_LIR_Nem_3	704	708	PF02991	0.383
LIG_LIR_Nem_3	832	837	PF02991	0.638
LIG_LIR_Nem_3	840	846	PF02991	0.640
LIG_LYPXL_S_1	387	391	PF13949	0.487
LIG_LYPXL_yS_3	388	391	PF13949	0.497
LIG_PAM2_1	657	669	PF00658	0.443
LIG_Pex14_1	9	13	PF04695	0.359
LIG_Pex14_2	195	199	PF04695	0.485
LIG_Pex14_2	468	472	PF04695	0.560
LIG_Pex14_2	87	91	PF04695	0.470
LIG_PTB_Apo_2	764	771	PF02174	0.451
LIG_PTB_Phospho_1	764	770	PF10480	0.454
LIG_RPA_C_Fungi	483	495	PF08784	0.484
LIG_SH2_CRK	377	381	PF00017	0.416
LIG_SH2_CRK	766	770	PF00017	0.517
LIG_SH2_CRK	834	838	PF00017	0.485
LIG_SH2_NCK_1	247	251	PF00017	0.389
LIG_SH2_NCK_1	377	381	PF00017	0.509
LIG_SH2_NCK_1	766	770	PF00017	0.517
LIG_SH2_STAP1	333	337	PF00017	0.455
LIG_SH2_STAT5	190	193	PF00017	0.382
LIG_SH2_STAT5	372	375	PF00017	0.583
LIG_SH2_STAT5	778	781	PF00017	0.657
LIG_SH3_2	728	733	PF14604	0.533
LIG_SH3_3	308	314	PF00018	0.596
LIG_SH3_3	334	340	PF00018	0.472
LIG_SH3_3	414	420	PF00018	0.779
LIG_SH3_3	512	518	PF00018	0.427
LIG_SH3_3	597	603	PF00018	0.422
LIG_SH3_3	725	731	PF00018	0.412
LIG_SH3_3	812	818	PF00018	0.589
LIG_SUMO_SIM_par_1	168	177	PF11976	0.374
LIG_SUMO_SIM_par_1	323	329	PF11976	0.325
LIG_SUMO_SIM_par_1	50	55	PF11976	0.479
LIG_TRAF2_1	542	545	PF00917	0.378
LIG_UBA3_1	240	246	PF00899	0.404
LIG_WRC_WIRS_1	349	354	PF05994	0.368
LIG_WRC_WIRS_1	693	698	PF05994	0.583
LIG_WRC_WIRS_1	702	707	PF05994	0.333
LIG_WW_2	818	821	PF00397	0.634
LIG_WW_3	601	605	PF00397	0.388
MOD_CDK_SPxK_1	550	556	PF00069	0.481
MOD_CK1_1	312	318	PF00069	0.486
MOD_CK1_1	487	493	PF00069	0.697
MOD_CK1_1	678	684	PF00069	0.678
MOD_CK1_1	81	87	PF00069	0.748
MOD_CK1_1	813	819	PF00069	0.774
MOD_CK1_1	90	96	PF00069	0.507
MOD_CK1_1	97	103	PF00069	0.463
MOD_CK2_1	15	21	PF00069	0.360
MOD_CK2_1	348	354	PF00069	0.374
MOD_CK2_1	436	442	PF00069	0.756
MOD_CK2_1	470	476	PF00069	0.607
MOD_CK2_1	505	511	PF00069	0.521
MOD_CK2_1	59	65	PF00069	0.512
MOD_CK2_1	692	698	PF00069	0.630
MOD_CK2_1	777	783	PF00069	0.634
MOD_CK2_1	799	805	PF00069	0.621
MOD_GlcNHglycan	105	108	PF01048	0.624
MOD_GlcNHglycan	113	116	PF01048	0.561
MOD_GlcNHglycan	121	124	PF01048	0.443
MOD_GlcNHglycan	132	135	PF01048	0.280
MOD_GlcNHglycan	168	171	PF01048	0.552
MOD_GlcNHglycan	176	179	PF01048	0.439
MOD_GlcNHglycan	38	41	PF01048	0.387
MOD_GlcNHglycan	620	623	PF01048	0.653
MOD_GlcNHglycan	627	630	PF01048	0.644
MOD_GlcNHglycan	635	638	PF01048	0.326
MOD_GlcNHglycan	687	690	PF01048	0.748
MOD_GlcNHglycan	746	749	PF01048	0.596
MOD_GSK3_1	103	110	PF00069	0.695
MOD_GSK3_1	126	133	PF00069	0.429
MOD_GSK3_1	146	153	PF00069	0.223
MOD_GSK3_1	184	191	PF00069	0.415
MOD_GSK3_1	231	238	PF00069	0.294
MOD_GSK3_1	312	319	PF00069	0.440
MOD_GSK3_1	429	436	PF00069	0.665
MOD_GSK3_1	550	557	PF00069	0.450
MOD_GSK3_1	575	582	PF00069	0.576
MOD_GSK3_1	608	615	PF00069	0.527
MOD_GSK3_1	737	744	PF00069	0.544
MOD_GSK3_1	746	753	PF00069	0.606
MOD_GSK3_1	81	88	PF00069	0.691
MOD_GSK3_1	829	836	PF00069	0.720
MOD_GSK3_1	90	97	PF00069	0.689
MOD_N-GLC_1	107	112	PF02516	0.731
MOD_N-GLC_2	478	480	PF02516	0.549
MOD_NEK2_1	103	108	PF00069	0.710
MOD_NEK2_1	130	135	PF00069	0.287
MOD_NEK2_1	184	189	PF00069	0.416
MOD_NEK2_1	235	240	PF00069	0.419
MOD_NEK2_1	299	304	PF00069	0.508
MOD_NEK2_1	326	331	PF00069	0.432
MOD_NEK2_1	35	40	PF00069	0.352
MOD_NEK2_1	484	489	PF00069	0.740
MOD_NEK2_1	59	64	PF00069	0.361
MOD_NEK2_1	676	681	PF00069	0.627
MOD_NEK2_1	736	741	PF00069	0.563
MOD_NEK2_1	799	804	PF00069	0.660
MOD_NEK2_1	87	92	PF00069	0.660
MOD_NEK2_2	383	388	PF00069	0.392
MOD_NEK2_2	608	613	PF00069	0.393
MOD_PIKK_1	146	152	PF00454	0.360
MOD_PIKK_1	198	204	PF00454	0.389
MOD_PIKK_1	206	212	PF00454	0.429
MOD_PIKK_1	612	618	PF00454	0.562
MOD_PIKK_1	829	835	PF00454	0.567
MOD_PIKK_1	91	97	PF00454	0.461
MOD_PKA_1	786	792	PF00069	0.587
MOD_PKA_2	118	124	PF00069	0.591
MOD_PKA_2	150	156	PF00069	0.398
MOD_PKA_2	174	180	PF00069	0.486
MOD_PKA_2	251	257	PF00069	0.423
MOD_PKA_2	26	32	PF00069	0.397
MOD_PKA_2	422	428	PF00069	0.701
MOD_PKA_2	487	493	PF00069	0.504
MOD_PKA_2	59	65	PF00069	0.404
MOD_PKA_2	794	800	PF00069	0.603
MOD_PKB_1	784	792	PF00069	0.501
MOD_Plk_1	4	10	PF00069	0.562
MOD_Plk_1	436	442	PF00069	0.642
MOD_Plk_1	443	449	PF00069	0.641
MOD_Plk_1	470	476	PF00069	0.607
MOD_Plk_4	191	197	PF00069	0.413
MOD_Plk_4	231	237	PF00069	0.276
MOD_Plk_4	306	312	PF00069	0.598
MOD_Plk_4	326	332	PF00069	0.191
MOD_Plk_4	383	389	PF00069	0.387
MOD_Plk_4	396	402	PF00069	0.333
MOD_Plk_4	429	435	PF00069	0.573
MOD_Plk_4	522	528	PF00069	0.485
MOD_Plk_4	608	614	PF00069	0.408
MOD_Plk_4	711	717	PF00069	0.328
MOD_Plk_4	94	100	PF00069	0.556
MOD_ProDKin_1	301	307	PF00069	0.610
MOD_ProDKin_1	550	556	PF00069	0.386
MOD_ProDKin_1	592	598	PF00069	0.431
MOD_ProDKin_1	614	620	PF00069	0.469
MOD_ProDKin_1	683	689	PF00069	0.501
MOD_ProDKin_1	759	765	PF00069	0.632
MOD_ProDKin_1	810	816	PF00069	0.690
TRG_DiLeu_BaEn_1	179	184	PF01217	0.602
TRG_DiLeu_BaEn_2	697	703	PF01217	0.385
TRG_DiLeu_BaLyEn_6	601	606	PF01217	0.538
TRG_DiLeu_BaLyEn_6	7	12	PF01217	0.516
TRG_ENDOCYTIC_2	258	261	PF00928	0.454
TRG_ENDOCYTIC_2	377	380	PF00928	0.531
TRG_ENDOCYTIC_2	388	391	PF00928	0.450
TRG_ENDOCYTIC_2	669	672	PF00928	0.499
TRG_ENDOCYTIC_2	770	773	PF00928	0.652
TRG_ENDOCYTIC_2	834	837	PF00928	0.609
TRG_ER_diArg_1	731	733	PF00400	0.529
TRG_NES_CRM1_1	137	150	PF08389	0.469
TRG_NES_CRM1_1	320	336	PF08389	0.458
TRG_NES_CRM1_1	707	719	PF08389	0.443
TRG_NLS_MonoExtN_4	784	789	PF00514	0.552
TRG_Pf-PMV_PEXEL_1	556	561	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4W8	Leptomonas seymouri	43%	99%
A0A1X0PA03	Trypanosomatidae	28%	100%
A0A3R7K2U6	Trypanosoma rangeli	27%	100%
A0A3S5H7X7	Leishmania donovani	90%	100%
A4HB76	Leishmania braziliensis	74%	99%
A4IAC4	Leishmania infantum	91%	100%
C9ZLW8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9B5E7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BW70	Trypanosoma cruzi	27%	100%